activity Elucidating the impact of oxygen functional groups on the catalytic activity of M–N4–C catalysts for the oxygen reduction reaction: a density functional theory and machine learning approach By pubs.rsc.org Published On :: Mater. Horiz., 2024, 11,1719-1731DOI: 10.1039/D3MH02115G, CommunicationLiang Xie, Wei Zhou, Yuming Huang, Zhibin Qu, Longhao Li, Chaowei Yang, Yani Ding, Junfeng Li, Xiaoxiao Meng, Fei Sun, Jihui Gao, Guangbo Zhao, Yukun QinWhile current experimental and computational studies often concentrate on introducing external structures or idealized MN4 models, we emphasize the often-overlooked impact of inherent OGs within the carbon structure of MN4 materials, presenting a new perspective on their catalytic activity origin.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Uncertainty and Economic Activity: A Multi-Country Perspective [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
activity Product Market Competition and the Relocation of Economic Activity: Evidence from the Supply Chain [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
activity Measuring Global Real Economic Activity: Do Recent Critiques Hold Up to Scrutiny? [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
activity M&A Activity and the Capital Structure of Target Firms [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
activity How the 1906 San Francisco Earthquake Shaped Economic Activity in the American West [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
activity Host-Country Financial Development and Multinational Activity [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
activity Connective Financing - Chinese Infrastructure Projects and the Diffusion of Economic Activity in Developing Countries [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
activity Bank intermediation activity in a low interest rate environment [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
activity Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products By pubs.rsc.org Published On :: Nat. Prod. Rep., 2024, 41,1543-1578DOI: 10.1039/D4NP00009A, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christine Mae F. Ancajas, Abiodun S. Oyedele, Caitlin M. Butt, Allison S. WalkerThis review highlights methods for studying structure activity relationships of natural products and proposes that these methods are complementary and could be used to build an iterative computational-experimental workflow.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity The dichapetalins and dichapetalin-type compounds: structural diversity, bioactivity, and future research perspectives By pubs.rsc.org Published On :: Nat. Prod. Rep., 2024, 41,1579-1603DOI: 10.1039/D3NP00039G, Review ArticleIvan Addae-Mensah, Godwin Akpeko Dziwornu, Mary Anti Chama, Dorcas Osei-SafoThis review discusses the structural diversity of the dichapetalins and related compounds from the genera Dichapetalum and Phyllanthus, their manifestation in the diversity of their biological activities, and areas of potential future research.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity The smallest endohedral borafullerene: structural isomerization, electronic properties, aromaticity and reactivity of U@C27B By pubs.rsc.org Published On :: Inorg. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QI00186A, Research ArticleXinde Li, Lei Lou, Peng JinU@C27B has three interconvertible isomers with the highest metal oxidation state and strong covalency, obeying the 32-electron principle and Hirsch's aromaticity rule.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Boosting structural variety and catalytic activity of porphyrinic metal–organic frameworks by harnessing bifunctional ligands By pubs.rsc.org Published On :: Inorg. Chem. Front., 2024, 11,2281-2289DOI: 10.1039/D4QI00314D, Research ArticleWei Wu, Xiu-Liang Lv, Tao He, Guang-Rui Si, Hongliang Huang, Lin-Hua Xie, Yabo Xie, Jian-Rong LiHigh catalytic performance of porphyrin-based MOFs has been achieved by introducing multiple functionality into their ligands and modulating their conformation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Enhancing hydrogen evolution reaction activity through defects and strain engineering in monolayer MoS2 By pubs.rsc.org Published On :: Chem. Sci., 2024, 15,18127-18134DOI: 10.1039/D4SC04874A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Renjith Nadarajan, Sraboni Dey, Arijit Kayal, Joy Mitra, Manikoth M. ShaijumonThe synergistic creation of vacancy defects, along with strain-induced active sites is shown to enhance hydrogen evolution reaction (HER) performance of CVD-grown monolayer MoS2.