rant This deal gets you all-you-can-eat tastings from the best Indianapolis restaurants By rssfeeds.indystar.com Published On :: Sun, 30 Sep 2018 14:21:45 +0000 Half-price tickets let you eat, drink wine and see Food Network's Scott Conant at the IndyStar Wine & Food Experience. Full Article
rant Liter House restaurant and brewery opens south of Broad Ripple By rssfeeds.indystar.com Published On :: Wed, 11 Jul 2018 14:44:50 +0000 Full Article
rant New Mass Ave. restaurants serve macarons, mac and cheese, brisket nachos, farm-to-table By rssfeeds.indystar.com Published On :: Tue, 19 Jun 2018 11:27:40 +0000 40 restaurants in all fill the small, Downtown Indianapolis neighborhood Full Article
rant Fountain Square restaurant Pioneer stops serving food By rssfeeds.indystar.com Published On :: Wed, 06 Jun 2018 19:21:52 +0000 Pioneer is not closed and a new menu is coming soon. Full Article
rant These rooftop bars and restaurants will help you live your best summer By rssfeeds.indystar.com Published On :: Wed, 24 Apr 2019 01:42:48 +0000 Indy has a range of high-altitude hotspots, and more are in the works. Full Article
rant House-ground burgers, sausage planned at new Mass Ave. restaurant Krueger's Tavern By rssfeeds.indystar.com Published On :: Thu, 10 Jan 2019 19:52:40 +0000 The restaurant opening in January 2019 is from the owners of Bakersfield. Full Article
rant Daredevil Brewing to bring restaurant/taproom to Ironworks Hotel By rssfeeds.indystar.com Published On :: Wed, 20 Jun 2018 22:45:30 +0000 Indianapolis chef Neal Brown will head the kitchen at the family-friendly restaurant. Full Article
rant The Vanguard restaurant closes in Broad Ripple after chef, bar manager quit By rssfeeds.indystar.com Published On :: Wed, 27 Jun 2018 14:12:23 +0000 The owner claims he was left no choice after sudden departure of the chef and bar manager. Full Article
rant 18 new restaurants in Carmel, Noblesville, Westfield and Indianapolis' north side By rssfeeds.indystar.com Published On :: Thu, 28 Jun 2018 14:28:55 +0000 A brunch cafe, wood-fired burgers, craft beer and pizza are a few of the new restaurants coming to or near Hamilton County. Full Article
rant This Indianapolis burger restaurant keeps winning best burger awards By rssfeeds.indystar.com Published On :: Thu, 28 Jun 2018 14:21:23 +0000 Every burger on the Flamme Burger menu is cooked over a live fire. Full Article
rant Another Patachou restaurant is coming to Downtown Indianapolis By rssfeeds.indystar.com Published On :: Mon, 02 Jul 2018 15:00:07 +0000 Public Greens funnels its profits to help feed food-insecure kids in Marion County. Full Article
rant Mexican restaurant opens: Rooftop tacos and margaritas in Fall Creek Place By rssfeeds.indystar.com Published On :: Thu, 05 Jul 2018 17:01:37 +0000 Loco Mexican Restaurant to fill space where LongBranch, 22nd Street Diner failed. Full Article
rant Here are all the new fried chicken restaurants in Indianapolis By rssfeeds.indystar.com Published On :: Tue, 17 Jul 2018 23:44:38 +0000 Celebrate National Fried Chicken Day at these shrines of hot and crispy goodness Full Article
rant Liter House restaurant brings German beer, food south of Broad Ripple By rssfeeds.indystar.com Published On :: Tue, 17 Jul 2018 23:41:49 +0000 A barbecue pavilion and a rooftop wine and whiskey bar are in the works out back. Full Article
rant This deal gets you all-you-can-eat tastings from the best Indianapolis restaurants By rssfeeds.indystar.com Published On :: Sun, 30 Sep 2018 14:21:45 +0000 Half-price tickets let you eat, drink wine and see Food Network's Scott Conant at the IndyStar Wine & Food Experience. Full Article
rant Retro Recipes: Want to make that famous Tee Pee restaurant salad dressing? By rssfeeds.indystar.com Published On :: Thu, 10 Oct 2019 13:59:52 +0000 The iconic restaurant still conjures up fond memories of the food and the cruising. Full Article
rant Fortville restaurant owner transforms into 'Tiger King's' Joe Exotic to help workers By rssfeeds.indystar.com Published On :: Tue, 31 Mar 2020 14:16:05 +0000 The owner of FoxGardin in Fortville transformed himself into Joe Exotic to help his workers. Full Article
rant More migrants intercepted at Dover amid lockdown spike By www.bbc.co.uk Published On :: Sat, 09 May 2020 16:17:29 GMT Border Force officials are dealing "with a number of small boat incidents" off Kent, officials say. Full Article
rant 'If they stare, fine.' Adults use kiddie pools as quarantine meets L.A. heat By www.latimes.com Published On :: Wed, 6 May 2020 18:19:56 -0400 Sidewalk splash pools have long been a summertime staple, particularly for families with young kids. But the virus pandemic has boosted their appeal. Full Article
rant Drug investigators serve warrants in North Hollywood, West Los Angeles By www.latimes.com Published On :: Wed, 6 May 2020 19:58:32 -0400 Investigators from the Drug Enforcement Administration and the Los Angeles Police Department served search warrants at a North Hollywood business in a federal drug trafficking investigation, authorities said. Full Article
