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Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

Org. Biomol. Chem., 2020, 18,3229-3233
DOI: 10.1039/D0OB00265H, Communication
Ying Han, Yifan Da, Mingjia Yu, Yaping Cheng, Xin Wang, Jiale Xiong, Guoying Guo, Yan Li, Xianxing Jiang, Xiaoqing Cai
An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of gem-difluoroalkenes via nickel-catalyzed allylic defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00535E, Communication
Xiao-Yu Lu, Run-Chuang Jiang, Jia-Mei Li, Chuang-Chuang Liu, Qing-Qing Wang, Hai-Pin Zhou
A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00910E, Paper
Jacob St-Gelais, Vincent Denavit, Denis Giguère
Selective galectin inhibitors are valuable research tools and could also be used as drug candidates. In that context, TD139, a thiodigalactoside galectin-3 inhibitor, is currently being evaluated clinically for the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Six held for forceful religious conversion

The arrests came soon after tribals demanded the arrest of those involved in the activity.




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'Treat the refugee issue as a matter of rights'

The refugee question in the Indian subcontinent dates back to 1947 when India was partitioned. A horrifying feature of the birth of free India – and Pakistan – was the large mass of refugees who were forced to relocate in the most adverse conditions and amidst brutal violence.




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Singapore appoints Sikh as Army chief

Singapore has appointed Brigadier General Ravinder Singh as its next army chief, the first Sikh in nearly 30 years to be given the force's baton.




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Covid warriors in Lucknow put duty before family




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Tears of relief at IGI arrival and departure

At 12.05pm on Friday, Air India flight AI-381 made a smooth landing at Indira Gandhi International Airport. Though half an hour late in arriving, the 234 passengers from Singapore were delighted to step on home soil after two months of anxiety and uncertainty. Their relatives weren’t allowed to meet them, and yet the relief of being back in India made them grin, wave their hands and give the thumbs up sign.




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Google and Apple partner up to defeat COVID-19 outbreak, tech giants to jointly develop technology for contact tracing

The multinational companies, which hold the largest market shares in the sphere of technology, have decided to put their joint efforts in developing technology that will help world governments to cut the spread of the virus and save lives




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Elon Musk's SpaceX, Jeff Bezos' Blue Origin selected by NASA to build lunar landing systems

Boeing Co, the aerospace company also submitted its concept for a lunar lander last year but it was not selected.





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Shraddha does something she has NEVER DONE BEFORE

'I have to pinch myself to believe that 10 years have just gone by.'





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[ASAP] Effect of Chelation on Iron–Chromium Redox Flow Batteries

ACS Energy Letters
DOI: 10.1021/acsenergylett.0c00761




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[ASAP] Toward Efficient Triple-Junction Polymer Solar Cells through Rational Selection of Middle Cells

ACS Energy Letters
DOI: 10.1021/acsenergylett.0c00857




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Eco-efficient concrete / edited by F. Pacheco-Torgal ... [et al.]

Barker Library - TA439.E36 2013




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Eco-efficient and sustainable concrete incorporating recycled post-consumer and industrial byproducts: held at the ACI Fall 2013 Convention, Phoenix, Arizona, USA, 20-24 October 2013 / Editor: Moncef L. Nehdi

Barker Library - TA441.E286 2013




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Hyperbolic and kinetic models for self-organised biological aggregations: a modelling and pattern formation approach / Raluca Eftimie

Online Resource




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Epigenetics in Human Disease / edited by Trygve O. Tollefsbol

Online Resource




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Biodefense in the age of synthetic biology / Committee on Strategies for Identifying and Addressing Potential Biodenfense Vulnerabilities Posed by Synthetic Biology, Board on Chemical Sciences and Technology, Board on Life Sciences, Division on Earth and

Online Resource




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Philosophy of biology before biology / Cécilia Bognon-Küss & Charles T. Wolfe

Hayden Library - QH305.B617 2019




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Evolutionary developmental biology: a reference guide / editors, Laura Nuno de la Rosa, Gerd Müller

Online Resource




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Hormones, Metabolism and the Benefits of Exercise.

Online Resource




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Cell migrations: causes and functions / edited by Caterina A. M. La Porta, Stefano Zapperi

Online Resource




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‘The borderless Republic’: Sheffield celebrates migration

Britain’s largest festival about refugees and sanctuary is more relevant than ever, writes Lydia Noon.




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This is Congo's top environmental defender: Rodrigue Mugaruka Katembo

He puts his life on the line to protect the Democratic Republic of Congo's national parks.




