Ganlu Deng, Yihong Chen, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Yaojie Fu, Changjing Cai, Hong Shen, and Shan Zeng

Epithelial-mesenchymal transition (EMT) is a crucial process for cancer cells to acquire metastatic potential, which primarily causes death in gastric cancer (GC) patients. Bone morphogenetic protein 4 (BMP4) is a member of the TGF-β family that plays an indispensable role in human cancers. However, little is known about its roles in GC metastasis. In this study, BMP4 was found to be frequently overexpressed in GC tissues and was correlated with patient's poor prognosis. BMP4 was upregulated in GC cell lines and promoted EMT and metastasis of GC cells both in vitro and in vivo, while knockdown of BMP4 significantly inhibited EMT and metastasis of GC cells. Meanwhile, the inhibitor of DNA binding 1 (Id1) was identified as a downstream target of BMP4 by PCR arrays and upregulated via Smad1/5/8 phosphorylation. Id1 knockdown attenuated BMP4-induced EMT and invasion in GC cells. Moreover, Id1 overexpression in BMP4 knockdown cells restored the promotion of EMT and cell invasion. In summary, BMP4 induced EMT to promote GC metastasis by upregulating Id1 expression. Antagonizing BMP4 may be a potential therapeutic strategy in GC metastasis.

Thomas O'Loughlin, Antonina J. Kruppa, Andre L. R. Ribeiro, James R. Edgar, Abdulaziz Ghannam, Andrew M. Smith, and Folma Buss

Optineurin (OPTN) is a multifunctional protein involved in autophagy, secretion as well as NF-B and IRF3 signalling and OPTN mutations are associated with several human diseases. Here we show that, in response to viral RNA, OPTN translocates to foci in the perinuclear region, where it negatively regulates NF-B and IRF3 signalling pathways and downstream pro-inflammatory cytokine secretion. These OPTN foci consist of a tight cluster of small membrane vesicles, which are positive for ATG9A. Disease mutations linked to POAG cause aberrant foci formation in the absence of stimuli, which correlates with the ability of OPTN to inhibit signalling. Using proximity labelling proteomics, we identify the LUBAC complex, CYLD and TBK1 as part of the OPTN interactome and show that these proteins are recruited to this OPTN-positive perinuclear compartment. Our work uncovers a crucial role for OPTN in dampening NF-B and IRF3 signalling through the sequestration of LUBAC and other positive regulators in this viral RNA-induced compartment leading to altered pro-inflammatory cytokine secretion.

Isabella Guardamagna, Elisabetta Bassi, Monica Savio, Paola Perucca, Ornella Cazzalini, Ennio Prosperi, and Lucia A. Stivala

Assessing DNA repair is an important endpoint to study the DNA damage response for investigating the biochemical mechanisms of this process and the efficacy of chemotherapy, which often uses DNA damaging compounds. Numerous in vitro methods to biochemically characterize DNA repair mechanisms have been developed so far. However, they show some limitations mainly due to the lack of chromatin organization. Here we describe a functional cell-free system to study DNA repair synthesis in vitro, using G1-phase nuclei isolated from human cells treated with different genotoxic agents. Upon incubation in the correspondent damage-activated cytosolic extracts, containing biotin-16-dUTP, nuclei are able to initiate DNA repair synthesis. The use of specific DNA synthesis inhibitors markedly decreased biotinylated dUTP incorporation, indicating the specificity of the repair response. Exogenously added human recombinant PCNA protein, but not the sensors of UV-DNA damage DDB2 or DDB1, stimulated UVC induced dUTP incorporation. In contrast, a DDB2^PCNA- mutant protein, unable to associate with PCNA, interfered with DNA repair synthesis. Given its responsiveness to different type of DNA lesions, this system offers an additional tool to study DNA repair mechanisms.

