Demi Lovato left fans gushing after she made a PDA-filled appearance with boyfriend Max Ehrich in Ariana Grande and Justin Bieber’s new track

ABSTRACT

The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most factors that could respond to oxidative stress (a host cell defense mechanism). We previously found that the C terminus of Ehrlichia surface invasin, entry-triggering protein of Ehrlichia (EtpE; EtpE-C) directly binds mammalian DNase X, a glycosylphosphatidylinositol-anchored cell surface receptor and that binding is required to induce bacterial entry and simultaneously to block the generation of reactive oxygen species (ROS) by host monocytes and macrophages. However, how the EtpE-C–DNase X complex mediates the ROS blockade was unknown. A mammalian transmembrane glycoprotein CD147 (basigin) binds to the EtpE-DNase X complex and is required for Ehrlichia entry and infection of host cells. Here, we found that bone marrow-derived macrophages (BMDM) from myeloid cell lineage-selective CD147-null mice had significantly reduced Ehrlichia-induced or EtpE-C-induced blockade of ROS generation in response to phorbol myristate acetate. In BMDM from CD147-null mice, nucleofection with CD147 partially restored the Ehrlichia-mediated inhibition of ROS generation. Indeed, CD147-null mice as well as their BMDM were resistant to Ehrlichia infection. Moreover, in human monocytes, anti-CD147 partially abrogated EtpE-C-induced blockade of ROS generation. Both Ehrlichia and EtpE-C could block activation of the small GTPase Rac1 (which in turn activates phagocyte NADPH oxidase) and suppress activation of Vav1, a hematopoietic-specific Rho/Rac guanine nucleotide exchange factor by phorbol myristate acetate. Vav1 suppression by Ehrlichia was CD147 dependent. E. chaffeensis is the first example of pathogens that block Rac1 activation to colonize macrophages. Furthermore, Ehrlichia uses EtpE to hijack the unique host DNase X-CD147-Vav1 signaling to block Rac1 activation.

IMPORTANCE Ehrlichia chaffeensis is an obligatory intracellular bacterium with the capability of causing an emerging infectious disease called human monocytic ehrlichiosis. E. chaffeensis preferentially infects monocytes and macrophages, professional phagocytes, equipped with an arsenal of antimicrobial mechanisms, including rapid reactive oxygen species (ROS) generation upon encountering bacteria. As Ehrlichia isolated from host cells are readily killed upon exposure to ROS, Ehrlichia must have evolved a unique mechanism to safely enter phagocytes. We discovered that binding of the Ehrlichia surface invasin to the host cell surface receptor not only triggers Ehrlichia entry but also blocks ROS generation by the host cells by mobilizing a novel intracellular signaling pathway. Knowledge of the mechanisms by which ROS production is inhibited may lead to the development of therapeutics for ehrlichiosis as well as other ROS-related pathologies.

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Astronomers using NASA’s Neil Gehrels Swift Observatory have tracked water loss from 2I/Borisov, the first known interstellar comet to visit our Solar System, as it approached and rounded the Sun. Their findings were published in the Astrophysical Journal Letters. 2I/Borisov was detected on August 30, 2019 by Gennady Borisov, an astronomer at the Crimean Astrophysical [...]

A look at some of the biggest moments in sports history to occur on May 2.

The research collaboration will seek to identify candidate biomarkers for a group of inflammatory conditions, using AI and other advanced technology.

Connecticut-based Boehringer Ingelheim Pharmaceuticals Inc. has agreed to pay $95 million to resolve allegations relating to the improper promotion of the stroke-prevention drug Aggrenox, the chronic obstructive pulmonary disease (COPD) drugs Atrovent and Combivent, and the hypertension drug Micardis, the Justice Department announced today.

Australia’s largest biotech company CSL says it is working on a plasma-based therapy for patients with more severe forms of COVID-19.

