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Potential neurotoxicity of 5-hydroxymethylfurfural and its oligomers: widespread substances in carbohydrate-containing foods

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02526J, Paper
Cheng Wang, Zhenru Liu, Tian Hu, Youjia Li, Rui Liu, Junjie Zhang, Huaizhen He
5-Hydroxymethylfurfural (5-HMF) and its acid-catalyzed oligomers can inhibit nerve cell proliferation and induce neurological deficits at near or below the reported 24 h dietary intake of 5-HMF in humans.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Kaempferol modulates TCDD- and t-BHQ-induced drug-metabolizing enzymes and luteolin enhances this effect

Food Funct., 2020, 11,3668-3680
DOI: 10.1039/C9FO02951F, Paper
Tomoya Kitakaze, Atsushi Makiyama, Rika Nakai, Yuki Kimura, Hitoshi Ashida
Co-treatment with kaempferol and luteolin inhibits AhR- and Nrf2-induced expression of drug-metabolizing enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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tert-Butyl-p-benzoquinone induces autophagy by inhibiting the Akt/mTOR signaling pathway in RAW 264.7 cells

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00281J, Paper
Xianghe Meng, Chaosheng Xia, Qin Ye, Xiaohua Nie
Autophagy mediate by p53/Akt/mTOR signaling was linked to overproduction of ROS by tert-butyl-p-benzoquinone.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluation of Tenebrio molitor protein as a source of peptides for modulating physiological processes

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00734J, Paper
Fernando Rivero Pino, Raúl Pérez Gálvez, F. Javier Espejo Carpio, Emilia M. Guadix
Tenebrio molitor hydrolysates produced with commercial proteases showed improved ACE inhibitory and antioxidant properties. This source could be employed as functional ingredient in food preparations.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Dietary supplementation of L-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00019A, Paper
Hao Zhang, Yi Ma, Mengzhi Wang, Mabrouk Elsabagh, Juan J. Loor, Hongrong Wang
The work aimed at investigating the effects of N-carbamylglutamate (NCG) or L-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Influences of dietary starch structure on intestinal morphology, barrier functions, and epithelium apoptosis in weaned pigs

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02652E, Paper
Open Access
Xiaoqian Gao, Bing Yu, Jie Yu, Xiangbing Mao, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Ping Zheng, Jun He, Daiwen Chen
The objective of the present study was to evaluate the effects of dietary starch structure on intestinal health of weaned pigs by determining the intestinal morphology, barrier functions, epithelium apoptosis and digestive enzymes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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10 ways to plan your finances right during the coronavirus crisis

Here's how to protect your finances during these difficult times and work on your short- and long-term financial goals efficiently




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Quick approval, grace period: Medical insurance process eased amid Covid-19

Use instalments to increase cover; benefit from quick approvals




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Apple Introduces watchOS 2 with Native Apps and New Apple Watch Sport Models

Apple has introduced new Apple Watch cases and bands, available starting today, including new gold and rose gold aluminum Apple Watch Sport models. watchOS 2 — which arrives as a free update on September 16 — makes apps faster and more fluid by running natively on Apple Watch, and introduces new watch faces, the ability for third-party apps to display information on the watch face as complications, and an innovative way to see future events, past headlines, and more with Time Travel. Apple Watch collections are expanding with new case colors and fresh new bands. With new standalone Sport Bands that range from rich vibrant colors to more neutral tones, Apple Watch is now more customizable than ever.




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Apple Introduces iPhone 6s and iPhone 6s Plus

Apple has announced iPhone 6s and iPhone 6s Plus, adding a powerful new dimension to iPhone’s revolutionary Multi-Touch interface. The new iPhones introduce 3D Touch, which enables intuitive new ways to access features and interact with content. iPhone 6s and iPhone 6s Plus feature Retina HD displays made from the strongest glass on any smartphone and 7000 series aluminum, the same alloy used in the aerospace industry, in metallic finishes that now include rose gold. The new iPhones also introduce a transformative new approach to photography called Live Photos, bringing still images to life by capturing a moment in motion. “The only thing that has changed with iPhone 6s and iPhone 6s Plus is everything — 3D Touch lets users interact with iPhone in entirely new and fun ways, and the innovative Live Photos brings your pictures to life,” said Philip Schiller, Apple’s senior vice president of Worldwide Marketing. “These are the most advanced iPhones ever, with 7000 series aluminum, ion-strengthened glass, the new 64-bit A9 chip, 12-megapixel iSight and 5-megapixel FaceTime HD cameras, faster Touch ID, LTE, and Wi-Fi. Customers are going to love them.”




