A collision avoidance system (CAS) is described that includes one or more sensor technologies, including, for example, an Ultra Wideband (UWB) sensing technology. The collision avoidance system is designed to reliably track the location and speed of vehicles and the distance between vehicles over a wide variety of track and terrain. The collision avoidance system may utilize information from a variety of sensor technologies to determine whether one or more vehicles violate speed and/or separation criteria, and may generate a warning.

A mobile device can obtain wireless network signal strength map data that indicates, for various nearby geographical regions, the wireless network signal strength in each such region. A mobile device can transmit that data to a vehicular navigation system responsible for automatically selecting a high-quality route of vehicular travel between a specified source and destination. The system can take the wireless network signal map data into account when selecting that route. When selecting from among multiple different routes of vehicular travel between a specified source and destination, the system may employ an algorithm that considers wireless network signal strengths along those routes, in addition to the other factors. Consequently, the system can select a longer route having better signal strength over a shorter route having worse signal strength. The system can present the selected route within a set of suggested routes, potentially along with reasons for each route's suggestion.

A method and apparatus for performing a quick search of a path display terminal are provided. The quick search device of a path display terminal comprises: a vehicle position display unit for displaying a position of a vehicle on a map generated based on map data; a quick search display unit for displaying a quick search area for inputting a search word in a portion of the map; a search unit for searching for a destination corresponding to the search word; and a path display unit for generating and displaying a path from the vehicle position to the destination.

An enhanced encryption keypad (100) capable of preventing illegal disassembly for an automated teller machine comprises a key panel (101) and a main control board (102). A removal detection protection circuit is disposed inside a main chip of the main control board (102), and at least one pin of the removal detection protection circuit is guided out from a surface (1021) of a side of the main control board (102) near the key panel to form a removal detection point (1022). The removal detection point (1022) has two opened signal contact points. The two opened signal contact points are conducted by a conductive adhesive (103) to activate the removal detection protection circuit. A conductive protection ring (1023) isolated from the removal detection point is disposed at the periphery of the removal detection point. The conductive protection ring (1023) is connected to the removal detection protection circuit inside the main control chip. A protection circle (1024) is disposed at the periphery of the conductive protection ring and the corresponding conductive adhesive. The present application effectively protects the encryption keypad from illegal attacks on the removal detection point from the side.

A configurable light timer adapted to receive data to control the operation of the configurable light timer is disclosed. The configurable light timer comprises a control circuit; an input portion coupled to receive a portable memory device by way of a connector on the configurable light timer, wherein the portable memory device stores data to be used by the configurable light timer and is adapted to be removed after the data is downloaded; and a memory coupled to receive the data stored on the portable memory device; wherein control circuit accesses the data from the memory after the data is downloaded and the portable memory device is removed. A method of receiving data to control the operation of the configurable light timer is also disclosed.

A device and method for detecting wheel loss from a vehicle when the vehicle is in motion. The device (1) is provided with a housing (11) configured for, in use, mounting the device to a wheel (3) such that the device (1) abuts a wheel hub (5) of an axle to which the wheel is attached. A detector (6) is provided for detecting a proximity of the device (1) to the wheel hub (5), and a transmitter (8) is provided for sending an alarm signal in the event that the detector (6) detects that the device (1) is no longer in proximity to the wheel hub (5). In this way, if the wheel starts to become detached from the wheel hub, the detector (1) detects this and can send an alarm to, for example, a receiver unit in the drivers cabin, allowing the driver to take appropriate steps.

A fatigue degree input unit inputs a fatigue degree of a user through use of a processing device, and writes an input value of the fatigue degree into a storage device. A recommended duration calculation unit reads the input value of the fatigue degree written by the fatigue degree input unit from the storage device. In accordance with the input value of the fatigue degree read from the storage device, the recommended duration calculation unit calculates a bath duration to be recommended to the user, as a recommended duration, through use of the processing device. A recommended duration informing unit informs the user of the recommended duration calculated by the recommended duration calculation unit, through an output device.

A physiological trend monitor has a sensor signal responsive to multiple wavelengths of light transmitted into a tissue site. The transmitted light is detected after attenuation by pulsatile blood flow within the tissue site. A processor has an input responsive to the sensor signal and a physiological parameter output. Features are extracted from the physiological parameter output. Criteria are applied to the features. An alarm output is generated when the criteria are satisfied.

Defining a radio frequency identification read area includes a radio frequency identification (RFID) reader operable to read RFID tags within a specified read area. An RFID transmitter is coupled with the RFID reader and is operable to radiating a modulated carrier in an area adjacent to the specified read area. The RFID reader controls the RFID transmitter to transmit the modulated carrier during a preamble transmission of the RFID reader to prevent any RFID tags in the adjacent area from recognizing an interrogation signal from the RFID reader.