rant 2 counties defied Newsom and reopened. Now California warns restaurants could lose licenses if opened too early By www.latimes.com Published On :: Thu, 7 May 2020 09:00:22 -0400 California says bars that reopen without state permission could lose alcohol license Full Article
rant Afghanistan investigates reports Iran guards forced migrants into river By www.bbc.co.uk Published On :: Sun, 03 May 2020 18:30:02 GMT Afghanistan is investigating the alleged torture and drowning of migrants at the Iranian border. Full Article
rant Coronavirus: Hong Kong to quarantine all arrivals from abroad By www.bbc.co.uk Published On :: Tue, 17 Mar 2020 04:31:43 GMT Hong Kong has seen 57 new infections over the past two weeks, 50 of which were imported. Full Article
rant 1984: Europe grants emergency aid for Ethiopia By news.bbc.co.uk Published On :: Thu, 14 Nov 2002 17:55:28 GMT The EEC is donating £1.8 million to help combat the famine in Ethiopia. Full Article 25
rant Coronavirus: Virus deepens struggle for migrants By www.bbc.co.uk Published On :: Fri, 10 Apr 2020 23:04:42 GMT Migrants in Calais and the UK say the Covid-19 pandemic is deepening the struggles they face. Full Article
rant After death, special trains take 16 migrant workers to home districts - The Tribune India By news.google.com Published On :: Sat, 09 May 2020 14:04:42 GMT After death, special trains take 16 migrant workers to home districts The Tribune IndiaUnable to Overcome Impact Of Tragedy: Aurangabad Train Accident Survivor NDTVNHRC issues notice to Maharashtra govt over deaths of migrant workers in Aurangabad train mishap, seeks det... Zee NewsTragedy on tracks The Indian ExpressCoronavirus Essential podcast | Aurangabad train mows down 17 migrant workers; COVID-19 spreads in 8 Maharashtra jails Moneycontrol.comView Full coverage on Google News Full Article
rant More than 140 migrants intercepted in Channel - highest number in one day By news.sky.com Published On :: Sat, 09 May 2020 07:36:00 +0100 A record number of migrants crossed the English Channel on Friday. Full Article
rant UK to bring in two-week quarantine for air passengers By news.sky.com Published On :: Sat, 09 May 2020 07:40:00 +0100 Air passengers arriving in Britain will soon have to quarantine for a fortnight as part of a move to avoid a second peak of the coronavirus. Full Article
rant This seafood restaurant’s latest catch: Chinese robots that greet customers and deliver food By www.washingtonpost.com Published On :: Tue, 02 Jul 2019 11:00:36 +0000 A newly opened Delaware seafood restaurant has a unique item on its menu: robot servers. The machines are the latest example of intelligent machines working in the restaurant industry. Full Article
rant ‘Real Housewives’ stars Ashley and Michael Darby are closing their Virginia restaurant By www.washingtonpost.com Published On :: Wed, 26 Jun 2019 16:46:54 +0000 The couple ran Oz, an Australian-themed eatery in Clarendon. Full Article
rant The Scene: D.C. restaurant workers let down their hair and celebrate at the 2019 RAMMY Awards By www.washingtonpost.com Published On :: Tue, 02 Jul 2019 17:57:00 +0000 Washington's service industry professionals left their bars and restaurants on Sunday to celebrate the 37th annual event. Full Article
rant For many immigrants, family separation happens long before the border By www.washingtonpost.com Published On :: Fri, 30 Aug 2019 14:00:45 +0000 Review of 'A Good Provider Is One Who Leaves: One Family and Migration in the 21st Century' by Jason DeParle Full Article
rant Trump’s anti-immigrant agenda isn’t about rule of law or economics at all By www.washingtonpost.com Published On :: Fri, 31 Jan 2020 00:44:15 +0000 The latest immigration rule is based on obvious lies. Full Article
rant Fin24.com | Regulator grants Telkom, MTN and Vodacom additional spectrum amid Covid-19 By www.fin24.com Published On :: Fri, 17 Apr 2020 10:33:33 +0200 A lack of high demand spectrum has been a long-running complaint by SA telecoms groups, who say that it is needed to reduce data prices and increase speed. Full Article
rant News24.com | International Covid-19 news: Migrants stranded all over the world, more apply for unemployment in US By www.news24.com Published On :: Thu, 07 May 2020 17:21:31 +0200 Here are the latest top Covid-19 stories from around the world. Full Article
rant Channel24.co.za | SABC granted a local TV content quota reprieve due to Covid-19 By www.channel24.co.za Published On :: Thu, 07 May 2020 10:10:37 +0200 South Africa's broadcasting regulator has approved an application from the SABC for its annual local TV content quotas to be waived because of the Covid-19 coronavirus pandemic. Full Article
