Mandatory drug and alcohol testing for elected representatives could soon be a reality for a second Tasmanian council, but the proposal is proving to be divisive with one councillor labelling it "highly invasive".

While new laws block predominantly Aboriginal people from buying takeaway alcohol in Alice Springs, the local casino has been overwhelmed with patrons, and has been fined by a court for not ejecting drunk patrons.

As alcohol-related presentations drop by a third in the Alice Springs Hospital Emergency Department, highly contested Government alcohol polices are being credited for the dramatic reduction.

A father who was on his L-plates drank "up to 40 cans of alcohol" before getting behind the wheel pleads guilty to causing the death of his son.

The high-profile host of SBS show Living Black says she was racially profiled by police in the Northern Territory, saying she was treated like a "grog runner" when she entered an Alice Springs bottle shop.

It was the first jurisdiction in the country to roll out a floor price on alcohol, alongside a raft of other measures, and data shows is it having a significant effect in the Northern Territory.

It may be convenient, but public health experts warn of the danger of convenient alcohol-delivery services to those who may be vulnerable.

Ronald Shirley is jailed for ripping off an an intellectually impaired patient in north Queensland, leaving the client with so little money he can no longer go on a planned bucket-list trip.

For Edward Daly, who was at a rehab centre on the NSW Central Coast to get over his ice, alcohol and gambling addictions, having his partner involved in his recovery made all the difference.

Very few young people think about the health risks of drinking but research is proving that alcohol is bad for your health.

Alcohol is linked to everything from cancers, liver and cardiovascular disease, stroke and depression.

Alcoholism is big problem in regional areas where health support is limited and the dangers of drink driving are made worse by distance.

The founder of an online discussion supporting hundreds trying to go dry believes drought, financial hardship, uncertainty, and isolation are causing more rural people to self-medicate with alcohol.

(United States Fifth Circuit) - Partially affirmed, remanded. A Texas ban on public corporations obtaining package store permits did not violate Equal Protection rights, but the district court erred in finding a discriminatory nature and burden imposed by the public corporation ban.

(California Court of Appeal) - In a petition for writ of review challenging the Department of Alcoholic Beverage Control's 15-day suspension of an off-sale general license held by a CVS Pharmacy Store after an administrative law judge found the store clerk sold alcohol to a minor decoy, the Alcohol Beverage Control Appeals Board's reversal of the suspension based on California Code of Regulations, title 4, section 141 (Rule 141) that allows a law enforcement agency to use an underage decoy only in a fashion that promotes fairness, is annulled where: 1) Rule 141 is not ambiguous in requiring minor decoys to answer truthfully only questions about their ages; 2) substantial evidence supports the administrative law judge's factual finding that the decoy was not questioned about his age; and 3) Rule 141 does not provide CVS with a defense to the accusation it sold an alcoholic beverage to an underage buyer.

(United States Fifth Circuit) - Partially affirmed, remanded. A Texas ban on public corporations obtaining package store permits did not violate Equal Protection rights, but the district court erred in finding a discriminatory nature and burden imposed by the public corporation ban.

The Alcohol and Other Drugs Committee's Centennial Paper to review what it has accomplished since its inception in the early 1970s, how it has evolved along with the field, and what challenges and opportunities it confronts going forward. To learn more about the history of impaired driving and the Standing Technical Committee on Alcohol, Other Drugs, and Transportation (ANB50), check out the Committee's Centennial Paper. As part of TRB's Centennial Celebration, the Technical Activities Council invited al...

Ohioans bought 1.36 million gallons of liquor in March, a nearly 25 percent increase over the same period last year. More of us are leaning on alcohol to beat quarantine doldrums and stress, but experts warn that extended overindulging could make it harder to put down the bottle when the lockdown is lifted.

A report from the Office of the Inspector General at the U.S. Department of Transportation

Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.

How many stupid, outrageous, maddening government failures can you document in just 500 words? Jim Doti and my former colleague Laurence Iannaccone should win a prize for this piece in the WSJ: …the U.S. is, by far, the world’s largest producer of alcohol. That distinction is a result of the Energy Policy Act of 2005, […]

The post World’s Largest Producer of Rubbing Alcohol Can’t Manufacturer Hand Sanitizer appeared first on Marginal REVOLUTION.

Dispatch from the pandemic: Times of stress can be life or death for a recovering alcoholic or addict

Indiana was among the last states to give up blue laws. Now, in response to the COVID-19 outbreak, alcohol is considered an essential product

A Bargersville man died in a head-on crash in Johnson County early Saturday morning. Police believe alcohol was a factor in the crash.

Shady Habash, whose video mocked the president, "mistook hand sanitiser for water", prosecutors say.

I am not suggesting, or recommending, you should sneak booze on your next next cruising vacation as you could, in worst case, risk being refused boarding if caught. However despite this, there are cruisers who use surprising and unusual techniques to smuggle alcohol on to a cruise ship to avoid having to buy drinks on board. In this video I explore the different ways that people are using to sneak their alcohol onto their cruise ship. The cost of drinking on a cruise is increasing, and with some of the drinks packages you could be spending almost as much as the cruise itself costs and some travellers are resorting to innovative methods to bring their own alcohol onto cruise ships. There are even companies making products, devices and accessories specifically designed to assist.

