CES 2020, LAS VEGAS – JANUARY 6, 2020 – HARMAN International Industries, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, is announcing its entry into the gaming...

CES 2020, LAS VEGAS – JANUARY 6, 2020 – HARMAN International Industries, a wholly-owned subsidiary of Samsung Electronics Co. Ltd., focused on connected technologies for automotive, consumer and enterprise markets, announces that the Personi-Fi platform...

BANGALORE, INDIA –  HARMAN (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, today announced the launch of limited edition JBL® Raaga Synchros S500AR headphones, autographed by academy award winner...

NORTHRIDGE, Calif.—HARMAN Professional Solutions, the global leader in audio, video, lighting and control systems, today announced new AKG K361-BT and K371-BT professional studio headphones featuring Bluetooth connectivity at the 2020 NAMM show in...

NORTHRIDGE, Calif. – APRIL 28, 2020 – Following the award-winning debut of the JBL Quantum Range gaming headsets earlier this year, today JBL continues to elevate the gaming space by teaming up with lifestyle power brand and leading esports organization...

STAMFORD, CT – May 5, 2016 – Today, HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced it will showcase the industry’s first  developer-ready ...

CES 2020 – LAS VEGAS, NV – JANUARY 6, 2020 – At CES, Harman Kardon launched its first new headphone series since 2014, the Harman Kardon FLY. This line-up of sophisticated headphones includes three models – FLY BT, (Bluetooth), FLY TWS (true wireless)...

Twitter used to be full of cat memes and had a culture of sharing. Now, I pay a company to make sure my presence on the site is extremely limited, writes Annalee Newitz

As a leading technology company with applications across a range of industries including automotive, audio and enterprise technology, HARMAN has a strong focus on recognizing our talented in-house engineers, developers and designers who help bring ...

Studies of the world's most unflappable people point to ways we can all better manage stress – and are even inspiring the first stress vaccine

The world's biggest brewer, AB InBev, says it sees signs of a rebound in China, but warns the next quarter will still be worse overall. Julian Satterthwaite reports.

Title: More Babies Today Have Irregular Head Shape: Expert
Category: Health News
Created: 4/27/2012 4:05:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Helmets Not Helpful for Babies With 'Flat Head' Syndrome: Study
Category: Health News
Created: 5/2/2014 9:35:00 AM
Last Editorial Review: 5/2/2014 12:00:00 AM

Title: Doctors Say Head Lice Should Not Bar Kids From School
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM

Title: Start Healthy Eating Habits Early to Head Off Obesity in Kids
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

Title: The Cold Truth About Migraine Headaches
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/4/2018 12:00:00 AM

Title: Workers With Cluster Headaches Take Twice as Many Sick Days
Category: Health News
Created: 2/6/2020 12:00:00 AM
Last Editorial Review: 2/6/2020 12:00:00 AM

Title: Heading to Work on a Bike? You Might Live Longer
Category: Health News
Created: 2/25/2020 12:00:00 AM
Last Editorial Review: 2/26/2020 12:00:00 AM

Title: Balanitis (Inflammation of the Head of the Penis)
Category: Diseases and Conditions
Created: 6/24/2013 12:00:00 AM
Last Editorial Review: 11/22/2019 12:00:00 AM

Title: Sinus Headache Pain, Symptoms, Treatments, Remedies, and Cures
Category: Diseases and Conditions
Created: 1/11/2010 12:00:00 AM
Last Editorial Review: 1/13/2020 12:00:00 AM

Title: Get Ready for Clocks to 'Spring Ahead'
Category: Health News
Created: 3/6/2020 12:00:00 AM
Last Editorial Review: 3/6/2020 12:00:00 AM

Forty miles from the state capital, Jackson County, West Virginia, is home to about 29,000 people and 25 hospital beds. Like much of the state, the rural county is reeling from the opioid epidemic.

Objective

De novo missense mutations in the RHOBTB2 gene have been described as causative for developmental and epileptic encephalopathy.

