1 Japanese Yen = 0.5327 Macedonian Denar

After an extended period of lockdown, economic stimulus is badly needed.

His remarks came a day after Tamil Nadu moved the Supreme Court, seeking a stay against a Madras High Court order directing closure of liquor shops in the state.

For State : Mr. S.K. Mahala, PP. HON'BLE MR. JUSTICE PANKAJ BHANDARI Order 08/05/2020

1. Heard counsel for the petitioners through video conferencing. Learned Public Prosecutor is present in person in the Court.

2. Counsel for the complainant has not given his detail, hence, could not be connected.

3. Petitioner has filed this bail application under Section 439 of Cr.P.C.

4. F.I.R. No.343/2019 was registered at Police Station Kotwali, Jhunjhunu for offence under Sections 323, 365, 201, 302/34 of I.P.C. (FIR has been lodged for offence under Section 302 of IPC.)

5. It is contended by counsel for the petitioner that eye witnesses have turned hostile. As per the FSL report, cause of death is inconclusive. There was only a bruise on the person of the prosecutrix.

2. The case of prosecution against the appellants, in short, is that Vijay Pratap Singh (PW-9) while posted as S.H.O. of Police Station, Kotwali, Shahdol received information on 10/04/2007 that one Ravi Sharma alias Gudda is dealing with fake Indian currency notes and he is coming at bus stand with fake currency notes. SHO- Vijay Pratap Singh called two Panch witnesses Chandrakant Soni (PW-10) and Md Jakir khan (PW-3). and after informing them recorded the said information in Rojnamcha Sanha (Ex.P/1) and moved to spot along with panch witnesses, ASI Pradeep Dwivedi (PW-8), Constable Arvind Pyasi (PW-7), Swatantra Singh, Arvind Dubey, Mahesh Yadav, Satya Narayan (PW-4), Rahees Khan, Pramod Pandey, Shailendra Chaturvedi and driver Chandra Prakas in Government Vehicle No.M.P.03 5682 3 and recorded that outgoing in Rojnamcha Sanha (Ex.P/31).

The iconic hot hatch is one of the first right hand drive models that ever arrived in the UK in 1979 and has been retained in 'museum quality' condition, having covered less than 17,000 miles from new.

Famke Janssen was glimpsed braving the cold for some takeaway on a snowy Saturday in New York City. The 55-year-old X-Men star made sure to keep her pale purple face mask and her gloves on.

2.The petitioner has been transferred from Tirunelveli to Chennai, Egmore Railway Police Station. The petitioner, who is working as a Head Constable in Tirunelveli Railway Police Station, has now been asked to join at Egmore Railway Police Station in the same post.

3.Since it is an issue of transfer and an administrative order, it may not be proper on the part of this Court to examine either reasons for transfer or also the grievances of the petitioner. It is for the http://www.judis.nic.in 2/5 W.P(MD)Nos.6127 of 2020 authorities to examine the same. The grievance of the petitioner is that he has been relieved from Tirunelveli with a direction to join at Chennai. But, he has still not joined at Chennai.

Superstar Rajinikanth on Sunday warned the ruling AIADMK against reopening state-run liquor outlets in Tamil Nadu, saying if it was done, it should not harbour "dreams" of coming to power again, apparently in next year's Assembly elections. In a tweet, he also asked the government to work out alternate modes of revenue generation. His remarks came a day after Tamil Nadu moved the Supreme Court, seeking a stay against a Madras High Court order directing closure of liquor shops in the state. The AIADMK cannot have "dreams of coming to power again if the government re-opens TASMAC shops at this juncture," the veteran said in the tweet. "Please #Look out for better ways of filling the coffers," he added. The Tamil Nadu government had on Saturday moved the apex court challenging the High Court order for closure of TASMAC (Tamil Nadu State Marketing Corporation) liquor outlets on grounds of violations of COVID-19 guidelines, arguing that it would lead to "grave losses" in ...

The passing of Rishi Kapoor has left a big hole in the hearts of audiences of the Hindi film industry. However, we may get to see Rishi on screen one last time. Reportedly, Rishi Kapoor's last film Sharmaji Namkeen will be

Anurag Kashyap's production Ghoomketu, starring Nawazuddin Siddiqui will finally release this month on the ZEE5 streaming platform, on May 22. Directed by  Pushpendra Nath Mishra, the film was originally set to release in 2018. The film also stars  Anurag Kashyap as

The Malawian inventor who built a windmill at the age of 14 stopped in last night for a visit with the Daily Show's Jon Stewart.

Coeval Now Includes Internet Speeds up to 1,000 Mbps in All Units and Common Areas

Banking space to see more pain going forward: Siddhartha Khemka

select banks in India can offer forex rates to Indian clients beyond the inter-bank market hours

​Saints batter Championship side MK Dons to progress through to the fourth round of the Capital One Cup at stadiummk.