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Apple Announces Record iPhone 6s and iPhone 6s Plus Sales

Apple has announced it has sold more than 13 million new iPhone 6s and iPhone 6s Plus models, a new record, just three days after launch. iPhone 6s and iPhone 6s Plus will be available in more than 40 additional countries beginning October 9 including Italy, Mexico, Russia, Spain, and Taiwan. The new iPhones will be available in over 130 countries by the end of the year. “Sales for iPhone 6s and iPhone 6s Plus have been phenomenal, blowing past any previous first weekend sales results in Apple’s history,” said Tim Cook, Apple’s CEO. “Customers’ feedback is incredible and they are loving 3D Touch and Live Photos, and we can’t wait to bring iPhone 6s and iPhone 6s Plus to customers in even more countries on October 9.”




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Apple Announces Advancements to ResearchKit

Apple today announced advancements to the open source ResearchKit framework that bring genetic data and a series of medical tests typically conducted in an exam room to iPhone apps. Medical researchers are adopting these new features to design targeted studies for diseases and conditions that affect billions of people and to gather more specific types of data from participants. “The response to ResearchKit has been fantastic. Virtually overnight, many ResearchKit studies became the largest in history and researchers are gaining insights and making discoveries that weren’t possible before,” said Jeff Williams, Apple’s chief operating officer.




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Apple Advances Health Apps with CareKit

Apple today announced CareKit, a new software framework designed to help developers enable people to actively manage their own medical conditions. iPhone apps using CareKit make it easier for individuals to keep track of care plans and monitor symptoms and medication, providing insights that help people better understand their own health. “We believe that giving individuals the tools to understand what is happening with their health is incredibly powerful, and apps designed using CareKit make this a reality by empowering people to take a more active role in their care,” said Jeff Williams, Apple’s chief operating officer.




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Apple Introduces iPhone SE — the Most Powerful Phone with a 4-inch Display

Apple today introduced iPhone SE, the most powerful phone with a 4-inch display, in a compact aluminum design that has been updated with matte-chamfered edges, a color-matched stainless steel Apple logo, and four metallic finishes. iPhone SE offers the same 64-bit A9 chip offered in iPhone 6s and iPhone 6s. “iPhone SE is packed with a stunning 4-inch Retina display, advanced 64-bit A9 chip with M9 motion co-processor, longer battery life, 12-megapixel iSight camera with True Tone flash, Live Photos, 4K video, faster LTE and Wi-Fi, and Touch ID with Apple Pay. Everyone who wants a smaller phone is going to love iPhone SE,” said Philip Schiller, Apple’s senior vice president of Worldwide Marketing.




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Apple Introduces 9.7-inch iPad Pro

Apple today introduced the 9.7-inch iPad Pro, which at just under one pound features a new pro Retina display with greater brightness, wider color gamut, lower reflectivity, Night Shift mode, and new True Tone display technology. The new iPad Pro also has a 64-bit A9X chip that rivals most portable PCs. “iPad Pro is a new generation of iPad that is indispensable and immersive, enabling people to be more productive and more creative. It’s incredibly fast, extremely portable, and completely natural to use with your fingers, Apple Pencil, and Smart Keyboard. And now it comes in two sizes,” said Philip Schiller, Apple’s senior vice president of Worldwide Marketing.




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Joint audit offers multiple advices for the same fee: Raghu Aiyar

Interview with CEO & senior partner, KS Aiyar & Co




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Google announces company holiday on May 22 to deal with ‘virus burnout’

Google announces company holiday on May 22 to deal with ‘virus burnout’




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Top Hizb terrorist Riyaz Naikoo killed by security forces in J&K; private phones and mobile internet suspended in Valley

Top Hizb terrorist Riyaz Naikoo killed by security forces in J&K; private phones and mobile internet suspended in Valley




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Vizag gas leak: Death toll mounts to 11; AP govt announces Rs 1 crore each to kin of those killed

Vizag gas leak: Death toll mounts to 11; AP govt announces Rs 1 crore each to kin of those killed




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Nobel laureate Bob Dylan announces first album of new music since 2012

Nobel laureate Bob Dylan announces first album of new music since 2012




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Taylor Swift announces 'City of Lover' concert

Taylor Swift announces 'City of Lover' concert




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F1 chairman evokes 'remote' possibility of no races in 2020

F1 chairman evokes 'remote' possibility of no races in 2020




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NASCAR's empty-oval return means lost races at three tracks

NASCAR's empty-oval return means lost races at three tracks




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Coronavirus forces Russia to hold slimmed down Victory Day in blow to Putin - Times of India

Coronavirus forces Russia to hold slimmed down Victory Day in blow to Putin - Times of India




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Gujarat: These super-specialists joined forces to save Covid-19 patients

Gujarat: These super-specialists joined forces to save Covid-19 patients




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Karnataka: Three days on, train services resume

Karnataka: Three days on, train services resume




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Mangaluru: Unique protest by greens against littering of public places | Mangaluru News - Times of India

Mangaluru: Unique protest by greens against littering of public places | Mangaluru News - Times of India




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[ASAP] Naphthacemycins from a <italic toggle="yes">Streptomyces</italic> sp. as Protein-Tyrosine Phosphatase Inhibitors

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00417




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[ASAP] Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus <italic toggle="yes">Talaromyces</italic> sp.

