Lynch Welcomed Steel Guitar Hall Of Famers Chubby Howard, Joe Wright, Lyn Owsley, Billy Robinson And Russ Hicks To Keepin’ It Country Farm In Ohio.

When it first made its debut fifteen years ago, this adorable Metallica "Master of Puppets" playset (made by Stevenson Entertainment...

The post Put on Your Own METALLICA Show During the Pandemic With This Mini-'Master of Puppets' Playset appeared first on Metal Injection.

Dan Dubuque is back again.

The post Dude Plays QUEENS OF THE STONE AGE On Slide Guitar In The Mountains appeared first on Metal Injection.

He thinks he can present Blackness.

Are you smarter than Kevin Hart?

Watch Rih work it behind the camera yet again.

В состав «армии Microsoft» попали как инди-студии, так и крупные разработчики.

A nationwide class action lawsuit filed against Apple in Northern California court this week accuses the company of knowingly concealing a defect with a display-related flex cable on recent 13-inch and 15-inch MacBook Pro models.


As discovered by repair website iFixit last year, some MacBook Pro models released in 2016 and 2017 have experienced issues with uneven backlighting caused by a delicate flex cable that can wear out and break after repeated opening and closing of the display. Impacted notebooks can exhibit uneven lighting at the bottom of the screen, which has been described as a "stage light" effect, and the backlighting system can eventually fail entirely.

Since the issue often takes time to manifest, the affected ‌MacBook Pro‌ units can be outside of Apple's one-year warranty period when they start exhibiting symptoms, resulting in an out-of-warranty repair fee of up to $850.

"Imagine spending more than $2,500 on a laptop only for it to fail shortly after the manufacturer's warranty expires," said PARRIS Law Firm attorney R. Rex Parris. "What's even more appalling is Apple requiring customers to spend an additional $600 to $850 to replace the screen."

Apple seemingly fixed the issue by extending the length of the flex cable by 2mm in the 2018 MacBook Pro. It also launched a free repair program in May 2019, but the program only applies to 13-inch MacBook Pro models released in 2016.

The award-winning title from ILMxLAB heads to PlayStation VR this summer.

https://www.cdkeys.com/playstation-network-psn/playstation-plus/1-year-playstation-plus-membership-ps3-ps4-ps-vita-digital-code

These has been in the 35-40s recently

Washington-based architect and designer Michael Mannhard has unveiled designs for BladeYARD, a proposal for a Burning Man 2021 installation built from recycled wind turbine blades. Created as a visual warning of the effects of climate change and shortsighted solutions, the installation mimics a large-scale ruin with parts of the blades submerged in the sands of Nevada’s Black Rock Desert.[...]

Sligo's busy Quayside Shopping Centre promotes its shops and events on four display screens throughout the centre, keeping shoppers updated with dynamic content.

Since arriving in 2017, assistant GM Mark Hughes has risen in the Clippers' ranks, filling many roles suited to his personality and skills.

Loyola Marymount asked Los Angeles residents to name their favorite athlete and favorite team. Who finished just behind LeBron James and the Lakers?

Before the coronavirus outbreak, Wrembel visited the Fresh Air studio to talk about his musical influences and to play, with his trio, songs from his new album, Django L'Impressionniste.

Anger at Xi Jinping's government over the coronavirus crisis is warranted, but treating a nuclear and economic superpower as an existential enemy to satisfy domestic political needs isn't the smart way to go.

Richard Nelson's new Apple Family play opens on YouTube to confront the pandemic. What can storytelling offer us right now?

Our culture watch list includes Alfred Molina as painter Mark Rothko in the Tony-winning drama "Red"

Brad Pitt played Dr. Anthony Fauci in 'Saturday Night Live' episode with musical guest Miley Cyrus and cameos from Adam Sandler and Paul Rudd.

RANGERS boss Steven Gerrard has played down his side’s chances of winning the league despite a stoppage-time winner in their season opener.

Higher education is prepared to play its part in a recovery that accelerates a stronger economy and personal opportunity, Teresa Lubbers writes.

Don’t be surprised to see the visionary "Paper Beast" on the year’s best list.

