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Direct access to pyrrole anhydrides via oxidative self-coupling of pyrrole carboxaldehydes

Org. Biomol. Chem., 2024, 22,3045-3052
DOI: 10.1039/D4OB00052H, Paper
Surabhi Panday, Tapas Maity, Pratibha Bhatti, Joydev K. Laha
An elegant synthesis of pyrrole-2-carboxylic acid anhydrides from pyrrole-2-carboxaldehydes using TBAI as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant is described herein.
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BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00274A, Communication
Gaurav Jaiswal, Subhas Chandra Pan
BBr3 mediated dearomative spirocyclization of biaryl ynones has been reported for the direct synthesis of spiro[5.5]dienones with a tri-substituted double bond.
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Exploring the mechanism of the reductive amination of acetophenones via Borch approach: the role of the acid catalyst

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00160E, Paper
João Pedro Albuquerque Souza, Amanda Krauskopf Jacobs, Leandro Piovan, Renan Borsoi Campos
The energetic viability of several mechanistic variations of the reductive amination of acetophenones via the Borch approach was reexamined through density functional theory calculations. The crucial involvement of the acid...
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Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00240G, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. Falconer
Herein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess–Martin periodinane oxidising agent.
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Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00432A, Paper
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...
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Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00015C, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
An effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.
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An FeCl3-catalyzed three-component reaction for the synthesis of β-(1,2,3-triazolyl)-ketones using DMF as a one-carbon source

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00207E, Communication
Ruilin Fang, Lei Zheng, Xuyang Chen, Can Wang, Yunfeng Chen
FeCl3-catalyzed oxidative condensation of NH-1,2,3-triazoles and aryl methyl ketones and DMF has been reported.
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Facile synthesis of tetrahydroquinoline containing dithiocarbamate derivatives via one-pot sequential multicomponent reaction

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00490F, Communication
SIDDHARTHA KUMAR SENAPATI, Anit Pal, Animesh Das
An efficient sequential multi-component method for the synthesis of tertrahydroquinoline containing dithiocarbamate has been developed. This reaction involved a boronic acid-catalyzed reduction of quinoline to tertrahydroquinoline, followed by nucleophilic addition...
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A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00610K, Communication
Chandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali Nair
We hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...
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Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
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Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00363B, Paper
Si-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong Xie
A three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.
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K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00488D, Paper
Meng-Yang Chang, Chin-Huey Ho, Hsing-Yin Chen
The K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....
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How long do commercial aircraft last?

What airlines can do to extend the longevity of their fleet




ia

As the price of aviation turbine fuel soars, airlines’ finances spin out of control




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Indian aviation: A study in paradox

Accurate reading of the market is critical




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Air India sale: Who will bag the Maharaja's crown?

Financial bid winner for sale of the State-owned airlines to be declared in three weeks; sources say it may take longer




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India ahead in tech to make airports safer

Airports are also keeping pace to ensure safe, touchless and seamless journeys




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As India builds its newest airports, it needs robust, fail-proof SOPs

A near air mishap on Bengaluru skies that put the lives of 430 people in danger shows safety risk norms require constant refresh




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From geopolitics strife to a war of words between two aviation giants

Qatar Airways and Airbus lock horns over safety concerns




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Aviation industry shifts focus to digital

The pandemic has helped usher in automated touchpoints for tech-savvy flight passengers




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Sustainable aviation fuels could be a game-changer

But adopting it in Indian aviation could take time




ia

Evolution of security in aviation

Data and technology need to be adopted




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Slots scarcity hits Indian airlines’ flight roadmap

The solution demands a comprehensive expansion of airside capacity across the country, but that has not materialised




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Blockchain: Piloting the future of aviation

Enables effective solutions that positively impact industry players and end consumers




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5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




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Mission to Net Zero: Aviation’s focus on making sustainable connections 

Flying the cleanest, greenest, youngest fleet possible can be a way towards the goal 




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How do commercial aircraft navigate?




