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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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GlobalLogic opens delivery centre in Hyderabad to spread wings, ramp up hiring in Telangana 

The company will consider spreading wings to one more such location, in addition to Mahbubnagar where it has about 350 employees




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Hyderabad to get regional centre of Indian Institute of Creative Technology

All activities are going to start quickly. The facility in Hyderabad will be set up in the IMAGE Tower, said Secretary, Union Ministry of Information and Broadcasting




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Hyderabad Airport wins global recognition for digital innovations




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Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM




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Why are countries fighting over climate finance at COP29?

Here is what you need to know about the November 11-22 summit talks on finance.




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Why US chess champ Levon Aronian is connecting with the Armenian community in Chennai

Chess champion Levon Aronian, who competed in Chennai Grand Masters recently, on future Indian chess superstars




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CRICKET | Tanmay’s 15th Ranji Trophy ton powers Hyderabad to position of strength

The opener makes Andhra pay a heavy price for a dropped catch early in his innings; off-spinner Vijay the pick of the bowlers with his three wickets




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Ranji Trophy | Tamil Nadu has Railways under the cosh with dominant show

CRICKET | Skipper Jagadeesan’s decision to field pays off handsomely as Ajith Ram and Gurjapneet take quick wickets; Ahuja, Saif and Merai hold out with half centuries




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Devotees, martial arts, chants fill Hyderabad streets for Guru Nanak’s birth anniversary




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Sindhu movers to pre-quarters, Lakshya bows out of Kumamoto Masters Japan




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Photographer from Gaza Strip among winners at top photography award in UAE

The Hamdan bin Mohammed bin Rashid Al Maktoum International Photography Award (HIPA) is the richest photography competition in the world.




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Defence Space Agency conducts maiden tabletop exercise ‘Antariksha Abhyas’

One of the aims of the exercise was also to identify vulnerabilities in conduct of operations in the event of denial or disruptions of space-based services




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Lanthanum-doped nickel-based composite metal oxide catalyst for hydrogenation of isophthalonitrile to produce meta-xylenediamine

Catal. Sci. Technol., 2024, Advance Article
DOI: 10.1039/D4CY00802B, Paper
Heng Shao, Jing Guo, Rulong Li, Dekun Ji, Long Huang, Haibin Chu
Lanthanum-doped nickel-based composite metal oxide catalysts exhibited excellent activity in IPN hydrogenation reactions with remarkable stability in fixed-bed reactors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Explained: What is climate change and why is the world meeting at COP29?




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Hyundai bets on buoyant Bharat, plans measures to boost sales

Rural demand now comprises 21% of Hyundai’s total sales, up from 18.5% two years ago, said Tarun Garg




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Why the Indian stock market is falling: Analysis of recent trends

Indian stock markets have shown notable volatility over the past two days, with sharp declines unsettling investors and signalling potential shifts in market sentiment




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Upendra Baxi writes: Why D Y Chandrachud’s legacy will matter




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Have you Contra-Dated? Here's Why You Should Try It

Contra-dating is all about pushing boundaries. rediffGURU Ravi Mittal, CEO of online dating app Quack Quack, lists 10 reasons why everyone should try it at least once.




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PV Sindhu shines, Lakshya stumbles in Kumamoto opener

Double Olympic medallist PV Sindhu sailed into the pre-quarterfinals but Lakshya Sen made an opening-round exit from the Kumamoto Masters Japan Super 500 tournament in Kumamoto, Japan on Wednesday.




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Why Do Some Parishes Reach Out and Others Don't?

Assembly of Bishops Researcher Alexei Krindatch joins Fr. Barnabas to discuss the latest study on evangelism in the Orthodox Church.




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Marygold & Co. partners with Griffin to support healthy financial habits

UK-based Marygold & Co. has...




