Dream Global Partners (Dream Chain) announced on Sep 4th that it will launch a highly  reliable real estate blockchain platform for developers and final users. The blockchain  technology minimizes the possibility of malicious frauds or forged documents, because the ledger is store in a decentralized way and not concentrated in the availability of the parties involved. When this technology is applied to real estate transactions, sources of conflicts for pos...

On 19 March 2018, a draft Agreement on the withdrawal of the UK from the EU was published. The Agreement’s objective is to set out the arrangements for the withdrawal of the UK from the EU. Amongst these arrangements are the transitional provi...

Starting 13 December 2014, businesses will be required to comply with the great majority of the rules set forth in the EU’s Food Information Regulation (1169/2011). The Regulation went into force on 12 December 2011 but provided for a long, 3-...

Bhumi Pednekar believes female representation in cinema is extremely important to her

ISLAMABAD: The COVID-19 pandemic has created immediate challenges for institutions that serve affected communities, a study says.It was prepared by six academics associated with prestigious...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The COVID-19 pandemic has created immediate challenges for institutions that serve affected communities, a study says.It was prepared by six academics associated with prestigious...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ISLAMABAD: The COVID-19 pandemic has created immediate challenges for institutions that serve affected communities, a study says.It was prepared by six academics associated with prestigious...

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

ADB is formulating an aggressive set of actions to protect the poor, the vulnerable, and wider populations across Asia and the Pacific. And to ensure economies will rebound as swiftly as possible.

MCHP to Present at Credit Suisse Conference

Credit Suisse Conference Presentation

MCHP to Present at JP Morgan Conference

MCHP to Present at Goldman Conference

What is the difference between hearing and listening? One is passive, the other is active. One is automatic, the other is intentional. One we use every day, the other we may not have used in years. Listening is a veritable art form, and the...

Game theory helps calculate the probabilities of an outcome in adversarial situations, and we use several games as models – but now there’s one that can cover many situations

M&A in the pharma sector marches on unabated - AstraZeneca buying a 55 percent stake in biotech Acerta Pharma for $4.0 billion to give it new cancer drugs. Hayley Platt reports.

NCBI has developed a new web presentation style called PubReader, which offers you an easier way to use your Web browser to read the articles in PMC. Designed particularly for enhancing readability and navigation on tablet and other small screen devices, PubReader can also be used on desktops and laptops and from multiple web browsers. For more information on PubReader, see the article in the November-December issue of the NLM Technical Bulletin.

Background:

Historically, some chiropractors have been critical of vaccination, and this has been the subject of recent media attention in Canada. We explored the association between media attention and public dissemination of vaccination information on Canadian chiropractors’ websites.

Chromosomal resistance islands containing the methicillin resistance gene mecD (McRI_mecD) have been reported in Macrococcus caseolyticus. Here, we identified novel macrolide resistance genes in Macrococcus canis on similar elements, called McRI_msr. These elements were also integrated into the 3' end of the 30S ribosomal protein S9 gene (rpsI), delimited by characteristic attachment (att) sites, and carried a related site-specific integrase gene (int) at the 5' end. They carried novel macrolide resistance genes belonging to the msr family of ABC subfamily F (ABC-F)-type ribosomal protection protein [msr(F) and msr(H)] and the macrolide efflux mef family [mef(D)]. Highly related mef(D)-msr(F) fragments were found on diverse McRI_msr elements in M. canis, M. caseolyticus, and Staphylococcus aureus. Another McRI_msr-like element identified in an M. canis strain lacked the classical att site at the 3' end and carried the msr(H) gene but no neighboring mef gene. The expression of the novel resistance genes in S. aureus resulted in a low-to-moderate increase in the MIC of erythromycin but not streptogramin B. In the mef(D)-msr(F) operon, the msr(F) gene was shown to be the crucial determinant for macrolide resistance. The detection of circular forms of McRI_msr and the mef(D)-msr(F) fragment suggested mobility of both the island and the resistance gene subunit. The discovery of McRI_msr in different Macrococcus species and S. aureus indicates that these islands have a potential for dissemination of antibiotic resistance within the Staphylococcaceae family.

We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

SUMMARY:

Use of mechanical thrombectomy for stroke has increased since the publication of trials describing outcome improvement when used in the anterior circulation. These results, however, cannot be directly translated to the posterior circulation. While a high NIHSS score has demonstrated an association with poor outcomes in posterior stroke, the NIHSS is weighted toward hemispheric disease, and complex scores potentially delay definitive imaging diagnosis. We performed a retrospective analysis to ascertain whether any rapidly obtainable demographic or clinical and imaging data have a correlation with patient outcome postthrombectomy. Seventy-three cases were audited between September 2010 and October 2017. Presenting with a Glasgow Coma Scale score of >13 meant that the odds of reaching the primary end point of functional independence (defined as a 90-day modified Rankin Scale score of 0–2) were 5.70 times greater; similarly, presenting with a posterior circulation ASPECTS of >9 resulted in the odds of reaching the primary end point being 4.03 times greater. Older age correlated to a lower odds of independence (0.97, p = .04).

In Céline Sciamma’s Portrait of a Lady on Fire, we finally steer away from seeing intimacy through the male gaze

The portrayal of lesbians in mainstream cinema tends to involve prosthetic vaginas and gratuitous sex scenes; so Céline Sciamma’s Portrait of a Lady on Fire comes as a breath of fresh air. It is the story of the burgeoning relationship between two young women – emancipated artist Marianne (Noémie Merlant), who is commissioned to paint a portrait of sexually repressed Héloïse (Adèle Haenel), leading to a heated romance.

On paper, it looks like the classic lesbian cinematic narrative – there is a buildup of tension, they finally kiss, and then their possibility of a future together seems doomed. However, what makes Portrait of a Lady on Fire different is its heightened self-awareness. The film is constructed with lesbian representation in mind through careful interrogation of the lesbian gaze. There is a lot of looking. Marianne looks at Héloïse because she has to secretly paint her, and Héloïse looks at Marianne out of curiosity. Eventually, there is a shift in the way they start looking at each other – out of desire.

Funerals must be allowed to take place to enable families to mourn their loved ones, the Government has said.

A war veteran has touched hearts around the country after he was given a "precious" cushion featuring a picture of his late wife.

Countdown presenter Rachel Riley has won the first round of a High Court libel case against a former aide to Jeremy Corbyn.

Tara Reade, the woman who has accused US Democrat presidential candidate Joe Biden of assault, will be legally represented by a donor for President Donald Trump.

Grubman Shire Meiselas & Sacks, a large media and entertainment law firm, appears to have been the victim of a cyberattack that resulted in the theft of an enormous batch of private information on dozens of celebrities, according to a data security researcher. The trove of data allegedly stolen from the New York-based firm by […]

A St. John’s genetics specialist has found DNA connections that link the long-vanished Beothuk people to contemporary people, almost two centuries after the last known Beothuk died. 

Cosby's representative claims that the sex offender qualifies for early release due to his vulnerability to the illness

Wood was best known for her work on BBC's Watchdog

Jennifer Garner, Lil Nas X and Awkwafina will also give speeches

The message will feature in this evening's Big Night In on BBC One