Hospice Northwest Services is inviting people to visit its third annual photography exhibit, "A Personal Lens on Grief." Here's what the project in Thunder Bay, Ont., entails, and why staff say it's important to find creative ways to express loss.

Dave Campbell of Thunder Bay, Ont., is resting his legs after taking the ride of his life through the Western Cape of South Africa in the 800-kilometre bikepacking 'Rhino Run.' Here are some of the photos he shared from his six-day expedition at the end of October.

As a troubled local gym goes dark, some members and the landlord say they haven’t heard from the owner about the future of the business in Thunder Bay, Ont.

Éric Boutilier and Mark Sherry are launching their new board game, Tripped, which was five years in the making.

Curling Canada says the Scotties Tournament of Hearts in Thunder Bay, Ont., will operate under Ontario's current public health measures and an approved framework from the office of the chief medical officer.

California

OM EAST - Just before Easter 2010, the Hitchings travelled to Serbia with Simon (OM EAST) to deliver 1200 copies of "My First Bible" in Arli to the Arli church...

OM EAST is helping meet the need for Bible study booklets to help Bayash Christians grow in their faith.

OM EAST helps bring God’s truth to a people who believe they are cursed.

In a village in Serbia, OM workers see Roma believers reaching Roma, encouraging them to let God put a new song in their mouths.

Shalini Passi became an overnight sensation after featuring in the Netflix reality show Fabulous Lives vs Bollywood Wives

All babies born at Bayhealth to receive first Imagination Library book WILMINGTON, Del.— Governor John Carney and the Delaware Division of Libraries announced on Wednesday that Bayhealth has partnered with Dover and Milford Public Libraries to ensure all babies born at Bayhealth Hospitals, as well as any eligible patients of Bayhealth Pediatrics in Milford, are […]

Piloting, or the navigation of ship, is one of the oldest and most important professions on the North American coast. Traversing unfamiliar shores and unforgiving waters, early American merchant ships heavily relied on skilled pilots to travel safely from port to port. Andrew Knopp’s history, “One Hundred Year History of the Pilot’s Association, Bay and […]

During a stop at the Delaware Agriculture Education & Commodities Building at the Delaware State Fair, Governor John Carney announced an additional 3,827 acres on 54 farms are now permanently preserved for future generations.

TOWNSEND, Del. (September 7, 2022) – Volunteers are needed to plant 2,000 hardwood seedlings along the Cypress Branch at Blackbird State Forest on Saturday, September 17 to provide scenic beauty, enhance wildlife habitat, fight invasive species, and improve water quality in the critical Chesapeake Bay Watershed. State Forester Michael Valenti said, “Planting trees is a […]

Funded by Barclays US Consumer Bank, program will leverage free training initiative to develop customer experience talent in Delaware Wilmington, DE – Tech Impact, the Delaware Department of Correction and the Delaware Department of Education announced today the launch of a pilot cohort of the Tech Impact customer experience training program, CXWorks, at Baylor Women’s […]

New Castle, DE – The Delaware Department of Correction announced today that Kimberly Hughey, Deputy Warden of Baylor Women’s Correctional Institution (BWCI), has been promoted to BWCI Warden effective December 18.  Hughey steps up to fill the vacancy created when BWCI Warden Brian Emig was recently promoted to Warden of Howard R. Young Correctional Institution in […]

New Castle, DE – The Delaware Department of Correction announced today that John Brennan, Security Superintendent of James T. Vaughn Correctional Center (JTVCC), has been promoted to Deputy Warden of Baylor Women’s Correctional Institution (BWCI), effective February 27.  Brennan fills the vacancy created when then-BWCI Deputy Warden Kimberly Hughey was promoted to BWCI Warden in December 2022. “Deputy Warden Brennan is a […]

DNREC invites families of all ages to participate in “Life in the Bay,” the popular youth education program geared toward children aged 6 and older, but with equal appeal to adults who want to learn about fish and other aquatic creatures that live in the Delaware Bay.