A communication process between two constitutive elements of the network of electricity distribution in a domestic or industrial premise including circuit breakers, electrical modules, switches, electrical plugs and light connection devices. The process including the following steps: assignment by a protocol such as DHCP, BootP or RARP of a first IP address to a first element of the power distribution network, assignment of a second IP address to a second element, and establishment of a communication between the first and second elements of the power distribution network.

A method and system for tracking a body's bio-readings and environmental information in which such bio-readings are generated is disclosed. Conventional bio-reading sensor technology may be used in combination with technology for receiving information from electronic tags associated with items in a body's environment. Such technology may include RFID smart tags associated with items in an environment. Such smart tags store information describing the item associated with the smart tag. An RFID smart tag reader may be provided for retrieving item description information stored in such smart tags. The combination of bio-reading data and environmental data provide a power tool in evaluating behavioral and environmental variables that affect a body's bio-readings.

The invention relates to a universal wireless trainable transceiver unit with integrated bidirectional wireless interface functionality, and a method for same. Using a scan, push button or untrained channel mode, a user may enter into a wireless bidirectional interface mode of a trainable transceiver. The interface mode allows a user to select a sub-set of modes that include diagnostics, flash and vehicle interface. Each mode provides the trainable transceiver to communicate wirelessly in a bidirectional manner with another remote device.

A system and method is provided for monitoring hygiene compliance.

The present disclosure relates to apparatuses and methods to detect a fluid contamination level of a fluid sample. The method may comprise providing a fluid sample downhole from a subterranean formation, applying a reactant to the fluid sample to create a combined fluid, observing the combined fluid, and determining if contaminants are present within the fluid sample based upon the observing the combined fluid.

The subject matter of the present disclosure is directed to developing a method of measuring the amount of producible oil and the producible oil saturation in shale-oil reservoirs using sample source rock. Further, the physical and chemical properties and amounts of producible oil in shale-oil reservoir samples may be determined. First and second solvents are applied to a sample source rock to extract petroleum from the sample source rock. The extracted source rock, the twice-extracted source rock, and the first and second extracted petroleum may be analyzed to determine the characteristics and properties of the reservoir rock.

A system for measuring a property of a sample is provided. The system comprises a diagnostic measuring device having a memory and a diagnostic test strip for collecting the sample. The strip has embedded thereon a pattern representative of at least first data and second data, the first data being data representing at least one of parameters related to measuring the property, codes usable for calibration of the diagnostic measuring device, or parameters indicating proper connection between the measuring device and the test strip and the second data usable for detecting and rejecting potential errors affecting the proper measurement of the property.

Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

A method of operating the automated sample workcell for processing one or more biological samples is presented. The method comprises receiving one or more biological samples. Each biological sample is contained in a sample tube. Each sample tube is a tube type. If a test order was received for at least one of the biological samples, the test order being indicative of one or more first processing steps, the workcell can automatically execute the one or more first processing steps. If the test order was not received, one or more second processing steps can be determined based on the tube type of the sample tube that contains the at least one biological sample and the one or more second processing steps can then be executed.

The subject of the invention is a method for determining the H2S content arising during the warm storage of sulfur-containing crude and residual oils and mineral distillates containing sulfur-containing crude and/or residual oils, in which a sample of the sulfur-containing mineral oil is dissolved in a solvent or solvent mixture that boils at more than 200° C. and a carrier gas is caused to flow through the solution of the sulfur-containing mineral oil at temperatures above 80° C., and the quantity of hydrogen sulfide carried out with the carrier gas is analyzed quantitatively.

A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.

Disclosed are methods and systems for the analysis of testosterone in a sample using supported liquid extraction and liquid chromatography-mass spectrometry.

A system and method for creating a plurality of denaturation curves is disclosed. In accordance with certain embodiments, one variable, such as salt content, pH or another parameter, is varied to create a plurality of different buffer solutions. Each is then used to create a denaturation graph. The plurality of denaturation graphs allows analysis of the effect of that variable on protein stability.

An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with evaporative light scattering detection (ELSD); the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.

A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an aqueous solvent; measuring a low frequency electromagnetic emission over time from the diluted extracted purified nucleic acids in an aqueous solvent; performing a signal analysis of the low frequency electromagnetic emission over time; and producing an output, based on the signal analysis, in dependence on the DNA in the sample. The DNA may be extracted from at least one of blood, feces, urine, saliva, tears, seminal fluid, sweat, seminal and vaginal fluids of a patient, or water to determine, e.g., potability. The samples may be frozen. The extracting and purifying may comprise diluting the sample with an aqueous buffer and mixing; degrading proteins in the diluted sample; precipitating DNA from the buffer solution; and resuspending the precipitated DNA in an aqueous solution.