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Rare-earth metal complexes bearing electrophilic and nucleophilic carbon centres and their unique reactivity patterns towards pyridine derivatives By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC04197F, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.weikang Wu, Thayalan Rajeshkumar, Shan Zhu, Fuxiang Chai, Dongjing Hong, ZeMing Huang, Qingbing Yuan, Laurent Maron, Shaowu WangThe rare-earth metal dialkyl complexes (κ2-L1)RE(CH2SiMe3)2(THF)2 [RE = Lu(1a), Yb(1b), Er(1c), Y(1d), Dy(1e)] (L1 = 1-(2-N-C5H10NCH2CH2)-3-(2,6-iPr2C6H3N=CH)-C8H4N) and the rare-earth metal monoalkyl complexes (κ2-L1)2RE(CH2SiMe3)(THF)n [n = 0, RE = Lu(2a), Yb(2b);...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Dual-mode detection of 2,6-pyridinedicarboxylic acid based on the enhanced peroxidase-like activity and fluorescence property of novel Eu-MOFs By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00331D, PaperJintao Yi, Xianqin Han, Jiahao Jian, Yayan Lai, Jun Lu, Lei Peng, Zhongkai Liu, Jun Xue, Hui Zhou, Xun LiThe dual-mode fluorescence and colorimetric detection of 2,6-pyridinedicarboxylic acid (DPA) based on the enhanced peroxidase-like activity and fluorescence property of a novel MOF.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Dual-signal detection of tannin acid in red wines based on peroxidase activity carbon dots By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D4AY00526K, PaperBin Liu, Yu Yin, qianwen Li, wanwan Li, Fubing Xiao, Jinquan Liu, Yan Tan, Shengyuan YangHerein, a novel sort of phosphorus and iron-doped carbon dots (P,Fe-CDs) with outstanding peroxidase activity and excellent fluorescence performance was hydrothermally synthesized to colorimetrically and fluorimetrically detect tannic acid (TA)....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3418-3432DOI: 10.1039/D4MD00170B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van TranMadecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3609-3615DOI: 10.1039/D4MD00501E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. VealeRationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3616-3624DOI: 10.1039/D4MD00306C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. SheldrakeCyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00257A, Research Article Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob AlamIn light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00537F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry LombergetA series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD90044H, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki FujiiTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00383G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia OueisAn AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00617H, Research ArticleAida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü BeydemirIn this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00597J, Research ArticleAlbert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken WittSomatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity ‘No religion encourages an activity that creates pollution: SC on firecrackers By www.thehindu.com Published On :: Mon, 11 Nov 2024 15:28:47 +0530 The Supreme Court wondered why the Delhi Government delayed imposition of the ban on firecrackers till October 14, when the order of ban was issued Full Article Delhi
activity Controlling wall–particle interactions with activity By pubs.rsc.org Published On :: Soft Matter, 2024, 20,8395-8406DOI: 10.1039/D4SM00634H, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Luke Neville, Jens Eggers, Tanniemola B. LiverpoolThe interaction between a disk and wall in an active nematic depends on a combination of activity and anchoring, with contractile nematics repelling disks with planar anchoring.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Active nematic coherence probed under spatial patterns of distributed activity By pubs.rsc.org Published On :: Soft Matter, 2024, Accepted ManuscriptDOI: 10.1039/D4SM00651H, PaperIgnasi Vélez Cerón, Jordi Ignes-Mullol, Francesc SaguesA photoresponsive variant of the paradigmatic active nematic fluid made of microtubules and powered by kinesin motors is studied in the conventional two-dimensional interfaced form when forced under blue-light illumination....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Tuning collective actuation of active solids by optimizing activity localization By pubs.rsc.org Published On :: Soft Matter, 2024, 20,8570-8580DOI: 10.1039/D4SM00868E, PaperDavi Lazzari, Olivier Dauchot, Carolina BritoActive solids, more specifically elastic lattices embedded with polar active units, exhibit collective actuation when the elasto-active feedback, generically present in such systems, exceeds some critical value.