rant On Beat Fitness is a dance party disguised as a workout for any quarantine mood By feedproxy.google.com Published On :: Sat, 09 May 2020 15:00:00 +0000 Work(out) From Home is a weekly column where we review smart fitness machines and apps in the wake of the coronavirus outbreak. Thanks to technology, there are still plenty of ways to exercise if your gym is closed. Read more... On Beat Fitness $120 (annual) View Product The Good Super fun workouts • Classes grouped by mood • Equipment-free workout options • Growing library of classes The Bad Lack of workout history • Expensive subscription • Inability to filter search The Bottom Line On Beat Fitness offers a variety of classes that cater to both your taste in music and your mood for the day. Not only are the workouts fun and effective, but exercising to the beat of the music makes it a lot easier to follow along. ⚡ Mashable Score 4.75 😎 Cool Factor 4.5 📘Learning Curve 5.0 💪Performance 5.0 💵Bang for the Buck 4.0 More about Apps, Fitness, Beauty, Fitness App, and Workout From Home Full Article Apps Fitness Beauty Fitness App Workout From Home
rant In quarantine, Thomas Dolby's kids turn dad's hit "Europa..." into "Corona..." By feedproxy.google.com Published On :: Fri, 08 May 2020 07:00:30 PDT A couple of days ago, Thomas Dolby posted this video to Twitter and YouTube of a track called "Corona and the Pirate Twins," a spoof of his 1982 hit, "Europa and the Pirate Twins." The song is credited to Dolby Kids. Thomas included the following note: "This is what my mischievous offspring have been getting up to during the Lockdown." Here is the original video for "Europa..." Bonus track: And here is Thomas Dolby doing a touching home solo version of his achingly beautiful "Screen Kiss" from 1984's Flat Earth. He did it as a tribute to Matthew Seligman, the celebrated bassist who recently died of COVID-19. Seligman played bass on Dolby's recordings, including Flat Earth, and also played for Bowie, Robyn Hitchcock, Peter Murphy, and countless others. He was also a member of the Soft Boys. Image: YouTube Read the rest Full Article Post pop music Shut In Sounds social distancing Thomas Dolby
rant Colt Clark and the Quarantine Kids play "Come Together" By feedproxy.google.com Published On :: Fri, 08 May 2020 10:01:09 PDT A family in lockdown performs the Beatles' "Come Together." Read the rest Full Article Video beatles family
rant Folks are getting creative with flyers in this quarantine By feedproxy.google.com Published On :: Sat, 09 May 2020 09:23:37 PDT My pal Jake has been taking regular "cigar walks" (as he calls them) here in our lovely island city of Alameda, California. On those walks, he started spotting some creative flyers... (I saved the best two for last...) photos by Jake Schaffer, used with permission Thanks, Susie! Read the rest Full Article Post Alameda california flyering flyers pop culture Save Ferris
rant Will restaurants be allowed to offer alcohol for take-out and delivery after pandemic? By bc.ctvnews.ca Published On :: Sat, 9 May 2020 09:32:56 -0700 Restaurants have been struggling to stay afloat since the pandemic hit, but there has been a silver lining: relaxed liquor laws mean customers can get their booze delivered along with their meals. Full Article
rant Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters By 100percentfedup.com Published On :: Wed, 06 May 2020 22:43:02 +0000 The following article, Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters, was first published on 100PercentFedUp.com. The media and even some governors are trying to paint the Americans who are protesting to open businesses up as racists and even Nazis. The Governor of Michigan recently made a derogatory statement about the protesters implying they are racists. Painting a negative picture of the people who want their freedom and businesses demonizes our […] Continue reading: Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters ... Full Article Featured Left News Political Correctness Politics
rant Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant” By 100percentfedup.com Published On :: Thu, 07 May 2020 02:33:27 +0000 The following article, Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant”, was first published on 100PercentFedUp.com. Warren Norred, attorney for Shelley Luther, joined Tucker Carlson to discuss the decision by an Obama loyalist Texas judge to jail his client for reopening her salon during the COVID-19 pandemic. Norred said the judge has exposed himself for the “tiny tyrant” that he is. The judge jailed Luther and even fined her $7,000. Texas […] Continue reading: Attorney for Jailed Dallas Salon Owner Shelley Luther Slams Obama Loyalist Judge as a “Tiny Tyrant” ... Full Article Featured Government Politics
rant Empty restaurant space could be turned into women's support centre By winnipeg.ctvnews.ca Published On :: Sat, 9 May 2020 09:25:54 -0600 The empty space next to Winnipeg City Hall that once housed restaurants could be turned into a place to help exploited women. Full Article