Sperm head shaping is a key event in spermiogenesis and is tightly controlled via the acrosome–manchette network. Linker of nucleoskeleton and cytoskeleton (LINC) complexes consist of Sad1 and UNC84 domain–containing (SUN) and Klarsicht/ANC-1/Syne-1 homology (KASH) domain proteins and form conserved nuclear envelope bridges implicated in transducing mechanical forces from the manchette to sculpt sperm nuclei into a hook-like shape. However, the role of LINC complexes in sperm head shaping is still poorly understood. Here we assessed the role of SUN3, a testis-specific LINC component harboring a conserved SUN domain, in spermiogenesis. We show that CRISPR/Cas9-generated Sun3 knockout male mice are infertile, displaying drastically reduced sperm counts and a globozoospermia-like phenotype, including a missing, mislocalized, or fragmented acrosome, as well as multiple defects in sperm flagella. Further examination revealed that the sperm head abnormalities are apparent at step 9 and that the sperm nuclei fail to elongate because of the absence of manchette microtubules and perinuclear rings. These observations indicate that Sun3 deletion likely impairs the ability of the LINC complex to transduce the cytoskeletal force to the nuclear envelope, required for sperm head elongation. We also found that SUN3 interacts with SUN4 in mouse testes and that the level of SUN4 proteins is drastically reduced in Sun3-null mice. Altogether, our results indicate that SUN3 is essential for sperm head shaping and male fertility, providing molecular clues regarding the underlying pathology of the globozoospermia-like phenotype.

Annelies Wouters, Jan-Pieter Ploem, Sabine A. S. Langie, Tom Artois, Aziz Aboobaker, and Karen Smeets

Pluripotent stem cells hold great potential for regenerative medicine. Increased replication and division, such is the case during regeneration, concomitantly increases the risk of adverse outcomes through the acquisition of mutations. Seeking for driving mechanisms of such outcomes, we challenged a pluripotent stem cell system during the tightly controlled regeneration process in the planarian Schmidtea mediterranea. Exposure to the genotoxic compound methyl methanesulfonate (MMS) revealed that despite a similar DNA-damaging effect along the anteroposterior axis of intact animals, responses differed between anterior and posterior fragments after amputation. Stem cell proliferation and differentiation proceeded successfully in the amputated heads, leading to regeneration of missing tissues. Stem cells in the amputated tails showed decreased proliferation and differentiation capacity. As a result, tails could not regenerate. Interference with the body-axis-associated component β-catenin-1 increased regenerative success in tail fragments by stimulating proliferation at an early time point. Our results suggest that differences in the Wnt signalling gradient along the body axis modulate stem cell responses to MMS.

Background:

Limited treatment options are available for oral mucositis, a common, debilitating complication of cancer therapy. We examined the association between daily delivery time of radiotherapy and the severity of oral mucositis in patients with head and neck cancer.

While smoking is inextricably linked to oral/head and neck cancer (HNSCC), only a small fraction of smokers develop HNSCC. Thus, we have sought to identify other factors, which may influence the development of HNSCC in smokers including microbiology. To determine microbial associations with HNSCC among tobacco users, we characterized oral microbiome composition in smokers with and without HNSCC. 16S rRNA MiSeq sequencing was used to examine the oral mucosa microbiome of 27 smokers with (cases) and 24 without HNSCC (controls). In addition, we correlated previously reported levels of DNA damage with the microbiome data. Smokers with HNSCC showed lower microbiome richness compared with controls (q = 0.012). Beta-diversity analyses, assessed as UniFrac (weighted and unweighted) and Bray–Curtis distances, showed significant differences in oral mucosal microbiome signatures between cases and controls (r² = 0.03; P = 0.03) and higher interindividual microbiome heterogeneity in the former (q ≤ 0.01). Higher relative abundance of Stenotrophomonas and Comamonadaceae and predicted bacterial pathways mainly involved in xenobiotic and amine degradation were found in cases compared with controls. The latter, in contrast, exhibited higher abundance of common oral commensals and predicted sugar degradation pathways. Finally, levels of DNA damage in the oral cavity were correlated with the microbiome profiles above. Oral microbiome traits differ in smokers with and without HNSCC, potentially informing the risk of eventual HNSCC and shedding light into possible microbially mediated mechanisms of disease. These findings present data that may be useful in screening efforts for HNSCC among smokers who are unable to quit.