You know about Beto O'Rourke on the guitar, of course, but what about Bernie Sanders's spoken-word album?

(University of Southampton) Scientists have published highly detailed images of lab-grown neurons using Extreme Ultraviolet radiation that could aid the analysis of neurodegenerative diseases.

(Dartmouth College) Expanded Dartmouth awards program gives prizes for 'spec fic' playwriting on what it means to be human in a computerized world.

Host Matt Egan is joined by Online Editor at Techworld.com Scott Carey to break down Microsoft's mega acquisition of LinkedIn. Staff Writer at PC Advisor Chris joins in to discuss all of the news coming out of E3 and how Xbox and Playstation are set to battle it out again this summer, or will Nintendo and Zelda steal the show? (13:00). Finally, David Price comes on to talk about all of the news coming out of Apple's WWDC developer conference this week, from Hair Force One to watchOS, tvOS, macOS and iOS (26:30) And please do share, rate and review the UK Tech Weekly Podcast.  

See acast.com/privacy for privacy and opt-out information.

In Matt Egan's absence first time host Henry Burrell heroically steps in to chat about Pokemon Go with producer Chris. Then fellow staff writer Chris Minasians discusses iOS 10 beta and all of the rumoured features for the latest Apple operating system, including dark mode (10:30). Finally, Lewis Painter, staff writer at PC Advisor, talks about Playstation VR being released for the PS4, pricing and games (23:30).  

See acast.com/privacy for privacy and opt-out information.

Henry Burrell is the master of ceremonies this week, dropping beats on the hottest tech topics. First up, producer Chris joins to chat about the latest Android OS: Nougat. Then staff writer at Techworld.com Scott Carey jumps in to chat about the Deliveroo strikes this week and what this means for sharing economy companies like Uber and Airbnb in general (15:30). Finally, staff writer at Tech Advisor Lewis Painter has some Playstation console rumours to discuss (27:00).  

See acast.com/privacy for privacy and opt-out information.

Matt Egan is back on hosting duties this week to break down the demise of the Samsung Galaxy Note 7 with producer Chris. Then staff writer at PC Advisor Lewis Painter comes on to talk about the Playstation VR release, games and pricing and compares it to the flagging Oculus Rift and HTC Vive (13:00). Finally, Scott Carey, online editor at Computerworld UK reports back from the biggest tech conference in the world, Dreamforce, chats about Salesforce's rumoured bid for Twitter and tries to make CRM interesting (25:00).  

See acast.com/privacy for privacy and opt-out information.

London : Published by J.B. Virtue & Co. Ltd. : Jean Boussod Manzi Joyant & Co., [1897]

The World pairs champion and Olympic gold medallist played the piano during a special hosted by fellow Canadian figure skater Kaitlyn Weaver, to raise funds for the United Nation's COVID-19 Solidarity Response Fund.

Youth exposure to retail tobacco advertisements and displays is associated with smoking initiation. The Family Smoking Prevention and Tobacco Control Act of 2009 gives states and local governments legal authority to regulate the time, place, and manner of tobacco advertising.

This is the first experimental study using a virtual store environment to provide evidence that a policy banning tobacco product displays at the point of sale may deter youth from attempting to purchase tobacco products at retail stores. (Read the full article)

Sony has been granted a patent for a new PlayStation controller that features two more buttons than the existing DualShock 4 model, but don't look for it with the PS5.

Lipid II is an essential precursor of the bacterial cell wall biosynthesis and thereby an important target for various antibiotics. Several lanthionine-containing peptide antibiotics target lipid II with lanthionine-stabilized lipid II-binding motifs. Here, we used the biosynthesis system of the lantibiotic nisin to synthesize a two lipid II binding motifs-containing lantibiotic, termed TL19, which contains the N-terminal lipid II binding motif of nisin and the distinct C-terminal lipid II binding motif of one peptide of the two-component haloduracin (i.e. HalA1). Further characterization demonstrated that (i) TL19 exerts 64-fold stronger antimicrobial activity against E. faecium than nisin (1-22), which has only one lipid II binding site, and (ii) both the N- and C-terminal domains are essential for the potent antimicrobial activity of TL19, as evidenced by mutagenesis of each single and double domains. These results show the feasibility of a new approach to synthesize potent lantibiotics with two different lipid II binding motifs to treat specific antibiotic-resistant pathogens.