Mei Wang, Luping Yu, Shu Wang, Fan Yang, Min Wang, Lufan Li, and Xin Wu

RNA-binding protein LIN28A is required for maintaining tissue homeostasis, including the reproductive system, but the underlying mechanisms on how LIN28A regulates germline progenitors remain unclear. Here, we dissected LIN28A-binding targets using high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) in the mouse testes. LIN28A preferentially binds to CDS or 3'UTR regions through these sites with GGAG(A) sequences enriched within mRNAs. Further investigation of Lin28a null mouse testes indicated that meiosis-associated mRNAs mediated by LIN28A were differentially expressed. Next, ribosome profiling revealed that the mRNA levels of these targets were significantly reduced in polysome fractions, and their protein expression levels decreased in the Lin28a null mouse testes, even when meiotic arrest in null mouse testes was not apparent. Collectively, these findings provide a set of binding targets that are regulated by LIN28A, which may potentially be the mechanism for the prominent role of LIN28A in regulating mammalian undifferentiated spermatogonia fates and male fertility.

Stephen Kershaw, David J. Morgan, James Boyd, David G. Spiller, Gareth Kitchen, Egor Zindy, Mudassar Iqbal, Magnus Rattray, Chris M. Sanderson, Andrew Brass, Claus Jorgensen, Tracy Hussell, Laura C. Matthews, and David W. Ray

Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) to regulate immunity, energy metabolism, and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. We show GCs rapidly inhibit cell migration, in response to both GR agonist and antagonist ligand binding. The inhibitory effect on migration is prevented by GR knockdown with siRNA, confirming GR specificity, but not by actinomycin D treatment, suggesting a non-transcriptional mechanism. We identified a rapid onset increase in microtubule polymerisation following glucocorticoid treatment, identifying cytoskeletal stabilisation as the likely mechanism of action. HDAC6 overexpression, but not knockdown of αTAT1, rescued the GC effect, implicating HDAC6 as the GR effector. Consistent with this hypothesis, ligand-dependent cytoplasmic interaction between GR and HDAC6 was demonstrated by quantitative imaging. Taken together, we propose that activated GR inhibits HDAC6 function and thereby increases the stability of the microtubule network to reduce cell motility. We therefore report a novel, non-transcriptional mechanism whereby GCs impair cell motility through inhibition of HDAC6 and rapid reorganization of the cell architecture.

A novel approach for finding and evaluating structural models of small metallic nanoparticles is presented. Rather than fitting a single model with many degrees of freedom, libraries of clusters from multiple structural motifs are built algorithmically and individually refined against experimental pair distribution functions. Each cluster fit is highly constrained. The approach, called cluster-mining, returns all candidate structure models that are consistent with the data as measured by a goodness of fit. It is highly automated, easy to use, and yields models that are more physically realistic and result in better agreement to the data than models based on cubic close-packed crystallographic cores, often reported in the literature for metallic nanoparticles.

Keepers at the Smithsonian's National Zoo perform an artificial insemination procedure on a pair of Stanley Cranes. A Stanley Crane chick was successfully hatched on May 23, 2011.

The post Bird keepers at the National Zoo demonstrate the art of artificially inseminating Stanley cranes appeared first on Smithsonian Insider.

It takes a Tlingit artist up to 2,000 hours, or 83 days, to weave just one ceremonial robe. Not surprisingly, this art form is practiced by a dedicated few including Tlingit artists Teri Rofkar and Shelly Laws of Alaska. In their presentation for the Smithsonian Spotlight series hosted by the Arctic Studies Center at the Anchorage Museum, Rofkar and Laws discuss the methods and cultural significance of robes, spruce root baskets and more.
For more information, go to http://www.mnh.si.edu/arctic/html/alaska.htm

The post The artistry of Tlingit weaving is practiced by a dedicated few including artists Teri Rofkar and Shelly Laws of Alaska appeared first on Smithsonian Insider.

The post National Zoo gorillas participate in heart disease study appeared first on Smithsonian Insider.

In an excerpt from “60 Minutes” on Sunday, Nov. 1 2016, Scott Pelley follows National Museum of African American History and Culture director Lonnie Burch […]

The post Slave Ship Artifacts Recovered appeared first on Smithsonian Insider.

 Inspired by Steampunk design, Richard Wilks talks about his larger than life 3-point mobile contraption. Through the merging of transportation and art, he created […]

The post Artist Richard Wilkes on “Evotrope” appeared first on Smithsonian Insider.