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Interactivity and Animation with Variable Fonts By 24ways.org Published On :: Thu, 05 Dec 2019 12:00:00 +0000 Mandy Michael turns the corner on our variable font adventure and stumbles into a grotto of wonder and amazement. Not forgetting the need for a proper performance budget, Mandy shows how variable fonts can free your creativity from bygone technical constraints. If you read Jason’s introductory article about variable fonts, you’ll understand the many benefits and opportunities that they offer in modern web development. From this point on we’ll assume that you have either read Jason’s introduction or have some prior knowledge of variable fonts so we can skip over the getting started information. If you haven’t read up on variable fonts before jump over to “Introduction to Variable Fonts: Everything you thought you knew about fonts just changed” first and then come join me back here so we can dive into using variable fonts for interactivity and animations! Creative Opportunities If we can use variable fonts to improve the performance of our websites while increasing the amount of style variations available to us, it means that we no longer need to trade off design for performance. Creativity can be the driving force behind our decisions, rather than performance and technical limitations. Cookie text effect font: This Man is a Monster, by Comic Book Fonts. My goal is to demonstrate how to create interactive, creative text on the web by combining variable fonts with CSS and JavaScript techniques that you may already be familiar with. With the introduction of variable fonts, designs which would have previously been a heavy burden on performance, or simply impossible due to technical limitations, are now completely possible. Still I Rise Poem by Maya Angelou, Demo emphasising different words with variable fonts. View on Codepen. Variable fonts demo with CSS Grid using multiple weights and font sizes to emphasise different parts of the message. View on Codepen. The tone and intent of our words can be more effectively represented with less worry over the impacts of loading in “too many font weights” (or other styles). This means that we can start a new path and focus on representing the content in more meaningful ways. For example, emphasising different words, or phrases depending on their importance in the story or content. Candy Cane Christmas Themed Text Effect with FS Pimlico Glow by Font Smith. View on Codepen. Note: using variable fonts does not negate the need for a good web font performance strategy! This is still important, because after all, they are still fonts. Keep that in mind and check out some of the great work done by Monica Dinculescu, Zach Leatherman or this incredible article by Helen Homes. Variable Fonts & Animations Because variable fonts can have an interpolated range of values we can leverage the flexibility and interactive nature of the web. Rather than using SVG, videos or JavaScript to accomplish these effects, we can create animations or transitions using real text, and we can do this using techniques we may already be familiar with. This means we can have editable, selectable, searchable, copy-pastable text, which is accessible via a screenreader. Grass Variable Font Demo Growing Grass Variable Font Text. Demo on Codepen. This effect is achieved using a font called Decovar, by David Berlow. To achieve the animation effect we only need a couple of things to get started. First, we set up the font-family and make use of the new property font-variation-settings to access the different axes available in Decovar. h1 { font-family: "Decovar"; font-variation-settings: 'INLN' 1000, 'SWRM' 1000; } For this effect, we use two custom axis – the first is called “inline” and is represented by the code INLI and the second is “skeleton worm” represented by the code SWRM. For both axes, the maximum value is 1000 and the minimum value is 0. For this effect, we’ll make the most of the full axis range. Once we have the base set up, we can create the animation. There are a number of ways to animate variable fonts. In this demo, we’ll use CSS keyframe animations and the font-variation-settings property, but you can also use CSS transitions and JavaScript as well. The code below will start with the “leaves” expanded and then shrink back until it disappears. @keyframes grow { 0% { font-variation-settings: 'INLN' 1000, 'SWRM' 1000; } 100% { font-variation-settings: 'INLN' 1000, 'SWRM' 0; } } Once we have created the keyframes we can add the animation to the h1 element, and that is the last piece needed in order to create