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Combination targeted treatment produces lasting remissions in people with resistant aggressive B-cell lymphoma

More than half of clinical trial participants treated with venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR) had substantial tumor shrinkage. Of those, 38% had tumors that disappeared completely.




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NIH clinical trial will test precision medicine treatments for myeloid cancers

NCI has launched myeloMATCH, a precision medicine treatment trial that will test treatment combinations targeting specific genetic changes in people with acute myeloid leukemia and myelodysplastic syndromes.




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Sandeshkhali residents celebrate arrest of TMC leader Shahjahan Sheikh

The residents, who for the last few days have been protesting in the riverine Sandeshkhali area, came out in the streets as they distributed sweets and danced in joy




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Rajya Sabha polls should be free and fearless, to be given ‘utmost protection’, says SC

The court said parliamentary privilege was not to be restricted to only law-making on the floor of the House but extended to other powers and responsibilities of elected members




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Tamil Nadu government lists various welfare programmes implemented by MAWS Department

The programmes included ‘AMRUT 2.0’ being implemented at a cost of ₹2,391.72 crore.




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Approach is to treat every game with utmost respect: Gukesh




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Chittoor district hails B.R. Naidu’s appointment as TTD chairman

B.R. Naidu hails from the remote village of Punepalli in Penumuru mandal, falling under Gangadhara Nellore Assembly constituency of Chittoor district




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Subtle adjustment of the cyclic potential on electro-activated glassy carbon electrodes for sensitive sensing of methyl parathion

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper
Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Detecting Specific Text Input with HTML and CSS

Recently I came across a CodePen demo by a developer/engineer named Jane that was Tweeted out by Šime Vidas. The demo has a neat collection of HTML and CSS tricks rolled into one that I thought was worth examining in detail.

The page displays a secret message based on specific text input. Ok, that’s no big deal, right? Well this is done using pure HTML and CSS – no JavaScript. I’ve seen stuff like this before, but I thought it would be cool to break down exactly how this works. There are a few notable things happening in the code so I’ll break down each of the parts.

The post Detecting Specific Text Input with HTML and CSS appeared first on Impressive Webs.




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective

RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article
Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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608: Can WordPress Kill Your Resume, Fav Parts of Web Dev, Exploring HTMX, and more!

We're opening up the ShopTalk mailbag and answering your questions, including does WordPress on your resume kill your job chances, what are our fav and least fav parts of web dev, our thoughts on HTMX, and what is it like to use pnpm instead of npm.




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639: DX, JSON, XML, HTML, and Databases! Oh My!

How important is the DX of software vs how important is the person showing off the software, Douglas Crockford and JSON, remembering XML, trying to write better HTML for email, new TC39 proposal, workshopping t-shirts, and what do you do if you want a little bit of database on your website?




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India seeks $70 million from Climate Investment Funds

India looks to accelerate proposed ‘renewable energy integration programme’




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Cannot change rules of the game once recruitment to public services commences: SC

The Constitution Bench says laws, rules and procedure governing recruitments to public services must be governed by the overarching principles of fundamental rights of equality and non-discrimination




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Delhi L-G approves recruitment of 701 nurses and 756 paramedical staff




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Investment limits for govt. bonds to be auctioned




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Domestic investment bankers outpace global brands in managing IPOs

The list of top 10 investment banks this year includes only one foreign entity.




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Local investment banks edge out global brands in managing IPOs

Domestic banks win on consistency, efficiency; HSBC is only foreign bank on top-10 list




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‘Investment norms for NIIF may be tweaked’




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Forest Department free coaching helps tribal youth in Jawadhu Hills to get government jobs




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Collector forwards complaint against teacher to Education Department




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T.N. lists achievements of Rural Development Department




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Self-consistent electrostatic formalism of bulk electrolytes based on the asymmetric treatment of the short- and long-range ion interactions

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01174K, Paper
Sahin Buyukdagli
Internal energy of monovalent electrolytes (left) and dimensionless screening parameter of multivalent electrolytes (right).
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Cholamandalam Investment posts 26% rise in Q2 net at ₹963 crore

Murugappa Group’s NBFC, Cholamandalam Investment & Finance Co Ltd, reported a strong double-digit growth across key metrics in the September quarter and the first half of this fiscal year. Net income for Q2 surged 37 per cent y-o-y to ₹3,238 crore, up from ₹2,367 crore.



  • Money & Banking

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SEBI proposes ₹1 crore minimum investment, mandatory demat form for securitised debt instruments

Securitised debt instruments (SDIs) issued privately to be offered to a maximum of 200 investors, public offers to remain open for a minimum of three days and a maximum of 10 days, proposes SEBI




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RBI designates 10-year Sovereign Green Bonds under FAR for investment by non-residents

Reserve Bank of India has decided to designate SGrBs of 10-year tenor to be issued by the government in the second half of the fiscal year 2024-25 as ‘specified securities’ under the FAR



  • Money & Banking

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Sand supply hits as 89 boatmen associations stay away from sand collection in Godavari river in A.P.

