Panelistas analizaron el panorama de desabastecimiento, caída en las reservas probadas y posibles importaciones para suplir la demanda interna de gas.

El parto natural y sus beneficios.

¿Cómo llevar a cabo un parto natural sano?

La naturaleza como mitigador de las condiciones físicas y mentales.

Tras la advertencia del gremio energético por una posible crisis de energía y gas ¿cómo podría actuar el gobierno para mitigar la problemática?

YouTuber Jake Paul and boxing heavyweight legend Mike Tyson are finally set to battle in their much-anticipated match at AT&T Stadium in Dallas on Friday night.

The post ‘I’m a Natural-Born Killer’: Mike Tyson Highlights the Difference Between Him and YouTuber Jake Paul appeared first on Breitbart.

NATURAL STUPIDITY skynet would never stand a chance

Queen Elizabeth wore a neon green outfit to her 90th birthday party. What could go wrong? Oh right, the internet...

How Organic Placement is Affected Some people seem to be hell-bent on believing that it matters. There is no problem with believing it does have a direct effect on organic placement, but the fact of the matter is; it does not. Although you are entitled to believe what you want to believe, but knowing whether […]

This End of Project Report describes an innovative Transition to Work Programme for young people with autistic spectrum diagnoses and is the result of a pilot programme developed by Lothian Autistic Society (LAS) and Scottish Outdoor Education Centres (SOEC) and made possible through funding from Scottish Natural Heritage (SNH). The pilot had the twin aims of developing employability skills and exploring the therapeutic value of the outdoors. 

Photo by NASA Natural disasters don’t just ravage landscapes—they also expose and deepen systemic inequalities. Recent hurricanes, Milton and Helene, tore through Florida, Georgia, and the Carolinas, destroying homes, businesses, and the lives built across generations. While governments rush to repair infrastructure and restore housing, they often overlook the people most impacted in the long term—especially […]

The post Natural Disasters Aren’t Gender Neutral – Hurricanes Milton and Helene Prove It appeared first on Feminist Majority Foundation.

Soapbox is a company dedicated to providing meticulously-crafted personal care products that focus on the health of humans and the environment. [...]

A new elevated wooden boardwalk in Fyresdal, Norway invites visitors to embrace a simultaneous expression of exceptional design and environmental sustainability. Traversing the natural landscape, the six-feet wide boardwalk gracefully snakes from the forest floor, skirting the picturesque Lake Fyresvatn. It ascends amidst the lofty treetops, culminating at the majestic summit of Klokkarhamaren, all while protecting the environment against unnecessary harm. [...]

The post Rare Natural Phenomenon Observed in Saint Petersburg appeared first on English Russia.

I blogged here before about things disappearing in my house — kitchen utensils, corkscrews, keys, etc. (See “Pixie Problems, or Working Things Out with the ‘Cousins’ (1)” and Part 2, Part 3, and Part 4.) Things have been better since then. … Continue reading →

With 23 short essays on creatures ranging from the wombat to the spider, Katherine Rundell's new book is essential reading for anyone whose wonder could use a jumpstart.

“This bill makes American liquefied natural gas accessible and cost-effective to regional allies."

The post Florida Lawmakers Want Accessible Liquefied Natural gas appeared first on Shark Tank.

By Ireland Owens President of the European Commission Ursula von der Leyen said Friday that she proposed to President-elect Donald Trump the idea that the U.S. could supply more natural gas to Europe to decrease the bloc’s reliance on Russia, according to Barron’s. The EU chief said the topic of tapping U.S. liquefied natural gas […]

The post With Trump Returning To Power, Europe Chief Weighs Idea Of Buying More Natural Gas From US Instead Of Russia appeared first on Liberty Unyielding.

Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: Gs, Gi/o, Gq/11, and G12/13. Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in Gs, Gi/o, or Gq/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Gα13 (encoded by GNA13) as potent activators of oncogenic signaling. First, we found that components of a G12/13-dependent signaling cascade that culminates in activation of the Hippo pathway effectors YAP and TAZ is frequently altered in bladder cancer. Up-regulation of this signaling cascade correlates with increased YAP/TAZ activation transcriptional signatures in this cancer type. Among the G12/13 pathway alterations were mutations in Arg-200 of Gα13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-dependent (SRE.L) transcriptional activity. We further showed that this mechanism relies on the same RhoGEF-RhoGTPase cascade components that are up-regulated in bladder cancers. Moreover, Gα13 Arg-200 mutants induced oncogenic transformation in vitro as determined by focus formation assays. In summary, our findings on Gα13 mutants establish that naturally occurring hotspot mutations in Gα subunits of any of the four families of heterotrimeric G-proteins are putative cancer drivers.

Sir David Attenborough and the BBC Studios Natural History Unit awarded Chatham House Prize 2019 for ocean advocacy News Release sysadmin 18 November 2019

The 2019 Chatham House Prize is awarded to Sir David Attenborough and Julian Hector, head of BBC Studios Natural History Unit, for the galvanizing impact of the Blue Planet II series on tackling ocean plastic pollution.

Time: 10:00 AM, Location: E1.012 (Hearing Room)

Managing natural resources

Research analyzing options for the sustainable management of natural resources and how to use them in a way that enhances the resilience of ecosystems.

Areas of focus include examining what is the future for fossil fuels and other extractive industries (especially coal, oil and natural gas), forest governance in light of continued illegal logging and deforestation, and ocean governance.

Natural resources are vital for the future sustainability of major industries such as agriculture, mining, tourism, fisheries and forestry. Research is carried out in areas such as land use planning, water management, biodiversity conservation, and the scientific and technical understanding of resources governance.

Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium tuberculosis, has less than 1% of the catalytic efficiency of a typical natural CM and requires complex formation with 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase for high activity. To explore the full potential of MtCM for catalyzing its native reaction, we applied diverse iterative cycles of mutagenesis and selection, thereby raising kcat/Km 270-fold to 5 × 105 m−1s−1, which is even higher than for the complex. Moreover, the evolutionarily optimized autonomous MtCM, which had 11 of its 90 amino acids exchanged, was stabilized compared with its progenitor, as indicated by a 9 °C increase in melting temperature. The 1.5 Å crystal structure of the top-evolved MtCM variant reveals the molecular underpinnings of this activity boost. Some acquired residues (e.g. Pro52 and Asp55) are conserved in naturally efficient CMs, but most of them lie beyond the active site. Our evolutionary trajectories reached a plateau at the level of the best natural enzymes, suggesting that we have exhausted the potential of MtCM. Taken together, these findings show that the scaffold of MtCM, which naturally evolved for mediocrity to enable inter-enzyme allosteric regulation of the shikimate pathway, is inherently capable of high activity.

A natural climate change priority for Africa Expert comment LJefferson 28 September 2022

Nature-based solutions can protect African nations’ shared natural endowment and meet the needs of their people.

Africa’s principal climate change negotiators have long understood the important contribution of ‘nature-based solutions’ (NBS) in delivering land (and sea) based options as part of the goals of the Paris Agreement. Limiting temperature rises to only 1.5°C by 2050 will demand finding innovative ways to protect Africa’s vast natural endowment that also meets the equally acute needs of its people. Nature-based solutions may do both.

The urgency for Africa cannot be overstated. At a Chatham House conference in Libreville, the Gabonese minister for the environment highlighted that if global warming surges by 2.5° or 3°C the impact would be at least 6°C for Africa. Decision-makers on the continent and across the world need to understand that ‘business as usual’ cannot be an option given the potential for loss of life, conflict and chaos.

Adaption, mitigation, or both?

Although adaptation to climate change has hitherto tended to be the continent’s main concern, there has also been growing recognition of the ways that Africa’s natural environments, from forests and grasslands, to peatlands and coastal and marine ecosystems, all also mitigate its impacts by sequestering carbon. The Congo Basin alone is said to store upwards of 4 per cent of global emissions annually.