TWO goals each by Craig Jeffrey and Micah Smithart, alongside a Ben Hibberd penalty stroke, swept Winchester to a 5-2 opening day win over ten-man Indian Gymkhana at Osterley in hockey's South Premier 1.

Sebi shall also appoint an independent audit firm for conducting a detailed forensic audit of the books of accounts of Ricoh for the financial year 2012-13 onwards till date, the cost of which shall be borne by Ricoh.

A month after demonetisation, the industry is yet to recover from the shock. Sales have dipped drastically, and small businesses have had to shut down.

I put together this course is for those new to the Maschine MK3, those upgrading from other controllers, and those just needing a hardware refresher. The videos in this course are focused, to the point, and designed to give you a solid foundation quickly so you can get back to making beats. Check it out, […]

The post Maschine MK3 Hardware Quickstart Course appeared first on Maschine Tutorials.

In the latest Maschine update (version 2.8.6) NI added the ability to change the color of your pads as well as move your pads and groups around directly from the controller. This may seem small, but for those who like to stay focused on the hardware it’s one less thing you have to go to […]

The post Maschine MK3 – Change Pad Color & Move Pads from the Hardware appeared first on Maschine Tutorials.

This plugin spotlight features the Cooper Time Cube MkII by Universal Audio, a unique emulation of the original garden hose-based mechanical delay device.

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The post Plugin Spotlight: Cooper Time Cube MkII by Universal Audio appeared first on Dubspot Blog.

Klanten die een internetabonnement van KPN hebben waren altijd verplicht om gebruik te maken van het modem dat de provider in bruikleen meeleverde; de zogenoemde Experia Box. KPN heeft deze verplichte voorwaarde nu gewijzigd. Daardoor is het nu ook mogelijk om een eigen modem te kiezen en aan te sluiten.

Today we'll do a simple run through of a valuation method used to estimate the attractiveness of Cheniere Energy, Inc...

(United States Second Circuit) - In a putative class action alleging that New York City grocery stores operated by Whole Foods Market-defendant systematically overstated the weights of pre‐packaged food products and overcharged customers as a result, the district court's grant of defendant's motion to dismiss plaintiff's complaint for lack of Article III standing because he failed to allege a sufficient injury in fact, is vacated where plaintiff plausibly alleged an injury in fact.

I have finally obtained the first batch of the printed "Programming Algorithms" books and will shortly be sending them to the 13 people who asked for a hardcopy.

Here is a short video showing the book "in action":

If you also want to get a copy, here's how you do it:

1. Send the money to my PayPal account: $30 if you want normal shipping or $35 if you want a tracking number. (The details on shipping are below).
2. Shoot me an email to vseloved@gmail.com with your postal address.
3. Once I see the donation, I'll go to the post office and send you the book.
4. Optionaly step: if you want it to be signed, please, indicate it in your letter.

Shipping details: As I said originally, the price of the dead-tree version will be $20+shipping. I'll ship via the Ukrainian national post. You can do the fee calculation online here (book weight is 0.58 kg, size is 23 x 17 x 2 cm): https://calc.ukrposhta.ua/international-calculator. Alas, the interface is only in Ukrainian. According to the examples I've tried, the cost will be approximately $10-15. To make it easier, I've just settled on $10 shipping without a tracking number of $15 if you want a tracking number. Regardless of your country. I don't know how long it will take - probably depends on the location (I'll try to inquire when sending).

The book was already downloaded more than 1170 times (I'm not putting the exact number here as it's constantly growing little by little). I wish I knew how many people have, actually, read it in full or in part. I've also received some error corrections (special thanks goes to Serge Kruk), several small reviews and letters of encouragement. Those were very valuable and I hope to see more :)

Greetings from the far away city of Lima, Peru!
I loved this part: "Only losers don't comment their code, and comments will be used extensively"
Thank you so much for putting this comprehensive collection of highly important data structures, i'm already recommending this to two of my developers, which I hope i'll induce into my Lisp addiction.
--Flavio Egoavil

And here's another one:

Massively impressive book you've written! I've been a Lisp programmer for a long time and truly appreciate the work put in here. Making Lisp accessible for more people in relation to practical algorithms is very hard to do. But you truly made it. You'll definitely end up in the gallery of great and modern Lisp contributions like "Land of Lisp" and "Let Over Lambda". Totally agree with your path to focus on practical algorithmic thinking with Lisp and not messing it up with macros, oop and other advanced concepts.
--Lars Hård

Thanks guys, it's really appreciated!

If you feel the same or you've liked the book in some respect and have found it useful, please, continue to share news about it: that definitely helps attract more readers. And my main goal is to make it as widely read as possible...