Smog-choked, traffic-clogged Tehran may seem an unlikely candidate for an environmental honor, but the Iranian capital's aggressive recent moves to improve its public-transit

While husband Dharmendra is at their Lonavala farm, Hema Malini is spending lockdown at her Juhu home with pet dogs. The veteran star provided a glimpse of her 'special family members' on Twitter. She shared pictures of Snoopy, the stray she adopted as a puppy. She also has a Golden Retriever called Gypsy "who has now grown old and spends the entire afternoon with me (sic)."

Song of the hills

Jubin Nautiyal is spending lockdown in hometown Dehradun. The Tum hi aana singer is keeping fans entertained through virtual performances from his rooftop. Considering the picturesque backdrop in the hilly terrain, fans have now asked for a virtual concert. He has lined up a show on April 26, which will stream live on his social media handles. Nautiyal will render Bollywood as well as English tracks.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

A slice of the verdant Nehru Science Centre in Worli has been taken over by the civic authorities for what Centre director Dr S Khened thinks must be for "an isolation centre, or for quarantine."

Khened said, "I do not know exactly for which. We got official communication a couple of days earlier that a portion of the centre's space will be acquired. The front portion of the Centre, just as you enter the main gate, has been taken. We usually use that space to hold Science exhibitions. We have also held a vintage car exhibition two years ago in that venue, so it is a massive space."

Centre officials said preparations are in full swing, with beds and mattresses and even mobile toilets being brought in. The Science Centre officials have tried to talk to those in charge at the site for details but without too much success.

They reasoned, "it is evident that the officials are extremely stressed and we are in fact, prepared for the worst. Authorities are working extremely hard to get this ready," they stated.

Khened said that the environs of the Centre are very green and will need to be maintained. "We need to have some skeletal staff inside to maintain the green patches, the trees, the many plants that we have. They need water and regular upkeep," he said adding that it was important that the Coronavirus facility is completely sealed off from the other parts of the sprawling complex.

The Centre also has skeletal staff quarters on the premises where currently eight senior officers are living with their families, "so it is vital that those who are going to be shifted into the facilities for Coronavirus, be confined to that space. I am sure this has been thought out and will be done," said Khened.

Physical space
The Science centre has moved its activities online, like most other institutions, with two virtual lectures scheduled on their YouTube channel on May 9 and May 11 respectively. The former will be a talk by Dr Vasant Shinde on Rakhigarhi Excavation and the latter is Dr Anil Kakodkar, on 'dealing with energy needs in the context of climate crisis'. Yet, said Dr Khened, "We will open again as a physical space when the government gives the green light. Children, the main visitors at the Centre, may have some apprehension about visiting since this will be used as a Coronavirus facility.

There is a great deal of wariness as the Centre is just next to the Jijamata Nagar slum area, which is a COVID hotspot. "However, with all the trepidation, we too understand that this is for the greater good, and everybody has to do their part in this fight," the director said.

Line up
The Worli area, with an unenviable record number of Coronavirus cases in Mumbai, is also being taken over as quarantine/isolation areas rapidly. Just around the corner from the Science Centre, the Nehru Centre, which is next to the Nehru Planetarium has also been acquired for Corona purposes.

S P Verma, Jt Director of Nehru Centre, said, "The two exhibition halls on the ground floor have been acquired, not the Nehru Planetarium. I think beds and other amenities will be moved in shortly, I do not know when exactly. We had been told to hand over possession of the spaces and have done so," he finished.

The Nehru Centre joins neighbour, NSCI club's The Dome and Mahalaxmi racecourse as an entire line of Haji Ali institutions, whose space has been acquired for Corona combat.

Catch up on all the latest Mumbai news, crime news, current affairs, and a complete guide from food to things to do and events across Mumbai. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

Amazon's latest announcement of their upcoming show Paatal Lok has created quite a buzz and has gripped the attention of the audiences. After back to back releases of character posters, the latest addition to the list is Sanjeev Mehra.

Sanjeev Mehra is played by actor Neeraj Kabi in a new and unique avatar. Sanjeev is a renowned journalist and virtually takes you behind the scenes of the fourth estate of democracy. What better day than World Press Freedom Day to introduce the journalist.