Restaurants have been struggling to stay afloat since the pandemic hit, but there has been a silver lining: relaxed liquor laws mean customers can get their booze delivered along with their meals.

Sookyoung Jeon
Apr 1, 2020; 61:470-479
Reviews

This manuscript has been withdrawn by the Author.

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.

Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancestry (EA) participants and in 401 Hispanic ancestry and 724 African ancestry participants from four population-based cohort studies. Hepatic fat was measured using computed tomography or ultrasound imaging and DNA methylation was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes using a commercial array. We identified 22 CpGs associated with hepatic fat in EA participants at a false discovery rate <0.05 (corresponding P = 6.9 x 10^–6) with replication at Bonferroni-corrected P < 8.6 x 10^–4. Mendelian randomization analyses supported the association of hypomethylation of cg08309687 (LINC00649) with NAFLD (P = 2.5 x 10^–4). Hypomethylation of the same CpG was also associated with risk for new-onset T2D (P = 0.005). Our study demonstrates that a peripheral blood–derived DNA methylation signature is robustly associated with hepatic fat accumulation. The hepatic fat–associated CpGs may represent attractive biomarkers for T2D. Future studies are warranted to explore mechanisms and to examine DNA methylation signatures of NAFLD across racial/ethnic groups.

Nonalcoholic steatohepatitis has emerged as a major cause of liver diseases with no effective therapies. Here, we evaluate the efficacies and pharmacokinetics of B1344, a long-acting PEGylated FGF21 analog, in a nongenetically modified nonhuman primate species that underwent liver biopsy, and demonstrate the potential for efficacies in humans. B1344 is sufficient to selectively activate signaling from the βKlotho/FGFR1c receptor complex. In cynomolgus monkeys with nonalcoholic fatty liver disease, administration of B1344 via subcutaneous injection for eleven weeks caused a profound reduction of hepatic steatosis, inflammation and fibrosis, and amelioration of liver injury and hepatocyte death as evidenced by liver biopsy and biochemical analysis. Moreover, improvement of metabolic parameters was observed in the monkey, including reduction of body weight and improvement of lipid profiles and glycemic control. To determine the role of B1344 in the progression of murine NAFLD independent of obesity, administration of B1344 were performed in mice fed with methionine and choline deficiency diet. Consistently, B1344 administration prevented the mice from lipotoxicity damage and nonalcoholic steatohepatitis at a dose-dependent manner. These results provide preclinical validation for an innovative therapeutics to NAFLD, and support further clinical testing of B1344 for treating nonalcoholic steatohepatitis and other metabolic diseases in humans.

Giulio Marchesini
Aug 1, 2001; 50:1844-1850
Pathophysiology

OBJECTIVE

To determine the effect of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptors, on biomarkers of nonalcoholic steatohepatitis (NASH) and fibrosis in patients with type 2 diabetes mellitus (T2DM).

Rockville, Maryland : National Institute on Drug Abuse, 1981.

Rockville, Maryland : National Institute on Drug Abuse, 1980.

Rockville, Maryland : National Institute on Drug Abuse, 1979.

Springfield, Virginia : National Technical Information Service, 1986.

Washington, D.C. : Department of Transportation, Federal Railroad Administration, 1976.

Washington : Dept. of Transportation, National Highway Traffic Safety Administration, 1976.

Washington, D.C. : Wynne Associates, 1974.

Washington, D.C. : Wynne Associates, [1974]

Chicago, Ill. : Joint Commission on Accreditation of Healthcare Organizations, 1987.

National Association of Wine Retailers Release Letter Delivered to Attorneys General and Alcohol Regulatory Chiefs Concerning Unconstitutional and Unenforceable Wine Shipping Bans

(PRWeb April 15, 2020)

Read the full story at https://www.prweb.com/releases/wine_retailers_seek_alcohol_shipping_compromise_with_18_states/prweb17050617.htm

Alcoholism in both men and woman is a huge problem in Poland. One young woman decides she’s had enough and turns to Christ.

SCOTS have been urged to give up smoking and cut down their alcohol consumption in a bid to reduce “complications linked to conroavirus”.

The American Academy of Pediatrics recommends routine alcohol screening for all adolescents. Problem-based substance use screens for adolescents exist, but have limitations. A consumption-based alcohol screen could provide an empirically validated, very brief method to screen youth for alcohol-related problems.

National sample data indicate that frequency of alcohol use has high sensitivity and specificity in identifying youth with alcohol-related problems. A range of age-specific frequency cut scores perform well; specific cut points can be selected based on the screening context. (Read the full article)

Some studies reveal an association between exposure to alcohol consumption in movies and youth drinking, but the evidence is sparse.

Exposure to alcohol consumption in movies is associated with youth binge drinking, is little influenced by cultural differences between countries (Germany, Iceland, Italy, Netherlands, Poland, and Scotland), and is specific to movie alcohol, not movie smoking, depictions. (Read the full article)