The agenda for City Commission - REVISED dated Wednesday, 03 June 2020 has been archived. Access it here:
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The agenda for City Commission - Work Session dated Wednesday, 03 June 2020 has been archived. Access it here:
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The agenda for City Commission - Special Emergency Meeting dated Sunday, 07 June 2020 has been archived. Access it here:
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The agenda for Planning Commission on 2020-06-08 7:00 PM dated Monday, 08 June 2020 has been archived. Access it here:
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The agenda for City Commission - Special Emergency Meeting dated Tuesday, 09 June 2020 has been archived. Access it here:
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The agenda for City Commission - Work Session dated Tuesday, 09 June 2020 has been archived. Access it here:
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The agenda for City Commission - REVISED dated Wednesday, 17 June 2020 has been archived. Access it here:
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The agenda for Planning Commission on 2020-06-22 7:00 PM dated Monday, 22 June 2020 has been archived. Access it here:
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The agenda for City Commission - REVISED dated Wednesday, 01 July 2020 has been archived. Access it here:
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The trade war that could stem from U.S. tariffs on steel and aluminum is unlikely to affect GDP, freeing the Fed to raise rates at its March 21 meeting.

The Florida Panthers have given out another big extension — this one, to their Stanley Cup-winning coach. Paul Maurice and the Panthers have agreed on an extended contract, the team announced Tuesday.

Hired in July by the Seattle Kraken as an assistant coach after two seasons with their AHL affiliate, Jessica Campbell is starting to get to know the team, schedule demands and managing "the vigorous push through it all." It's also about managing the attention as a trailblazer.

St. Louis Blues forward Dylan Holloway was back at the team's practice facility Wednesday and appeared to escape serious injury a day after being struck in the neck by a puck and leaving the ice on a stretcher against the Tampa Bay Lightning.

An Israeli airstrike killed seven people late Monday at a café near the southern Gaza city of Khan Younis, Palestinian medics said, bringing the death toll from Israeli strikes since Sunday night to at least 37.

An investigation found that he failed to inform police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it.

An Ontario court has declined to review a decision to deny Peter Nygard bail while the former fashion mogul appeals his sexual assault convictions and sentence.

A Mississauga couple is in the midst of a war of words with their townhouse complex's board of directors — which a handful of residents say is imposing unnecessarily strict new rules on the complex's roughly 140 homeowners.

One person is dead after a motorcycle and an SUV collided in Mount Albert, Ont., on Monday, Ontario Provincial Police say.

Sgt. Harman Dhaliwal, who is from Calgary, says he's proud to be a part of the growing exhibit that highlights the relationship between the Sikh faith and military service.

A new course offered to nursing students at the University of Calgary is shining a light on the impacts of colonization on the health experiences of Indigenous peoples.

After Canada Post workers gave a 72-hour notice to strike early Tuesday, some Calgary business owners are worried about what this means for holiday season sales. 

After COVID-19 challenges forced the cancellation of Canada's mixed doubles trials, several top curlers are anxiously waiting to learn whether they will be chosen to represent the country in the discipline at the Beijing Games.

The OCA's decision Friday to announce that Rachel Homan's team would only represent the province at the national championship if the skip wasn't picked for the Olympic mixed doubles team generated criticism from some corners and confusion from others.

CME Group, the world's leading derivatives marketplace, today announced it has received approval from the National Futures Association (NFA) to establish a futures commission merchant (FCM). "We...

Indiana University took first place, with the rest of the top five from outside the United States Record participation from nearly 570 teams across 24 countries CHICAGO, Nov. 7, 2024 /PRNewswire/...

Chief Financial Officer Lynne Fitzpatrick Appointed to President and CFO Chief Operating Officer Julie Holzrichter to Step Down and Assume Advisory Role Suzanne Sprague to Succeed Holzrichter CHICAGO,

Sleep is likely a whole-brain phenomenon, with most of the brain probably benefiting from this state of decreased arousal. Recent advances in our understanding of some potential sleep functions, such as metabolite clearance and synaptic homeostasis, make it evident why the whole brain is likely impacted by sleep: All neurons have synapses, and all neurons produce waste metabolites. Sleep experiments in the fly Drosophila melanogaster suggest that diverse sleep functions appear to be conserved across all animals. Studies of brain activity during sleep in humans typically involve multidimensional data sets, such as those acquired by electroencephalograms (EEGs) or functional magnetic resonance imaging (fMRI), and these whole-brain read-outs often reveal important qualities of different sleep stages, such as changes in frequency dynamics or connectivity. Recently, various techniques have been developed that allow for the recording of neural activity simultaneously across multiple regions of the fly brain. These whole-brain-recording approaches will be important for better understanding sleep physiology and function, as they provide a more comprehensive view of neural dynamics during sleep and wake in a relevant model system. Here, we present a brief summary of some of the findings derived from sleep activity recording studies in sleeping Drosophila flies and discuss the value of electrophysiological versus calcium imaging techniques. Although these involve very different preparations, they both highlight the value of multidimensional data for studying sleep in this model system, like the use of both EEG and fMRI in humans.

