This is Sample Size, our weekly new music feature with KOSU's Ryan LaCroix and LOOKatOKC music critic Matt Carney. Today, Matt plays new music from Frank Ocean , Joyce Manor & M.I.A. Follow Matt & Ryan on Twitter at @mdotcarney and @KOSUryan .

Just eight months from forming, South Australian punk band Chelsea Manor found themselves playing before 15,000 screaming people at their first live gig.

U.S. Senate candidate Andrew Romanoff secured a dominant victory Saturday at a Democratic Party assembly, earning him a slot in the June 30 primary and setting the stage for a likely one-on-one contest between him and John Hickenlooper.

(US 4th Circuit) - No. 19-1369

Tune in at 8pm to hear Puccini's first operatic success Manon Lescaut staring Renata Tebaldi and Mario del Monaco recorded in 1960.

It's a long one and it gets weird.

The post Hear TOOL Drummer Danny Carey Guest On New DANIEL ROMANO'S OUTFIT Single appeared first on Metal Injection.

The pop star is taking over the fashion world.

The post Reel Review: What’s New with the Shimano Stella SW 2020? appeared first on Ocean Blue Fishing Adventures.

El Grupo BBVA acaba de formalizar un acuerdo con IBM para que esta firma asuma la operación y transformación de la infraestructura tecnológica actual de BBVA y el procesamiento de datos en América Latina y EE.UU., actualmente gestionada por su filial ATA en México.

IBM y VON DER HEIDE, compañía especializada en servicios de consultoría de Recursos Humanos, informan que han firmado una importante alianza para expandir su oferta de servicios de Employee Engagement y HR Analytics en toda América Latina. Por medio de las tecnologías de IBM, esta alianza le permitirá a VON DER HEIDE brindar a sus clientes una oferta de consultoría única en el mercado, para transformar estrategias de talento en resultados de negocio.

1. Happy birthday Sai Pallavi: 4 times the actress redefined female superstar tag  Onmanorama
2. Birthday Special! Sai Pallavi is the epitome of elegance and grace in sarees. PHOTOS  Times of India
3. Happy Birthday Sai Pallavi: 5 Instagram Pictures Of The Actress You Can’t Miss  News18
4. Happy birthday Sai Pallavi: A powerhouse performer  Deccan Herald
5. Sai Pallavi birthday: Rana Daggubati, Naga Chaitanya and others send wishes  The Indian Express
6. View Full coverage on Google News

The 12-speed trickle down continues as Shimano unveils their new Deore drivetrain, along with new brakes and wheels.
( Photos: 14, Comments: 471 )

The fire is believed to have been caused by self-heating of textiles within a tumble dryer

Three years ago it was barely walking. Now, Atlas, the humanoid robot from Boston Dynamics is performing gymnastic routines that mimic professional athletes.

How do you help millions of passengers navigate one of the world's largest airports? In Turkey, the answer is a fleet of humanoid robots.

A British firm claims it has been hired by a mysterious robotics company to find the perfect face for a new fleet of humanoid robots.

Hear about hiking the Kumano Koto trek in Japan as the Amateur Traveler talks to Sherry Ott about her experience on this trail that was used by medieval emperors on the Kii Peninsula. 

[Paris] : [publisher not identified], 1895.

Havniae : Typis N. Christensen, 1792.

A Toronto law firm has filed to launch a class action lawsuit against a Niagara Falls long-term care home where 18 residents have died from COVID-19, saying the home had a pub night in the midst of the pandemic.