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00024




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[ASAP] Antitubercular Ilamycins from Marine-Derived <italic toggle="yes">Streptomyces atratus</italic> SCSIO ZH16 ?<italic toggle="yes">ilaR</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00151




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[ASAP] <italic toggle="yes">Streptomyces albogriseolus</italic> SY67903 Produces Eunicellin Diterpenoids Structurally Similar to Terpenes of the Gorgonian <italic toggle="yes">Muricella sibogae</italic>, the Bac

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00147




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[ASAP] Advances in the Biosynthesis of Pyranocoumarins: Isolation and <sup>13</sup>C-Incorporation Analysis by High-Performance Liquid Chromatography–Ultraviolet–Solid-Phase Extraction–Nuclear Magnetic Resonance Data

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00607




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ITC is first to hike cigarette prices post budget; makes them 10-20% dearer

Price increase brought on by spike in National Calamity Contingency Duty announced in Budget




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Utilization of Anesthesia Services During Outpatient Endoscopies and Colonoscopies and Associated Spending in 2003-2009

Interview with Soeren Mattke, MD, DSc, author of Utilization of Anesthesia Services During Outpatient Endoscopies and Colonoscopies and Associated Spending in 2003-2009




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Out-of-Pocket Medication Costs and Use of Medications and Health Care Services Among Children With Asthma

Interview with Dana P. Goldman, PhD, author of Out-of-Pocket Medication Costs and Use of Medications and Health Care Services Among Children With Asthma




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Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma

Interview with Samuel M. Galvagno Jr, DO, PhD, author of Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma




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Association of Online Patient Access to Clinicians and Medical Records With Use of Clinical Services

Interview with Ted E. Palen, MD, PhD, MSPH, author of Association of Online Patient Access to Clinicians and Medical Records With Use of Clinical Services




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Association Between World Trade Center Exposure and Excess Cancer Risk

Interview with Steven D. Stellman, PhD, MPH, author of Association Between World Trade Center Exposure and Excess Cancer Risk




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Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among People With and Without Diabetes

Interview with James B. Meigs, MD, MPH, author of Association of Smoking Cessation and Weight Change With Cardiovascular Disease Among People With and Without Diabetes




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Relationship Between Occurrence of Surgical Complications and Hospital Finances, and Uwe E. Reinhardt, PhD, author of Making Surgical Complications Pay

Interview with Atul A. Gawande, MD, MPH, author of Relationship Between Occurrence of Surgical Complications and Hospital Finances, and Uwe E. Reinhardt, PhD, author of Making Surgical Complications Pay




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Relationship Between Occurrence of Surgical Complications and Hospital Finances, and Uwe E. Reinhardt, PhD, author of Making Surgical Complications Pay

Interview with Atul A. Gawande, MD, MPH, author of Relationship Between Occurrence of Surgical Complications and Hospital Finances, and Uwe E. Reinhardt, PhD, author of Making Surgical Complications Pay




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Elective Cesarean Delivery on Maternal Request

Interview with Jeffrey Ecker, MD, author of Elective Cesarean Delivery on Maternal Request




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Sustained Care Intervention and Postdischarge Smoking Cessation Among Hospitalized Adults

Interview with Nancy A. Rigotti, MD, author of Sustained Care Intervention and Postdischarge Smoking Cessation Among Hospitalized Adults




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Vascular Closure Devices vs Manual Compression

Interview with Stefanie Schulz-Schüpke, MD, author of Comparison of Vascular Closure Devices vs Manual Compression After Femoral Artery Puncture: The ISAR-CLOSURE Randomized Clinical Trial




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Varenicline for Smoking Cessation Through Smoking Reduction

Interview with Jon O. Ebbert, MD, MSc, author of Effect of Varenicline on Smoking Cessation Through Smoking Reduction




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Sex Differences in Academic Rank in US Medical Schools

Interview with Anupam Jena, MD, PhD, author of Sex Differences in Academic Rank in US Medical Schools in 2014





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Advances in Diagnosis and Treatment of Constipation

Constipation is one of the most frequent problems clinicians are asked to deal with. Despite how common it is, constipation is frequently not treated adequately. In this podcast, Arnold Wald, MD, explains a stepwise approach to the management of constipation ranging from very simple measures to the most novel and complicated new medical therapies.




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Treating Geriatric Polypharmacy by Deintensifying Unnecessary Diabetes Treatment

Polypharmacy is a rapidly worsening problem that hits elderly patients particularly hard.  As patients grow older, they need more medications but at the same time become less capable of managing the complexity of drug treatments.  In order to simplify treatment regimens for older patients, it is necessary to consider the evidence supporting treatment of various conditions and when the evidence is not particularly strong, reduce or eliminate medications accordingly.  Diabetes management in the elderly is highlighted in this podcast with specific attention given to deintensifying diabetes treatment in the elderly.

Articles discussed in this episode: