London : J. & A. Churchill, 1887.

Edinburgh : Oliver & Boyd, 1862.

Paris : G. Carre, 1895.

London : Waterlow Bros. & Layton, 1885.

London : Bailliere, Tindall and Cox, 1884.

London : Bailliere, Tindall and Cox, 1886.

Wien : SafÏar, 1905.

The West Virginia House of Delegates passed its version of a sweeping education omnibus bill, which would allow the state's first charter schools.

[London?] : [Endell Street Military Hospital?], [1920] (Harlesden, London N.W. 10 : Leveridge & Co.)

London (Braynes-Row, Spa-Fields) : Publish'd ... by R. Pollard printseller, Jany: 30th; 1797.

[London] : [Wellcome Trust], [2009]

How to tune in to Tom Wilson's best games on Sunday.

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

Capitals forward Evgeny Kuznetsov doesn't consider his series-winning goal against the Penguins in 2018 is the biggest goal of his life.

The Washington Capitals on Friday placed Brendan Leipsic on unconditional waivers to terminate his contract after he made disparaging comments about women and teammates in a private social media chat. In a conversation involving his brother and Florida Panthers minor leaguer Jack Rodewald, Leipsic commented on the physical appearances of Vancouver forward Tanner Pearson's wife and Edmonton captain Connor McDavid's girlfriend. The NHL called it ''inexcusable conduct'' and said it would address the matter with the Capitals and Panthers.

A few nights after one of their players was injured by a dirty hit, the Johnstown Jets plotted to exact some revenge on Buffalo's Greg Neeld. An all-out brawl broke out during warmups and the North American Hockey League game was postponed, much to the dismay of ownership and presumably the fans at a sold-out War Memorial Arena. It just so happened that director George Roy Hill was in the arena that night, cameras rolling.

The Washington Capitals have placed former Winterhawks wing Brendan Leipsic on unconditional waivers with the intention of his contract being terminated after private messages revealed misogynistic comments. > The Washington Capitals have placed Brendan Leipsic on unconditional waivers for purposes of terminating his contract.https://t.co/UnADibu2yQ

The Washington Capitals decided to part ways with forward Brendan Leipsic on Friday after he made vulgar and disparaging comments on an social media chat group. The 25-year old Canadian was placed on waivers by the NHL club after his Instagram group chat messages were leaked earlier this week. The chat included inappropriate remarks about Edmonton Oilers forward Connor McDavid's girlfriend and the wife of Vancouver Canucks player Tanner Pearson.

Troy Brouwer scored the game-winning goal as the Capitals beat the Blackhawks at Nationals Park on Jan. 1, 2015. Relive the excitement with Monday night's replay.

Washington announced it is terminating the contract of forward Brendan Leipsic after his mysogynistic comments on Instagram were leaked.

2019

Norbert Hirschauer, Sven Grüner, Oliver Mußhoff, Claudia Becker.

Source: Statistics Surveys, Volume 12, 136--172.

Abstract:
Data on how many scientific findings are reproducible are generally bleak and a wealth of papers have warned against misuses of the $p$-value and resulting false findings in recent years. This paper discusses the question of what we can(not) learn from the $p$-value, which is still widely considered as the gold standard of statistical validity. We aim to provide a non-technical and easily accessible resource for statistical practitioners who wish to spot and avoid misinterpretations and misuses of statistical significance tests. For this purpose, we first classify and describe the most widely discussed (“classical”) pitfalls of significance testing, and review published work on these misuses with a focus on regression-based “confirmatory” study. This includes a description of the single-study bias and a simulation-based illustration of how proper meta-analysis compares to misleading significance counts (“vote counting”). Going beyond the classical pitfalls, we also use simulation to provide intuition that relying on the statistical estimate “$p$-value” as a measure of evidence without considering its sample-to-sample variability falls short of the mark even within an otherwise appropriate interpretation. We conclude with a discussion of the exigencies of informed approaches to statistical inference and corresponding institutional reforms.

Lisa Schlosser, Torsten Hothorn, Reto Stauffer, Achim Zeileis.

Source: The Annals of Applied Statistics, Volume 13, Number 3, 1564--1589.

Abstract:
To obtain a probabilistic model for a dependent variable based on some set of explanatory variables, a distributional approach is often adopted where the parameters of the distribution are linked to regressors. In many classical models this only captures the location of the distribution but over the last decade there has been increasing interest in distributional regression approaches modeling all parameters including location, scale and shape. Notably, so-called nonhomogeneous Gaussian regression (NGR) models both mean and variance of a Gaussian response and is particularly popular in weather forecasting. Moreover, generalized additive models for location, scale and shape (GAMLSS) provide a framework where each distribution parameter is modeled separately capturing smooth linear or nonlinear effects. However, when variable selection is required and/or there are nonsmooth dependencies or interactions (especially unknown or of high-order), it is challenging to establish a good GAMLSS. A natural alternative in these situations would be the application of regression trees or random forests but, so far, no general distributional framework is available for these. Therefore, a framework for distributional regression trees and forests is proposed that blends regression trees and random forests with classical distributions from the GAMLSS framework as well as their censored or truncated counterparts. To illustrate these novel approaches in practice, they are employed to obtain probabilistic precipitation forecasts at numerous sites in a mountainous region (Tyrol, Austria) based on a large number of numerical weather prediction quantities. It is shown that the novel distributional regression forests automatically select variables and interactions, performing on par or often even better than GAMLSS specified either through prior meteorological knowledge or a computationally more demanding boosting approach.