Mucormycosis is a life-threatening infection with high mortality that occurs predominantly in immunocompromised patients. Manogepix (MGX) is a novel antifungal that targets Gwt1, an early step in the conserved glycosylphosphotidyl inositol (GPI) post-translational modification pathway of surface proteins in eukaryotic cells. Inhibition of inositol acylation by MGX results in pleiotropic effects including inhibition of maturation of GPI-anchored proteins necessary for growth and virulence. MGX has been previously shown to have in vitro activity against some strains of Mucorales. Here we assessed the in vivo activity of the prodrug fosmanogepix, currently in clinical development for the treatment of invasive fungal infections, against two Rhizopus arrhizus strains with high (4.0 μg/ml) and low (0.25 μg/ml) minimum effective concentration (MEC) values. In both invasive pulmonary infection models, treatment of mice with 78 mg/kg or 104 mg/kg fosmanogepix, along with 1-aminobenzotriazole to enhance the serum half-live of MGX in mice, significantly increased median survival time and prolonged overall survival by day 21 post infection when compared to placebo. In addition, administration of fosmanogepix resulted in a 1-2 log reduction in both lung and kidney fungal burden. For the 104 mg/kg fosmanogepix dose, tissue clearance and survival were comparable to clinically relevant doses of isavuconazole (ISA), which is FDA approved for the treatment of mucormycosis. These results support continued development of fosmanogepix as a first in class treatment for invasive mucormycosis.

Manogepix (APX001A) is the active moiety of the novel drug candidate fosmanogepix (APX001). We previously reported the broad-spectrum activity of manogepix but also observed a correlation between increased manogepix and fluconazole MICs. Here we extended this study and included isolates with acquired fluconazole resistance.

Isolates (n=835) were identified using CHROMagar, MALDI-TOF and, when needed, ITS-sequencing. EUCAST E.Def 7.3.1 susceptibility testing included manogepix, amphotericin B, anidulafungin, micafungin, fluconazole and voriconazole. Manogepix wildtype-upper-limit (WT-UL) values were established following EUCAST-principles for ECOFF setting allowing wildtype/non-wildtype classification. Drug-specific MIC correlations were investigated using Pearson's correlation.

Manogepix modal MICs were low (range 0.004-0.06 mg/L against 16/20 included species). Exceptions were C. krusei and C. inconspicua, and to a lesser extent C. kefyr and Pichia kluyveri. The activity was independent of Fks echinocandin hot-spot alterations (n=17). Adopting the WT-UL established for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis, 14/724 (1.9%) isolates were non-wildtype for manogepix. Twelve of these (85.7%) were also non-wildtype for fluconazole. A statistically significant correlation was observed between manogepix and fluconazole MICs for C. albicans, C. dubliniensis, C. glabrata, C. parapsilosis and C. tropicalis (Pearson r=0.401-0.575), but not between manogepix and micafungin or amphotericin B MICs for any species except C. tropicalis (r=0.519 for manogepix versus micafungin).

Broad-spectrum activity was confirmed for manogepix against contemporary yeast. However, a 1-4 two-fold-dilution increase in manogepix MICs is observed in a subset of isolates with acquired fluconazole resistance. Further studies on the potential underlying mechanism and implication for optimal dosing are warranted.

This settlement resolves allegations that Newark Manor provided substandard and worthless care to residents of the nursing facility. Attorney General Kathy Jennings announced today that the State of Delaware has reached an agreement with Newark Manor Nursing Home (also known as Premiere Healthcare, Inc.), its owner Bruce Boyer, administrator David Boyer and former administrator Susan […]

Although the main body of Section 2(q) expressly states that a respondent is an “adult male person”, the proviso widens the scope of proceedings by stating that an aggrieved wife or female living in a relationship in the nature of marriage can file a complaint against a relative of her husband/male partner. This rescinds the argument that the legislative intent was to exclude females. The Appeal was allowed with a direction to the Trial Courts to consider R2 and R3 as respondents in the proceedings.

Through key exhibitions and texts, Celant was an influential proponent of the work of young Italian artists in Turin, Milan, Genoa and Rome, working with natural materials and elements such as dirt, sticks or rags who were seeking to challenge the commercial art scene at the time

A decade after joining politics, Manoj Tiwari is seen as one of the contenders for the top post in Delhi if the BJP wins Saturday's assembly elections -- at least by Chief Minister Arvind Kejriwal.

Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix susceptibility. In C. albicans, a gain-of-function mutation in the transcription factor gene ZCF29 activated expression of ATP-binding cassette transporter genes CDR11 and SNQ2. In C. parapsilosis, a mitochondrial deletion activated expression of the major facilitator superfamily transporter gene MDR1.

Skybot F-850 will spend a week on the ISS charming astronauts with its sense of humor

Job postings from a NASA contractor suggest that a new humanoid robot is under development

Your weekly selection of awesome robot videos

PAX is history but Chris is still feeling the siren’s call of some of its best games. Alice is busy fending off aliens and hedgehogs....

The Chief Minister of Goa, Manohar Parrikar, will be our guest at Idea Exchange on Tuesday, April 17.

Fatima Sana Shaikh is an actress who brings life to characters with her passionate acting skills. With a busy 2020, she has multiple releases between Ludo where she will be seen alongside actor Rajkumar Rao and Suraj Pe Mangal Bhari alongside Manoj Bajpayee.

The actress has really made a huge impact on the industry, from being a child actress to her spectacular performance in Dangal and Thugs of Hindostan. Suraj pe Mangal Bhari will see Fatima in the avatar of a Marathi girl for which she learnt how to deliver dialogues in Marathi with fluency.

Recently, in an interview with a daily, Fatima's Suraj pe Mangal Bhari co-star Manoj Bajpayee was all praises for the actress, he said, "Fatima comes from a middle class family and despite her recent successes has held on to the values she grew up with, and that's what makes her special. We stay in touch through video chat these days."

No matter how far you go and how much success you achieve it is important to remember your roots and your core values and actress Fatima Sana Shaikh does just that. The actress grasps and absorbs skills working alongside remarkable actors while also holding on to her values and adding color of her own authenticity which is what makes for Fatima's exceptional acting skills. Hang on tight for her next release!

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Manoj Bajpayee is celebrating his 51st birthday today with his family, and there cannot be a greater feeling for any actor to spend time with his loved ones and that too on such a special occasion. But how will he be bringing on the special day? Speaking to Mumbai Mirror, he spilled the beans on the same.

He said, "I am in the hills with my family. There can be no better setting." However, since nobody can step out due to the lockdown, Bajpayee even spoke about this and said, "The only problem is that we're not allowed to go out of the compound here, and as all the houses are far apart from each other, there is hardly any human contact." His wife Shabana and his parents are in Delhi right now and he also talked about his concern.

He said, "We are constantly in touch with them and have asked friends to check on both our parents." The actor has been working in Hindi Cinema for the last 25 years and given some unforgettable performances in films like Satya, Kaun, Shool, Gangs of Wasseypur, Aligarh, and more recently, The Family Man. He's now gearing up for Suraj Pe Mangal Bhari and Mrs. Serial Killer!

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Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

Jacqueline is one of the most successful actresses who has given commercially hits as well as some great performances. With every project, the actress has entertained the audiences and will be soon making her digital debut with Mrs. Serial Killer up next.

Stirring things up a bit this time, Jacqueline has opted for a role which is completely opposite of her Miss sunshine avatar, in reel-life with her OTT debut Mrs. Serial Killer which is just a couple of days away from the release. The film is all set to premiere on 1st May.

The actress will be seen alongside celebrated actor Manoj Bajpayee and sharing her experience on working with the actor for the first time, Jacqueline says, "I met him at the shoots in the high altitudes; he is so full of energy and has so may stories to tell you. He is a bit funny as well and that made the shoot worth the while."

Earlier as well the actress had shared how she is a big fan of Manoj Bajpayee's body of work and for her OTT debut grabbed the opportunity to work with him. The actress also loved Manoj's work in 'The Family Man.'

Jacqueline loves to always experiment with her projects and never shies away from trying out something new. Her OTT debut performance is something we are all looking forward to. From the trailer itself, Jacqueline looks extremely promising and we're excited!