South Africa's net death rate has decreased amid the Covid-19 pandemic over the past five weeks, despite the 186 deaths thus far, Health Minister Zweli Mkhize says.

The autosomal dominant disorder Schnyder corneal dystrophy (SCD) is caused by mutations in UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K₂ subtype menaquinone-4 (MK-4). SCD is characterized by opacification of the cornea, owing to aberrant build-up of cholesterol in the tissue. We previously discovered that sterols stimulate association of UBIAD1 with ER-localized HMG-CoA reductase, which catalyzes a rate-limiting step in the synthesis of cholesterol and nonsterol isoprenoids, including GGpp. Binding to UBIAD1 inhibits sterol-accelerated ER-associated degradation (ERAD) of reductase and permits continued synthesis of GGpp in cholesterol-replete cells. GGpp disrupts UBIAD1-reductase binding and thereby allows for maximal ERAD of reductase as well as ER-to-Golgi translocation of UBIAD1. SCD-associated UBIAD1 is refractory to GGpp-mediated dissociation from reductase and remains sequestered in the ER to inhibit ERAD. Here, we report development of a biochemical assay for UBIAD1-mediated synthesis of MK-4 in isolated membranes and intact cells. Using this assay, we compared enzymatic activity of WT UBIAD1 with that of SCD-associated variants. Our studies revealed that SCD-associated UBIAD1 exhibited reduced MK-4 synthetic activity, which may result from its reduced affinity for GGpp. Sequestration in the ER protects SCD-associated UBIAD1 from autophagy and allows intracellular accumulation of the mutant protein, which amplifies the inhibitory effect on reductase ERAD. These findings have important implications not only for the understanding of SCD etiology but also for the efficacy of cholesterol-lowering statin therapy, which becomes limited, in part, because of UBIAD1-mediated inhibition of reductase ERAD.

Dong-Jae Jun
May 1, 2020; 61:746-757
Research Articles

The autosomal dominant disorder Schnyder corneal dystrophy (SCD) is caused by mutations in UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K₂ subtype menaquinone-4 (MK-4). SCD is characterized by opacification of the cornea, owing to aberrant build-up of cholesterol in the tissue. We previously discovered that sterols stimulate association of UBIAD1 with ER-localized HMG-CoA reductase, which catalyzes a rate-limiting step in the synthesis of cholesterol and nonsterol isoprenoids, including GGpp. Binding to UBIAD1 inhibits sterol-accelerated ER-associated degradation (ERAD) of reductase and permits continued synthesis of GGpp in cholesterol-replete cells. GGpp disrupts UBIAD1-reductase binding and thereby allows for maximal ERAD of reductase as well as ER-to-Golgi translocation of UBIAD1. SCD-associated UBIAD1 is refractory to GGpp-mediated dissociation from reductase and remains sequestered in the ER to inhibit ERAD. Here, we report development of a biochemical assay for UBIAD1-mediated synthesis of MK-4 in isolated membranes and intact cells. Using this assay, we compared enzymatic activity of WT UBIAD1 with that of SCD-associated variants. Our studies revealed that SCD-associated UBIAD1 exhibited reduced MK-4 synthetic activity, which may result from its reduced affinity for GGpp. Sequestration in the ER protects SCD-associated UBIAD1 from autophagy and allows intracellular accumulation of the mutant protein, which amplifies the inhibitory effect on reductase ERAD. These findings have important implications not only for the understanding of SCD etiology but also for the efficacy of cholesterol-lowering statin therapy, which becomes limited, in part, because of UBIAD1-mediated inhibition of reductase ERAD.

OBJECTIVE

To assess the efficacy and safety of MK-0941, a glucokinase activator (GKA), when added to stable-dose insulin glargine in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS

In this double-blind study, 587 patients taking stable-dose insulin glargine (±metformin ≥1,500 mg/day) were randomized (1:1:1:1:1) to MK-0941 10, 20, 30, or 40 mg or matching placebo t.i.d. before meals (a.c.). This study included an initial 14-week, dose-ranging phase followed by a 40-week treatment phase during which patients were to be uptitrated as tolerated to 40 mg (or placebo) t.i.d. a.c. The primary efficacy end point was change from baseline in A1C at Week 14.

RESULTS

At Week 14, A1C and 2-h postmeal glucose (PMG) improved significantly versus placebo with all MK-0941 doses. Maximal placebo-adjusted least squares mean changes from baseline in A1C (baseline A1C 9.0%) and 2-h PMG were –0.8% and –37 mg/dL (–2 mmol/L), respectively. No significant effects on fasting plasma glucose were observed at any dose versus placebo. By 30 weeks, the initial glycemic responses noted at 14 weeks were not sustained. MK-0941 at one or more doses was associated with significant increases in the incidence of hypoglycemia, triglycerides, systolic blood pressure, and proportion of patients meeting criteria for predefined limits of change for increased diastolic blood pressure.

