The serious inflammatory syndrome sending some children and teens to the hospital remains extremely uncommon, doctors say. But if your child spikes a high, persistent fever, and has severe abdominal pain and vomiting that doesn't make them feel better, call your doctor as a precaution.; Credit: Sally Anscombe/Getty Images

Sixty-four children and teens in New York State are suspected of having a mysterious inflammatory syndrome that is believed to be linked to COVID-19, the New York Department of Health said in an alert issued Wednesday. A growing number of similar cases — including at least one death — have been reported in other parts of the U.S. and Europe, though the phenomenon is still not well-understood.

Pediatricians say parents should not panic; the condition remains extremely rare. But researchers also are taking a close look at this emerging syndrome, and say parents should be on the lookout for symptoms in their kids that might warrant a quick call to the doctor — a persistent high fever over several days and significant abdominal pains with repeated vomiting, after which the child does not feel better.

"If [the child is] looking particularly ill, you should definitely call the doctor," says Dr. Sean O'Leary, a pediatric infectious disease specialist at Children's Hospital Colorado Anschutz Medical Campus and member of the infectious disease committee for the American Academy of Pediatrics.

The new condition associated with COVID-19 is called Pediatric Multi-System Inflammatory Syndrome. Symptoms include persistent fever, extreme inflammation, and evidence of one or more organs that are not functioning properly, says cardiologist Jane Newburger, a professor of pediatrics at Harvard Medical School and director of the Kawasaki Program at Boston Children's Hospital.

"It's still very rare, but there's been a wave of cases. Physicians and scientists are working hard to understanding the mechanisms at play, and why only some children are so severely affected," Newburger says.

Some symptoms can resemble features of Kawasaki Disease Shock Syndrome. Kawasaki Disease is an acute illness in children involving fever, together with symptoms of rash, conjunctivitis, redness in the lips, tongue and mucous membranes of the mouth and throat, swollen hands and/or feet, and sometimes a large group of lymph nodes on one side of the neck, says Newburger. Some children with the condition develop enlargement of the coronary arteries and aneurysms in those blood vessels.

A small percentage of Kawasaki cases go on to develop symptoms of shock – which can include a steep drop in systolic blood pressure and difficulty with sufficient blood supply to the body's organs. Kawasaki disease and KDSS more often affect young children, although they can sometimes affect teens, Newburger says.

Some cases of the new inflammatory syndrome have features that overlap with KD or with KDSS — including rash, conjunctivitis, and swollen hands or feet. The new inflammatory syndrome can affect not only young children but also older children and teens.

But patients with the new syndrome have lab results that look very different, in particular, "cardiac inflammation to a greater degree than we typically see in Kawasaki shock syndrome," which is usually very rare, O'Leary says. In New York City and London, which have seen large numbers of cases of COVID-19 cases, "those types of patients are being seen with greater frequency."

Some patients "come in very, very sick," with low blood pressure and high fever, O'Leary says. Some children have had coronary artery aneurysms, though most have not, he adds.

Other patients exhibit symptoms more similar to toxic shock syndrome, with abdominal pain, vomiting and diarrhea and high levels of inflammation in the body, as well as the heart, O'Leary says. Most cases are treated in the intensive care unit, he says. Treatment includes intravenous immunoglobulin, which can "calm the immune system," says Newburger, as well as steroids and cytokine blockers.

The evidence so far from Europe, where reports of the syndrome first emerged, suggests most children will recover with proper supportive care, says O'Leary, though one adolescent, a 14-year-old boy in London, has died, according to a report published Wednesday in The Lancet.

Most children with the syndrome, O'Leary and Newburger note, have either tested positive for a current infection with the coronavirus, or for antibodies to the virus, which would suggest they were infected earlier and recovered from it.

And, according to case reports, some of the kids with the inflammatory syndrome who tested negative on coronavirus tests had been exposed at some point to someone known to have COVID-19. The inflammatory syndrome can appear days to weeks after COVID-19 illness, doctors say, suggesting the syndrome arises out of the immune system's response to the virus.

"One theory is that as one begins to make antibodies to SARS-COV-2, the antibody itself may be provoking an immune response," says Newburger. "This is only happening in susceptible individuals whose immune systems are built in a particular way. It doesn't happen in everybody. It's still a really uncommon event in children."

In late April, the U.K.'s National Health Service issued an alert to pediatricians about the syndrome. Reports have also surfaced in France, Spain and Italy, and probably number in the dozens globally, Newburger and O'Leary say, though doctors still don't have hard numbers. Newburger says there needs to be a registry where doctors can report cases "so we can begin to generate some statistics."