The partial federal government shutdown is one week old, but economists are still saying that its impact in Southern California and elsewhere will be limited.

Susanne Whatley: Business analyst Mark Lacter, why is that?

Mark Lacter: If you look back on the history of these things, Susanne, you see that the disputes are resolved before too much damage gets done.  As for Southern California, I notice that KPCC's Alice Walton was asking around over the weekend about the shutdown, and most folks gave it a shrug.  The regional economy is just too diversified - and not especially tied to federal employment.  You have about 46,000 federal workers employed in L.A. County in one capacity or another - that's out of a workforce of nearly 5 million.  And, now it appears as if the federal employees who have been furloughed are going to receive their back wages whenever the shutdown finally ends.

Whatley: That still might make things dicey when it comes time to pay the monthly mortgage...

Lacter: ...but at least money will be available before most folks run into serious liquidity issues.  That's what the shutdown really comes down to - inconvenience rather than dislocation.  And, you see this with the various government services affected: the E-Verify website is down - that lets business owners know whether the people they're wanting to hire can work legally in the U.S., which obviously is important.  The Small Business Administration has stopped processing loan applications, and the Federal Housing Administration is reporting delays in its loan processing, which could mean a home buyer might not complete his or her paperwork all that quickly.

Whatley: But, what if this were to go on for months?

Lacter: Well, then it would create problems, but nobody really thinks that's going to happen.  The real issue, not just nationally and regionally - but globally - is the refusal by Congress to raise the debt ceiling.  The deadline is a week from Thursday, and - of course - there's been all sorts of debate about what this would mean for the economy.

Whatley: All right, so what would this mean for the economy?

Lacter: Well, no one knows exactly.  But, then again, no one knows exactly what would happen if you fell out of a airplane without a parachute.  I just wouldn't want to test it out.  And, of course, let's keep in mind that these are manufactured crises - not reflective of anything that's going on with the real economy.  It's certainly not reflective of anything that's going on in L.A., which saw a big jump in payroll jobs for 2012 - actually it was the sharpest increase since 2005, and nearly double the national rate (that's despite an unemployment rate that remains very high in certain parts of Los Angeles).

Whatley: What about some of the big locally based companies?

Lacter: Well, if your company is publicly traded, there's a good chance your shares took a dip these past few days.  Going back to September 18, the Dow has lost almost 700 points, which - percentage-wise - is not very much, but it is reflective of how uneasy Wall Street has become.  Public companies based in the L.A. area are taking it on the chin - Disney, Amgen, Mattel, DirecTV - their stock prices are all down going back to the middle of September.

Whatley: Even so, hasn't this been a good year for the stock market?

Lacter: It has - those local companies are up anywhere from 13 percent 30 percent year to date, and the Dow is up 14 percent year to date.  Of course, the stock price of a company doesn't always match the amount of money it makes, and this year, even before worries about the debt ceiling, the numbers haven't been as good as they should be at this stage of a recovery.  And, that's why there's particular concern about next week.  You do have to wonder whether a default could have ripple effects involving trade, consumer spending, the dollar - who knows what?  Now, it's still a pretty good bet that saner heads will prevail, although there are no guarantees - and again, if worse came to worse, do you really want to be jumping out of that plane?  Guess we'll find out.

Mark Lacter writes for Los Angeles Magazine and pens the business blog at LA Observed.com.

This content is from Southern California Public Radio. View the original story at SCPR.org.

This work presents a technique for extracting the detailed shape of peaks with extended, overlapping tails in an X-ray powder diffraction pattern. The application discussed here concerns crystallite size broadening, though the technique can be applied to spectra of any origin and without regard to how the profiles are to be subsequently analyzed. Historically, the extraction of profile shapes has been difficult due to the complexity of determining the background under the peak, resulting in an offset of the low-frequency components of the Fourier transform of the peak known as the `hook' problem. The use of a carefully considered statistical weighting function in a non-linear least-squares fit, followed by summing the residuals from such a fit with the fit itself, allows one to extract the full shape of an isolated peak, without contributions from either the background or adjacent peaks. The extracted shape, consisting of the fit function recombined with the residuals, is not dependent on any specific shape model. The application of this to analysis of microstructure is performed independently of global parametric models, which would reduce the number of refined parameters; therefore the technique requires high-quality data to produce results of interest. The effectiveness of the technique is demonstrated by extraction of Fourier transforms of peaks from two sets of size-broadened materials with two differing pieces of equipment.