These environments are under increasing pressure. Deforestation is a sad reality, caused mostly by unsustainable and extensive agricultural practices focused on cash crops for export more than food production to feed local populations. And arguing that African states and peoples should slow the development of their economies and infrastructure in response to a crisis born of the already-industrialized world does not find a responsive audience in a continent hungry for jobs and opportunity.

Nature-based solutions offer an answer to this conundrum. There is growing evidence that natural habitats both help avoid losses from climate change-related disasters and can drive economic growth. There is thus potential for NBS to tackle both adaptation and mitigation challenges at relatively low cost.

NBS – the rocky road from commitment to policy

It was logical therefore for Africa and like-minded countries to work to integrate NBS more strongly into the climate change agenda at COP26. The final Glasgow Climate Pact duly emphasized the importance of protecting ecosystems. The Global Forest Finance Pledge signed in the margins was also significant. African focus, with COP 27 in Egypt soon to take place, is now on domestic implementation and delivery of these pledges. The new African Union Climate Change and Resilient Development strategy (2022-2032) sets out many of the challenges and opportunities.

Choosing the right development pathway is tough, requiring political will and inclusive governance. Besides the challenge of securing alternative national revenue if a country moves away from fossil-intensive fuels – particularly acute for Africa’s resource-producing states – there is a dizzying array of policy decisions to be taken. African governments need to choose the most appropriate renewable energy sources, secure alternative livelihoods and continue to meet basic needs of the most vulnerable in the context of radical restructuring.  

Towards African solutions

There can be no one-size-fits-all answer to these questions – it is sadly still necessary to underline the enormous geographic, cultural and political diversity of the continent – but African experts have begun to draw together some emerging common themes from work already underway.  

Maintaining the ‘status quo’ in agricultural practices is no longer an option. Emphasis on sustainable agriculture is urgently needed andthat includes the elaboration of a ‘new deal’ between nature and people.  

Conservation also needs to be reframed as an economic opportunity, particularly in the elaboration and development of ecosystem services that deliver the true value of Africa’s forests, and that involve, value and reward local communities, respecting their rights and livelihoods.

Regional cooperation is likewise key, including on the management of forest, wildlife and water resources – Africa’s ecosystems do not respect arbitrary political boundaries, and accomplishing the dual feat of protecting cross-border systems at the same time as realizing their economic potential will demand effective collaboration, as well as training, education and communication at all levels.

The imperative of finance

A further imperative will be securing sufficient developed country financing – whether that be to secure value for net sequestration and effective forest management or for models of context-appropriate ‘smarter’ sustainable rural conservation and ecosystem resilience.

DNA polymerase from bacteriophage T7 undergoes large, substrate-induced conformational changes that are thought to account for high replication fidelity, but prior studies were adversely affected by mutations required to construct a Cys-lite variant needed for site-specific fluorescence labeling. Here we have optimized the direct incorporation of a fluorescent un-natural amino acid, (7-hydroxy-4-coumarin-yl)-ethylglycine, using orthogonal amber suppression machinery in Escherichia coli. MS methods verify that the unnatural amino acid is only incorporated at one position with minimal background. We show that the single fluorophore provides a signal to detect nucleotide-induced conformational changes through equilibrium and stopped-flow kinetic measurements of correct nucleotide binding and incorporation. Pre-steady-state chemical quench methods show that the kinetics and fidelity of DNA replication catalyzed by the labeled enzyme are largely unaffected by the unnatural amino acid. These advances enable rigorous analysis to establish the kinetic and mechanistic basis for high-fidelity DNA replication.