the animation. h1 { font-family: "Decovar"; font-variation-settings: 'INLN' 1000, 'SWRM' 1000; animation: grow 4s linear alternate infinite; } What this demonstrates is that typically, to accomplish effects like this, the heavy lifting is done by the font. We really only need a few lines of CSS for the animation, which if you think about it, is pretty incredible. There are all sorts of interesting, creative applications of variable fonts, and a lot of incredible fonts you can make the most of. Whether you want to create that “hand-writing” effect that we often see represented with SVG, or something a little different, there are a lot of different options. Duos Writer: Hand Writing Demo of hand writing variable font, Duos Writer by Underware. Decovar: Disappearing Text See the Pen CSS-only variable font demo using Decovar Regular by Mandy Michael (@mandymichael) on CodePen. Cheee: Snow Text Snow Text Effect - Text fills up with snow and gets “heavier” at the bottom as more snow gathers. Featuring “Cheee” by OhNoTypeCo. View on Codepen. Variable Fonts, Media Queries and Customisation It’s not that these are just beautiful or cool effects, what they demonstrate is that as developers and designers we can now control the font itself and that that means is that variable fonts allow typography on the web to adapt to the flexible nature of our screens, environments and devices. We can even make use of different CSS media queries to provide more control over our designs based on environments, light contrast and colour schemes. Though the CSS Media Queries Level 5 Spec is still in draft stages, we can experiment with the prefers-color-scheme (also known as dark mode) media query right now! Dark Mode featuring Oozing Cheee by OhNoTypeCo Oozing Dark Mode Text featuring “Cheee” by OhNoTypeCo. View Demo on Codepen. The above example uses a font called “Cheee” by OhNoTypeCo and demonstrates how to make use of a CSS Transition and the prefers-color-scheme media query to transition the axis of a variable font. h1 { font-family: “Cheee" font-variation-settings: "TEMP" 0; transition: all 4s linear; } @media (prefers-color-scheme: dark) { h1 { font-variation-settings: "TEMP" 1000; } } Dark mode isn’t just about changing the colours, it’s important to consider things like weight as well. It’s the combination of the weight, colour and size of a font that determines how legible and accessible it is for the user. In the example above, I’m creating a fun effect – but more practically, dark mode allows us to modify the contrast and styles to ensure better legibility and usability in different environments. What is even more exciting about variable fonts in this context is that if developers and designers can have this finer control over our fonts to create more legible, accessible text, it also means the user has access to this as well. As a result, users that create their own stylesheets to customise the experience to their specific requirements, can now adjust the pages font weight, width or other available axis to what best suits them. Providing users with this kind of flexibility is such an incredible opportunity that we have never had before! As CSS develops, we’ll have access to different environmental and system features that allow us to take advantage of our users unique circumstances. We can start to design our typography to adjust to things like screen width - which might allow us to tweak the font weight, width, optical size or other axes to be more readable on smaller or larger screens. Where the viewport is wide we can have more detail, when its smaller in a more confined space we might look at reducing the width of the font—this helps to maintain the integrity of the design as the viewport gets smaller or, to fit text into a particular space. See the Pen CSS is Awesome - Variable fonts Edition. by Mandy Michael (@mandymichael) on CodePen. We have all been in the situation where we just need the text to be slightly narrower to fit within the available space. If you use a variable font with a width axis you can slightly modify the width to adjust to the space available, and do so in a way that the font was designed to do, rather than using things like letter spacing which doesn’t consider the kerning of the characters. Variable Fonts, JavaScript and Interactive Effects We can take these concepts even further and mix in a little JavaScript to make use of a whole suite of different interactions, events, sensors and apis. The best part about this is whether you are using device orientation, light sensors, viewport resizes, scroll events or mouse movement, the base JavaScript doesn’t really change. To demonstrate this, we’ll use a straightforward example – we’ll