Unspecific bone uptake (UBU) related to [¹⁸F]PSMA-1007 PET/CT imaging represents a clinical challenge. We aimed to assess whether a combination of clinical, biochemical, and imaging parameters could predict skeletal metastases in patients with [¹⁸F]PSMA-1007 bone focal uptake, aiding in result interpretation. Methods: We retrospectively analyzed [¹⁸F]PSMA-1007 PET/CT performed in hormone-sensitive prostate cancer (PCa) patients at 3 tertiary-level cancer centers. A fourth center was involved in performing an external validation. For each, a volume of interest was drawn using a threshold method to extract SUV_max, SUV_mean, PSMA tumor volume, and total lesion PSMA. The same volume of interest was applied to CT images to calculate the mean Hounsfield units (HU_mean) and maximum Hounsfield units. Clinical and laboratory data were collected from electronic medical records. A composite reference standard, including follow-up histopathology, biochemistry, and imaging data, was used to distinguish between PCa bone metastases and UBU. PET readers with less (n = 2) or more (n = 2) experience, masked to the reference standard, were asked to visually rate a subset of focal bone uptake (n = 178) as PCa metastases or not. Results: In total, 448 bone [¹⁸F]PSMA-1007 focal uptake specimens were identified in 267 PCa patients. Of the 448 uptake samples, 188 (41.9%) corresponded to PCa metastases. Ongoing androgen deprivation therapy at PET/CT (P < 0.001) with determination of SUV_max (P < 0.001) and HU_mean (P < 0.001) independently predicted bone metastases. A composite prediction score, the bone uptake metastatic probability (BUMP) score, achieving an area under the receiver-operating-characteristic curve (AUC) of 0.87, was validated through a 10-fold internal and external validation (n = 89 bone uptake, 51% metastatic; AUC, 0.92). The BUMP score’s AUC was significantly higher than that of HU_mean (AUC, 0.62) and remained high among lesions with HU_mean in the first tertile (AUC, 0.80). A decision-curve analysis showed a higher net benefit with the score. Compared with the visual assessment, the BUMP score provided added value in terms of specificity in less-experienced PET readers (88% vs. 54%, P < 0.001). Conclusion: The BUMP score accurately distinguished UBU from bone metastases in PCa patients with [¹⁸F]PSMA-1007 focal bone uptake at PET imaging, offering additional value compared with the simple assessment of the osteoblastic CT correlate. Its use could help clinicians interpret imaging results, particularly those with less experience, potentially reducing the risk of patient overstaging.

Billy Napier will remain in place as head football coach at Florida, despite the Gators producing another lackluster campaign during his third season, athletic director Scott Stricklin announced Thursday.

Aug. 19, 2024 — SURF’s innovation department recently collaborated with Cornelis Networks to advance networking capabilities for high-performance computing (HPC) clusters. The collaboration marks a new step forward for SURF […]

The post Cornelis Networks Partners with SURF to Enhance HPC Cluster Networking Capabilities appeared first on HPCwire.

The 2024 Egg Fair in Mexico broke a Guinness World Record when more than 2,000 young people participated in a race while balancing eggs on spoons.

A British YouTube star and professional wrestling superfan showed off his knowledge by breaking the Guinness World Record for the most WWE wrestlers identified by their entrance music in one minute.

BARCELONA, Spain, Nov. 7, 2024 — Codee, a provider of software developer tools for automated code review and testing specializing in correctness, modernization and optimization of Fortran/C/C++ code, is pleased […]

The post Do IT Now and Codee Partner to Enhance Code Correctness, Modernization and Optimization appeared first on HPCwire.

Nov. 11, 2024 — University of Sydney quantum researchers Dominic Williamson and Nouédyn Baspin have revealed a new architecture for managing errors that emerge in the operation of quantum computers. Their […]

The post University of Sydney Scientists Unveil Quantum Code to Enhance Error Correction with Fewer Qubits appeared first on HPCwire.

Quantum error correction specialist Riverlane today released a fascinating report — The Quantum Error Correction Report 2024 — that’s worth scanning; IBM and 28 collaborators last week released V-score, a […]

The post Quantum Nuggets: Riverlane’s 2024 QEC Study, IBM’s V-score, Twisted Semiconductors appeared first on HPCwire.

