The novel coronavirus has destroyed lives and livelihoods in both the United States and China. But instead of bonding the two nations together to fight the pandemic, it has sent their already strained relations on a rapid downward spiral — and fanned the flames of a potentially dangerous strain of nationalism. China has been criticized at home and abroad over its handling of the virus, especially during the initial outbreak. Pushing back such criticism with increasingly fierce rhetoric, Beijing says it is merely “responding” to false accusations, particularly from the US. In March, as the pandemic raged across the globe, Chinese Foreign Ministry spokesman Zhao Lijian...

Milan's mayor has condemned "shameful" crowds heading to a popular area of the city during Italy’s relaxed lockdown. Images...

An Italian nurse working on the frontline against the Chinese coronavirus was brutally sexually assaulted by an African migrant after finishing her shift and heading to her home. ......

Manuel Manonelles is Associate Professor of International Relations, Blanquerna/University Ramon Llull, Barcelona

The post Hegemony Shift in Times of COVID-19 appeared first on Inter Press Service.

Some of the restrictions imposed on open marketplaces as part of the measures to take the spread of the coronavirus outbreak under control have been lifted, the Interior Ministry has announced in a circular sent to 81 provinces across the country.

Some customers are returning to restaurants, bars and other shops in night entertainment districts that resumed operations.

Gold, frankincense, and myrrh—those are perhaps the three most famous Christmas gifts ever given, for one historic reason. Matthew 2:11 records their delivery to Christ in His childhood by wise men from the East. And all three gifts have been memorialized by the many nativity scenes featuring them each Christmas. But what about the next time Jesus comes?

South Sudan Doctors’ Union say this may hurt millions of South Sudanese.

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Kim Kardashian and Kanye West tied the knot in 2014 and have four children together

Taylor Swift performed songs from her latest album in September in Paris

Kim Kardashian on Friday said she has started missing her sisters.

Miley Cyrus shot to fame courtesy of Disney’s Hannah Montana

The surge in online learning in the People’s Republic of China during the coronavirus outbreak highlights the importance of infrastructure, platforms and the preparedness of teachers, students and parents.

With timely and well-targeted programs, policy makers can prevent the health crisis from deepening into a wider economic and financial crisis. This could sow the seeds of economic recovery.  

Prime Minister Boris Johnson will keep Britain under a coronavirus lockdown until at least next month -- to the frustration of some in his Cabinet, who behind the scenes are arguing that Downing Street now needs to prioritize the economy, which is heading for its worst recession in 300 years.Cabinet...

HC for inclusion of Gurgaon MC Commissioner in panel Tribune News Service Chandigarh, March 11 The Punjab and Haryana High Court today expressed dissatisfaction with the nine-member committee constituted by the Cabinet Secretary for looking into the shifting of the ammunition dump at Gurgaon and Faridabad. Directing the reconstitution of the committee, the Division Bench of Chief Justice Sanjay Kishan Kaul and Justice Arun Palli made it clear that it was in favour of including Gurgaon Municipal Commissioner Praveen Kumar’s name in the committee. As the case came up for resumed hearing, counsel for the Union of India Onkar Singh Batalvi placed before the Bench the details of the committee […]

Usually the kingdom of water tanks and satellite dishes, Lebanon's rooftops have recently been graced by unlikely scenes of locked-down residents fleeing their flats.

Dentons has advised KPS Capital Partners, a global private equity firm focused on investing in manufacturing and industrial companies across a diverse array of industries, on its acquisition of the Lufkin rod lift solutions business from Baker Hughes. 

Approved project 45009-003 in Mongolia.

Summers are the best time of year, when we go for our annual vacations, plan outings and trips with family and friends and HARMAN is known to be elevating such experiences. This summer, we decided to take a delve into how our iconic brands are creating...

A 2016 experiment pointed towards the existence of an undiscovered force of nature. Now researchers say they've seen a second sign

When the nightclub in which she touted for business in southern Chile was shut down by the authorities as the new coronavirus spread, sex worker Camila Hormazabal was left without access to her sole...