CONCLUSIONS

In patients receiving stable-dose insulin glargine, the GKA MK-0941 led to improvements in glycemic control that were not sustained. MK-0941 was associated with an increased incidence of hypoglycemia and elevations in triglycerides and blood pressure.

Wien : Urban & Schwarzenberg, 1893-1895.

Hannover : Köllner, 1898.

Leipzig : Veit, 1888.

Zürich : Speidel, 1895.

Jena : Fischer, 1904.

Stuttgart : F. Enke, 1891.

Stuttgart : Enke, 1904.

[Place of publication not identified] : [publisher not identified], [18--?]

The quinoline MK-571 is the most commonly used inhibitor of multidrug resistance protein-1 (MRP-1) but was originally developed as a cysteinyl leukotriene receptor 1 (CysLTR1) antagonist. While studying the modulatory effect of MRP-1 on anti-hepatitis C virus (HCV) direct acting-antivirals (DAA) efficiency, we observed an unexpected anti-HCV effect of compound MK-571 alone. This anti-HCV activity was characterized in Huh7.5 cells stably harboring a subgenomic genotype 1b replicon. A dose-dependent decrease of HCV RNA levels was observed upon MK-571 administration, with an EC₅₀ of 9±0.3 μM and a maximum HCV RNA level reduction of approximatively 1 Log₁₀. MK-571 also reduced the replication of the HCV full-length J6/JFH1 model in a dose-dependent manner. However, probenecid and apigenin homodimer (APN), two specific inhibitors of MRP-1, had no effect on HCV replication. In contrast, the CysLTR1 antagonists SR2640 increased HCV-SGR RNA levels in a dose-dependent manner, with a maximum increase of 10-fold. In addition, a combination of natural CysLTR1 agonist (LTD4) or antagonists (zafirlukast, cinalukast, and SR2640) with MK-571 completely reversed its antiviral effect, suggesting its anti-HCV activity is related to CysLTR1 rather to MRP-1 inhibition. In conclusion, we showed that MK-571 inhibits HCV replication in hepatoma cell cultures by acting as a CysLTR1 receptor antagonist, thus unraveling a new host-virus interaction in the HCV life cycle.

Armenia's most famous footballing son, Henrikh Mkhitaryan is the U19 EURO ambassador and looks back at his own youth career.

Budget 2018 initiatives to stimulate industrialisation in various sectors of the economy is a welcome issue, says Zweli Mkhize, former ANC treasurer general.

Youtube tyre shredding sensation, Ken Block has roped in latest batmobile designer to make his next hooning machine. Here are the renderings of the new Fox-body Mustang called the Hoonifox and a tyre shredding video may on the way soon.

Besides the Integrated L-40 stages, HAL is also manufacturing the riveted structures, propellant tanks, feed lines of PSLV, GSLV MKII and GSLV MKIII launch vehicles and structures of various satellites for the space agency.

Arduino’s MKR family of products got two new wireless connectivity boards added to its range of products. These include MKR WiFi 1010 and MKR NB 1500, both aimed at streamlining IoT product/service development.

Arduino’s blog notes that “the Arduino MKR WiFi 1010 is the new version of the MKR1000 with ESP32 module on board made by U-BLOX.”

MKR WiFi 1010: For prototyping of WI-FI based IoT applications

The core difference of MKR WiFi 1010 compared to MKR WiFi 1000 is that the former can be put to use in production-grade IoT apps and it has ESP32-based module manufactured by u-blox. The former enables to add 2.4GHz WiFi and Bluetooth capability to the application. Additionally, it comes with a programmable dual-processor system (an ARM processor and a dual-core Espressif IC).

MKR NB 1500: For on-field monitoring systems and remote-controlled LTE-enabled modules

The Arduino MKR NB 1500 is based on new low-power NB-IoT (narrowband IoT) standard. This makes it appropriate for IoT apps running over cellular/LTE networks.

Key use cases of this board are remote monitoring systems and remote-controlled LTE-enabled modules. It supports AT&T, T-Mobile USA, Telstra, Verizon over the Cat M1/NB1 deployed bands 2, 3, 4, 5, 8, 12, 13, 20 and 28.

Arduino also pitches this board to be used in IoT apps which used to rely on alternative IoT networks such as LoRa and Sigfox. It promises to save power compared to GSM or 3G cellular-based connections.

“The new boards bring new communication options to satisfy the needs of the most demanding use cases, giving users one of the widest range of options on the market of certified products.” Arduino co-founder and CTO Massimo Banzi

1 Seychellois Rupee = 302.2757 Zambian Kwacha

1 Seychellois Rupee = 3.31 Macedonian Denar