match our font weight to the size of our viewport – as the viewport gets smaller, the font weight gets heavier. Demo: As the viewport width changes, the weight of the text “Jello” becomes heavier. We’ll start off by setting our base values. We need to define the minimum and maximum axis values for the font weight, and the minimum and maximum event range, in this case the viewport size. Basically we’re defining the start and end points for both the font and the event. // Font weight axis range const minAxisValue = 200 const maxAxisValue = 900 // Viewport range const minEventValue = 320px const maxEventValue = 1440px Next we determine the current viewport width, which we can access with something like window.innerWidth. // Current viewport width const windowWidth = window.innerWidth Using the current viewport width value, we create the new scale for the viewport, so rather than the pixels values we convert it to a range of 0 - 0.99. const windowSize = (windowWidth - minEventValue) / (maxEventValue - minEventValue) // Outputs a value from 0 - 0.99 We then take that new viewport decimal value and use it to determine the font weight based on viewport scale. const fontWeight = windowSize * (minAxisValue - maxAxisValue) + maxAxisValue; // Outputs a value from 200 - 900 including decimal places This final value is what we use to update our CSS. You can do this however you want – lately I like to use CSS Custom Properties. This will pass the newly calculated font weight value into our CSS and update the weight as needed. // JavaScript p.style.setProperty("--weight", fontWeight); Finally, we can put all this inside a function and inside an event listener for window resize. You can modify this however you need to in order to improve performance, but in essence, this is all you need to achieve the desired outcome. function fluidAxisVariation() { // Current viewport width const windowWidth = window.innerWidth // Get new scales for viewport and font weight const viewportScale = (windowWidth - 320) / (1440 - 320); const fontWeightScale = viewportScale * (200 - 900) + 900; // Set in CSS using CSS Custom Property p.style.setProperty("--weight", fontWeightScale); } window.addEventListener("resize", fluidAxisVariation); You can apply this to single elements, or multiple. In this case, I’m changing the paragraph font weights and different rates, but also reducing the width axis of the headline so it doesn’t wrap onto multiple lines. As previously mentioned, this code can be used to create all sorts of really amazing, interesting effects. All that’s required is passing in different event and axis values. In the following example, I’m using mouse position events to change the direction and rotation of the stretchy slinky effect provided by the font “Whoa” by Scribble Tone. See the Pen Slinky Text - WHOA Variable font demo by Mandy Michael (@mandymichael) on CodePen. We can also take the dark mode/colour schemes idea further by making use of the Ambient Light Sensor to modify the font to be more legible and readable in low light environments. This effect uses Tiny by Jack Halten Fahnestock from Velvetyne Type Foundry and demonstrates how we modify our text based by query the characteristics of the user’s display or light-level, sound or other sensors. It’s only because Variable fonts give us more control over each of these elements that we can fine-tune the font characteristics to maximise the legibility, readability and overall accessibility of our website text. And while these examples might seem trivial, they are great demonstrations of the possibilities. This is a level of control over our fonts and text that is unprecedented. Using device orientation to change the scale and weight of individual characters. View on Codepen. Variable Fonts offer a new world of interactivity, usability and accessibility, but they are still a new technology. This means we have the opportunity to figure out how and what we can achieve with them. From where I stand, the possibilities are endless, so don’t be limited by what we can already do – the web is still young and there is so much for us to create. Variable fonts open up doors that never existed before and they give us an opportunity to think more creatively about how we can create better experiences for our users. At the very least, we can improve the performance of our websites, but at best, we can make more usable, more accessible, and more meaningful content - and that, is what gets me really excited about the future of web typography with variable fonts. About the author Mandy is a community organiser, speaker, and developer working as the Front End Development Manager at Seven West Media in Western Australia. She is a co-organiser and Director of Mixin Conf, and the founder and co-organiser of Fenders, a local meetup for front-end developers providing events, mentoring and support to the Perth web community. Mandy’s passion is CSS, HTML and JS and hopes to inspire that passion in others. She loves the supportive and collaborative nature of the web and strives to encourage this environment through the community groups she is a part of. Her aim is to create a community of web developers who can share, mentor, learn and grow together. More articles by Mandy Full Article Code Design typography