A new report from the National Academies of Sciences, Engineering, and Medicine that examines the regulations governing federally funded research recommends that Congress authorize and the president appoint an independent national commission to examine and update the ethical, legal, and institutional frameworks governing research involving human subjects.

The National Academies Committee on Genetically Engineered Crops - Past Experiences and Future Prospects authored an almost 600-page landmark report, released in May 2016. It was perhaps the most comprehensive analysis of genetically engineered crops to date.

Assistive products and technologies – such as wheelchairs, upper-limb prostheses, and hearing and speech devices – hold promise for partially or fully mitigating the effects of impairments and enabling people with disabilities to work, but in some cases environmental and personal factors create additional barriers to employment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

When conducting research involving the testing of human biospecimens, investigators and their institutions should routinely consider whether and how to return individual research results on a study-specific basis through an informed decision-making process, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Today the national science academies of the G-7 countries issued three joint statements to their respective governments, to inform discussions during the G-7 summit to be held in August in France, as well as to inform ongoing policymaking.

The U.S. National Academies recognize the significance of the opioid crisis and have been at the forefront of efforts to advise our nation on how to combat it.

On Feb. 26 the National Academies convened leaders from Congress, federal agencies, universities, and industry to explore how to structure science for the next 75 years to respond to the nation’s emerging needs and future challenges.

We started our new schedule for "AirTalk" this week. With the expansion of "Brand & Martinez" to two hours, we're now on from 11 a.m. to 1 p.m. Friday's Film Week on AirTalk moves into the noon hour.

I’ve been asked many times in the past couple of days how I feel about the shift. My answer is that it’s working out great for our “AirTalk” team.  We still get in at 8 each morning, but now have three hours to prepare our timeliest topics. It also puts us into the noon hour, where we have the chance to connect with folks heading to lunch. 

I know it’s not all good for some listeners, who might have a harder time listening an hour later. There are also, undoubtedly, fans of “The World” who would’ve rather had it stay at noon instead of moving to 2 p.m. I hope you’ll give us a chance in the new slot and that you find the new lineup still fits your schedule. 

If it doesn’t, remember that you can hear all of our local programs online, at the time of your choosing, at www.kpcc.org.

As for the irreplaceable Patt Morrison, she’ll continue to provide her talents to KPCC listeners with regular features and interviews throughout our day. Though I know many fans of Patt are very sad to see her daily program end, I think Patt’s high-profile segments will be a terrific boost to all the other shows where they’ll be heard.

This will make Patt a presence everywhere on our schedule, including “AirTalk,” which is pretty exciting.

This content is from Southern California Public Radio. View the original story at SCPR.org.

US President Barack Obama and Republican Presidential nominee Mitt Romney debate on October 16, 2012 at Hofstra University in Hempstead, New York. Undecided voters asked questions during a town hall format.; Credit: STAN HONDA/AFP/Getty Images

There continue to be questions about how moderators approach Presidential debates and about whether the extra time President Obama has received in the first two debates indicates moderator bias in his favor. 

I had chalked up the concerns to Republican hyper-partisanship, such as we saw with many Democrats criticizing Jim Lehrer for his moderating — as though Obama would’ve won the first debate if only Lehrer had asserted himself more.   However, even CNN has been doing significant follow-up on its own Candy Crowley’s performance in debate number two. 

Maybe it’s not just hardcore GOP loyalists who are questioning Crowley’s decision-making on when to cut in and when to allow the candidates to take more time. I thought she did pretty well, but there are plenty of critics.

As someone who has moderated hundreds of debates, I thought I’d share my thoughts on what we’ve seen so far in this election. Though I’ve never moderated a Presidential debate, with its incredible level of attention, concern about rules, and demands by campaigns, there are certain fundamentals regardless of the office or issue at stake.