SpaceX launched 23 Starlink satellites from Cape Canaveral Space Force Center on Wednesday to match its own record of launches in one year.

The Mediterranean island nation of Cyprus signed the U.S.-led Artemis Accords on Wednesday, becoming the 46th signatory to the agreement that establishes principles for the safe exploration of space.

SpaceX on Saturday successfully launched a Falcon 9 rocket carrying a payload of 22 Starlink Internet communications satellite from Cape Canaveral in Florida, marking a state record 73rd orbital rocket launch this year.

In this whimsical talk and performance, musician and comedian Elle Cordova ponders what happened before the Big Bang. She’s then joined by guitarist Toni Lindgren for the original song “Carl Sagan,” exploring social media, human connection and how we’re all just reaching out like stars in the night sky.

The core beliefs that cause the most common problems fall into the following 3 categories. These core beliefs commonly underlie depression and anxiety. Helpless Core Beliefs such as: “I’m incompetent” “I’m needy” “I’m weak” “I’m defective, I don’t measure up” “I’m a failure” Unlovable Core Beliefs such as: “I’m unlovable” “I’m different” “I’m bound to […]

The post How To Change Negative Core Beliefs: A Straightforward Guide to Cognitive Behavioral Therapy (CBT) appeared first on Dr Alice Boyes.

Schools must make the critical decision whether to reinforce the learning that students have already done this year or introduce new content.

Social distancing is forcing school business to be conducted virtually, putting school boards in the difficult spot of making crucial decisions on spending and other issues without the same level of public input.

A state-by-state breakdown shows that Colorado, Rhode Island and Illinois found some evidence that students' familiarity with technology impacted scores on 2014-15 PARCC exams. An analysis in Maryland is pending.

North Dakota lawmakers fended off an effort to ensure that the state's new standards, and any tests that might be used with them, won't mirror the common core.

"We have a responsibility to save lives," Ohio Gov. Mike DeWine said on Twitter. "We could have waited to close schools, but based on advice from health experts, this is the time to do it."

"In communities most devastated by COVID-19, academic achievement is pretty far down on the priority list—this is the reality," says Wyoming state chief Jillian Balow.

Schools may have to continue closures in the fall if the coronavirus resurges, state schools chiefs in Maryland and Washington said. The warnings came the same week thata key federal official predicted schools would be able to reopen for the 2020-21 school year.

School districts are competing against each other for purchases of digital devices as remote learning expands to schools across the country.

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.

The momentum to raise teacher salaries in several states has ground to a halt amid fears of coronavirus’ massive economic blow.

Districts that can screen, interview, and select candidates virtually will have less disruption to their hiring, despite how coronavirus is upending every aspect of school operations.

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.

Spending millions to guard against COVID-19 spread, district leaders also must convince parents school buildings are safe.

The New York state legislature passed a bill that would make the use of state test scores in these evaluations optional, leaving the decision up to districts and making it subject to collective bargaining.

Dez-Ann Romain, a Brooklyn principal, is believed to be the first full-time, front-line educator to die from COVID-19.

The days are a technology overload, mixed with the joy of seeing her students' faces and worry about her own family's health and safety, New York City teacher Ariel Sacks writes.

More than half of all states have ordered schools closed for multiple weeks to help slow the pandemic.

Board members didn't act on a resolution to revoke Alabama's version of the Common Core State Standards.

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.

Recent Census data finds households in the South and Midwest lagging those in other regions in access to remote learning technologies and learning interactions with teachers and family members.

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.

Dougherty County, a largely black school district in an region heavily affected by coronavirus, is no longer subject to desegregation orders first imposed in 1963.

The state's supreme court ruled that it is not its role to tell the legislature how to spend its money, ending a 24-year school-funding battle.

Republican gubernatorial nominee Ron DeSantis is renewing a political trend that had fallen dormant: calling for the end of the use of the shared standards.

Officials say a high school baseball coach and his wife were electrocuted while installing a new scoreboard at a Florida baseball field to replace one that had been destroyed by Hurricane Michael.

Florida's governor declares a standards overhaul would "remove all vestiges" of the common core. But it remains unclear how much is really changing under the Florida Benchmarks for Excellent Student Thinking.

The state's board voted not to open the Common Core to revision, but its commissioner still plans to review them informally, with an eye to future changes.