Shell has raised the environmental stakes among major oil and gas producers with plans to dramatically reduce the carbon impact of its business.

One has been promoting environmental regulation for decades, while the other is bent on dismantling such policies. It makes for clear battle lines in the upcoming presidential election.

Sorry. A short dip in carbon emissions won’t save the planet after all. Things may even get worse, say the experts.

Puzzling, slow-living microbes named after Loki, the trickster of Norse mythology, are helping solve one of evolution's biggest mysteries: the origin of complex life

Climate change is leading to lower numbers of marine life towards the equator – including mammals, birds, fish and plankton – while populations nearer the poles increase

The next season of the ABB FIA Formula E Championship kicks off in December 2018, and is already shaping up to be exceptional. Featuring new cars, a new race format, new cities, new power modes, new teams, and new drivers, season five promises to ramp up...

The fifth season of the ABB FIA Formula E Championship has kicked off in style in December 2018 with the SAUDIA Ad Diriyah E-Prix. Since then, the Championship’s 22 participating Gen2 electric cars and drivers have been crisscrossing the planet in 13...

A London bus stop has been transformed into a children's art gallery by a local resident who wanted to brighten the drudgery of lockdown life, creating a colourful community hub amid the anxiety and isolation of the COVID-19 pandemic.

Puzzling, slow-living microbes named after Loki, the trickster of Norse mythology, are helping solve one of evolution's biggest mysteries: the origin of complex life

U.S. President Donald Trump said on Wednesday his White House coronavirus task force would remain in place but with a focus on medical treatments and easing restrictions on businesses and social life and perhaps with different advisers. This report produced by Chris Dignam.

Britain's Princess Charlotte, daughter of Prince William and his wife Kate, celebrates her fifth birthday on Saturday - an occasion marked by the release of four new photographs of the young royal.

Title: New Finding Could Mark Shift in Alzheimer's Research
Category: Health News
Created: 4/29/2010 8:10:00 AM
Last Editorial Review: 4/29/2010 12:00:00 AM

Title: Night Shift Work May Be Tough on a Woman's Heart
Category: Health News
Created: 4/26/2016 12:00:00 AM
Last Editorial Review: 4/27/2016 12:00:00 AM

PMC has recently undergone another redesign to improve the look and feel and functionality of the site, featuring more white space, cleaner lines and enhanced navigation on its article, issue, and journal archive pages. For more information, see the article in the July-August 2012 issue of the NLM Technical Bulletin.

ABSTRACT

The availability of energy has significant impact on cell physiology. However, the role of cellular metabolism in bacterial pathogenesis is not understood. We investigated the dynamics of central metabolism during virulence induction by surface sensing and quorum sensing in early-stage biofilms of the multidrug-resistant bacterium Pseudomonas aeruginosa. We established a metabolic profile for P. aeruginosa using fluorescence lifetime imaging microscopy (FLIM), which reports the activity of NADH in live cells. We identified a critical growth transition period during which virulence is activated. We performed FLIM measurements and direct measurements of NADH and NAD⁺ concentrations during this period. Here, planktonic (low-virulence) and surface-attached (virulence-activated) populations diverged into distinct metabolic states, with the surface-attached population exhibiting FLIM lifetimes that were associated with lower levels of enzyme-bound NADH and decreasing total NAD(H) production. We inhibited virulence by perturbing central metabolism using citrate and pyruvate, which further decreased the enzyme-bound NADH fraction and total NAD(H) production and suggested the involvement of the glyoxylate pathway in virulence activation in surface-attached populations. In addition, we induced virulence at an earlier time using the electron transport chain oxidase inhibitor antimycin A. Our results demonstrate the use of FLIM to noninvasively measure NADH dynamics in biofilms and suggest a model in which a metabolic rearrangement accompanies the virulence activation period.