Time Doesn't Matter...Too Much
First, as strange as this may sound, the time taken by each candidate has little to do with who has an advantage.   Yes, it’s always possible for a candidate to use another minute to fire off the defining line of the night. However, the well-practiced zingers or essential policy explainers are not left to the end of a candidate’s statement, as the clock is running out. 

I’m sure Mitt Romney wasn’t thinking after the last debate, “If only I would’ve had that extra 90-seconds, and Obama hadn’t gotten 90 more than he deserved.”  Both men front-loaded their major talking points and were going to get them in. Neither man could legitimately say he didn’t have a chance to make his strongest points. At some point, a time advantage could make a difference in who wins or loses, but an extra 90-seconds in a debate longer than 90-minutes isn’t going to do it.

Serving The Audience
As a moderator, you also have to think about what best serves your audience. I never guarantee candidates equal time, as it’s my job to serve the listeners, not their campaigns. I strive to get close to equal time, but can’t make any guarantee. Some speakers get to the point succinctly and have their points well put together. Others are messier in their arguments and eat up time just building up any head of steam. 

If the moderator holds to a strict time limit, you run the risk of frustrating listeners by cutting off the rambler just as the candidate is getting to the point. There are methods a moderator can use to help guide the speaker toward being more succinct, but there’s no guarantee the person will be able to comply.

Isn’t this inherently unfair to the succinct speaker? No. The purpose of the debate is to allow the ideas to compete.  It’s not a boxing match that’s about landing punches in a given time. The succinct debater has a big advantage, regardless of how much time the candidate has. That’s why Mitt Romney’s victory in the first debate was so lopsided — he won on the conciseness and clarity of his answers, coupled with Obama’s inability to get to his central points.  Obviously, there are those who thought Obama’s arguments were still more compelling than Romney’s, and that Romney lacked essential details.  However, for most viewers of the first debate, it was stylistically no contest.

Equal Time Is Not A Guarantee
When candidates are allowed to talk to each other directly, it’s very difficult to assure equal time. Even CNN’s clock that registers elapsed time for each candidate is subject to squishiness. Unless a debate is extremely formal, with carefully controlled time limits and a ban on candidates following-up with each other, you’re only going to have an approximation of time balance. I thought Crowley did pretty well to land the second debate with the balance she did. I’m not sure I could get it that close for a debate of that length. She had the added challenge of trying to determine when to cut in on President Obama’s lengthier answers. Also, Romney’s speaking rhythm allows more space for interruption. It’s tougher to break in on Obama.

Moderating Is A Balancing Act
Moderators are always trying to balance a need to move on to the next topic with allowing a candidate to answer an opponent’s charge. Sometimes, you open that door for a candidate, only to regret it later when the politician starts into a monologue, instead of confining the response to the previous challenge. Sometimes moderators, having gotten burned, will become less tolerant of such expansive rebuttals, as the debate goes on. Moderators are always juggling competing goals, and it’s a difficult job (at least for me).

Unfortunately, there are those who think debate moderators attempt to influence the outcome of the debate and the performances of the candidates. Maybe I’m naïve, but I can’t imagine any journalist who’s worked hard enough to get to the position of Presidential debate moderator subordinating his or her career in an effort to getting someone elected. Mainstream political journalism is like national sports reporting. You really don’t care who wins the Super Bowl, you want great story lines to explore with your audience. Yes, sports reporters have affinities for the hometown teams of their youth, but that can’t compete with the professional goal of covering great stories. 

Yes, most journalists in mainstream media probably have a stronger cultural and political affinity for Obama, as he’s more like them. However, it doesn’t mean a journalist is going to sacrifice the better story to intentionally provide a benefit to the President.

This content is from Southern California Public Radio. View the original story at SCPR.org.

The Getty spent $65m (and change) for this late Manet masterpiece, "Spring."

A  132-year-old vision of springtime has landed permanently at the Getty Museum, smack in the middle of this California autumn: "Spring (Jeanne Demarsy)," one of Impressionist painter Edouard Manet’s  last completed pictures.

Here's what Getty Director Timothy Potts had to say about the artist:

Manet was the ultimate painter’s painter: totally committed to his craft, solidly grounded in the history of painting and yet determined to carve out a new path for himself and for modern art. ... Alone of his contemporaries (the only one who comes near is Degas), Manet achieved this almost impossible balancing act, absorbing and channeling the achievements of the past into a radically new vision of what painting could be.