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Muscovite dehydration melting; reaction mechanisms, microstructures, and implications for anatexis

Dyck, B; Waters, D J; St-Onge, M R; Searle, M P. Journal of Metamorphic Geology 2019 p. 1-24, https://doi.org/10.1111/jmg.12511
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20160157.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20160157.jpg" title="Journal of Metamorphic Geology 2019 p. 1-24, https://doi.org/10.1111/jmg.12511" height="150" border="1" /></a>




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Offshore bedrock geology of Eclipse Sound and Pond Inlet: connecting the structure and stratigraphy of Bylot and northern Baffin islands

Currie, L D; Brent, T A; Turner, E C. Canadian Journal of Earth Sciences vol. 57, no. 10, 2020 p. 1254-1267, https://doi.org/10.1139/cjes-2019-0159
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210388.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210388.jpg" title="Canadian Journal of Earth Sciences vol. 57, no. 10, 2020 p. 1254-1267, https://doi.org/10.1139/cjes-2019-0159" height="150" border="1" /></a>




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Integrated bio-chemostratigraphy of Lower and Middle Triassic marine successions at Spiti in the Indian Himalaya: implications for the Early Triassic nutrient crisis

Sun, Y D; Richoz, S; Krystyn, L; Grasby, S E; Chen, Y L; Banerjee, D; Joachimski, M M. Global and Planetary Change vol. 196, 103363, 2020 p. 1-25, https://doi.org/10.1016/j.gloplacha.2020.103363
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200602.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200602.jpg" title="Global and Planetary Change vol. 196, 103363, 2020 p. 1-25, https://doi.org/10.1016/j.gloplacha.2020.103363" height="150" border="1" /></a>




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Neoproterozoic-Cambrian stratigraphy of the Mackenzie Mountains, northwestern Canada, part II: archival stratigraphic data for the Backbone Ranges Formation and related units, Mackenzie Mountains, Northwest Territories, Canada (NTS 95-L and 105-P)

MacNaughton, R B. Geological Survey of Canada, Open File 8668, 2020, 26 pages, https://doi.org/10.4095/327238
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327238.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327238.jpg" title="Geological Survey of Canada, Open File 8668, 2020, 26 pages, https://doi.org/10.4095/327238" height="150" border="1" /></a>




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Neoproterozoic-Cambrian stratigraphy of the Mackenzie Mountains, northwestern Canada, part I: Ediacaran measured sections and updated lithostratigraphy, NE Sekwi Mountain map area (NTS 105-P)

MacNaughton, R B. Geological Survey of Canada, Open File 7315, 2020, 22 pages, https://doi.org/10.4095/327237
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327237.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327237.jpg" title="Geological Survey of Canada, Open File 7315, 2020, 22 pages, https://doi.org/10.4095/327237" height="150" border="1" /></a>




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Middle-Upper Devonian conodont faunas and biostratigraphy of the Horn River Group in the northern Mackenzie Mountains and Plain (NWT, Canada)

Gouwy, S A. Geoconvention 2020, abstract archive; 2020 p. 1
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200407.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200407.jpg" title="Geoconvention 2020, abstract archive; 2020 p. 1" height="150" border="1" /></a>




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A quasi-annual record of time-transgressive esker formation: implications for ice-sheet reconstruction and subglacial hydrology

Livingstone, S J; Lewington, E L M; Clark, C D; Storrar, R D; Sole, A J; McMartin, I; Dewald, N; Ng, F. The Cryosphere vol. 14, issue 6, 2020 p. 1989-2004, https://doi.org/10.5194/tc-14-1989-2020




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Lithostratigraphy of Devonian basinal mudrocks in frontier areas of northwestern Canada augmented with ED-XRF technique

Kabanov, P; Vandenberg, R; Pelchat, P; Cameron, M; Dewing, K. arktos 2020 p. 1-14, https://doi.org/10.1007/s41063-020-00074-z
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20180326.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20180326.jpg" title="arktos 2020 p. 1-14, https://doi.org/10.1007/s41063-020-00074-z" height="150" border="1" /></a>




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A summary of the Paleozoic biostratigraphy and reexamination of palynology samples from the 9590 to 10 000 ft. (2923.0-3048.0 m) interval of the Gannet O-54 well, Grand Banks of Newfoundland

Bingham-Koslowski, N; Miller, M A. Geological Survey of Canada, Open File 8819, 2021, 7 pages, https://doi.org/10.4095/328813
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328813.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328813.jpg" title="Geological Survey of Canada, Open File 8819, 2021, 7 pages, https://doi.org/10.4095/328813" height="150" border="1" /></a>




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Mercury record of intense hydrothermal activity during the early Cambrian, South China

Zhu, G; Wang, P; Li, T; Zhao, K; Zheng, W; Feng, X; Shen, J; Grasby, S E; Sun, G; Tang, S; Yan, H. Palaeogeography, Palaeoclimatology, Palaeoecology vol. 568, 110294, 2021 p. 1-10, https://doi.org/10.1016/j.palaeo.2021.110294
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210155.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210155.jpg" title="Palaeogeography, Palaeoclimatology, Palaeoecology vol. 568, 110294, 2021 p. 1-10, https://doi.org/10.1016/j.palaeo.2021.110294" height="150" border="1" /></a>