IMPORTANCE The rise of antibiotic resistance requires the development of new strategies to combat bacterial infection and pathogenesis. A major direction has been the development of drugs that broadly target virulence. However, few targets have been identified due to the species-specific nature of many virulence regulators. The lack of a virulence regulator that is conserved across species has presented a further challenge to the development of therapeutics. Here, we identify that NADH activity has an important role in the induction of virulence in the pathogen P. aeruginosa. This finding, coupled with the ubiquity of NADH in bacterial pathogens, opens up the possibility of targeting enzymes that process NADH as a potential broad antivirulence approach.

In order to establish sustainable heat loading (heat removal and storage) in abandoned flooded mine workings it is important to understand the geomechanical impact of the cyclical heat loading caused by fluid injection and extraction. This is particularly important where significantly more thermal loading is planned than naturally occurs. A simple calculation shows that the sustainable geothermal heat flux from abandoned coal mines can provide less than a tenth of Scotland's annual domestic heating demand. Any heat removal greater than the natural heat flux will lead to heat mining unless heat storage options are also considered.

As a first step, a steady-state, fully saturated, 2D coupled hydromechanical model of a generalized section of pillar-and-stall workings has been created. Mine water rebound was modelled by increasing the hydrostatic pressure sequentially, in line with monitored mine water-level data from Midlothian, Scotland. The modelled uplift to water-level rise ratio of 1.4 mm m^–1 is of the same order of magnitude (1 mm m^–1) as that observed through interferometric synthetic aperture radar (InSAR) data in the coalfield due to mine water rebound. The modelled magnitude of shear stress at the pillar corners, as a result of horizontal and vertical displacement, is shown to increase linearly with water level. Mine heat systems are expected to cause smaller changes in pressure than those modelled but the results provide initial implications on the potential geomechanical impacts of mine water heat schemes which abstract or inject water and heat into pillar-and-stall coal mine workings.

Thematic collection: This article is part of the SJG Collection on Early-Career Research available at: https://www.lyellcollection.org/cc/SJG-early-career-research

Interpretation of a 3D seismic survey located on the western margin of the Northern North Sea Basin demonstrates how the propagation, overlap and linkage of two north–south-striking, en echelon normal fault segments exerted a powerful influence over prospective subtle stratigraphic traps. The relay ramp that formed between the segments appears to have focused sediment dispersal, controlled reservoir distribution and aided post-depositional petroleum migration. Integration of electrical well log data, root-mean-square (RMS)-amplitude analysis and biostratigraphy with seismic interpretation demonstrates that a series of elongate, linear, sand-prone (reservoir) channel complexes characterize the depositional slopes generated by fault growth. The combination of synsedimentary rotation of bedding due to fault propagation and associated footwall uplift led to erosion and truncation of a laterally extensive, older channelized system (Lower Sequence), the downdip parts of which extend beyond the relay ramp. Its subsequent drape by transgressive shales created the subtle stratigraphic trap that now hosts the Cladhan Field, with charge occurring because the sandstones belonging to the Lower Sequence extend as far as the active kitchen in the neighbouring (hanging-wall) depocentre situated downdip and to the east. In contrast, the exploration of a younger, Upper Sequence of sandstones has proven to be disappointing due to their more restricted distribution, lack of access to charge, and occurrence of faults that offset and breach the thin end of the stratigraphic wedge. The implication is that partially breached relay ramps not only provide a preferential site for syn-rift clastic reservoirs to develop but also form important migration pathways through which oil passed from a petroleum kitchen into a trap.

Thematic collection: This article is part of the Under-explored plays and frontier basins of the UK continental shelf collection available at: http://www.lyellcollection.org/cc/under-explored-plays-and-frontier-basins-of-the-uk-continental-shelf

OBJECTIVE

The aim of this study was to quantify the excess risk of autoimmune hypothyroidism and hyperthyroidism, Addison disease, celiac disease, and atrophic gastritis in adults with type 1 diabetes (T1D) compared with nondiabetic individuals in Finland.

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय

Ramadan 2020 Today Sehri & Iftar Time Table : जानिए रमजान में सहरी और इफ्तार का समय