Cryogenic electron microscopy (cryo-EM) is a pivotal technique for imaging macromolecular structures. However, despite extensive processing of large image sets collected in cryo-EM experiments to amplify the signal-to-noise ratio, the reconstructed 3D protein-density maps are often limited in quality due to residual noise, which in turn affects the accuracy of the macromolecular representation. Here, crefDenoiser is introduced, a denoising neural network model designed to enhance the signal in 3D cryo-EM maps produced with standard processing pipelines. The crefDenoiser model is trained without the need for `clean' ground-truth target maps. Instead, a custom dataset is employed, composed of real noisy protein half-maps sourced from the Electron Microscopy Data Bank repository. Competing with the current state-of-the-art, crefDenoiser is designed to optimize for the theoretical noise-free map during self-supervised training. We demonstrate that our model successfully amplifies the signal across a wide variety of protein maps, outperforming a classic map denoiser and following a network-based sharpening model. Without biasing the map, the proposed denoising method leads to improved visibility of protein structural features, including protein domains, secondary structure elements and modest high-resolution feature restoration.

Here, a morphologically based approach is used for the in situ characterization of 3D growth rates of facetted crystals from the solution phase. Crystal images of single crystals of the β-form of l-glutamic acid are captured in situ during their growth at a relative supersaturation of 1.05 using transmission optical microscopy. The crystal growth rates estimated for both the {101} capping and {021} prismatic faces through image processing are consistent with those determined using reflection light mode [Jiang, Ma, Hazlehurst, Ilett, Jackson, Hogg & Roberts (2024). Cryst. Growth Des. 24, 3277–3288]. The growth rate in the {010} face is, for the first time, estimated from the shadow widths of the {021} prismatic faces and found to be typically about half that of the {021} prismatic faces. Analysis of the 3D shape during growth reveals that the initial needle-like crystal morphology develops during the growth process to become more tabular, associated with the Zingg factor evolving from 2.9 to 1.7 (>1). The change in relative solution supersaturation during the growth process is estimated from calculations of the crystal volume, offering an alternative approach to determine this dynamically from visual observations.

Floating point arithmetic doesn't get the respect it deserves. Many people consider it mysterious, fuzzy, unpredictable. These misgivings often occur in discussion of vector sums. Our provocatively named SuperSum is intended to calm these fears.... read more >>

Brian Drum, one of the supervisors of the Catawba County 911 Communications Center, who has been called upon to increase his supervising duties over the past year and has a record of dedication to 911 dispatch that spans more than ten years, has been recognized by his peers in the North Carolina Chapter of the National Emergency Number Association (NC NENA) as Supervisor of the Year.

While the U.S. Department of Veterans Affairs (VA) provides mental health care of comparable or superior quality to care provided in private and non-VA public sectors, accessibility and quality of services vary across the VA health system, leaving a substantial unmet need for mental health services among veterans of the recent wars in Afghanistan and Iraq, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

The supercritical water oxidation (SCWO) system is a secondary waste processing reactor of the Blue Grass Chemical Agent Destruction Pilot Plant (BGCAPP). It is perhaps second in importance behind the agent neutralization reactors, which perform base hydrolysis of chemical warfare agents stored at the Blue Grass Army Depot.

The National Nuclear Security Administration needs to fundamentally rethink the strategy for its next generation of high-performance computing and cannot continue with ‘business as usual’ through shifting technical and geopolitical landscapes. Advanced computing capabilities help the NNSA ensure that the U.S. maintains a safe, secure, and reliable nuclear stockpile.

Satellite data from NASA revealed that powerful storms in Super Typhoon Meranti were generating almost a foot or almost 300 millimeters of rainfall per hour. The Global Precipitation Measurement mission or GPM core satellite measured the heavy rainfall on one side of the Category 5 super typhoon.

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Supernatural teamed up with King Arthur Baking Company and Vital Farms to launch ten brand-new kits for baking festive treats like gingerbread houses, Hanukkah sugar cookies, buttermilk doughnuts, themed sprinkle sets, and more.

Pecans can help product developers take the food and snacking industry to the next level. 

For its latest coated honey roast nut production line, Trigon Snacks selected a customized linear Stealth metal detector with an innovative retractable conveyor reject system.
 

Junior's announced that its new Oreo Cheesecake, a partnership with Mondelēz, the maker of Oreos, is now on the shelves in grocery stores across the country.

The B.T.R. x Blue Bottle Spiced Chocolate Chip Cookie Dough Superfood Protein Bar can be found at all Blue Bottle Coffee locations nationally.

