Qingying Bu
Proc. Amer. Math. Soc. 148 (2020), 2459-2467.
Abstract, references and article information

Dalton signed with the Cowboys on Monday after he was released May 30. Dak Prescott has started every game for the Cowboys since 2016.

Australian fiction.

Pac-12 Networks' Yogi Roth and Ashley Adamson talk with Hall of Fame player and Pac-12 Networks talent Bill Walton during Thursday's Pac-12 Perspective podcast.

Andy Dalton is coming home to Texas as Dak Prescott's backup with the Dallas Cowboys.

Amanda Moore, of Chambersburg, Pennsylvania, is on track to graduate from Penn State Mont Alto this May with a degree in psychology. She credits her academic success with Mont Alto's strong focus on research and varied program offerings.

As college campuses closed and the COVID-19 virus began casting a larger shadow in south central Pennsylvania, members of the nursing and physical therapist assistant programs at Penn State Mont Alto took stock of all the medical personal protection equipment (PPE) items in their labs. The two programs were supplied with hundreds of gloves and dozens of medical gowns and masks, plus other items such as disposable stethoscopes, shoe covers and safety glasses — items no longer needed as the campus transitioned to remote instruction.

Penn State Mont Alto recognizes and honors winners during awards ceremony

The Penn State Mont Alto campus held its annual Academic and Leadership Awards Ceremony online on Sunday, April 19. Eighty-eight students were recognized for their academic achievements and campus leadership during the 2019-20 academic year. Three faculty members and one staff member were also recognized for their above-and-beyond contributions to the learning environment at Penn State Mont Alto.

Penn State Mont Alto unveiled its new project and supply chain management degree in response to a local and global need.

As the tally of conference championships grows and more teams get bids for national playoffs, student-athletes at Penn State Mont Alto have their eyes on a bigger prize: academic success.

Two Mont Alto student-athletes named to the USCAA All-Academic Team; Corrine Custer-Grassmyer recognized as John Fritz Sportsmanship Award Honoree.

Visual Art Studies program seniors Andrea Regalbuto and Gary Weyandt are showcasing their respective exhibitions “Flap/Flutter” and “MEDIAted” online via websites, Instagram, and virtual exhibits.

The singer has been dating the real estate agent for a couple of months now

Local officials can now find information from all sectors, such as health, education, women’s empowerment, child protection, and human rights and law, to help them address child and teen marriage in their area.

NEW DELHI: Real estate developers and property consultants today welcomed the RBI decision to cut statutory liquidity ratio (SLR), saying this would enable banks to lend more to industry, including cash-starved realty sector. However, developers demanded easing of interest rates to boost housing sales. RBI today decided to keep the key policy rate unchanged but slashed statutory liquidity ratio (SLR) by 0.5 per cent to unlock about Rs 40,000 crore into the system. “The RBI’s move to cut SLR by 50 basis points to 22 per cent will give banks more headroom to lend and thereby spur lending in future. However, the much anticipated cut in rates would have been […]

ABSTRACT

During infection of human parvovirus B19 (B19V), one viral precursor mRNA (pre-mRNA) is transcribed by a single promoter and is alternatively spliced and alternatively polyadenylated. Here, we identified a novel cis-acting sequence (5'-GUA AAG CUA CGG GAC GGU-3'), intronic splicing enhancer 3 (ISE3), which lies 72 nucleotides upstream of the second splice acceptor (A2-2) site of the second intron that defines the exon of the mRNA encoding the 11-kDa viral nonstructural protein. RNA binding motif protein 45 (RBM45) specifically binds to ISE3 with high affinity (equilibrium dissociation constant [K_D] = 33 nM) mediated by its RNA recognition domain and 2-homo-oligomer assembly domain (RRM2-HOA). Knockdown of RBM45 expression or ectopic overexpression of RRM2-HOA in human erythroid progenitor cells (EPCs) expanded ex vivo significantly decreased the level of viral mRNA spliced at the A2-2 acceptor but not that of the mRNA spliced at A2-1 that encodes VP2. Moreover, silent mutations of ISE3 in an infectious DNA of B19V significantly reduced 11-kDa expression. Notably, RBM45 also specifically interacts in vitro with ISE2, which shares the octanucleotide (GGGACGGU) with ISE3. Taken together, our results suggest that RBM45, through binding to both ISE2 and ISE3, is an essential host factor for maturation of 11-kDa-encoding mRNA.

