Postoperative recurrence from microscopic residual disease must be prevented to cure intractable cancers, including pancreatic cancer. Key to this goal is the elimination of cancer stem cells (CSCs) endowed with tumor-initiating capacity and drug resistance. However, current therapeutic strategies capable of accomplishing this are insufficient. Using in vitro models of CSCs and in vivo models of tumor initiation in which CSCs give rise to xenograft tumors, we show that dexamethasone induces expression of MKP-1, a MAPK phosphatase, via glucocorticoid receptor activation, thereby inactivating JNK, which is required for self-renewal and tumor initiation by pancreatic CSCs as well as for their expression of survivin, an anti-apoptotic protein implicated in multidrug resistance. We also demonstrate that systemic administration of clinically relevant doses of dexamethasone together with gemcitabine prevents tumor formation by CSCs in a pancreatic cancer xenograft model. Our study thus provides preclinical evidence for the efficacy of dexamethasone as an adjuvant therapy to prevent postoperative recurrence in patients with pancreatic cancer.

The Army has successfully tested the MK-22 Precision Sniper Rifle to clear it for fielding.

War of words between Tamil Nadu's ruling DMK and actor-politician Vijay's fledgling Tamizhaga Vetri Kazhagam flared up again Monday, with Chief Minister MK Stalin accusing "new parties" of wanting to "eliminate" his party

Read the in depth Review of Keychron K8 Pro QMK/VIA Wireless Mechanical Keyboard PC Components. Know detailed info about Keychron K8 Pro QMK/VIA Wireless Mechanical Keyboard configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Arduino’s MKR family of products got two new wireless connectivity boards added to its range of products. These include MKR WiFi 1010 and MKR NB 1500, both aimed at streamlining IoT product/service development.

Arduino’s blog notes that “the Arduino MKR WiFi 1010 is the new version of the MKR1000 with ESP32 module on board made by U-BLOX.”

MKR WiFi 1010: For prototyping of WI-FI based IoT applications

The core difference of MKR WiFi 1010 compared to MKR WiFi 1000 is that the former can be put to use in production-grade IoT apps and it has ESP32-based module manufactured by u-blox. The former enables to add 2.4GHz WiFi and Bluetooth capability to the application. Additionally, it comes with a programmable dual-processor system (an ARM processor and a dual-core Espressif IC).

MKR NB 1500: For on-field monitoring systems and remote-controlled LTE-enabled modules

The Arduino MKR NB 1500 is based on new low-power NB-IoT (narrowband IoT) standard. This makes it appropriate for IoT apps running over cellular/LTE networks.

Key use cases of this board are remote monitoring systems and remote-controlled LTE-enabled modules. It supports AT&T, T-Mobile USA, Telstra, Verizon over the Cat M1/NB1 deployed bands 2, 3, 4, 5, 8, 12, 13, 20 and 28.

Arduino also pitches this board to be used in IoT apps which used to rely on alternative IoT networks such as LoRa and Sigfox. It promises to save power compared to GSM or 3G cellular-based connections.

During an in-house podcast interview, the Economic Freedom Fighters leader said he had been surprised by the suggestion

The resignation drama has helped distract attention from the DMK party's woes in advance of next years Parliamentary elections.

Aug 15, 2023

As a Predoctoral Research Fellow at the Belfer Center’s Environment and Natural Resources Program and Science, Technology, and Public Policy Program, Lydia Zemke has spent the last two years studying climate finance in developing countries. As she rounds out her time at the Belfer Center, Zemke she reflects on her research interests, her experience conducting fieldwork in Kenya and Costa Rica, and her advice for other early-career researchers. 

For Petitioner(s) : Mr. Meghraj Meena For Respondent(s) : Mr. Vijay Singh Yadav, PP HON'BLE MR. JUSTICE GANESH RAM MEENA Order 07/11/2024

1. This bail application has been filed by the accused-petitioner under Section 483 B.N.S.S., in connection with F.I.R. No.438/2024, registered at the Police Station Niwai, District Tonk for the offences punishable under Sections 3, 25(1)(b) & 25(8) of Arms Act.

2. Heard.

3. Considered.

4. Having regard the submissions made by counsel for the petitioner so also the fact that no recovery has been effective from the accused-petitioner and more particularly the co-accused have already been enlarged on bail by this Court on 24.10.2024 and the accused-petitioner is in custody since long time, this Court without expressing any opinion on the merits and demerits of the case, [2024:RJ-JP:46152] (2 of 2) [CRLMB-13712/2024] deems just and proper to enlarge the petitioner on bail.

A 5ft 8 inch guy captured hearts worldwide with his iconic pose-the hand stretch that began in Dilwale Dulhania Le Jayenge and still makes fans want to run into his embrace. Known as the undisputed 'King Khan' of Bollywood, Shah Rukh

Berlin ; Boston : De Gruyter Saur, [2023]

New York : Routledge, 2011.

Ekta Kapoor's telly show passes a milestone.

Meet the winners at the Zee Rishtey Awards.

Kamkwamba, William, 1987- author

Cambridge, Mass. : National Bureau of Economic Research 2023

Actor Bellamkonda Sreenivas talks about his debut in Hindi cinema with the redux of Rajamouli-Prabhas blockbuster ‘Chatrapathi’

Director Neill Blomkamp sits down with WIRED to talk about the innovative camera rig his team created for his video game-inspired horror film, Demonic.

Sweetmeat attracts 5 per cent GST. However, namkeen or savoury items like fruit and vegetable chips, bhuijas, and other snack foods etc attract GST at the rate of 12 per cent

AIADMK secretary A. Anbalagan and former MLA A. Baskar led the demonstration against the govt.’s ‘failure’ to supply free rice and sugar as promised; the former alleged that only beneficiaries in constituencies of those in power received the gift

The pair put India in the driver’s seat against Pakistan in the World Group play-o in Islamabad; the Swedes have dropped only two rubbers in ve ties against the Indians over the years

Palaniswami urged the DMK Government to go to Delhi with 38 MPs of the DMK and its allies to stop attempts and prevent the proposal to construct a dam across the Cauvery at Mekedatu

Police suspect previous enmity to be the reason behind the incident

The Coimbatore police question IMK youth wing leader for threatening to “chop off editor’s tongue”, sparking legal action and protests

Former Fisheries Minister D. Jayakumar told journalists at the party headquarters that the AIADMK would have no truck with the BJP not only in 2026 but also in other elections in the future

BJP’s Tamilisai Soundararajan says that it is not necessary that only parties with similar ideologies should form an alliance

The parties spotlight a letter ostensibly written by the District Congress Committee to the party’s national leadership requesting K. Muraleedharan’s candidature in Palakkad. Mr. Muraleedharan later confirms that his name was on the DCC list.

A select list of stories to read before you start your day

Asserting that “the ground realities are different”, AIADMK general secretary Edappadi K. Palaniswami said “we will emerge victorious with the support of the people”

Diljit Dosanjh's switch in singing style as he smoothly assumes Chamkila's vocal persona highlights the brilliance of his artistry, observes Sukanya Verma.

The latest updates from the Malayalam film industry.

RmKv Silks which turned 100 this year, has launched their range of thematic handloom silk saris with natural dye this festive season