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Ice-flow history and regional stratigraphy of the northwestern Laurentide Ice Sheet, evidence from the Great Slave Lake area

Hagedorn, G; Ross, M; Paulen, R; Smith, R. GAC®-MAC 2021, London, Canada: Exploring Geosciences Through Time and Space/GAC®-MAC 2021, London, Canada : Explorer les géosciences à travers le temps et l'espace; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 122
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210032.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210032.jpg" title="GAC®-MAC 2021, London, Canada: Exploring Geosciences Through Time and Space/GAC®-MAC 2021, London, Canada : Explorer les géosciences à travers le temps et l'espace; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 122" height="150" border="1" /></a>




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Neoproterozoic-Cambrian stratigraphy of the Mackenzie Mountains, northwestern Canada, part III: measured sections from Neoproterozoic and Cambrian formations, NTS 96-D

MacNaughton, R B. Geological Survey of Canada, Open File 8771, 2021, 39 pages, https://doi.org/10.4095/328118
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328118.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328118.jpg" title="Geological Survey of Canada, Open File 8771, 2021, 39 pages, https://doi.org/10.4095/328118" height="150" border="1" /></a>




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Calibration of Middle to Upper Jurassic palynostratigraphy with Boreal ammonite zonations in the Canadian Arctic

Nguyen, A V; Galloway, J M; Poulton, T P; Dutchak, A. Bulletin of Canadian Petroleum Geology vol. 68, no. 3, 2021 p. 65-90, https://doi.org/10.35767/gscpgbull.68.3.65
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200747.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200747.jpg" title="Bulletin of Canadian Petroleum Geology vol. 68, no. 3, 2021 p. 65-90, https://doi.org/10.35767/gscpgbull.68.3.65" height="150" border="1" /></a>




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Overpressure detection from geophysical, drilling and well testing data for petroleum exploration wells in the Beaufort-Mackenzie Basin, Yukon and Northwest Territories

Hu, K; Issler, D R; Chen, Z. Geological Survey of Canada, Open File 6692, 2021, 37 pages, https://doi.org/10.4095/327948
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327948.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_327948.jpg" title="Geological Survey of Canada, Open File 6692, 2021, 37 pages, https://doi.org/10.4095/327948" height="150" border="1" /></a>




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Introduction to the "Circum-Arctic Palynological Event Stratigraphy" (CAPE) series of papers

Bujak, J; Fensome, R; Mangerud, G; Williams, G. Atlantic Geology vol. 57, 2021 p. 1-5, https://doi.org/10.4138/atlgeol.2021.001
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200615.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200615.jpg" title="Atlantic Geology vol. 57, 2021 p. 1-5, https://doi.org/10.4138/atlgeol.2021.001" height="150" border="1" /></a>




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Geophysical characteristics of the northern Cordillera

Hayward, N; Ryan, J J. Northern Cordillera geology: a synthesis of research from the Geo-mapping for Energy and Minerals program, British Columbia and Yukon; by Ryan, J J (ed.); Zagorevski, A (ed.); Geological Survey of Canada, Bulletin 610, 2021 p. 145-176, https://doi.org/10.4095/326069




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On the Statherian-Calymmian palaeogeography of northwestern Laurentia

Rainbird, R H; Davis, W J. Journal of the Geological Society vol. 179, issue 5, 2022 p. 1-20, https://doi.org/10.1144/jgs2022-062
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220491.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220491.jpg" title="Journal of the Geological Society vol. 179, issue 5, 2022 p. 1-20, https://doi.org/10.1144/jgs2022-062" height="150" border="1" /></a>




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Geophysical contributions to a synthesis of western Churchill geology and metallogeny

Re-release; Tschirhart, V; Pehrsson, S; Wodicka, N; Percival, J A; Jefferson, C W; Peterson, T; Berman, R G. Geological Survey of Canada, Preprint 3, 2022, 47 pages, https://doi.org/10.4095/330639
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_330639.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_330639.jpg" title="Geological Survey of Canada, Preprint 3, 2022, 47 pages, https://doi.org/10.4095/330639" height="150" border="1" /></a>




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Linking clinoform trajectory analysis and sequence stratigraphy: improved stratigraphic understanding of the Labrador margin, offshore eastern Canada

