JACKSON, Miss. (May 7, 2020) – Today, the U.S. Environmental Protection Agency (EPA) announced four grant recipients in Mississippi have been selected to receive awards totaling $1,464,000 to assess and clean up contaminated properties under the agency’s Brownfields program.

EXPRESS SPORT brings you all the latest transfer news ahead of tomorrow's deadline - here is what happened.

Hear about travel to the Northern Mississippi River Valley in Minnesota and Wisconsin as the Amateur Traveler talks to Dean Klinkenberg from MississippiValleyTraveler.com about this stretch of America's mightiest river.

Hear about travel to the Mississippi Gulf Coast as the Amateur Traveler talks to Charles McCool from McCoolTravel.com about this tasty area with great beaches.

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications.

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications.

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fermentation extracts of Streptomyces conglobatus, here we discovered four new neoantimycin analogs, unantimycins B–E, in which 3-formamidosalicylates are replaced by an unusual 3-hydroxybenzoate (3-HBA) moiety. Unantimycins B–E exhibited levels of anticancer activities similar to those of the chemotherapeutic drug cisplatin in human lung cancer, colorectal cancer, and melanoma cells. Notably, they mostly displayed no significant toxicity toward noncancerous cells, unlike the serious toxicities generally reported for antimycin-type natural products. Using site-directed mutagenesis and heterologous expression, we found that unantimycin productions are correlated with the activity of a chorismatase homolog, the nat-hyg5 gene, from a type I PKS gene cluster. Biochemical analysis confirmed that the catalytic activity of Nat-hyg5 generates 3-HBA from chorismate. Finally, we achieved selective production of unantimycins B and C by engineering a chassis host. On the basis of these findings, we propose that unantimycin biosynthesis is directed by the neoantimycin-producing NRPS–PKS complex and initiated with the starter unit of 3-HBA. The elucidation of the biosynthetic unantimycin pathway reported here paves the way to improve the yield of these compounds for evaluation in oncotherapeutic applications.

Diabetes is synonymous with sugar, but diabetes insipidus, "water diabetes", can't be forgotten. Between 2009 and 2016, 4 people died in hospital in England, when lifesaving treatment for the condition was not given. In this podcast, we hear some practical tips for non-specialists to aid diagnosis, and how patients should be managed during...

Paris : A. Parent, 1874.

Detroit, Mich. : G.S. Davis, 1889.

Cincinnati : R. Clarke, 1874.

A Greenville, Miss. teacher was fired and a superintendent placed on administrative leave after a video of a student being dragged by her hair surfaced on social media.

State lawmakers have made it illegal for school districts to spend any public money on the Mississippi Association of School Superintendents, saying district leaders personally attacked state officials while they were seeking votes for a school funding initiative last year.

State of the States: Education highlights from latest governor's address before the legislature.

The name change comes as leaders of the school district in Mississippi's capital city, where more than 95 percent of students are African-American, are reconsidering Confederacy-linked names on three campuses.

Education remains Mississippi’s top priority, but programs won’t see increases this year as steep as in years past, Gov. Barbour told lawmakers.

Mississippi’s outdated textbooks teach an abbreviated version of civil rights, undermining the state’s new ‘innovative’ standards.

The Mississippi education department will be the first to operate a teacher residency program, which aims to increase retention and diversity in the profession.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

The state, which earned a D-plus, scored low on the Chance for Success Index, which tracks a host of socioeconomic factors that can affect the educational environment.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

The court revived a lawsuit claiming that Mississippi's lack of a "uniform" education system violates the 1868 federal law that readmitted the state to the Union.

London (No. 4, Hanover Street) : Published ... for the proprietor by T.G. March ; [London] (Threadneedle Street) : Sold also by F. G. Moon ; [London] (Strand) : [Sold also by] Ackermann & Co., April 10, 1842 ([London?] : Printed by R. Lloyd)

Texas moved quickly to hire a new women's basketball coach, luring Vic Schaefer away from powerhouse Mississippi State on Sunday. Texas athletic director Chris Del Conte announced the move by tweeting a picture of himself with Schaefer and his family holding up the “Hook'em Horns” hand signal. The move comes just two days after Texas dismissed eight-year coach Karen Aston, who had only one losing season in her tenure and had led the Longhorns to the Sweet 16 or farther four times.

Mississippi State hired former Old Dominion women’s basketball coach Nikki McCray-Penson to replace Vic Schaefer as the Bulldogs’ head coach. Athletic director John Cohen called McCray-Penson “a proven winner who will lead one of the best programs in the nation” on the department’s website. McCray-Penson, a former Tennessee star and Women’s Basketball Hall of Famer, said it’s been a dream to coach in the Southeastern Conference and she’s “grateful and blessed for this incredible honor and opportunity.”

02020-02-06: Flooding in Louisiana and Mississippi

Previous research on injuries related to bottle, pacifier, and sippy cup use has largely focused on case reports of infant injuries or fatalities attributed to pacifiers or pacifier parts causing asphyxiation or to bottle warming causing burns.

This study is the first to use a nationally representative sample to investigate the range of injuries requiring emergency department visits associated with bottles, pacifiers, and sippy cups among children aged <3 years. (Read the full article)

By Bishop Arthur Serratelli

On January 18, 2019, a video of Covington Catholic High School student Nick Sandmann went viral. He was at the Lincoln Memorial standing face to face with a Native American man during the March to Life in Washington, D.C. On the basis of that picture, a frenzy of condemnations from reporters, commentators and politicians were heaped upon this student, accusing him of prejudice and hatred. Misinformation and lies spread like wild fire. Finally, when the facts were uncovered, the high school student was exonerated of any wrong-doing, even though much wrong had been done to him and his family. It was a rush to judgment. 