"Doctors across countries are talking to each other, but we need for there to be some structure and some science so that everybody can interpret," she says.

Earlier this week, the New York City Health Department issued an alert saying 15 children ranging in age from 2 to 15 had been hospitalized with the syndrome. Newburger says that she's been contacted about cases in New Jersey and Philadelphia, as well.

While the syndrome's precise connection to the coronavirus isn't yet clear, O'Leary says the fact that the children in most of these cases are testing positive for exposure to the virus, one way or another, provides one point of evidence. The sheer number of cases — small in absolute terms, but still "much higher than we would expect normally for things like severe Kawasaki or toxic shock syndrome" — provides another, he says.

And then there's the fact that most reports of the syndrome have come out of the U.K. and New York City, places that have been hit with large numbers of COVID-19 cases.

"It's pure speculation at this point," he says, "but the U.K. cluster kind of went up about a month after their COVID-19 infections went up, which would suggest that it is some kind of an immune phenomenon."

This content is from Southern California Public Radio. View the original story at SCPR.org.

Patt Morrison and Stephen Hawking at Cal-Tech. ; Credit: Dave Coelho/KPCC

The renowned physicist, cosmologist and lover of Indian food is at Caltech for his annual dinner and lecture visit. I broke naan across from him Thursday at dinner, which was cooked by a class of adept Caltech students.

I had a short interview with him, and with the student-chefs, which will be airing on “Off-Ramp” soon. As we took the photograph, I had just made a little joke, which accounts for his smile [producer Dave Coelho didn’t get a smile, but maybe he’s not as funny nor as glamorous as I am].  

This content is from Southern California Public Radio. View the original story at SCPR.org.

Circus of Books storefront.; Credit: Netflix/Circus Of Books (2020)

Rachel Mason had, to a certain extent, the normal upbringing you’d imagine a family of five with small business owner parents would have. But in her documentary, ‘Circus of Books’, she pulls the curtain on the double-life her parents led as modest business owners and pillars of the LGBTQ community.

Karen and Barry Mason established West Hollywood’s Circus of Books on Santa Monica Boulevard in the 1980s. What seemed like an unassuming bookstore was actually a gay porn shop that became an institution in the LGBTQ community during a time when homosexuality was still largely unaccepted. The store was far from being a “bookstore with a circus theme”. The Los Angeles-based shop was the central hub for gay pornography around the country, once one of the main distributors for adult films. 

While the store was becoming a home for gay culture and pride, the Masons largely kept their business a secret from colleagues, friends, family, even their own children. It’s a central conflict that Rachel Mason explores throughout the film as the daughter of two shop owners caught between the pressures of maintaining a traditional family image and making a living as gay pornography distributors.

Today on FilmWeek, we’re joined by ‘Circus of Books’ director Rachel Mason for a conversation on her documentary and the experience of creating a film with her parents and their secret as the subject.

‘Circus Of Books’ is currently streaming on Netflix. For more on the film from LAist’s Mike Roe, click here.

Guest:

Rachel Mason, director of the Netflix documentary ‘Circus of Books’ and daughter of Circus of Books owners Karen and Barry Mason; she tweets @RachelMasonArt

This content is from Southern California Public Radio. View the original story at SCPR.org.

World War II veterans Pyotr Vorobyev (left), 90, and Pavel Yeroshenko, 94, attend a performance in Minsk by the 120th Rogachev Guards Mechanized Brigade of the Belarusian Armed Forces ahead of the 75th anniversary of the victory in World War II. Belarus is raising eyebrows — and concerns — by going ahead with a mass military parade marking the anniversary on Saturday.; Credit: Natalia Fedosenko/TASS

With the coronavirus forcing much of Europe to tone down public celebrations this week marking the 75th anniversary of the end of World War II, the small nation of Belarus is raising eyebrows — and concerns — by going ahead with a mass military parade in the capital Minsk on Saturday.

The move reflects the business-as-usual approach of the country's longtime president, Alexander Lukashenko — a former Soviet collective farm director leading what the U.S. once dubbed the last dictatorship in Europe.

As the coronavirus has raced across the globe, Lukashenko has dismissed the pandemic as mass "psychosis" — a disease easily cured with a bit of vodka, a hot sauna or time spent playing hockey or doing farm work on one of country's legendary Soviet-designed tractors.

The country's soccer league still competes. Belarus' schools opened after a short delay. And annual Victory Day celebrations will go on.

The government "simply cannot cancel the parade," the Belarusian leader said in a Cabinet meeting this week. "It's an emotional, deeply ideological event."