The makers first released a teaser followed by motion posters of Hathiram Chaudhary played by Jaideep Ahlawat, followed by Vishal Tyagi aka Hathoda Tyagi. Produced by Clean Slate Films, the trailer of the Amazon Original series is set to release on May 5, 2020.

Have a look at his character right here:

 

 

 

View this post on Instagram

sanjeev mehra - journalism ki duniya ka ek aisa naam jiska har shabd logon ke liye sach bann jaata hai. #PaatalLok trailer: may 5, 11:34 am

A post shared by amazon prime video IN (@primevideoin) onMay 2, 2020 at 11:15pm PDT

The highly anticipated Amazon Original Series, by creator Sudip Sharma (writer for Udta Punjab, NH10), Paatal Lok is all set to walk viewers through the virtual gates of purgatory on May 15, 2020.

The official trailer for the highly anticipated series drops this Tuesday - May 5, 2020, at 11:34 am.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

Actress Neha Dhupia and her daughter Mehr turned to art on Monday. Taking to Instagram, Neha shared a photograph that shows her and her little girl playing with paint. "Piece of (he)-art," she captioned the image. Netizens were amused to see paint splattered all over Mehr and Neha.

 

 

 

View this post on Instagram

Piece of (he)-art ❤ï¸Â

A post shared by Neha Dhupia (@nehadhupia) onMay 4, 2020 at 1:49am PDT

Reacting to the picture, filmmaker Tahir Kashyap wrote: "hahah so cute. What fun." Actress Dia Mirza commented with a heart emoji on the mother-daughter's adorable snap.

Mehr was born to Neha and Angad Bedi in November 2018.

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

Actor Lakshay Khurana says that he is a "shy guy" in real life and is not like his character in the TV show "Naagin Bhagya Ka Zehreela Khel".

"In real life I'm very shy. I am not the one who flirts with girls. I'm totally opposite of what I play on screen. Hardik (his character) is a guy who can date many girls at one time. The character has many shades and I play that honestly," he said.

"Initially my friends used to tease me because of my character. They never thought that I could play something like this. My family also enjoy watching me and appreciates my acting," he added.

He is happy with his role right now, but in the future he would like to play a protagonist.

"I really like to experiment with my roles. So far the roles that I have played, I have done those parts honestly. In the future also, I am looking forward to doing something very challenging and I want to see myself playing a protagonist," he said.

The actor had earlier appeared in the show "Lajwanti".

Catch up on all the latest entertainment news and gossip here. Also, download the new mid-day Android and iOS apps.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

Saliva and sweat are components that cannot be entirely done away with, insist a few distinguished India cricketers, as the ICC contemplates legalising ball tampering post COVID-19 by using artificial substances to prevent virus spread. Former India pacer Ashish Nehra and spinner Harbhajan Singh feel that saliva's use in shining the ball is a "must". While discussions are at nascent stage, questions are already being asked about what external substances could be used if ball tampering becomes legal?

Is it going to be bottle cap in pocket to scuff up one side of the ball, vaseline to shine (made famous by English cricketer John Lever) or chain zipper? "Get one thing clear at the onset. The ball will not swing if you don't apply sweat or saliva on the ball. That's basic necessity of swing bowling. The moment ball gets scuffed up from one side, sweat and saliva must be applied on the other side," said Nehra, who completely shot down the idea of using external substances. "Now let's understand why do you need saliva? Sweat is heavier than saliva but both are heavy enough to make one side of the ball heavier for reverse swing. Vaseline comes into the picture only after sweat and saliva, not before that.

"It is lighter and doesn't even ensure conventional swing. It can keep the shine, but doesn't make the ball heavy," he added. Harbhajan also agreed that saliva if one has already chewed mint, which has sugar in it, makes it heavier. But when it comes to using external substance, he wants to know what can be the options. "It's not that murray mint can be used without putting it in your mouth.