Advance International Inc. has introduced a premium, ultra-sustainable & highly nutritious ocean-based super-protein that will revolutionize the global supply chain.

United Supermarkets has acquired the rights to the name and recipes of August’s Pies, an iconic West Texas brand.

Jar Joy has introduced its new innovative line of multi-layered desserts. 

The bite-sized snacks are filled with hemp hearts, pumpkin seeds, sunflower seeds, chai, flax, and quinoa, and are Manitoba’s debut into the snacking category.

Supermarket Italy, an online destination for authentic gourmet imported products from Italy since 2009, has expanded its offerings to include snack and bakery baskets.

The company creates plant-powered, gluten-free products rooted in Konjac—a fiber-rich Asian root plant that can be used to empower flour substitute applications.

Nationally recognized SUPERPRETZEL  Soft Pretzel brand is expanding its snack offerings, as it was announced that J&J Snack Foods Corp. is introducing SUPERPRETZEL Filled Soft Pretzel Bites.

The Hunter’s Supermoon appearing in the sky this week reportedly will be this year’s biggest.

Stellar Snacks recently debuted grain-free pretzels crafted with superfood ingredients, now officially available at select grocery stores throughout the U.S.

Known for its plant-based, real-food ingredients, Laird Superfood’s Pumpkin Spice line is crafted with a signature blend of ginger, nutmeg, cloves, and cinnamon, plus real pumpkin.

We keep super glue on the truck for any time we run into needing an O-ring, but don't have the exact size. 

One of New York man's employees died after a fall from an improperly secured roof.

Chobani LLC, New Berlin, N.Y., launched its first-ever shelf-stable low-fat dairy milk: Chobani Super Milk. This latest product innovation is nutrient rich and is made specifically to be donated to support people impacted by disasters as well as help some of the most vulnerable in Chobani’s hometowns, the company says.

Uncle Matt's Organic is adding a new functional juice-based beverage to its portfolio: Uncle Matt's Organic Superfruit Punch.

Natalie's Orchid Island Juice Co. announced the introduction of two tomato-centric blends: Red Tomato Reishi and Green Tomato Lion's Mane. 

RATED AS THE #1 EVENT ON SUPER BOWL SUNDAY YEAR AFTER YEAR THE PLAYERS TAILGATE 2023 WILL BRING A LITERAL "WHO'S WHO" OF CELEBRITY CHEFS TO PHOENIX, AZ

Taking Place at Axiom Contemporary, the Biggest Sports Stars and Celebrities Partied at the Most Talked About Immersive Experience of Super Bowl Weekend

SuperBites Freeze-Dried Raw Cat Treats Feature Delicious Meaty Flavors Sure to Satisfy Any Cat's Inner Carnivore.

First 3D SRAM Debut

"Specially handcrafted to enhance superyacht interiors, Carol Bruton's artwork mimics the reflections and ripples of water"

Following a rebrand earlier this year, TJB Super Yachts - a boutique brokerage specialising in yachts for charter and sale - is unveiling their new website www.tjbsuperyachts.com with a unique bespoke itinerary builder function.

A Celestial Marketing Strategy: Execution of JayQ The Legend's galactic anthem "Back 2 Back"

Launches on the global crowdfunding platform Kickstarter.

Charlotte-based personal injury law firm, Brown Moore & Associates, recognized for over a decade as the top 5% of attorneys by Super Lawyers.

Award reflects company's consistent level of customer service

The Community Organization Based out of Nebraska Grants ALSF nearly $69,000.

New Brand Launches with Award-Winning Game that Empowers All Children

Sacramento boat sales and service company excited to sell and stock the first 100% groundbreaking electric towboat in the United States.

Luxurious high performance Italian Superyacht for Sale

The 34 metre sailing superyacht "MiTi One" has been launched and delivered and is now on en-route to the French Riviera where she will be for sale and available for inspection.

New fabric jeans best for climbing, cycling, work, gym and every day

Residents and businesses in the Salinas, Monterey Bay area are encouraged to take advantage of Ferrante's enhanced air duct cleaning services to improve their indoor air quality and protect the health of their families, customers, and employees.

Thousands of decision makers from across the private capital universe will come together in Monaco, November 5-8, for a SuperInvestor like never before. Nico Rosberg shifts into high gear for the event.

Author who is set to air on BRAVO's Millionaire Matchmaker February 5th spoofed a brand new Superbowl Ad, before it airs, to promote her new book crowd funding.

Global media outlets attended the media session hosted by the Incheon Free Economic Zone Authority.

Craft Holsters, a custom leather holster maker, launches new break-in kits that will make leather holster break-in smooth and easy.