Faithful replication of the mitochondrial genome is carried out by a set of key nuclear-encoded proteins. DNA polymerase γ is a core component of the mtDNA replisome and the only replicative DNA polymerase localized to mitochondria. The asynchronous mechanism of mtDNA replication predicts that the replication machinery encounters dsDNA and unique physical barriers such as structured genes, G-quadruplexes, and other obstacles. In vitro experiments here provide evidence that the polymerase γ heterotrimer is well-adapted to efficiently synthesize DNA, despite the presence of many naturally occurring roadblocks. However, we identified a specific G-quadruplex–forming sequence at the heavy-strand promoter (HSP1) that has the potential to cause significant stalling of mtDNA replication. Furthermore, this structured region of DNA corresponds to the break site for a large (3,895 bp) deletion observed in mitochondrial disease patients. The presence of this deletion in humans correlates with UV exposure, and we have found that efficiency of polymerase γ DNA synthesis is reduced after this quadruplex is exposed to UV in vitro.

Governors in several natural resource-dependent states said recently they will have to continue to cut public education funding because prices for oil and coal have not rebounded.

Governors in several natural resource-dependent states said recently they will have to continue to cut public education funding because prices for oil and coal have not rebounded.

Corey M. Ziemba
Oct 16, 2024; 44:e0349242024-e0349242024
Systems/Circuits

The visual world is richly adorned with texture, which can serve to delineate important elements of natural scenes. In anesthetized macaque monkeys, selectivity for the statistical features of natural texture is weak in V1, but substantial in V2, suggesting that neuronal activity in V2 might directly support texture perception. To test this, we investigated the relation between single cell activity in macaque V1 and V2 and simultaneously measured behavioral judgments of texture. We generated stimuli along a continuum between naturalistic texture and phase-randomized noise and trained two macaque monkeys to judge whether a sample texture more closely resembled one or the other extreme. Analysis of responses revealed that individual V1 and V2 neurons carried much less information about texture naturalness than behavioral reports. However, the sensitivity of V2 neurons, especially those preferring naturalistic textures, was significantly closer to that of behavior compared with V1. The firing of both V1 and V2 neurons predicted perceptual choices in response to repeated presentations of the same ambiguous stimulus in one monkey, despite low individual neural sensitivity. However, neither population predicted choice in the second monkey. We conclude that neural responses supporting texture perception likely continue to develop downstream of V2. Further, combined with neural data recorded while the same two monkeys performed an orientation discrimination task, our results demonstrate that choice-correlated neural activity in early sensory cortex is unstable across observers and tasks, untethered from neuronal sensitivity, and therefore unlikely to directly reflect the formation of perceptual decisions.

Seven guest collaborators bring new eyes to a Smithsonian museum founder’s collection of American art

Discover evidence of natural selection and evolution at the Smithsonian's Natural History Museum (Meredith Bragg)

http://j.mp/196BLpQ From her salon in Maryland, Camille Reed sees more black women embracing natural hair

Our host, Eric Schulze, explains how science is tackling this puzzling question from space.

The agenda for Natural Resources Committee on 2019-10-09 7:00 PM dated Wednesday, 09 October 2019 has been archived. Access it here:
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The agenda for Natural Resources Committee on 2019-11-13 7:00 PM dated Wednesday, 13 November 2019 has been archived. Access it here:
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The agenda for Natural Resources Committee on 2019-12-11 7:00 PM dated Wednesday, 11 December 2019 has been archived. Access it here:
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The agenda for Natural Resources Committee on 2020-01-08 7:00 PM dated Wednesday, 08 January 2020 has been archived. Access it here:
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The agenda for Natural Resources Committee on 2020-03-11 7:00 PM - REVISED dated Wednesday, 11 March 2020 has been archived. Access it here:
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Makeda Brome, Pia Hansen, Linda Gojak, Marian Small, Kenneth Baum and David Krulwich share their thoughts on the biggest challenges facing math teachers.

Dover, Del—Natural gas prices have spiked in the past six months and are up more than 30 percent since the end of August 2021. This is largely due to increased U.S. demand and the ongoing energy crisis in Europe. According to the Energy Information Administration, about 43 percent of Delaware households rely on natural gas […]

Free one-day-only affair showcases one of Delaware’s most historic estates.