"Spring" somehow manages to be the evocation of youth itself and all its hopes. The subject is 16-year-old actress Jeanne Demarsy, just then seeing her stage career ascend at the same time Manet neared the end of his own career. (He died at age 51 in 1883,  soon after the painting went on display.) 

For most of the years since its creation, the picture has been in private hands. It was recently on loan to the National Gallery.

Getty Assistant Curator Scott Allan said that the Getty worked hard to acquire "Spring" and was lucky to get her. According to news reports, the Christie's auction price paid was an eyebrow-lifting $65 million — about double the top previous sale price for a Manet. "We don’t discuss the price," Potts said.

At the Getty, "Spring (Jeanne Demarsy)" hangs next to an early Manet in the museum's Impressionist-Post Impressionist gallery. It was intended to be one of the "Four Seasons" by the late-19th century French master. The series was never completed (although "Autumn" hangs in a museum in France).

(More seasoning: Manet's "Autumn." Museum of Fine Arts of Nancy, France)

Allan said that, unlike many of Manet's early works, "Spring" was intended to hang in the Salon, the French art establishment’s showplace of traditional painting, which had rejected innovators like the Impressionists for decades. That led most of the Impressionists to disdain the Salon. But Allan said Manet was extremely pleased that his late work was accepted there. 

Here's Potts again:

So popular was it that "Spring" became the subject of one of the first color photographs of a work of art. Its acquisition by the Getty brings to Los Angeles the most important — and beautiful! — painting by this artist left in private hands and one of the great masterpieces of late-19th-century art. 

The painting depicts a lovely teenager, dressed in the peak of 1880s fashion in a blue-on-white printed dress; a flowered, fringed hat; and a parasol balanced on her left shoulder. The background features white rhododendrons, barely in blossom.

Mlle. Demarsy stares off to the left, the demure image of a confident young woman at the earliest spring of her adulthood, with an entire creative life before her, already immortalized before the world by one of the century’s greatest artists.

But Manet was himself at the peak of his accomplishments,  just before his sudden demise.
 
"Spring" became one of Manet’s most popular works, deeply appreciated by art lovers young and old and by critics of both the old guard and the avant garde. It was his last picture to hang in the Salon. Manet’s powers would soon decline, and he devoted much of his last few months to watercolors, said Allan.

(Getty director Timothy Potts looks at the Getty's new painting, Manet's "Spring." Getty Museum)

This content is from Southern California Public Radio. View the original story at SCPR.org.

Home State restaurant sells groceries to stay afloat in reaction to the coronavirus on April 16, 2020 in Los Angeles, California. ; Credit: Amy Sussman/Getty Images

This Friday, California will take the first steps toward easing its statewide stay-at-home order.

In Stage 2 of Newsom’s reopening plan, lower risk workplaces like schools, childcare facilities, retail businesses (curbside pickup) and offices where working remotely is not possible will be allowed to reopen. For counties and cities, the reopening will be slightly adjusted according to regional demands. Los Angeles Mayor Eric Garcetti has announced that some low risk businesses will be allowed to reopen this Friday, as will city-owned hiking trails and golf courses (excluding Runyon Canyon). In Orange County, many beaches have already been reopened. The county has also seen some businesses open up in defiance of Governor Newsom’s stay-at-home order.

Today, California restaurants are submitting a plan to Governor Newsom to reopen sit-down service with safeguards.Under these guidelines, only family members or people who live together would sit at the same table. Buffets, salad bars and shared bread baskets would be out. Salt and pepper shakers could be replaced by bottles of hand sanitizer. And meals could arrive from food servers sheathed in face masks.

What will the partial reopening look like in Southern California? And how will reopening progress in the weeks ahead? We speak with an epidemiologist, restaurant industry advocate, barber and hair salon advocate and economics commentator to learn more.