Julyan Arbel, Pierpaolo De Blasi, Igor Prünster.

Source: Bayesian Analysis, Volume 14, Number 3, 753--771.

Abstract:
In this paper we consider approximations to the popular Pitman–Yor process obtained by truncating the stick-breaking representation. The truncation is determined by a random stopping rule that achieves an almost sure control on the approximation error in total variation distance. We derive the asymptotic distribution of the random truncation point as the approximation error $epsilon$ goes to zero in terms of a polynomially tilted positive stable random variable. The practical usefulness and effectiveness of this theoretical result is demonstrated by devising a sampling algorithm to approximate functionals of the $epsilon$ -version of the Pitman–Yor process.

Roderick J. Little.

Source: Statistical Science, Volume 34, Number 4, 580--583.

Gregor Thut
Sep 13, 2006; 26:9494-9502
BehavioralSystemsCognitive

Spanish translation of "Frequently asked questions on market risk capital requirements" by the Basel Committee, March 2018.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

A recent excavation located the first physical evidence of the capital of the Maya kingdom of Sak Tz'i', founded in 750 B.C.

Major League Baseball players and team employees to participate in 10,000-person COVID-19 study

Canine-equid pairs can mimic each other’s facial expressions during play, which has never been seen between animals of different species

Modified hospital designs have become necessary as the first wave of the pandemic tears through U.S. communities

Find the capital cities, working from a list of state names

A caver climbs a nylon rope the exit a moulin on the Greenland Ice Sheet.

The Kent State shootings further widened the chasm among a citizenry divided over the Vietnam War

The tourism and hospitality industries, which play a large role in the economy of almost every community in northwestern Ontario, are taking a beating during the COVID-19 pandemic. Now, the manager of Tourism Thunder Bay is figuring out how “dire” the situation is, and what could be done to help.

Provincial Police have a suspect in custody after a firearms incident Thursday morning at the hospital in the small northwestern Ontario community of Rainy River.

Parents-to-be who will have their new child delivered at the Thunder Bay Regional Health Sciences Centre have to follow a different set of guidelines than found at many other hospitals across Ontario.

The only way to solubilize many antigens for immunoprecipitation is by denaturation. This cell lysis protocol is ideally suited for this purpose to release proteins from complex structures or reveal antibody epitopes hidden within native proteins. Short linear epitopes may not be accessible to antibodies within the native tertiary and quaternary protein structures, but they become exposed upon the unraveling of proteins, exposing their secondary structure. Antibodies otherwise not suitable for the immunoprecipitation of proteins prepared under nondenaturing conditions are now able to bind these antigens of interest in cell lysates prepared under denaturing conditions. These antibodies may also work well for immunoblotting purposes when the protein target is completely denatured. Harvested cells in this protocol are washed in tris-buffered saline (TBS) before lysis in 2% sodium dodecyl sulfate (SDS)-containing Lysis buffer for 10 min at 100°C. The resulting sample is diluted 20-fold in TBS to reduce the SDS concentration to ≤0.1% before the addition of an antibody for immunoprecipitation. Addition of 2% bovine serum albumin (BSA) or 0.1% Nonidet P-40 to the TBS before an immunoprecipitation, respectively, ensures either removal of SDS from the target protein or retaining denatured proteins in solution.

Differential detergent fractionation of cells is a rapid method for extraction of cytoplasmic and nuclear proteins in preparation of an immunoprecipitation. This method can be applied for use of adherent or suspension cells and can significantly reduce nonspecific background in an immunoprecipitation by separation of cellular compartments into individual fractions. The lysis of cells by differential detergents permits the rapid extraction of proteins from the cytoplasm (digitonin), the cytoplasmic membranes, and organelles (Triton X-100), and nucleoplasm (Tween/DOC), facilitated through the use of distinct extraction buffers. Cytoplasmic and nuclear matrix proteins as well as DNA are left behind during the detergent-based extraction.

Purified RNA may need to be concentrated by precipitation for downstream applications. Precipitation of RNA with ethanol (or isopropanol) is the standard method to recover RNA from aqueous solutions.

We assess the dynamics of volatility spillovers among global systemically important banks (G-SIBs). We measure spillovers using vector-autoregressive models of range volatility of the equity prices of G-SIBs, together with machine learning methods. We then compare the size of these spillovers with the degree of systemic importance measured by the Basel Committee on Banking Supervision's G-SIB bucket designations.

No global real estate market despite higher price synchronisation and growing role of international investors, central banks find (Press release, 18 February 2020)

Cleveland Indians reliever Emmanuel Clase was suspended 80 games by Major League Baseball on Friday for testing positive for a banned performance-enhancing drug.