IMPORTANCE Human parvovirus B19 (B19V) is a human pathogen that causes severe hematological disorders in immunocompromised individuals. B19V infection has a remarkable tropism with respect to human erythroid progenitor cells (EPCs) in human bone marrow and fetal liver. During B19V infection, only one viral precursor mRNA (pre-mRNA) is transcribed by a single promoter of the viral genome and is alternatively spliced and alternatively polyadenylated, a process which plays a key role in expression of viral proteins. Our studies revealed that a cellular RNA binding protein, RBM45, binds to two intron splicing enhancers and is essential for the maturation of the small nonstructural protein 11-kDa-encoding mRNA. The 11-kDa protein plays an important role not only in B19V infection-induced apoptosis but also in viral DNA replication. Thus, the identification of the RBM45 protein and its cognate binding site in B19V pre-mRNA provides a novel target for antiviral development to combat B19V infection-caused severe hematological disorders.

The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic environmental Gram-negative bacilli responsible for a variety of infections in both humans and animals. Beyond its large genetic diversity, its genetic organization in genogroups was recently confirmed through the whole-genome sequencing of human and environmental strains. As they are poorly represented in these analyses, we sequenced the whole genomes of 93 animal strains to determine their genetic background and characteristics. Combining these data with 81 newly sequenced human strains and the genomes available from RefSeq, we performed a genomic analysis that included 375 nonduplicated genomes with various origins (animal, 104; human, 226; environment, 30; unknown, 15). Phylogenetic analysis and clustering based on genome-wide average nucleotide identity confirmed and specified the genetic organization of Smc in at least 20 genogroups. Two new genogroups were identified, and two previously described groups were further divided into two subgroups each. Comparing the strains isolated from different host types and their genogroup affiliation, we observed a clear disequilibrium in certain groups. Surprisingly, some antimicrobial resistance genes, integrons, and/or clusters of attC sites lacking integron-integrase (CALIN) sequences targeting antimicrobial compounds extensively used in animals were mainly identified in animal strains. We also identified genes commonly found in animal strains coding for efflux systems. The result of a large whole-genome analysis performed by us supports the hypothesis of the putative contribution of animals as a reservoir of Stenotrophomonas maltophilia complex strains and/or resistance genes for strains in humans.

IMPORTANCE Given its naturally large antimicrobial resistance profile, the Stenotrophomonas maltophilia complex (Smc) is a set of emerging pathogens of immunosuppressed and cystic fibrosis patients. As it is group of environmental microorganisms, this adaptation to humans is an opportunity to understand the genetic and metabolic selective mechanisms involved in this process. The previously reported genomic organization was incomplete, as data from animal strains were underrepresented. We added the missing piece of the puzzle with whole-genome sequencing of 93 strains of animal origin. Beyond describing the phylogenetic organization, we confirmed the genetic diversity of the Smc, which could not be estimated through routine phenotype- or matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF)-based laboratory tests. Animals strains seem to play a key role in the diversity of Smc and could act as a reservoir for mobile resistance genes. Some genogroups seem to be associated with particular hosts; the genetic support of this association and the role of the determinants/corresponding genes need to be explored.

Marilyn Rivera Torres, a realtor in Puerto Rico, says the lockdown has dried up her finances. Confusion over the governor's executive orders also make it unclear how to resume her business.

Ariana Grande has confirmed her relationship with real estate agent Dalton Gomez in a new music video.

RE/MAX East-West, a real estate firm in Elmhurst, Ill., and one of its former real estate agents, John DeJohn, have agreed to pay $120,000 to settle allegations that they illegally steered prospective homebuyers toward and away from certain neighborhoods based on race and national origin. The consent decree was signed on Feb. 17, 2009, by U.S. District Judge Ruben Castillo.

A federal grand jury has returned an 18-count superseding indictment charging Thomas E. Parenteau of Columbus, Ohio; Dennis G. Sartain of Hilliard, Ohio; and Bonnie Helt-Adams of Dublin, Ohio, with tax fraud, bank and wire fraud, money laundering and obstruction of justice.

Dennis G. Sartain of Hilliard, Ohio; and Bonnie Helt, of Columbus, Ohio, pleaded guilty today to conspiring to commit mortgage fraud, money laundering and obstruction of justice.

Atlanta real estate firms Coldwell Banker Joe T. Lane Realty Inc., Coldwell Banker Bullard Realty Company Inc. and Rodney Lee Foreman, one of their former real estate agents, have agreed to pay $160,000 to settle allegations that they illegally steered prospective homebuyers toward and away from certain neighborhoods based on race and color.

The lawsuit, filed in U.S. District Court for the Western District of Michigan, charges that the township discriminated against persons with disabilities based on its treatment of a group home for persons recovering from drug and alcohol addiction and its failure to grant a reasonable accommodation or modification to the owner of the group home.

The Justice Department today announced that Harry Norman Realtors (HNR) and Jennifer Sherrouse have agreed to pay monetary damages and civil penalties of $60,000 to settle a Fair Housing Act lawsuit alleging that they discriminated against families with children.