activity The reactivity of alkenyl boron reagents in catalytic reactions: recent advances and perspectives By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01703J, Review ArticleYa-Li Feng, Bo-Wen Zhang, Youzhi Xu, Shengnan Jin, Daniele Mazzarella, Zhong-Yan CaoRecent advances focusing on novel reactivity of alkenyl boron reagents in polar or radical pathways within catalytic reactions by employing transition metal catalysis, organocatalysis have been summarized and discussed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity In vitro bioactivity, mechanical, and cell interaction of sodium chloride-added calcium sulfate–hydroxyapatite composite bone cements By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35460-35474DOI: 10.1039/D4RA06034B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pharatree Jaita, Chamnan Randorn, Anucha Watcharapasorn, Parkpoom JarupoomIn this research, sodium chloride-added calcium sulfate–hydroxyapatite composite bone cements (0.70CaS–0.30HAP)/xNaCl were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Superior low temperature activity over α-MnO2/β-MnOOH catalyst for selective catalytic reduction of NOx with ammonia By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35498-35504DOI: 10.1039/D4RA05934D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Masanori Takemoto, Haruko Fujinuma, Yoshihiro Sugawara, Yukichi Sasaki, Kenta Iyoki, Tatsuya Okubo, Kazuya Yamaguchi, Toru Wakiharaα-MnO2/β-MnOOH catalysts were synthesized by post-synthetic planetary ball milling for OMS-2, enhancing catalytic activity in low-temperature NH3-SCR.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Synthesis and antiproliferative activity of 2-oxo-3-phenylquinoxaline derivatives and related compounds against colon cancer By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35679-35695DOI: 10.1039/D4RA06822J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.M. S. Gomaa, Abdulghany H. A. Ahmed, S. M. El Rayes, Ibrahim A. I. Ali, Walid Fathalla, Mansour S. Alturki, Abdulaziz Hassan Al Khzem, Atiah H. Almalki, Mohammed F. Aldawsari, F. H. Pottoo, Firdos A. Khan, Mohd AmirThe impact of compound 7j on colon cancer cells (HCT-116). Fig. (A) shows the control cells Fig. (B) shows the treatment cells. The arrows show chromatin condensation, nuclear augmentation, and formation of apoptotic bodies.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity In silico molecular docking and ADMET prediction of biogenic zinc oxide nanoparticles: characterization, and in vitro antimicrobial and photocatalytic activity By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36209-36225DOI: 10.1039/D4RA06890D, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hajara Akhter, Susmita Sarker Ritu, Shahariar Siddique, Fariha Chowdhury, Rehnuma Tasmiyah Chowdhury, Samina Akhter, Mahmuda HakimA facile green route to synthesize zinc oxide nanoparticles using watermelon rind extract with antimicrobial and photocatalytic potential.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Physicochemical properties and mechanism of action of a new copper(II) pyrazine-based complex with high anticancer activity and selectivity towards cancer cells By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36295-36307DOI: 10.1039/D4RA06874B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.B. Rogalewicz, T. Sierański, M. Szczesio, A. Olczak, K. Gobis, C. Orlewska, I. Korona-Głowniak, A. Korga-Plewko, M. Iwan, M. Michalczuk, J. Kubik, G. Adamczuk, M. Korga, N. Rutkowska, T. Boruta, K. Gas, M. Sawicki, E. Poleszak, W. Maniukiewicz, M. Świątkowski, A. CzylkowskaThe presented work underlines the importance of coordination compounds in the development of new anticancer agents that are safer and more efficient.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity An octanuclear 3-phenyl-5-(2-pyridyl)pyrazolate/phenylsilsesquioxane complex: synthesis, unique structure, and catalytic activity By pubs.rsc.org Published On :: Dalton Trans., 2024, Accepted ManuscriptDOI: 10.1039/D4DT02690J, CommunicationAlexey Bilyachenko, Victor N Khrustalev, Zhibin Huang, Lidia S. Shul'pina, Pavel Dorovatovskii, Elena Shubina, Nikolay S. Ikonnikov, Nikolai N. Lobanov, Karim G. Rahimov, Di SunFirst metallasilsesquioxane bearing pyrazolylpyridine ligands, Cu8-based complex 1, adopts cage structure with two zigzag-like copper tetramers sandwiched by two cyclic Si5 silsesquioxane ligands. Four 3-phenyl-5-(2-pyridyl)pyrazolate ligands in 1 exhibit dual...