ia

Air India’s roadmap can be tricky to pull off

The airline has to work hard to drastically grow its network and fleet while improving reliability as well




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Compliance with regulation: Staying ahead is key




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Why has private capital not been taken to Indian aviation 

With banks becoming increasingly cautious and credit flows tightening, private capital must be explored and enticed




ia

Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




ia

Hong Kong unveils responsible AI framework for financial sector

Hong Kong’s responsible AI framework comes amid increasing international competition and tensions affecting access to AI technology




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Meta builds AI search engine to cut Google, Bing reliance, the Information reports

The Facebook-owner currently relies on Google and Bing search engines to give users answers on news, stocks and sports




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Indonesia bans sales of Google phones days after blocking Apple's iPhone 16

Indonesia said it has banned sales of smartphones made by Alphabet's Google due to rules requiring the use of locally manufactured components




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Perplexity AI CEO says “still haven’t gotten” a green card amid immigration debate ahead of U.S. Presidential Election 2024

Srinivas went on to work with OpenAI for a year before co-founding Perplexity AI in 2022




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WHO certifies Egypt as malaria-free; calls it ‘historic feat’ ending ancient scourge

Globally, 44 countries and one territory have now been certified as malaria-free




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Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained

India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy




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Over 77 per cent of India’s children lack WHO-suggested diversity in diet, study finds

The states of Uttar Pradesh, Rajasthan, Gujarat, Maharashtra and Madhya Pradesh reported the highest levels of inadequate diversity in children's diets -- all above 80 per cent -- while Sikkim and Meghalaya were the only two to report an under-50 per cent prevalence




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Trachoma eliminated as a public health problem in India; what next?

The achievement marks a significant public health victory and has profound economic implications. Trachoma’s impact, through blindness and visual impairment, results in an estimated economic loss of $2.9 to 5.3 billion annually due to reduced productivity




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For type 2 diabetes, focusing on when you eat – not what – can help control blood sugar

Time-restricted eating, also known as the 16:8 diet, became popular for weight loss around 2015. Studies have since shown it is also an effective way for people with type 2 diabetes to manage blood glucose




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Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies

Global efforts to understand and manage long Covid post-pandemic, with varied symptoms and limited treatment guidelines worldwide




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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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Bridging the gap in mental healthcare services: NGOs launch dementia clinics in Hyderabad’s slums

India continues to grapple with a dearth of mental healthcare services, even as the number of persons with dementia is expected to rise over the next two decades




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AIIMS-Bibinagar to boost tuberculosis care in Telangana with aerial aid

Inaugurated virtually by Prime Minister Narendra Modi, the drone service is part of a series of health projects designed to enhance access to essential services in remote and underserved areas




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Malaria elimination: Egypt’s success and a roadmap for India’s WHO certification

India has made remarkable strides in reducing malaria, with reported cases dropping over the years; however, there is a long journey ahead, with climate change raising the potential for malaria transmission in areas that have already achieved elimination




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ICMR invites expression of interest from firms for making anaemia detection device

The council wants to expand the effective screening network of anaemia among different age populations across India




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Telemedicine in India: is the government’s eSanjeevani platform living up to its potential?

While the eSanjeevani numbers are impressive, doctors and experts point out that unless a number of systemic issues -- including low doctor numbers on the platform are fixed -- telemedicine in the country will not be able to move past infancy




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Following WHO guidelines for sodium content in packaged food could prevent 3 lakh deaths in India in 10 years: study

Additionally, about 1.7 million new cardiovascular disease cases and 7,00,000 new chronic kidney disease cases could be prevented compared to current practices, the study said




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What is breast density and how is it associated with cancer? Explained

Breast density matters because of two main reasons: it may make it harder to detect signs of cancer on a mammogram, and it is linked with an increased risk of breast cancer




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Understanding orphan drugs: what are they, how are they classified and what are their challenges in the Indian context

While orphan drugs are crucial to treating rare, sometimes debilitating conditions, the high cost of their research and development is a major barrier to their development in India