rant Stavros Niarchos Foundation makes £3m grant for expansion at Chatham House By feedproxy.google.com Published On :: Fri, 18 Dec 2015 13:54:27 +0000 18 December 2015 The Royal Institute of International Affairs is pleased to announce a Cornerstone Contribution of £3m by the Stavros Niarchos Foundation (SNF) towards the Chatham House Second Century Initiative to support the expansion and renovation of the institute’s ground floor. 20141208CHfront.jpg Following the institute’s purchase of the ground floor of the adjoining building (Ames House) in 2013, this generous grant from SNF will enable Chatham House to occupy this space and undertake a significant renovation project to create the ‘Stavros Niarchos Foundation Floor’ at Chatham House.This will help the institute meet the growing demand for its research and analysis and take full advantage of its location in central London, given the city’s exceptional international connectivity and status as a global hub.The SNF Floor will contain state-of-the-art meeting facilities for the institute’s research staff and fellows of the Queen Elizabeth II Academy for Leadership in International Affairs, and will significantly enhance the institute’s convening and communication capacities. To this end, the renovated space will include a ‘simulation room’, the Asfari Centre and a media room, as well as new breakout and meeting areas. The SNF Floor will be directly accessible from the ground floor of 10 St James’s Square, the institute’s main building.The SNF grant is an important step forward for the institute’s Second Century Initiative which aims to ensure the institute’s long-term financial independence. The initiative has three principal targets:● to endow a number of Research Fellowships and interdisciplinary Research Centres;● to secure endowments to support the Queen Elizabeth II Academy for Leadership in International Affairs in order to nurture independent thinking on international policy among a new generation from around the world; and● to secure the necessary physical space and infrastructure here in London to meet the growing demand for and scope of the institute’s work.Dr Robin Niblett, director of Chatham House said: ‘We are enormously grateful to the Stavros Niarchos Foundation for this transformational grant which will significantly enhance Chatham House’s capacity to serve as a trusted and creative space for addressing the most important challenges in international affairs.’Andreas Dracopoulos, co-president of SNF’s board of directors, said: ‘We are delighted to support the growth of Chatham House, one of Europe’s leading independent, non partisan policy institutes, at a time when the risks to global prosperity and stability are expanding. Chatham House’s reputation for providing world-leading analysis needs to remain as strong as ever and I am confident that this grant will help the institute take its research and convening activities in new interactive and interdisciplinary directions.’ Editor's notes Chatham House launched its Second Century Initiative in November 2014 as part of its preparations for its centenary in 2020. The Initiative aims to help secure the institute’s financial base and independence by strengthening its capacity to innovate in an increasingly competitive field of thought leadership and policy ideas. Renovation work on the ground floor of Ames House is expected to begin in the spring of 2016.The Stavros Niarchos Foundation is one of the world’s leading international philanthropic organizations, making grants in the areas of arts and culture, education, health, medicine and sports, and social welfare. The Foundation funds organizations and projects that exhibit strong leadership and sound management and are expected to achieve a broad, lasting and positive impact for society at large. The Foundation also seeks actively to support projects that facilitate the formation of public-private partnerships as an effective means for serving public welfare. Full Article
rant Chatham House awarded major centenary grant to establish Stavros Niarchos Foundation Wing By feedproxy.google.com Published On :: Tue, 16 Apr 2019 11:32:22 +0000 17 April 2019 Chatham House has been awarded a transformational £10m grant ahead of its upcoming 2020 centenary. Chatham House_Stavros Niarchos Wing Options (A3)-1-WEB_RESOLUTION (002).jpg The gift will create the Stavros Niarchos Foundation (SNF) Wing, enabling a permanent expansion of the institute’s research and providing a home to its Queen Elizabeth II Academy for Leadership in International Affairs. The wing will also house the ‘Chatham House SNF CoLab’, an initiative to open Chatham House’s policy research to wider public audiences.The funds from the Stavros Niarchos Foundation (SNF) will be used to integrate a three-storey wing