The present invention relates to a method of identifying a natural substance that is capable of complexation with Ni2+, Cu2+ and/or Fe2+ ions, wherein an extract containing natural substances is led over a stationary phase loaded with Ni2+, Cu2+ and/or Fe2+ ions, which is suitable for immobilized metal affinity chromatography (IMAC).

This invention relates to the field of preparation technology of optical pH sensor by co-intercalated fluorescein and 1-heptanesulfonic acid sodium into layered double hydroxide. The sensor is composed by conductive materials and the surface LDH films by co-interacted FLU and HES. The synthesis method is: first: synthesis of LDH colloid suspension, subsequently, the FLU and HES co-intercalated LDH colloid solution was prepared following the ion-exchange method, then the thin film of FLU-HES/LDH was spreaded on the surface of the conductive material by electrophoretic deposition, and the oriental pH sensor was synthesized. The advantages of the present invention is: first, the LDH matrix provides chromophore molecules with a confined and stable environment; the novel electrophoretic deposition strategy in this work provides a method for precise control of thickness (ranging from nanometers to micrometers), and the oriental pH sensor show good pH responsive.

A biosensor and method of making are disclosed. The biosensor is configured to detect a target and may include a peptide immobilized on a sensing component, the sensing component having an anode and a cathode. The immobilized peptide may comprise an antimicrobial peptide binding motif for the target. The sensing component has an electrical conductivity that changes in response to binding of the immobilized peptide to the target. The immobilized peptide may bind one or more targets selected from the list consisting of: bacteria, Gram-negative bacteria, Gram-positive bacteria, pathogens, protozoa, fungi, viruses, and cancerous cells. The biosensor may have a display with a readout that is responsive to changes in electrical conductivity of the sensing component. The display unit may be wirelessly coupled to the sensing component. A resonant circuit with an inductive coil may be electrically coupled to the sensing component. A planar coil antenna may be disposed in proximity to the resonant circuit, the planar coil antenna being configured to provide power to the sensing component.

Microfluidic devices having a protein renaturation component and methods for using the same are provided. Aspects of the present disclosure include microfluidic devices that include a separation medium with a first flow path and a protein renaturation component in fluid communication with the separation medium and having a second flow path. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.

Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.

The present disclosure relates to a molecularly imprinted structure for detection of a pentraxin protein and a method for preparing the same by synthesizing a reactive group-pentraxin protein ligand complex specifically reacting with the pentraxin protein and being polymerizable with a crosslink agent to detect a pentraxin protein by using the complex. The present disclosure also provides a chip for detection of a C-reactive protein and a method for preparing the same, the chip including a molecularly imprinted layer having excellent sensitivity to a C-reactive protein and an improved binding force to a metal substrate by using click chemistry.

A molecularly imprinted polymer (MIP) sensor including a substrate, two or more electrodes, a conductive layer applied to the substrate and a molecularly imprinted polymer layer applied to the conductive layer is disclosed herein The MIP sensor may form part of an MIP sensor system that can be used to detect and quantify target molecules.

The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.

A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.

The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.

A pancreatic disease is tested for with high sensitivity even with simple equipment and a simple procedure. Provided is a method of detecting pancreatic disease including detecting a concentration of S100P in at least one of a pancreatic juice and a body fluid containing pancreatic juice collected from a test subject by immunochromatography. Additionally provided is a pancreas testing kit including an immunochromatography device that holds an anti-S100P antibody and a collection vessel that retains a protease inhibitor that inhibits an activity of a protease contained in the pancreatic juice.

This invention relates to methods and apparatus for determination of ion concentrations, particularly in downhole water from hydrocarbon wells, aquifers etc. It is useful in a wide range of applications, including predicting the formation of scale and fingerprinting waters from different sources. More particularly, the invention relates to the use of ligands whose electronic configuration is altered by the binding of the scaling ions within a water sample. These alterations are detected electrochemically by applying varying potential to electrodes and measuring current flow as potential is varied, from which is derived the concentration of scaling ions in the fluid.

The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

A method for analyzing the liquefied petroleum gas includes the following steps. Provide a sample of the liquefied petroleum gas, and one main component group of the liquefied petroleum gas includes at least one sub component group. Analyze the sample of the liquefied petroleum gas so as to obtain a first measured THC corresponding to the main component group and a second measured THC corresponding to the sub component group. Obtain a regressed THC according to the second measured THC and a predetermined relationship of THC. Obtain a result of THC according to the first measured THC, the regressed THC, and a predetermined range of THC. The predetermined range of THC corresponds to the main component group. The device for analyzing the liquefied petroleum gas includes an inlet, a multiposition valve, a first column, a second column, an analyzing apparatus, and a computing unit.

Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications.

The present invention provides methods, devices, compositions (e.g., capture complexes), and kits useful for enhancing the detection of antibodies in a test sample. The methods, devices, and compositions utilize detectable Fc-binding molecules such as Protein A, Protein G, and/or an Fc-specific antibody to amplify the signal of a detected antibody in immunoassays, such as lateral flow assays.

A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location; allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location; and, after a predetermined period of time, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and which is dried on the lateral flow matrix at a location upstream of the sample port delivery of the sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species and bind with any IgE antibody bound to the immobilized IgE antigen species, and to travel to a second location downstream of the first location where the mobilized labeled reagent causes a visible change to occur at the second location.

Methods and systems for selectively capturing analytes, such as cells, e.g., circulating tumor cells (CTCs), from fluid samples are disclosed. The methods include contacting the sample with an analyte binding moiety that selectively binds to the analytes; optionally separating first components of the sample including a majority of the analytes bound to the binding moieties from second components of the sample using size-based separation, e.g., in a microfluidic channel; adding to the first components of the sample a plurality of binding agents under conditions that enable a plurality of the binding agents to be linked to the analyte binding moieties to form multivalent tagging agents bound to the analyte; passing the first components of the sample past a surface to which is attached a plurality of capture agents that selectively bind to the binding agents; and capturing the analytes by providing conditions that enable the multivalent tagging agents bound to the analytes to bind to one or more of the capture agents.

A chemiresistive biosensor for detecting an analyte can include a high specific surface area substrate conformally coated with a conductive polymer, and a binding reagent immobilized on the conductive polymer, wherein the binding reagent has a specific affinity for the analyte. The conductive polymer can be deposited on a substrate by oCVD.

A first set of antibodies are bonded to a substrate, and are exposed to and bonded with target antigens. A second set of antibodies are bonded to nanoparticles, and the nanoparticle labeled antibodies are exposed to the targeted antigens. An electromagnetic write-head magnetizes the nanoparticles, and then a read-sensor detects the freshly magnetized nanoparticles. The substrate comprises a flexible film or a Peltier material to allow selective heating and cooling of the antigens and antibodies. Nanoparticles of different magnetic properties may be selectively paired with antibodies associated with different antigens to allow different antigens to be detected upon a single scan by the read-sensor.

There is disclosed a method for producing a molecule immobilizing substrate, comprising at least the steps of: forming, on a substrate, a monomolecular film including hydroxyl groups, cyano groups, or oxiranyl groups, which are oriented toward an outmost surface of the monomolecular film; andchemically modifying the hydroxyl groups, cyano groups, or oxiranyl groups of the monomolecular film to transform them into carboxyl groups, to thereby form, on the substrate, the monomolecular film including the carboxyl groups, which are oriented toward an outmost surface of the monomolecular film. There can be provided: a method for producing a molecule immobilizing substrate which is free of occurrence of an immobilized-molecule peeling problem in the case of conducting an assay by immobilizing molecules on the substrate.

A method for disabling and re-enabling third-party advertisements is disclosed. An Internet accessible “virtual world” or interactive on-line community can have its advertisements disabled by the entering and subsequent validation of a registration code that is associated with a toy into a website, once validated, displaying a virtual representation of the toy on the website, providing virtual world content so that the virtual representation of the toy is caused to interact with the virtual world content and the toy virtual representations of other users, displaying advertisement on the website in a first mode and allowing customization of the virtual world content including the disabling of advertisements in a second mode. In a similar manner the third party advertisements can be re-enabled.

This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.

A testing cartridge for metering of a sample to be tested. The testing cartridge includes a casing defining a casing opening and a sliding member defining a sliding member opening. The casing opening or the sliding member opening can define a specified volume, wherein the casing opening and the sliding member opening collectively define a sample application region dimensioned to accommodate receiving an amount of sample exceeding the specified volume. The sliding member is movable transversely to the casing opening by having the sliding member and the casing traverse across each other's respective openings to remove excess sample from the received amount of sample and retain the specified volume from the received amount of sample.

Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

This invention provides a biomolecule modifying substrate comprising biomolecules selectively fixed to given regions thereon. The biomolecule modifying substrate comprises: a substrate at least comprising a first surface and a second surface; a first linker molecule comprising a hydrocarbon chain and a functional group capable of selectively binding to the first surface at one end of the hydrocarbon chain, which is bound to the first surface via such functional group; a second linker molecule comprising a reactive group capable of binding to the hydrocarbon chain of the first linker molecule, which is bound to the first linker molecule via a bond between the reactive group and the hydrocarbon chain; and a biomolecule bound thereto via the second linker molecule.