Only 30 boatmen associations out of the permitted 119 are active reportedly due to unviable payment fixed by the government under the sand policy




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IG orders departmental inquiry into ‘preferential treatment’ to Borugadda Anil Kumar

The events came to light after a video clip went viral on social media on Saturday, in which police can be seen offering him a table, bed sheet and allowing him to sleep outside the lock up, but within the station




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Grand Vijayawada by GRT Hotels rings in Christmas celebrations




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Boatmen’s associations reluctant to collect sand from Godavari’s banks over lack of remuneration

Permissions of 89 associations revoked by govt.; officials assure direct payments to workers’ bank accounts from Monday in order to prevent a shortage of sand




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Engineering workers in Vijayawada demand increase in honorarium, compassionate recruitment

In the event of death of a serving employee, ex gratia should be increased from ₹5 lakh to ₹7 lakh, vacant posts should be filled immediately, and the kin of family should be considered for employment in cases where a worker dies, the municipal workers say in their list of demands




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Postmodern analysis [electronic resource] / Jürgen Jost

Berlin : Springer, [2005]




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India’s retail equity investment cult rises to a new high amid record FPI outflows




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Flender India mulls multi-crore investment in Walajabad plant




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RBI announces rules to reclassify FPI investment as FDI once it crosses 10% holding in Indian firms

Investment made by foreign portfolio investor along with its investor group (hereinafter referred to as ‘FPI’) shall be less than 10% of the total paid-up equity capital on a fully diluted basis




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Ebbs and flows in 'atmospheric rivers' and their impact

So when they swing up, these waves suck warm air from the tropics to Europe, Russia, or the US, and when they swing down, they do the same thing with cold air from the Arctic.




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Pulkit TMT introduces innovative ‘Lab on Wheels’ for quality testing in Kerala 

The initiative aims to raise awareness about the significance of using high-quality TMT bars in construction projects and empower consumers, builders, and dealers to make informed decisions about their steel choices.




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Dholera SIR attracting ₹2,000-3,000 crore investment annually in land and plots

Formed in 2016, DICDL is owned 51 per cent by the Gujarat government and 49 per cent by the central government




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Institutional investments in real estate advance 45% in July-September: Colliers

Alternate assets, which include data centres, life sciences and schools, did not receive any funding in July-September.




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Sattva Group plans ₹14,000-crore investment to build 80 m sft of residential, commercial projects

Co-living space a focus area for Sattva Group, eyes co-living capacity of 15-16,000 beds by year-end




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Brigade to invest ₹800 crore to develop 1 million sq ft residential apartments in West Chennai

West Chennai is one of the fastest growing parts of the city




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ART of investment

London-based Anders Petterson, who was in city to launch the Chennai Art Club recently, shared his views on art investment in the global market




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LiTMP-LiBr complex-induced lateral lithiation and cross ester condensation: direct access to isocoumarins from 2-methoxy o-toluate esters

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01678E, Research Article
Open Access
Mintu Rehman, Sajib Daimary, Rasajna Madhusudhana, Rajendar Goreti
LiTMP-LiBr complex promotes cross-ester coupling of 2-methoxy o-toluate esters to directly yield isocoumarin is demonstrated. Method applied to many natural product precursors including synthesis of (+)- and (−)-lunatinins.
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Cash-strapped Archaeology Department takes MGNREGA route for upkeep of monuments in Karnataka

The proposed initiative will cover the protected and unprotected sites in Karnataka, most of which lack even a fence, so as to prevent encroachment




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Synthesis of Cu/Mn/Ce polymetallic oxide catalysts and catalytic ozone treatment of wastewater

RSC Adv., 2024, 14,35993-36004
DOI: 10.1039/D4RA06052K, Paper
Open Access
Jinlong Zhong, Xue feng Mao, Guanyu Wang, Heng Li, Junfang Li, Sijian Qu, Jianwei Zhao
Non-homogeneous ozone-catalyzed oxidation technology is one of the effective ways of treating wastewater, the core of which lies in the development of efficient ozone oxidation catalysts.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rajasthan High Court grants parole to Asaram Bapu for Ayurvedic treatment

The treatment is for heart-related ailments




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Has semaglutide transformed treatment of diabetes and obesity in India?

While the injectable forms of semaglutide have taken the world by storm, the oral form, available in India, is helping doctors see results in diabetes control, with the added benefit of weight loss, even though the cost remains a deterrent