The U.S. Army Corps of Engineers and the Delaware Department of Natural Resources and Environmental Control have signed an agreement to protect and restore beaches along the Delaware Bay.

ferrard Tue, 10/03/2023 - 13:35

Title: How Your Medicines Make Their Way Into Rivers, Lakes and Bays
Category: Health News
Created: 8/23/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

SIGNIFICANCE STATEMENT

This study examined the disconnect between the in vitro synergy and in vivo efficacy of elimusertib/temozolomide combination therapy by exploring systemic and central nervous system (CNS) distributional pharmacokinetics. Results indicate that the lack of improvement in in vivo efficacy in glioblastoma (GBM) patient-derived xenograft (PDX) models could be attributed to inadequate exposure of pharmacologically active drug concentrations in the CNS. These observations can guide further exploration of elimusertib for the treatment of GBM or other CNS tumors.

In all honesty, Toads Of The Bayou could have been several notches less ribbet-ing than its Steam demo ended up being, because its stylised pixel fly-snatchers are just that good. There’s only one of the three characters available in the freebie (one of the others is a toad nun with a shotgun), but he’s got a little cutlass, a flintlock pistol, and a can-do attitude - at least when it comes to either stabbing or shooting things. The game itself is a little bit deckbuilder, a little bit Into The Breach: turn based strategy with perfect information and various tricks you can pull to make enemies hit each other instead of the thing you’re trying to protect. Indulge yourself on the gourmet tray-tray below.

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… advice from former New Zealand Davis Cup player Dan Willman, who has … challenges Taranaki for the Christie Cup, the symbol of Central … place at the World Junior Davis Cup tournament in the Czech … ; Willman added. The Christie Cup has been played for since ….

SURFING legend Kelly Slater has revealed how miserable he was starring alongside Pamela Anderson on Baywatch.

Discover how Dr. Shino Bay Aguilera found his inner peace and strived in the world of science and medicine.

Pollination: Busy as a Bee

Bayer MSMS �Say TkU� Campaign

This or any DORK TOWER strip is now available as a signed, high-quality print, from just $25!  CLICK HERE to find out more! HEY! Want to help keep DORK TOWER going? Then consider joining the DORK TOWER Patreon and ENLIST IN THE ARMY OF DORKNESS TODAY! (We have COOKIES!) (And SWAG!) (And GRATITUDE!)

Sittin' in the morning sun

(oops)

I like wreckin' 'til the evening comes!

 

Stuffin' some flotsam in.

Grab another cake and do it again.

Yeah...

 

I'm thinkin' they'll be dockin' my pay.

I thought that's what they wanted to say!

Oooo -oo -oo -ooo

I'm thinkin' they'll be dockin' my pay...

Meh, looks fine. (Hiiii-iiine.)

 

The cake you want'll bore ya.

Thought I'd go a disco way.

 

I got nothin' against George.

It's just I'm tired of frosting him all day.

So...

I'm thinkin' they'll be dockin' my pay.

No one could read the French, anyway!

Ooh!

Maybe they'll be dockin' my pay...

Nah, it's fine.

 

Thankfully, our faithful Wreckporters -- Laurel G., Anna C., Kate P., Stacey W., Sammi K., Kathryn R., Bath C., Sylvie C., and Teresa P. -- weren't wasting time. Now, I think I'm supposed to end this with harmonic whistling, so here goes...

::whistles badly for 3 seconds::

Nope, hang on, I found a prettier option:

A rainbow whistling tea kettle? YES PLEASE.

*****

And from my other blog, Epbot:

Washing your hands often and keeping them clean could be the best way to avoid healthcare-associated infections (HAIs). Five medical organizations

Once inside, the house's modern style flows across an open floor plan marked by clean lines and quality craftsmanship from the kitchen and dining areas to the living room. Hardwood flooring and walls of windows frame the picturesque views from nearly every room.

Lincoln : University of Nebraska Press, [1998]

Durham : Duke University Press, [2023]

Manchester : Manchester University Press, [2020]

Dordrecht : Springer-Science+Business Media, B.V., 2001.

Looking at the red carpet arrivals.

Bagnaia's victory moved him up to 275 points, five more than Martin, with Bastianini maintaining his hold on third place on 214.

The State government said possession of 30.16 acre of land will be handed over to the High Court in a phased manner, adding the first tranche measuring 4.39 acres has already been given

The artworks were seized in 2023 over allegations of obscenity

Suraj Chavan was arrested on January 17, 2024, for his alleged irregularities in distributing khichdi to migrant workers during the COVID-19 pandemic