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

Though Irrfan and I did not share screen space, we featured together in two films, Akash Deep's Ghaath (2000), and Suparn Verma's Acid Factory (2009).

In the second, we were together in only one fleeting scene. We knew each other because our roots [lay in] theatre. I knew him from the time we began our careers, and we followed each other's journey in films. I looked at him with tremendous regard. We went through the same [experiences] at the same time: We struggled together, and as outsiders, fought for the same thing: to earn our place in different types of films.

We faced both rejection and acceptance from the audience, and the industry.

It is difficult to come to terms with the fact that Irrfan is no more. His contribution to the industry and the world of acting will live on. He still had a lot more [to offer], so his passing away is difficult for a colleague and contemporary [to come to terms with].

As told to Shaheen Parkar

Priyadarshan: He wanted to do a comedy when he came back

Irrfan was a dear friend. We worked together in Billoo, and often spent the evenings together. He would talk about his struggles and [being apprehensive about] carving his place as an actor, in movies, because of his looks. He'd say he was advised to stick to theatre because he didn't have the qualities of a hero, but [would remind himself] that 'somebody needs [to see] somebody like me [as a hero]'.

He had told people that if he came back [following his treatment in London], they should keep scripts [ready] for him. But when he returned, he told me he [was easily] tired, and couldn't work for more than five hours. I spoke to him four months ago, and he said that though the treatment had made him weak, he [had been] cured. He wanted to do a comedy and told me to call him with a script.

As told to Upala KBR

Mithila Palkar: He taught me to focus on nuances

My fondest memory of Irrfan sir was him referring to me as Binaca Geetmala, because I'd always sing on the sets of Karwaan. If he liked something that I was humming, he would request [me to sing] it.

I haven't been to acting school. But merely [being in his] presence was like attending one. My lesson from observing him was to focus on the small details in a scene, and understanding nuances. We lost a gem and I don't think this void can be filled.

As told to Sonia Lulla

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Actor Manoj Bajpayee struggles to put his thoughts into words, and says everything has just gone "haywire" ever since he heard the news of Irrfan Khan's demise. The actor says though Irrfan wasn't his "best friend", they were connected with a very unique thread of rejection and acceptance in showbiz.

"For me to put my feelings in words and really frame it in a way that it all looks organised is tough. After hearing the news of his demise, everything went haywire mentally," Manoj told IANS. "I don't know how to react to it. The only emotion which is happening inside of me is extreme sadness. I am so sad that it is difficult for me to even think of anything. And I feel exhausted with the heaviness that I am feeling," he added.

Manoj has immense respect for Irrfan as "a contemporary, a colleague, co-actor and as somebody who started at the same time". "We faced similar kinds of rejections, struggles and acceptance. I feel that I lost a co-traveler. Though he was not my best friend, somewhere I felt that he was somebody whose journey was known to me and who knew my journey," said the actor, who will soon be seen in Netflix's "Mrs. Serial Killer".

Manoj continued: "It is like we were traveling in the same compartment, looking at each other from a distance but not fully knowing personally. It was enough to look at each other from a distance and admire each other. His contribution to cinema and the world of acting is going to be lauded and appreciated for very long."

Irrfan breathed his last early on Wednesday at the age of 54. Irrfan was admitted to Mumbai's Kokilaben Dhirubhai Ambani hospital with a colon infection earlier this week. However, unfortunately he succumbed to his ailment. The actor is survived by his wife Sutapa Sikdar and two sons Babil and Ayan.

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Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

In an exclusive conversation with International Business Times India, Manoj Bajpayee spoke about his role in Mrs Serial Killer, his experience of working with Shirish Kundar and Jacqueline Fernandez and further went on to speak about the rise of OTT platforms and also spills the beans on how he is spending his lockdown time with family amidst nature.

Lawsuit Case: 276

Dominic Jermano -Vs- Nanning City Municipal Court

November 27,...