In a rare concession to at least some social distancing measures, Lukashenko has urged Belarusian men to spend time with their families, rather than their mistresses. But behind the theatrics sits a wily politician who plays to his base in the country's towns and villages, analysts say.

"Lukashenko prioritizes combating panic rather than combating the pandemic," Artyom Shraibman, a Minsk-based political analyst with Sense Analytics, tells NPR. "He downplays the threat, and of course he's very concerned about [the] state of [the] economy."

Shraibman notes similar echoes coming out of the Trump White House.

Belarus has reported over 21,000 suspected coronavirus cases and more than 120 deaths — comparatively low in the global count, but one of the fastest-growing infection rates in Europe, the World Health Organization says.

Amid the growing crisis, Belarusian civil society is rallying to fix what Lukashenko will not. With many Belarusians now self-isolating by choice, even the country's health ministry has endorsed some public distancing measures over Lukashenko's advice.

Volunteers have raised money to buy personal protective gear for hospitals. Restaurants have donated food. Hotels provide rooms pro bono to medical workers. Private businesses have raised funds.

"People who normally don't talk to each other are working together to help," says Andrej Stryzhak of #ByCovid19, a group of volunteer activists leading crowdfunded efforts to equip health workers across the country. "It's been magical and I don't use that word lightly."

Stryzhak says many are bracing for the aftershocks of Saturday's Victory parade, where attendance isn't required but there are reports of pay bonuses given to those who show up.

"We believe in statistics. And the experts and doctors tell us that if there's a crowd, then expect a new spike in cases a week or two later," says Stryzhak. "Belarus isn't Mars," he adds, noting that the country is as susceptible to the virus as any other.

Meanwhile, Lukashenko's contrarian approach has also fueled a rift with Belarus' big brother to the east. Russia has embraced lockdowns amid its own soaring coronavirus infection rates.

This week, the Belarusian leader ordered the expulsion of a journalist from Russia's Channel 1 state television network after it aired a report criticizing Lukashenko for risking lives and ignoring the pandemic.

"Leave us alone and don't count your chickens before they hatch," said Lukashenko. "Later we'll sit and find out who was right."

This content is from Southern California Public Radio. View the original story at SCPR.org.

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

A cache of exquisitely preserved bones, found in a coal mine in the state of Gujarat, India, appear to be the most primitive primate bones yet discovered, according to an analysis led by researchers from The Johns Hopkins University and Des Moines University. Their assessment of the bones, belonging to ancient, rat-sized, tree-dwelling primates, bolsters the controversial idea that primates native to what is now India played an important role in the very early evolution of primates, mammals that include humans, apes and monkeys.

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The factors enabling eco-innovation have been analysed across 19 European countries in a new study. Regulations and environmental subsidies were found to be more important factors in Eastern Europe than in wealthier Western European countries. External research and development (R&D) was also more relevant in Eastern Europe, demonstrating the need for specific technology transfers from other countries and competitors.

A new study has investigated the possibility of a regional industrial symbiosis of metal industries across the Sweden-Finland border. The analysis suggests that it is technologically feasible, but that regulatory support may be inefficient, particularly with respect to changing the status of a waste product to a by-product.

Constructed wetlands can effectively remove veterinary drugs from wastewater, preventing contamination of the environment, research suggests. A recent study has demonstrated that laboratory-scale constructed wetlands were able to remove between 94 and 98% of two commonly used antibiotics from pig farm wastewater.

Khudoleĭ, K. M

Ireland’s Environmental Protection Agency (EPA) established the Network for Ireland’s Environmental Compliance and Enforcement (NIECE) over 10 years ago to ensure an effective, integrated, national approach to the enforcement of environmental legislation, as presented in a recent conference paper and a report from the EPA.

Policymakers often have to make decisions under great complexity, uncertainty and time pressure. A new study presents a support tool for the first stage of policymaking: identifying and exploring alternatives to solve problems. The software tool, called QUICKScan, increases the speed of this process and combines the input of many stakeholders in participatory workshops. It has been applied 70 times in 20 different countries, for a wide range of environmental policy issues.

Public participation is an essential part of integrated water management. In a recent study, researchers following the development of a UK catchment management plan found greater cooperation between land managers and environmental regulatory bodies as a result of a participatory process.

New research suggests that many Ruffs are changing their migratory route when flying north to their breeding grounds in northern Europe and to Asia from Africa. This is because their food supply has been reduced by the effects of intensive agriculture in the Netherlands, where they commonly stop off, causing them to shift eastwards to stopping-off points in Eastern Europe instead.