On January 29, 2019, American actor and singer Jussie Smollett reported that two masked men attacked him at 2 AM near his apartment in Chicago. He claimed that the attack was racist and homophobic. After Smollett’s initial report, friends and fans, celebrities and politicians expressed outrage at this hate crime. Twitter and Instagram fueled the frenzy of self-righteous indignation. However, in just three weeks, it was discovered that the whole event had been orchestrated by Smollett. Yet, before the facts were fully known, there was the rush to judgment and much chatter.

Gifted with reason, we are wired to make judgments. Discerning the good from the bad, the beautiful from the ugly, the right from the wrong, and virtue from vice: this is an essential part of our being human. However, every judgment must be founded on truth, not rumor; on fact, not fiction; on substance, not appearance. And every judgment must always be tempered with compassion. Albeit from opposite directions, the Sandmann and Smollett incidents show how quick we are to believe or disbelieve, to accuse or defend and how easily we pick a side and draw a line in the sand. And, all the while, truth grows ever more fragile.

Today’s rush to judgment gathers speed along the newly constructed digital highway. We get information instantaneously and, because we want solutions just as fast, we are quick to judge. As a result of this incessant communication about other people’s lives, we live on the edge between truth and falsehood. What years ago was whispered between a few people now goes viral and can never be retrieved. As a result, in this environment, deliberately passing on stories that destroy other people’s good names is nothing less than cyber bullying.

There is no area of modern society that is exempt from someone passing on false information, half-truths or blatant, deliberate lies. In a society of fast-paced information sharing, gossip has become so commonplace that people justify it as a way to right wrongs, correct others and unseat those whom they deem unfit for their chosen work. However, unlike the surgeon’s scalpel that removes the cancer, gossip is the arrow that destroys the other. 

As a statement sometimes attributed to Mark Twain says, “a lie can travel halfway around the world before the truth can get its boots.” In a similar vein, Jonathan Swift once wrote, “if a lie be believ’d only for an hour, it has done its work, and there is no further occasion for it. Falsehood flies, and the truth comes limping after it; so that, when men come to be undeceiv’d, it is too late…the tale has had its effect” (Jonathan Swift, The Examiner, Number 15, November, 1710).  For this reason, people of good faith should be slow to judge others. And never should they gossip. People who constantly judge or criticize others truly lack compassion.

Sadly, making negative judgments on others on the basis of appearances and then spreading those judgments to others is found among those who consider themselves Church-going people. It is especially found among those who set themselves as crusaders for a just cause and, then by their lack of charity, become unjust themselves. The fondness to judge and criticize others may well be a way of not facing one’s own sins. "It is often easier or more convenient to see and condemn the faults and sins of others than it is to see our own” (Pope Francis, Angelus, March 3, 2019).

In speech after speech, Pope Francis has been courageously warning us of the evil of gossip. “Gossip is a weapon and it threatens the human community every day; it sows envy, jealousy and power struggles… We might welcome someone and speak well of him the first day but little by little that worm eats away at our minds until our gossip banishes him from good opinion. That person in a community who gossips against his or her neighbor is, in a sense, killing him.” (Pope Francis, Homily, Domus Sanctae Marthae, September 2, 2013).  

Few things can match the harmful effects of gossip, whether it be slander or detraction. Defamation inflicts grave harm on the individual and destroys the community. It is against charity and, since God is love, it is against God himself. Charles Spurgeon, one of the most popular Baptist preachers of the 19th century, summed up the evil of talking about other people by saying, “the tale-bearer carries the devil in his tongue, and the tale-hearer carries the devil in his ear.” Gossip makes the devil laugh!

Retail investors should stay away from small and mid-cap stocks until the volatility settles. Instead, they should look at value investing.

More units are bought when the market price of shares is low and lesser units are bought when the price is high.

Equity markets in India and across the globe have corrected sharply on concerns over global growth amid the coronavirus outbreak.

https://community.cadence.com/cadence_blogs_8/b/breakfast-bytes/posts/cowos-info

I came across cadence old article that discussing about TSMC advance packaging technology such as InFO & CoWoS. However, I couldn’t find information such as what I/O interface standard is required to realize this multi-chip SiP. For example, Intel using their proprietary AIB interface for EMIB solution.

Besides, any idea if inFO also able to supports multi-chip integration for older node process to new node process such as 40-nm to 16-nm?

Iam new to Package design SIP tool.

I had created the DIE package using SIP. Kindly give the direction how to map the created DIE package in Allegro pcb editor 17.2 ver.

In Allegro design capture CIS tool we had created the schematics file. The DIE which we are using is having 100pins, We had created the DIE in SIP tool. Out of 100 Die pins, only 90 pins is getting connected others are NC pins. We had mapped the Bond fingers only for 90 Die pins in the SIP package. But in the Schematics we had created the DIE logic symbol for 100 pins. Please advice whether we can able to import the DIE package in the allegro tool. In this scenario while importing the 100 pin DIE package in allegro pcb editor will the net connectivity will be shown from the DIE pad to Bond fingers and from Bond fingers to respective components? Please suggest whether we are going in the right path or please advice what we have to proceed with.

Thanks in Advance,

Rajesh

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

SIPVicious tools address the need for traditional security tools to be ported to SIP. This package consists of a SIP scanner, a SIP wardialer, and a SIP PBX cracker. Written in Python.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.