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Zn(II) coordination influences the secondary structure, but not antimicrobial activity of the N-terminal histatin 3 hydrolysis product By pubs.rsc.org Published On :: Dalton Trans., 2024, Advance ArticleDOI: 10.1039/D4DT02274B, PaperEmilia Dzień, Joanna Wątły, Aleksandra Hecel, Aleksandra Mikołajczyk, Agnieszka Matera-Witkiewicz, Miquel Adrover, Miquel Barceló-Oliver, Alicia Domínguez-Martín, Magdalena Rowińska-ŻyrekHistatin 3 and 4 have greater activity against Gram(+) than Gram(−) bacteria, and Cu(II) or Zn(II) binding can moderately increase their antimicrobial activity. The N-terminal part of histatin 3 becomes α-helical upon Zn(II) binding.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Syntheses and structures of dimesitylphosphinite complexes of alkali metals and their catalytic activity in hydrophosphorylation reactions By pubs.rsc.org Published On :: Dalton Trans., 2024, Advance ArticleDOI: 10.1039/D4DT02721C, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Benjamin E. Fener, Philipp Schüler, Phil Liebing, Helmar Görls, Matthias WesterhausenThe diarylphosphinite complexes of the alkali metals exhibit a broad structural variety. Especially for potassium dimesitylphosphinite, the heterocubane cage can be broken down into dimeric K2O2 units by adding oligodentate ether molecules.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Advances in metal–organic frameworks for optically selective alkaline phosphatase activity monitoring: a perspective By pubs.rsc.org Published On :: Dalton Trans., 2024, 53,17742-17755DOI: 10.1039/D4DT01727G, PerspectiveEduarda Andrade, Filipe A. Almeida Paz, Flávio FigueiraMOFs can play three essential roles in ALP monitoring: they can serve as fluorescent probes, function in oxidation or peroxidation mechanisms, or combine both processes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Direct O2 mediated oxidation of a Ni(II)N3O structural model complex for the active site of nickel acireductone dioxygenase (Ni-ARD): characterization, biomimetic reactivity, and enzymatic implications By pubs.rsc.org Published On :: Dalton Trans., 2024, 53,17852-17863DOI: 10.1039/D4DT02538E, PaperKelsey E. Kirsch, Mary E. Little, Thomas R. Cundari, Emily El-Shaer, Georgia Barone, Vincent M. Lynch, Santiago A. ToledoA structural and functional biomimetic Ni(II)N3O complex, capable of O2 mediated dioxygenase like C–C bond cleavage, via a putative high-valent Ni intermediate.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Asymmetric magnetic nanosnowman loaded with AgPd nanocage toward NIR-enhanced catalytic activity By pubs.rsc.org Published On :: Dalton Trans., 2024, 53,17864-17879DOI: 10.1039/D4DT02425G, PaperJie Jin, Haoran Li, Hongfa Wang, Qunling Fang, Yunqi Xu, Weili Kong, Xia Chen, Ken Cham-Fai Leung, Hailong Wang, Shouhu XuanAn asymmetric Fe3O4@AgPd/PDA nanosnowman embedded with an AgPd nanocage shows significantly enhanced catalytic activity under near-infrared (NIR) light.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity A bioinspired water oxidation catalyst that is ∼1/10th as active as the photosystem II oxygen evolving center at pH 7: a study of activity and stability factors By pubs.rsc.org Published On :: Dalton Trans., 2024, 53,17783-17788DOI: 10.1039/D4DT02336F, CommunicationDanijel Boskovic, Richard Terrett, Matthew Longhurst, Sabeel Basheer, Alireza Ariafard, Pawel Wagner, Ronald J. Pace, Rob Stranger, Gerhard F. SwiegersCa-doped birnessite MnOx on liquid crystalline reduced graphene oxide exhibits unprecedented performance for an abiological catalyst at pH 7, including a very low onset overpotential of 0.52 V and high activity per unit area at 0.56 V overpotential.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
activity Understanding the structure–activity relationship of additives for durable Zn metal batteries: a case study of aromatic molecules By pubs.rsc.org Published On :: Energy Environ. Sci., 2024, 17,8349-8359DOI: 10.1039/D4EE03232B, PaperDa-Qian Cai, Haiyang Cheng, Jin-Lin Yang, Huan Liu, Tao Xiao, Xin Liu, Minghua Chen, Hong Jin FanThe Zn/electrolyte interface with parallelly adsorbed Pym molecules can efficiently suppress corrosion and HER and simultaneously accelerate Zn redox kinetics by inducing zincophilicity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article