Dafoe, L T; Dickie, K; Williams, G L. GAC-MAC-IAH-CNC-CSPG, Halifax 2022; 2022 p. 79
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210585.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210585.jpg" title="GAC-MAC-IAH-CNC-CSPG, Halifax 2022; 2022 p. 79" height="150" border="1" /></a>




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Lower Paleozoic stratigraphy and geology, Richardson Mountains, Yukon (with stratigraphic and paleontological appendices)

Cecile, M P; Norford, B S; Nowlan, G S; Uyeno, T T. Geological Survey of Canada, Bulletin 614, 2022, 53 pages, https://doi.org/10.4095/329454
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_329454.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_329454.jpg" title="Geological Survey of Canada, Bulletin 614, 2022, 53 pages, https://doi.org/10.4095/329454" height="150" border="1" /></a>




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Upper Triassic to Lower Jurassic stratigraphy along the northeastern margin of the Sverdrup Basin, Axel Heiberg and Ellesmere islands, Nunavut: new data from measured sections

Midwinter, D; Hadlari, T; Dewing, K. Geological Survey of Canada, Open File 8855, 2022, 17 pages, https://doi.org/10.4095/329398
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_329398.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_329398.jpg" title="Geological Survey of Canada, Open File 8855, 2022, 17 pages, https://doi.org/10.4095/329398" height="150" border="1" /></a>




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Biostratigraphy and paleoecology of the trilobite faunas from the Mount Clark and Mount Cap formations (early and middle Cambrian), eastern Mackenzie Mountains, northwestern Canada

Handkamer, N M; Pratt, B R; MacNaughton, R B. Journal of Paleontology vol. 96, S89, 2022, 47 pages, https://doi.org/10.1017/jpa.2022.13
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210288.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210288.jpg" title="Journal of Paleontology vol. 96, S89, 2022, 47 pages, https://doi.org/10.1017/jpa.2022.13" height="150" border="1" /></a>




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The 2020 Canada datapack for TimeScale Creator: a new tool for Mesozoic - Cenozoic stratigraphy of the Canadian north

Re-release; Bringué, M; Fensome, R A; Poulton, T P; Galloway, J M; Bujak, J P; Golding, M L; Orchard, M J; Williams, G L. Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 237-286, 10 sheets, https://doi.org/10.4095/326099
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326099.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326099.jpg" title="Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 237-286, 10 sheets, https://doi.org/10.4095/326099" height="150" border="1" /></a>




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Devonian conodont biostratigraphy of the Mackenzie Mountains, western part of the Northwest Territories

Re-release; Gouwy, S A. Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 159-184, https://doi.org/10.4095/326098
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326098.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326098.jpg" title="Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 159-184, https://doi.org/10.4095/326098" height="150" border="1" /></a>




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Hydrocarbon resource potential in the Labrador-Baffin Seaway and onshore West Greenland

Bingham-Koslowski, N; McCartney, T; Bojesen-Koefoed, J; Jauer, C. Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 409-432, https://doi.org/10.4095/321859
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321859.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321859.jpg" title="Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 409-432, https://doi.org/10.4095/321859" height="150" border="1" /></a>




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Overview of the stratigraphy, paleoclimate, and paleoceanography of the Labrador-Baffin Seaway

Dafoe, L T; Williams, G L; Dickie, K; Gregersen, U; Knutz, P C; Dam, G; Pedersen, G K; Nøhr-Hansen, H; Haggart, J W; DesRoches, K J. Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 311-339, https://doi.org/10.4095/321853
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321853.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321853.jpg" title="Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 311-339, https://doi.org/10.4095/321853" height="150" border="1" /></a>




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Stratigraphy of the West Greenland Margin

Gregersen, U; Knutz, P C; Pedersen, G K; Nøhr-Hansen, H; Ineson, J R; Larsen, L M; Hopper, J R; Bojesen-Koefoed, J A; Dam, G; Funck, T; Hovikoski, J. Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 247-309, https://doi.org/10.4095/321849
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321849.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321849.jpg" title="Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 247-309, https://doi.org/10.4095/321849" height="150" border="1" /></a>




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Stratigraphy of western Baffin Bay: a review of existing knowledge and some new insights

Dafoe, L T; Dickie, K; Williams, G L. Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 219-246, https://doi.org/10.4095/321846
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321846.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321846.jpg" title="Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 219-246, https://doi.org/10.4095/321846" height="150" border="1" /></a>