With files from the Associated Press

Guests:

Richard Jackson, M.D., pediatrician, epidemiologist and professor emeritus at the UCLA Fielding School of Public Health, he’s served in many leadership positions with the California Health Department, including as the State Health Officer, for nine years he served as director of the CDC’s National Center for Environmental Health

Jot Condie, president & CEO of the California Restaurant Association, an advocacy organization for the restaurant industry that has submitted an reopening plan for the restaurant industry today to Governor Gavin Newsom

Ted D. Nelson, president and CEO of the Professional Beauty Federation of California, which represents barbers and salon professionals; the organization says it will sue California Governor Gavin Newsom this week over the statewide stay-at-home order

Greg Ip, chief economics commentator for the The Wall Street Journal; he tweets @greg_ip

This content is from Southern California Public Radio. View the original story at SCPR.org.

; Credit: Patrick Semansky/AP

The U.S. Supreme Court has once again punted on the question of gun rights, throwing out as moot a challenge to New York City's strict gun regulations on transporting licensed guns outside the home.

New York City, in the name of public safety, has very strict gun regulations. It allows people to have a permit for guns in their homes, but those regulations originally barred people from transporting their guns anywhere except shooting ranges within the city. The New York State Rifle & Pistol Association challenged the regulation as a violation of the Second Amendment right to bear arms and lost in the lower courts.

But, after the Supreme Court agreed to review the case, New York state and New York City changed their laws to allow gun owners to transport their guns outside the city to shooting ranges, to competitions, and to second homes. That gave the challengers exactly what they asked for in their lawsuit, and so on Monday, the court, by a 6-to-3 vote, dismissed the case as moot--in short, it no longer presented a live controversy.

The unsigned opinion was joined by Chief Justice John Roberts, the court's four liberals, and Trump appointee Brett Kavanaugh.

But Kavanaugh wrote separately to stress that while he agreed with the majority on procedural grounds, he agreed with the dissenters--Justices Samuel Alito, Clarence Thomas, and Neil Gorsuch--on one key issue.

Those three said that the lower courts were using the wrong test to evaluate gun laws, a test that is far too deferential to gun regulators. The dissenters mainly argued however, that the court essentially had been gamed on the mootness question, and that the justices should have decided the case, and decided it for the gun owners.

Gun-safety advocates breathed a sigh of relief that there was no decision adverse to gun regulations. But they worry that gains they are making in some state legislatures may be taken away by a conservative court majority.

"The reality is that the gun-safety movement is winning in state houses and at the ballot box, so the NRA is turning to the court to try to change the tide," says Eric Tirschwell, managing mirector of Everytown for Gun Safety.

Monday's decision was the first in a major gun case in 10 years, the first since a landmark set of decisions in 2008 and 2010. In those cases, a sharply divided court ruled that the Second Amendment right to bear arms is an individual right, not a right associated with the militia, as the court had previously implied. Those decisions marked a huge victory for the NRA and other gun-rights organizations.

In the decade following that decision, however, the court did not agree to hear any of the dozens of challenges to gun restrictions in cases appealed to the court. In part because the composition of the court made outcomes uncertain.

The previous big gun cases were decided by 5-to-4 votes, with Justice Anthony Kennedy casting the fifth and decisive vote. Kennedy, according to court sources, insisted, as the price of his vote, on adding limiting language that likely would have resulted in some, maybe even most, gun restrictions being upheld. With neither side of the court sure how Kennedy would vote on most regulations, neither the pro-gun, nor the pro-gun-control side wanted to risk an adverse ruling.

That changed when Kennedy retired in 2018 to be replaced by Justice Kavanaugh, who has a much more gun-friendly record than Kennedy did.

Nothing Kavanaugh said in his concurring opinion Monday would dissuade anyone from thinking he has changed his mind.

Bottom line here is that when it comes to gun control, there look to be four pretty solid votes against a lot of the measures enacted in recent years after mass shootings. Specifically, laws that bar carrying weapons in public places, and bans on assault weapons and large ammo magazines. All these, plus so called red-flag laws and other measures could be in jeopardy.