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Private Banks' Q4 nos may not reflect full extent of Covid-19 hit: Analysts

Among large banks, the brokerage sees ICICI Bank's PAT declining 49 per cent QoQ to Rs 2,100 crore in Q4FY20, followed by a 68 per cent sequential decline in Axis Bank's PAT at Rs 564.6 crore.




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Socially just pedagogies : posthumanist, feminist and materialist perspectives in higher education / edited by Vivienne Bozalek, Rosi Braidotti, Tamara Shefer and Michalinos Zembylas

London ; New York : Bloomsbury Academic, 2018




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Birth to three matters [electronic resource] : supporting the framework of effective practice / [edited by] Lesley Abbott and Ann Langston

Maidenhead ; New York : Open University Press, 2005




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Stino Da Napoli Recalls Various Meat Products Produced without Benefit of Inspection

Stino Da Napoli, a Rocky River, Ohio establishment, is recalling approximately 11,392 pounds of various meat products that were produced, packed and distributed without the benefit of federal inspection.




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TV Food LLC. Recalls Siluriformes Products Produced Without Benefit of Inspection

TV Food LLC., a San Leandro, Calif. non-federally inspected establishment, is recalling approximately 27,956 pounds of Siluriformes, specifically Yellow Hito (catfish), products because the products were not presented for import re-inspection into the United States.




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BEF Foods, Inc. Recalls Beef Products Produced without Benefit of Inspection

BEF Foods, Inc., a Lima, Ohio establishment, is recalling approximately 527 pounds of beef pasta products that were produced without the benefit of federal inspection and outside of inspection hours.




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[ASAP] Effects of Trichloroethylene on the Expression of Long Intergenic Noncoding RNAs in B6C3F1 Mouse Liver

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00382




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[ASAP] Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00004




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[ASAP] Interactions of TiO<sub>2</sub> Nanoparticles with Ingredients from Modern Lifestyle Products and Their Effects on Human Skin Cells

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00428




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[ASAP] Perspective on Health Effects of Endocrine Disruptors with a Focus on Data Gaps

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00529




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[ASAP] Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00055




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[ASAP] Effects of Arsenic on wnt/ß-catenin Signaling Pathway: A Systematic Review and Meta-analysis

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00019




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On property and contract / Jeffrey Gilbert ; edited for the Selden Society by Michael Lobban.

London : Selden Society, 2019.




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Chef Ferran Adria of El Bulli

Ferran Adria on why the knife is the most essential tool in your kitchen.




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CES 2012 Reflections

As Wired's Gadget Lab reporters prepare for one final day of CES coverage, they take time to reflect on the most noteworthy trends and products they’ve covered at the show so far.




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Kinect Makes Yelling At Mass Effect 3 Actually Work

Casey Hudson, Executive Producer of the Mass Effect series walks us through the voice-activated controls in Mass Effect 3.




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CES 2013: Samsung T9000 Four-Door Refrigerator

The built-in 10-inch tablet, the brain of the appliance, is fun to play with and comes packed with apps. If you're a neat freak, the on-board software can definitely help you keep your fridge organized.




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Jeff Bezos Recovers Apollo Engines

Jeff Bezos Recovers Apollo Engines




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Last Reef

Last Reef




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Design FX - Fast & Furious 6: Explosive Effects Exclusive

In this exclusive video from WIRED and Conde Nast Entertainment, find out how director Justin Lin filmed Dominic Toretto's (Vin Diesel's) blazing last minute escape from a massive, crashing and exploding Antonov aircraft for his new #1 blockbuster film "Fast & Furious 6." Don't miss this unbelievable behind the scenes look at the genius work of renowned visual effects house "Double Negative." Huge thanks to our good friends at fxguide.com.




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Angry Nerd - Chris Baker Responds To YouTubers And Defends His View on Doctor Who

Chris Baker responds to a few comments from viewers on his opinion of the latest incarnation of Doctor Who. The Angry Nerd respects people with the temerity to disagree with his opinions. But he respects them angrily.




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Codefellas - When Topple met Winters

WIRED's new animated series takes you inside the secretive world of a slightly askew NSA, with the eccentric Agent Topple, played by John Hodgman, and his young hacker protégé, Nicole Winters.




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Codefellas - Meet Big Data

Agent Topple reveals a few tricks of the pre-digital trade when Winters attempts to explain to him how computers work. Agent Topple is Not Impressed.




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Design FX - Man of Steel: Designing Krypton's Tech Effects Exclusive

WIRED and fxguide.com traveled to Wellington, New Zealand for an exclusive look at the work of acclaimed visual effects studio WETA Digital on Man of Steel. In this exclusive video, find out how Krypton's "Liquid Geo" display tech was designed and brought to life.