Conserving West African coastal waters is also important for conserving European seabirds, suggests new research. The study shows that both adult and juvenile northern gannets and Scopoli’s shearwaters migrate to coastal waters of West Africa for winter. However, they are at risk of death from unsustainable and illegal fishing activities in this region.

There are differences in the assessment and restriction of chemicals exempt from the EU’s regulatory instrument REACH. A new study has analysed the differences between several regulatory frameworks that govern these chemicals and recommended greater harmonisation in assessment criteria and regulatory follow-up.

Two chemicals used as co-formulants in pesticides have been found to reduce the predatory behaviour of the wolf spider Pardosa agrestis, an insect predator found within agricultural landscapes. A third co-formulant was found not to affect the predatory behaviour of females and increased the prey behaviour of male spiders. This is the first time that pesticide additives have been shown to alter the predatory activity of a potential biological control agent of crop pests.

According to most EU legislation, regulatory assessment of chemicals should make use of all available and relevant studies. However, in practice, assessments tend to be predominantly based on research sponsored and provided by industry as part of their legal obligations to show safety of their products, rather than on independent peer-reviewed findings. To bridge this science–policy gap, a team of Swedish researchers, in combination with regulators at three Swedish governmental agencies, have published a list of recommendations aimed at increasing the regulatory usability and impact of academic research. This advice is aimed at researchers, for whom it clarifies relevant regulatory data requirements and quality criteria. However, it is also relevant to policymakers, in that it highlights the advantages and availability of relevant, reliable peer-reviewed research for use in the regulatory assessment of chemicals. The study’s recommendations contribute to the formulation of more science-based, sustainable policies.

Evidence from modelling studies suggests that climate change is likely to increase concentrations of ozone, one of the most important urban air pollutants responsible for respiratory problems. Under this assumption, rapid reductions of emissions from fossil fuel burning are needed to protect the health of both current and future generations.

Levels of the air pollutant PM_2.5 in Europe will continue to fall in 2020, concludes a recent study. Furthermore, deposition of nitrogen from air pollution will also drop. The outlook seems less positive for ground-level ozone, however, as large amounts of this pollutant continue drift over to Europe from other continents.

This will go down as the worst negotiation blunder in Australian sporting history.

The post First crush makes wine history for Eyre Peninsula appeared first on The Lead SA.

Watford are out of the relegation zone tonight after storming to a stunning 3-0 victory over champions elect Liverpool in a result that will reverberate around the football world.

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Beam Suntory SVP of corporate communications and public affairs Clarkson Hine chats about the effects of COVID-19 on consumer brands and the latest industry news.

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NTU Singapore, the Singapore National Eye Centre (SNEC), and the Singapore Eye Research Institute (SERI) have launched a joint laboratory that will develop advanced eye imaging technologies and drug delivery systems....

Proposition 37 was shot down in California yesterday. Is this the end for the debate on GMO labeling? Not if we do our part.

Looking for a shortcut to salvation? The pope has an offer too good to resist.

It may invoke images of hearts and flowers, but the origins of Valentine's Day are more gruesome than you might think.

As the Supreme Court prepares to hear arguments in two gay marriage cases, it's easy to forget how far opinions have moved on the issue.

Food and Water Watch parodies “Portlandia’s” awesome chicken sketch to make a point about factory farming inspections and urges consumers to take action.

A request for a USDA Process Verified label for its non-GMO product has raised questions. Here are some answers.

Egmont Key National Wildlife Refuge is rich with wildlife and history — and it's under siege from the waters that surround it. And it's only to get worse.

A key focus of this week's Transformational Media Summit is how sharing stories can change attitudes to help us create a more peaceful world.

These robotic labs, called ESPs, collect water samples in the open water and can determine if a beach is safe for swimming or water is clean enough to drink

From the birth of Jesus in a manger to the Star of Bethlehem, the details of the Nativity story show up in Christmas pageants and storefront windows everywhere.

Five years in the making, the film takes audiences on an interfaith journey through one of the world's 'most storied' cities.

Chronic inflammation has been linked to many illnesses, so skipping these foods may improve your health.

The Nissan Leaf will be produced in Tennessee, in America's largest auto plant under one roof. Take a tour with me on the electric tram.

Meet the author, farmer, entrepreneur and leader of the local food movement as he shares his thoughts on modern farming and the needs of animals.

In "Ajijaak on Turtle Island," a young crane's migration journey brings Native American stories to life.

Smithsonian Channel special celebrates the surprising history behind the flag that inspired our national anthem more than 200 years ago.

With Pluto's unveiling on the horizon, here's a quick look at past and present efforts to study the elusive world.

NASA scientists hatch proposal to redefine what it means to be a planet in our solar system.