SUMMARY:

The olfactory bulbs and tracts are central nervous system white matter tracts maintained by central neuroglia. Although rare, gliomas can originate from and progress to involve the olfactory apparatus. Through a Health Insurance Portability and Accountability Act–compliant retrospective review of the institutional teaching files and brain MR imaging reports spanning 10 years, we identified 12 cases of gliomas involving the olfactory bulbs and tracts, including 6 cases of glioblastoma, 2 cases of anaplastic oligodendroglioma, and 1 case each of pilocytic astrocytoma, diffuse (grade II) astrocytoma, anaplastic astrocytoma (grade III), and diffuse midline glioma. All except the pilocytic astrocytoma occurred in patients with known primary glial tumors elsewhere. Imaging findings of olfactory tumor involvement ranged from well-demarcated enhancing masses to ill-defined enhancing infiltrative lesions to nonenhancing masslike FLAIR signal abnormality within the olfactory tracts. Familiarity with the imaging findings of glioma involvement of the olfactory nerves is important for timely diagnosis and treatment of recurrent gliomas and to distinguish them from other disease processes.

BACKGROUND AND PURPOSE:

Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences.

Tens of thousands of new apartments enter the Ho Chi Minh City market every year, putting pressure on investors who want to reap returns from rental apartments.

Publisher Playism and developer FYQD-Studio announced Bright Memory: Infinite will launch for Xbox Series X alongside the previously announced PlayStation 4, Xbox One and Windows PC versions.

View the Xbox Series X trailer below:

Here is an overview of the game:

A Rich Sci-fi Story

Bright Memory: Infinite is set in a sprawling, futuristic metropolis in the year 2036.

The player will take on the role of Shelia, a member of the Supernatural Science Research Organization (SRO), an organization in possession of more advanced science and technology than even the military. Bright Memory: Infinite is full of breathtaking fun and exciting action, such as navigating a spaceship that can travel through time, battling ancient samurai displaced from 1000 years ago to the present, and exploring a wormhole that has appeared on Earth.

High-Speed 3D Combat

By now I’m sure everyone has seen Bright Memory: Infinite‘s appearance on Inside Xbox. In addition to the deep and rich story, another main feature of the game is its adrenaline-pumping gameplay design. With the way I’ve designed the battle system, players can experience lightning-fast combat using a variety of skills to create their own personalized style of fighting. Basically, any skills can be combined and will generate different effects when utilized and it’s up to the player to figure out how to best use these skills both in and out of battle. Some skills can be used to overcome certain obstacles or solve certain puzzles, be it in combat or while exploring the futuristic world.

Stunning Visual Effects

The quality of the graphics of Bright Memory: Infinite for the Xbox Series X is the aspect I focused most on throughout the game’s development, in order to truly harness and show off the abilities of the next-gen system. This can particularly be seen in the wormholes appearing in the game. I’ve also made use of the dramatic visual effects made possible by the Xbox Series X, which can be seen in dynamic scenes in which wind, rain, leaves, and pebbles are visibly sucked toward a wormhole as the player explores their surroundings. These stunning visual effects are all possible thanks to DirectX Raytracing (DXR) on the Xbox Series X.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443426/bright-memory-infinite-headed-to-xbox-series-x/

Twitter used to be full of cat memes and had a culture of sharing. Now, I pay a company to make sure my presence on the site is extremely limited, writes Annalee Newitz

Earlier this week, a depressing economic prognosis linked on the Drudge Report concluded: "A whole lot more pain is on the way, and it is going to shake our nation to the core."

Alex, Johnathan, and Chris run through the past two weeks of news, bemoan the lack of time to play games, and then commit to not trying to play anything new. Ring Fit Adventure wins RPG of the year. But seriously, why isn't Shining Force II on that thing?

That's actually better than usual.

A new poll from Montana State University shows Democratic Gov. Steve Bullock leading incumbent GOP Sen. Steve Daines, and Joe Biden inching toward President Trump's lead.