The establishment of neural connectivity is a major part of neural development. The central nervous system (CNS) midline is the most characterized axon guidance choice point, and work in Drosophila has played a pivotal role in understanding the molecular mechanisms responsible. Axons respond to attractive cues such as Netrin via the Frazzled receptor, and repulsive cues such as Slit via Robo receptors. Both signals are expressed at the CNS midline, affect pioneer axons, and have dramatic effects on the axon scaffold as a whole. Here, we focus on previous research analyzing classic mutants in the Slit/Robo pathway, which can readily be detected with a dissecting microscope. We also discuss analyzing these mutants in a teaching lab situation. The combination of sophisticated genetics and reliable axonal markers in Drosophila allows phenotypic analysis to be performed at the single-cell level. The elaborate architecture of neurons is very sensitive to disruption by genetic mutations, allowing the effects of novel mutations to be easily detected and assessed.

CRISPR–Cas9 has revolutionized gene editing for traditional and nontraditional model organisms alike. This tool has opened the door to new mechanistic studies of basic mosquito biology as well as the development of novel vector control strategies based on CRISPR–Cas9, including gene drives that spread genetic elements in the population. Although the promise of the specificity, flexibility, and ease of deployment CRISPR is real, its implementation still requires empirical optimization for each new species of interest, as well as to each genomic target within a given species. Here, we provide an overview of designing and testing single-guide RNAs for the use of CRISPR-based gene editing tools.

The host associations of mosquitoes vary by species, with some species being relative generalists, whereas others specialize, to varying extents, on a particular subset of the available host community. These host associations are driving factors in transmission dynamics of mosquito-vectored pathogens. For this reason, characterizing the host associations of mosquito species is critical for understanding the epidemiology of mosquito-vectored pathogens. Diverse methods have been used to associate mosquito species with their hosts. These typically include collecting mosquitoes that bite a restrained host (bait) or collecting wild blood-engorged mosquitoes and matching their blood meal to reference samples (blood meal analysis). Blood meal analysis refers to a collection of molecular techniques for determining the taxonomic identity of the source of a mosquito blood meal using cytological, serological, or DNA-based characteristics of the blood meal. Blood meal analyses that are based on DNA markers have advantages over cytological and serological methods and are effective for determining species-level identities of hosts from a broad range of potential host taxa. Here, we discuss effective techniques for analyzing blood meals.

Transposon-mediated transgenesis of mosquito vectors of disease pathogens followed the early success of transgenesis in the vinegar fly, Drosophila melanogaster. The P transposable element used in Drosophila does not function canonically in mosquitoes, and repeatable, routine transgenesis in mosquitoes was not accomplished until new transposable elements were discovered and validated. A number of distinct transposons were subsequently identified that mediate the introduction of exogenous DNA in a stable and heritable manner in mosquito species, including members of the genera Aedes, Anopheles, and Culex. The most versatile element, piggyBac, is functional in all of these mosquito genera, as well as in many other insects in diverse orders, and has been used extensively outside the class. Transposon-mediated transgenesis of recessive and dominant marker genes and reporter systems has been used to define functional fragments of gene control sequences, introduce exogenous DNA encoding products beneficial to medical interests, and act as "enhancer traps" to identify endogenous genes with specific expression characteristics.

She only came for a week, but impacted lives of several families with children with autism. Isabel Black shares about her experiences in Montenegro.

Even if things don't go quite to plan, the kids' craft sessions at OM Montenegro's Lighthouse centre result in wonderful presents for families.

Centuries-old university standardizes on SolidWorks Education Edition software so students can learn CAD and design validation skills

Knee replacement doesn’t have to be ‘total’

With 3D CAD, Company Reduces Design Cycle from Three Weeks to Three or Four Days

Quick design turnaround and easy documentation process help UK-based company move products to market faster

Robotics programmers can now use SolidWorks 3D CAD models for more powerful simulations

Austrian manufacturer also optimizes creation of assembly documentation and related bills of material

Eliminates the Cost and Complexity of Maintaining Online Parts Catalogs; Improves Search, Navigation, and Communication for Engineers Seeking 3D Part Models

Solutions Catch Problems Early and Drive Cost Out of Designs

Vault Structures Saves $150,000 in Prototyping Costs, Cuts Development Time by 70 Percent Using SolidWorks Software

Leading elevator components supplier implements 550 licenses of the SolidWorks PDM solution

One Of Only Four Companies To Place Among Top Employers In Each Year Of The Publication’s Survey

3D CAD Software’s Superior Data Translation Capabilities Support Growth of Tech Publishing and Engineering Services

Non-Profit Cooperative Assembled Virtual Team to Prove $1,000 Incubator Was Possible, Safe, and Reliable

Engineers Use 3D CAD and Simulation To Customize Products With Quick Modifications, Testing, and Demonstrations