The coat of sugar on the saliva makes it heavier after one side gets scuffed. A scuffed up ball is also good for spinners as it ensures a better grip than a shiny new ball. But my question is, if you allow, what's the limit?" Harbhajan questioned.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

Former India pacer Ashish Nehra went down the memory lane with ex-teammate Aakash Chropra during a chat on Chopra's show Aakashvani. Nehra said how he had only one pair of shoes which he used for Ranji Trophy games as well as his Test debut against Sri Lanka in Colombo in 1999.

"I wore them for the first time in Ranji Trophy and had only one pair which I took them with me to play in my first Test match in 1999. I still remember I used to get the shoe stitched after each innings and that is how it survived the entire Test," Nehra said.

Talking about practicing bowling action at the Delhi Cantonment Railway station with the club's bowling coach, Nehra said: "I wasn't alone. There used to be a bunch of us who would go to drop sir at the railway station. He would ask us to show him different bowling actions. I remember we would pick up the stones at the station and bowl with them."

The pair also discussed a game they had played at the Race Course ground in Delhi for their club team. "You remember we had to bowl into the wind and against the wind? The coach asked me why I didn't bowl you from that end. I told him that you wanted to bowl from the other end," said Chopra as the two had a good laugh going down memory lane. Left-arm pacer Nehra played 17 Tests, 120 ODIs and 27 T20Is for India.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

Virat Kohli's Indian team still has a long way to go before it is spoken of in the same breath as Australia of 2000s, feels former India pacer Ashish Nehra. Under Kohli's leadership, India earned its maiden series victory in Australia in 2018-19, achieving the feat after trying for seven decades. However, it can't be discounted that absence of Steve Smith and David Warner due to ball tampering ban turned out to be an important factor.

"This Indian team has to still cover a lot of distance in order to match up with that Australia team (led by Steve Waugh and then Ricky Ponting)," Nehra said during an interaction with ex-player Aakash Chopra on his show 'Aakash Vani'. "You are talking about an Australian team which won three consecutive World Cups and before that reached the final in 1996, won 18-19 Test matches in home and away conditions," Nehra added. He also did not appreciate the fact that every now and then team combination is being tinkered with. "It's not like this Indian team can not reach there but I believe the core group is very important. A person gets confused after watching many dishes on the table and so it's important to have fewer but better dishes," Nehra made his displeasure clear. He the went on to cite how team management had handled Rishabh Pant's career so far.

"KL Rahul is playing on the fifth position and Pant, the person you were preparing to succeed M.S. Dhoni, is serving drinks," the left-arm fast bowler, known for his straight forward views, said. Thanks to his inconsistency, Pant had lost his place in the Indian team in white-ball cricket to Rahul. "I know he (Pant) has missed his chances and there is no doubt about it but then you have kept him in the team because you saw the potential in him at 22-23 years," Nehra said.

Ashish Nehra

"There are a lot of talented players but they should be backed for a longer duration. Today also when we talk about the number five and six slots in Indian ODI side, then we are not sure about it," Nehra said. Nehra, who played 17 Tests, 120 ODIs and 27 T20 Internationals, feels Kohli's captaincy is still a work in progress. "Virat Kohli as a player needs no recognition as his career graph tells the entire story. Kohli as a player has done amazingly well. In captaincy, I still feel he is a work in progress. I can say he is a little bit of an impulsive captain," said the 41-year-old.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

Former India pacer Ashish Nehra has said that M.S. Dhoni was always open to a chat with his players after a match and his hotel room would always be open for them after the games. "People think that Dhoni doesn't talk much. That is not the case. His room would remain open in the night after matches. Anyone could walk in, order food and discuss cricket," Nehra said while speaking to former India opener Aakash Chopra on his show 'Aakash Vani'.

"Be it in CSK or in the Indian team, Dhoni would pass on the message on what he thinks a player needs to do during a conversation and that would be enough for the players to get the drift," added Nehra who played a lot of cricket under Dhoni's captaincy both for India and at Chennai Super Kings in the Indian Premier League (IPL). Nehra also spoke on former India captain and current Board of Control for Cricket in India (BCCI) President Sourav Ganguly, saying he was a leader who used to back his players to the hilt.