Antimicrobial peptides and proteins play critical roles in the host defense against invading pathogens. We recently discovered that recombinantly expressed human and mouse serum amyloid A1 (rhSAA1 and rmSAA1) proteins have potent antifungal activities against the major human fungal pathogen Candida albicans. At high concentrations, rhSAA1 disrupts C. albicans membrane integrity and induces rapid fungal cell death. In the current study, we find that rhSAA1 promotes cell aggregation and targets the C. albicans cell wall adhesin Als3. Inactivation of ALS3 in C. albicans leads to a striking decrease in cell aggregation and cell death upon rhSAA1 treatment, suggesting that Als3 plays a critical role in SAA1 sensing. We further demonstrate that deletion of the transcriptional regulators controlling the expression of ALS3, such as AHR1, BCR1, and EFG1 in C. albicans results in similar effects to that of the als3/als3 mutant upon rhSAA1 treatment. Global gene expression profiling indicates that rhSAA1 has a discernible impact on the expression of cell wall- and metabolism-related genes, suggesting that rhSAA1 treatment could lead to a nutrient starvation effect on C. albicans cells.

Manogepix (APX001A) is the active moiety of the novel drug candidate fosmanogepix (APX001). We previously reported the broad-spectrum activity of manogepix but also observed a correlation between increased manogepix and fluconazole MICs. Here we extended this study and included isolates with acquired fluconazole resistance.

Isolates (n=835) were identified using CHROMagar, MALDI-TOF and, when needed, ITS-sequencing. EUCAST E.Def 7.3.1 susceptibility testing included manogepix, amphotericin B, anidulafungin, micafungin, fluconazole and voriconazole. Manogepix wildtype-upper-limit (WT-UL) values were established following EUCAST-principles for ECOFF setting allowing wildtype/non-wildtype classification. Drug-specific MIC correlations were investigated using Pearson's correlation.

Manogepix modal MICs were low (range 0.004-0.06 mg/L against 16/20 included species). Exceptions were C. krusei and C. inconspicua, and to a lesser extent C. kefyr and Pichia kluyveri. The activity was independent of Fks echinocandin hot-spot alterations (n=17). Adopting the WT-UL established for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis, 14/724 (1.9%) isolates were non-wildtype for manogepix. Twelve of these (85.7%) were also non-wildtype for fluconazole. A statistically significant correlation was observed between manogepix and fluconazole MICs for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis (Pearson r=0.401-0.575), but not between manogepix and micafungin or amphotericin B MICs for any species except C. tropicalis (r=0.519 for manogepix versus micafungin).

Broad-spectrum activity was confirmed for manogepix against contemporary yeast. However, a 1-4 two-fold-dilution increase in manogepix MICs is observed in a subset of isolates with acquired fluconazole resistance. Further studies on the potential underlying mechanism and implication for optimal dosing are warranted.

UEFA is delighted to announce it will be the official sponsor of Rita Ora's The Girls Tour as part of our Together #WePlayStrong campaign.

Nilla Fischer, Fran Kirby and Shanice van de Sanden feature in UEFA's new Strong Is... mini-series.

Europe's most famous footballing families are supporting a new TV campaign by UEFA which calls on dads to encourage their daughters to play football.

After a lengthy teaser campaign, Meizu finally unveiled its latest flagships with the Meizu 17 and 17 Pro. Spec-wise the two are nearly identical with the Pro featuring better auxiliary cameras, wireless charging and faster RAM. Visually the two are also almost indistinguishable with the only difference being the 17 Pro comes with a ceramic back. These are also the first 5G entries in Meizu's lineup. The Meizu 17 duo is built around 6.6-inch Super AMOLED displays with 90Hz refresh rate and a first for Meizu punch-hole cutout for the 20MP selfie camera. The panels come with an...

With rumours that Kim Yo-jong might take over the leadership of North Korea after Kim Jong-un, we take a look at the role gender plays in society, especially politics.

ESPN's team of college writers and reporters reflects on the amazing plays they've seen during their decades of collective coverage.