with the institute’s renowned building at 10 St James’s Square. The SNF Wing will support research collaboration and provide a stimulating environment to explore ways to engage people in the institute’s research, using interactive multimedia and other digital tools. Inauguration of the Chatham House SNF CoLab and the SNF Wing is anticipated in fall of 2019.The gift from SNF is one of the largest in the institute’s history and is a major milestone in the foundation’s long-standing support of Chatham House, which dates back to 2007 and includes grants for research, infrastructure and student outreach totalling over £4.5m in the past 5 years.Chairman of Chatham House, Lord Jim O’Neill said, 'This exceptional gift from SNF is a vote of confidence in the independence, quality and impact of the institute’s work. It will guarantee that the institute can innovate for the future, especially by engaging younger generations into its research and ideas, which is essential.'Director of Chatham House Dr Robin Niblett said the gift will encourage informed public debate at a time of unprecedented global uncertainty and deepening political polarisation.'The SNF Wing and Chatham House SNF CoLab will ensure Chatham House can continue to serve as a trusted hub for dialogue and a source of credible information, analysis and ideas on international affairs. It is an enormous boost to our staff and their work as we begin our second century, and of special value in such turbulent times.'SNF Co-President Andreas Dracopoulos said, 'Chatham House is one of our key partners, and this grant marks an important new stage in our collaboration. At a time of uncertainty in international affairs, supporting the world-class independent analysis that can help citizens around the world engage in informed decisions about their future is essential. We are proud to help Chatham House maintain its independent voice while deepening its engagement with the public.'The Stavros Niarchos Foundation’s past support has enabled Chatham House to establish an ‘SNF Floor’ with a broadcast media studio, a purpose-built simulation centre and training facilities, which will now be incorporated into the larger SNF Wing. The floor was officially opened by His Royal Highness the Duke of Sussex in 2017, when he took part in a scenario exercise exploring how to respond to a humanitarian emergency that required landmine clearance, drawing on the Duke’s ongoing work in this field.For more information please contact:pressoffice@chathamhouse.orgPhone: +44 (0)207 957 5739 Editor's notes Chatham House, the Royal Institute of International Affairs, is a world-leading policy institute based in London. Our mission is to help governments and societies build a sustainably secure, prosperous and just world.We engage governments, the private sector, civil society and our members in open debate and private discussions about the most significant developments in international affairs. Our research and policy ideas involve rigorous analysis of critical global, regional and country-specific challenges and opportunities.The Stavros Niarchos Foundation (SNF) is one of the world’s leading private, international philanthropic organizations, making grants to non-profit organizations in the areas of arts and culture, education, health and sports, and social welfare. Since 1996, the Foundation has committed more than $2.8 billion, through more than 4,400 grants to non-profit organizations in 124 nations around the world.The SNF funds organizations and projects worldwide that aim to achieve a broad, lasting and positive impact for society at large and exhibit strong leadership and sound management. The Foundation also supports projects that facilitate the formation of public-private partnerships as an effective means for serving public welfare. Full Article
rant New Coronavirus Outbreak: Concern Is Warranted, Panic Is Not By feedproxy.google.com Published On :: Thu, 23 Jan 2020 12:03:21 +0000 23 January 2020 Professor David Heymann CBE Distinguished Fellow, Global Health Programme Lara Hollmann Research Assistant, Global Health Programme @lara_hollmann LinkedIn Whenever there is a new infection in humans, such as the novel coronavirus, it is appropriate to be concerned because we do not know enough about its potential. Explainer: Coronavirus - What You Need to Know World-renowned global health expert Professor David Heymann CBE explains the key facts and work being done on the Coronavirus outbreak. When it comes to emerging infectious diseases – those newly recognized in humans or in new locations – it is not only what we know that matters but also what we do not know.An outbreak of a new coronavirus first reported in Wuhan, China, which has so far led to more than 500 confirmed cases and multiple deaths across five countries (and two continents) has prompted the question from several corners of the world: Should we be worried?Although expert teams coordinated by the World Health Organization (WHO) are working on key questions to get answers as soon as possible, the level of uncertainty is still high.We do not yet know exactly how deadly the disease is, how best to treat those who get sick, precisely how it is spreading, nor how stable the virus is. It is thought that the virus spread from an animal source, but the exact source is yet to be confirmed and the disease is now in human populations and appears to be spreading from human to human.It is such uncertainty, inherent in emerging infectious disease outbreaks, that warrants concern. Until they are resolved, it is appropriate for the world to be concerned. It is useful to remember that most established scourges of humanity such as HIV, influenza and tuberculosis likely started as emerging infectious diseases that jumped the species barrier from animals to humans.Shortly after the Chinese authorities reported the first cases of ‘mystery pneumonia’ in Wuhan, China, to WHO, the virus causing the disease was isolated and identified as being part of the coronavirus family. It belongs to the same virus family as SARS, a highly contagious and life-threatening coronavirus that caused a nine-month epidemic in 2003 that affected 26 countries and resulted in more than 8,000 infections and nearly 800 deaths.A second novel coronavirus that emerged in 2012 and persists today – MERS, or Middle East Respiratory Syndrome – is less contagious (spread by close contact rather than coughing and sneezing).The differences between the SARS coronavirus and the MERS coronavirus highlight that, despite belonging to the same virus family, pathogens do not necessarily behave in the same way. It is as yet unknown whether the new virus is, or will turn out to be, more like SARS or MERS, or neither. Chinese authorities have confirmed that there is human-to-human transmission. However, it is not yet established whether it is sustained, which would make the outbreak more difficult to control. As of 23 January, the number of cases range from 500 confirmed cases up to an estimated 1,700 cases, according to a disease outbreak model by Imperial College London.Likewise, we do not know to what extent the virus is able to mutate and if so, how rapidly. Generally, coronaviruses are known to be able to mutate, with the risk that a less contagious form of the virus becomes highly contagious. This could have an impact not only on the transmission pattern and rate but also the death rate. The virus could change in either direction, to become either more or less of a threat.It is important to take a precautionary approach while uncertainty persists. It is also important not to overreact and for measures to be scientifically sound. Concern over this outbreak is due, but panic is not.Three virtual networks of experts supporting the response – one of virologists, one of epidemiologists and one of clinicians – are working on the key pieces of the jigsaw puzzle: watching the virus, watching the transmission patterns, and watching the people who have been infected. It is crucial to maintain the ongoing investigation of the disease, stay focused on the science and to keep sharing the necessary information. Full Article
rant The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins [Research] By feedproxy.google.com Published On :: 2020-05-01T00:05:26-07:00 The respiratory epithelium comprises polarized cells at the interface between the environment and airway tissues. Polarized apical and basolateral protein secretions are a feature of airway epithelium homeostasis. Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targets the respiratory epithelium. However, the consequences of hRSV infection on epithelium secretome polarity and content remain poorly understood. To investigate the hRSV-associated apical and basolateral secretomes, a proteomics approach was combined with an ex vivo pediatric human airway epithelial (HAE) model of hRSV infection (data are available via ProteomeXchange and can be accessed at https://www.ebi.ac.uk/pride/ with identifier PXD013661). Following infection, a skewing of apical/basolateral abundance ratios was identified for several individual proteins. Novel modulators of neutrophil and lymphocyte activation (CXCL6, CSF3, SECTM1 or CXCL16), and antiviral proteins (BST2 or CEACAM1) were detected in infected, but not in uninfected cultures. Importantly, CXCL6, CXCL16, CSF3 were also detected in nasopharyngeal aspirates (NPA) from hRSV-infected infants but not healthy controls. Furthermore, the antiviral activity of CEACAM1 against RSV was confirmed in vitro using BEAS-2B cells. hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome and was associated with immune modulating proteins (CXCL6, CXCL16, CSF3) never linked with this virus before. In addition, the antiviral activity of CEACAM1 against hRSV had also never been previously characterized. This study, therefore, provides novel insights into RSV pathogenesis and endogenous antiviral responses in pediatric airway epithelium. Full Article
rant New Coronavirus Outbreak: Concern Is Warranted, Panic Is Not By feedproxy.google.com Published On :: Thu, 23 Jan 2020 12:03:21 +0000 23 January 2020 Professor David Heymann CBE Distinguished Fellow, Global Health Programme Lara Hollmann Research Assistant, Global Health Programme @lara_hollmann LinkedIn Whenever there is a new infection in humans, such as the novel coronavirus, it is appropriate to be concerned because we do not know enough about its potential. Explainer: Coronavirus - What You Need to Know World-renowned global health expert Professor David Heymann CBE explains the key facts and work being done on the Coronavirus outbreak. When it comes to emerging infectious diseases – those newly recognized in humans or in new locations – it is not only what we know that matters but also what we do not know.An outbreak of a new coronavirus first reported in Wuhan, China, which has so far led to more than 500 confirmed cases and multiple deaths across five countries (and two continents) has prompted the question from several corners of the world: Should we be worried?Although expert teams coordinated by the World Health Organization (WHO) are working on key questions to get answers as soon as possible, the level of uncertainty is still high.We do not yet know exactly how deadly the disease is, how best to treat those who get sick, precisely how it is spreading, nor how stable the virus is. It is thought that the virus spread from an animal source, but the exact source is yet to be confirmed and the disease is now in human populations and appears to be spreading from human to human.It is such uncertainty, inherent in emerging infectious disease outbreaks, that warrants concern. Until they are resolved, it is appropriate for the world to be concerned. It is useful to remember that most established scourges of humanity such as HIV, influenza and tuberculosis likely started as emerging infectious diseases that jumped the species barrier from animals to humans.Shortly after the Chinese authorities reported the first cases of ‘mystery pneumonia’ in Wuhan, China, to WHO, the virus causing the disease was isolated and identified as being part of the coronavirus family. It belongs to the same virus family as SARS, a highly contagious and life-threatening coronavirus that caused a nine-month epidemic in 2003 that affected 26 countries and resulted in more than 8,000 infections and nearly 800 deaths.A second novel coronavirus that emerged in 2012 and persists today – MERS, or Middle East Respiratory Syndrome – is less contagious (spread by close contact rather than coughing and sneezing).The differences between the SARS coronavirus and the MERS coronavirus highlight that, despite belonging to the same virus family, pathogens do not necessarily behave in the same way. It is as yet unknown whether the new virus is, or will turn out to be, more like SARS or MERS, or neither. Chinese authorities have confirmed that there is human-to-human transmission. However, it is not yet established whether it is sustained, which would make the outbreak more difficult to control. As of 23 January, the number of cases range from 500 confirmed cases up to an estimated 1,700 cases, according to a disease outbreak model by Imperial College London.Likewise, we do not know to what extent the virus is able to mutate and if so, how rapidly. Generally, coronaviruses are known to be able to mutate, with the risk that a less contagious form of the virus becomes highly contagious. This could have an impact not only on the transmission pattern and rate but also the death rate. The virus could change in either direction, to become either more or less of a threat.It is important to take a precautionary approach while uncertainty persists. It is also important not to overreact and for measures to be scientifically sound. Concern over this outbreak is due, but panic is not.Three virtual networks of experts supporting the response – one of virologists, one of epidemiologists and one of clinicians – are working on the key pieces of the jigsaw puzzle: watching the virus, watching the transmission patterns, and watching the people who have been infected. It is crucial to maintain the ongoing investigation of the disease, stay focused on the science and to keep sharing the necessary information. Full Article
rant A Balancing Act for Europe: Stop the Migrants, Support Greece, Assuage Turkey By feedproxy.google.com Published On :: Fri, 06 Mar 2020 16:30:44 +0000 Source The New York Times URL https://www.nytimes.com/2020/03/04/world/europe/europe-migrants-turkey-greece.ht... Release date 04 March 2020 Expert Robin Niblett In the news type Op-ed Hide date on homepage Full Article