"Dhoni had senior players around him when he took over and the challenge was how to manage them. Dada had a team of juniors and he backed them to the hilt. He would go all out to back his players," said the former left-arm pacer who played 17 Tests, 120 ODIs and 27 T20Is.

Catch up on all the latest sports news and updates here. Also download the new mid-day Android and iOS apps to get latest updates.

Mid-Day is now on Telegram. Click here to join our channel (@middayinfomedialtd) and stay updated with the latest news

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

India's First Prime Minister Pt.Jawaharlal Nehru is credited with the undeniable title of most popular Prime Minister and the man who built a resurgent India.No doubt his stint of Prime Mininstership had its own shortcomings such as the...

1. The last supermoon of 2020  Tehran Times
2. See the Full Flower Moon, last supermoon of 2020, bloom in these stunning photos  Space.com
3. Here Are 23 Stunning Pics Of The Last Supermoon Of 2020 From Across The World  ScoopWhoop
4. Stunning shots of last supermoon of 2020  The Siasat Daily
5. 'Full-flower supermoon' rises on world starting to emerge from pandemic lockdowns  Times of India
6. View Full coverage on Google News

Saeed Tahmasebi had flown to Tehran with new wife Niloofar Ebrahim and had stayed behind to collect their wedding photos following their celebrations.

PETER OBORNE: The firing of ballistic missiles at US bases is the biggest and most dangerous military confrontation between America and Iran since the American hostage crisis in 1979.

Demi Lovato beamed as she pulled her boyfriend Max Ehrich in for the kiss in the star-studded new Stuck With U music video. The song is the first in a string of charity singles by SB Projects.

Things appear to be getting serious with Ehrich, 28, with whom she's reportedly been quarantined with: ''Max plans to propose to Demi after this whole pandemic is resolved.'

Bashing Nehru may be fashionable but flawed. He broke free from the exploitative colonial economic structure and laid strong economic foundations; and above all, India grew fast

Darryl D'Monte talks about his recent participation in a discussion on Nayantara Sahgal's book on Nehru, which delves into Nehruvian policies, his cherished dreams, his lasting legacy and its importance in today's time.

A note on Tehri Dam case heard in Supreme Court by Vimal Bhai of the Matu People's organisation.

As an unexpected outcome of the coronavirus lockdown, Ayatollah-ruled Iran has partly lifted its veil of strict orthodoxy which inhibits social interaction between the genders by allowing the reopening of Tehran’s one and only drive-in...

The school time friends had dreams about getting married, which were eventually fulfilled with the help of Pune police.

Nehra then gave the example of Englishman Lever who created a furore during his team's 1976 tour of India by applying vaseline during a Test match.

The former left-arm pacer also gave his views on Virat Kohli's captaincy, saying the latter is still a work in progress when it comes to him in the role of a skipper.

Nehra also spoke on former India captain and current Board of Control for Cricket in India (BCCI) President Sourav Ganguly, saying he was a leader who used to back his players to the hilt.

Punjab Police and Punjab National Bank players got into an ugly on-field fight during the Nehru Hockey Tournament final.

Hockey India took stringent actions after violence broke out during the Nehru Cup final between Punjab Armed Police and Punjab National Bank.

Nehru said, whatever confusion the present may contain, in the future, India will be a land, as in the past, of many faiths equally honoured and respected, within a tolerant, creative nationalism, not a narrow nationalism living in its own shell.

The father of the deceased filed a complaint with the police alleging that his 19-year-old daughter was killed by her husband for failing to serve him a hot meal for Sehri in the ongoing month of Ramzan.

Karan and Nisha have a boy named Kavish who was born in 2017.

On 8 October 2019, Dussehra or Vijayadashami is celebrated all over India. Dussehra comes from two Sanskrit words, 'Dush' means evil and 'Hara' means destroying. Although Dussehra celebrates the victory of good over evil, the stories behind the festival are different

One section hopes sales will match last year's figures, others fear fall