The Justice Department announced today that Dalton Township, Mich., will pay $62,500 to settle a lawsuit alleging that the township discriminated against a group home for persons recovering from drug and alcohol addiction, in violation of the federal Fair Housing Act and Title II of the Americans with Disabilities Act.

Brent E. Wells, a former police sergeant with the East Alton, Ill., Police Department, pleaded guilty yesterday in U.S. District Court in East St. Louis, Ill., to violating the civil rights of a civilian by assaulting the man during an arrest in front of Wells’s home on Sept. 11, 2010.

The United States has entered into two settlements worth more than $50 million to clean up contamination from the B.F. Goodrich Superfund Site in San Bernardino County, Calif.

If you like a little sugar in your morning (and late morning, and afternoon) coffee, but don't like the calories, there's a good chance you use one of the many artificial sweeteners on the market. But there's plenty of evidence

The Scandinavian master designed a gem of a building promoting Nordic cooperation.

The vase designed and named after Finnish designer Alvar Aalto is an icon among the design-savvy. The now-classic piece was released in 1937 at the World Fair in Paris. Today, the vase is produced by Iittala, which has slightly changed the size and

Home sales took a deep dive in March as the coronavirus pandemic shut down much of the economy, and homebuyers and sellers pulled out of the normally busy spring market.

April Coolidge used to work in real estate but now she makes more money driving a truck than she ever did selling houses.

Realtor.com chief economist Danielle Hale discusses the firm's latest housing trends report, including whether demand for home buying will return this summer if the U.S. can effectively contain the coronavirus pandemic.

A growing number of companies has nixed earnings guidance amid the coronavirus pandemic, and some in the corporate world say they should be dropped permanently.

Imports - Sugars Nesoi, Incl Chem Pure Lactose, Maltose, Glucose in Mexico increased to 49973 USD THO in March from 49798 USD THO in February of 2020. Imports - Sugars Nesoi, Incl Chem Pure Lactose, Ma in Mexico averaged 53760.66 USD THO from 2014 until 2020, reaching an all time high of 67331 USD THO in May of 2017 and a record low of 37448 USD THO in January of 2016. This page includes a chart with historical data for Mexico Imports of Sugars Nesoi, Incl Chem Pure Lactose,.

DEREK LAWRENSON - WORLD OF GOLF: There could be no more appropriate venue than Walton Heath as the Ryder Cup golfers keep their celebratory vibe going at the British Masters.

The Finnish singer, 32, revealed they tied the knot in a private ceremony in Helsinki after being forced to cancel their wedding due to the coronavirus pandemic.

The X Factor star, 32, revealed that she and her wife Meri were in floods of tears as they tied the knot at their 'bittersweet' lockdown wedding which had no guests or fancy wedding dress.

Stephanie Hunter, main, from Spring, Texas, is facing charges of fraud and making a false statement to obtain credit after her arrest earlier this month. Walton and Fertitta are inset.

Saara Aalto dazzled in a show-stopping silver jumpsuit, before she changed into a short flirt red number for the opening night of X Factor live shows in Nottingham on Thursday

Ariana Grande and fellow hit maker Justin Bieber released the highly anticipated music video for their quarantine themed duet Stuck With U on Thursday evening. 

Our scout is a top football expert who attends matches searching for the next star. This week they give you the lowdown on Brighton keeper Christian Walton, who is playing on loan at Blackburn.

Wests Tigers star player Josh Reynolds' ex girlfriend Arabella Del Busso, whose real name is Donna Preusker, was hounded by a reporter outside Melbourne's Rialto Towers.

Roxanne Pallett's romance with fiance Lee Walton seems to still be going strong despite her recent drama on Celebrity Big Brother.

Reality couple Mikey Dalton, 34 and Grace Adams-Short continue to go from strength to strength after they announced they're expecting their third child

Realtors' apex body Credai on Saturday said cement and steel rates have increased by 40-50 per cent in last few weeks despite the lockdown and alleged price cartelisation and unfair trade practices by the manufacturers. The association has written a letter to Minister of Housing and Urban Affairs Hardeep Singh Puri seeking his intervention in the matter. "We would like to bring your attention to the cartelization by the cement and the steel manufacturers by imposing a sudden increase in their selling price," Credai said in the letter. Across various states, there has been an increase of Rs 100-250 per bag cement and about Rs 2,000-2,500 per tonne of steel, it added. During the past few weeks, there has been a sudden, steep increase in prices of essential raw materials such as cement and steel by 40-50 per cent despite the nationwide lockdown. The Centre has allowed construction work on sites where labourers are already available. Given the current crisis faced by the real estate ...