The question is where Chief Justice Roberts will be on these and other gun-control questions. To date, he has never been much of a supporter of gun-control laws, but he hasn't been an outspoken opponent, either. All we really know is that he was part of the 2008 and 2010 majority that for the first time declared that the Second Amendment is an individual right, not, as the court had previously implied, a collective right that was attached to the colonial militia.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Today’s post is by Owen Paul, who is a Student Ambassador Technical Program Specialis. He himself was a student ambassador before joining MathWorks, and he was featured in the Community... read more >>

The scam machine shows no signs of slowing down, as fraudsters dispense bogus health advice, peddle fake testing kits and issue malware-laced purchase orders

The post Coronavirus con artists continue to spread infections of their own appeared first on WeLiveSecurity

Fragments of crushed rock released into the ocean during oil and gas exploration can physically bury organisms that live on the seafloor, accounting for 55% of offshore drilling???s environmental impact, according to a recent study. To allow more informed marine policy decisions, this physical impact must be recognised alongside the impact of chemicals released in drilling waste.

Researchers have discovered high levels of plastic particles and fibres, as well as black carbon (BC), which is formed by the incomplete burning of fossil fuels, in the waters of the Jade Bay, an inshore basin off the coast of Germany in the Southern North Sea. The concentration of suspended particles are of concern because they have the potential to be ingested by fish and other marine life, and enter the food chain.

Public participation in developing coastal management plans can have numerous benefits, such as augmenting expert information with local knowledge and building trust, a new study has confirmed; however, challenges remain, say the researchers. They use the experiences of 10 case studies to make a series of recommendations regarding how to improve the efficiency of the process.

A team of psychologists, kinesiologists and archaeologists at Indiana University and elsewhere are throwing new light on a longstanding archaeological mystery: the purpose of a large number of spherical stone artifacts found at a major archaeological site in South Africa.

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Acute exacerbations of chronic obstructive pulmonary disease, or COPD, are associated with significant long-term lung function loss, according to research published online, ahead of print in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

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Crop rotation is gaining increasing research- and policy attention as an environmentally friendly way to manage weeds. In such rotations, crops are introduced that release chemicals into the environment known to inhibit weed germination or growth (so-called allelopathic crops). Previous studies have identified Cynara cardunculus L., a perennial thistle, including varieties of globe artichoke and cardoon, as a potential allelopathic candidate. This study conducted field experiments using three botanical varieties of C. cardunculus to evaluate their effect on weeds within an ecosystem. The results confirm that C. cardunculus has an allelopathic effect in monoculture, reducing the amount of weed seeds present in soil. This paves the way for its inclusion in crop rotation as part of eco-friendly, sustainable weed-management strategies.

Monitoring the effects of chemicals in the human body provides useful data for assessing and managing environmental risks to health, but it also raises ethical questions about how the results of such studies should be reported to participants. New research suggests that changes are needed to the research process to allow study participants to play a greater role in interpreting, disseminating and using the results.

The presence of plastics in aquatic environments is a growing concern across the EU. This study explored the amount of microplastic particles present in raw and treated water at three water-treatment plants in the Czech Republic. While treated water contained fewer particles than raw1 fresh water, the amount found in treated water was not negligible, and largely comprised tiny particles of <10 micrometres (μm) in diameter. Ways to filter microplastics from potable water must be identified and their risk to humans, sources and routes into drinking water determined, say the researchers.

Recent research from China suggests that partially converting both natural gas and coal into 'syngas' fuel for power generation can generate around 6 per cent more electricity than competing 'conventional' gasification methods. The savings arise from more efficient use of the chemical energy in gas and coal which is lost in a conventional burner.

A participatory approach to waste management has been tested in Naples, Italy, a city which has experienced ongoing problems with the collection of municipal waste. This study tested a toolkit, which uses stakeholder engagement to improve waste-management decision-making. Residents and other stakeholders supported the use of a technological innovation to develop biomass fuel from municipal waste.

Desktop three-dimensional (3D) printers, available for use in offices and homes, can release between 20 and 200 billion ultra-fine particles (UFPs) per minute, finds new research. UFPs may pose a risk to health, and the study’s authors recommend caution when operating 3D printers inside unventilated or unfiltered indoor environments.

Some of the mysterious grooves on the surface of Mars' moon Phobos are the result of debris ejected by impacts eventually falling back onto the surface to form linear chains of craters, according to a new study.

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