(MENAFN - Saudi Press Agency) Riyadh, May 9, 2020, SPA -- The General Authority of Meteorology and Environment Protection forecasted the weather for t... ......

(MENAFN - Kuwait News Agency (KUNA)) KUWAIT, May 9 (KUNA) -- The Kuwaiti Ministry of Health reported, Saturday, 641 new coronavirus (COVID-19) infecti... ......

(MENAFN)Health authorities in Brunei said that there have been no new coronavirus cases reported in the country on Saturday, as the total number of co... ......

Bill Maher is rather frustrated with Democrats and the liberal media . In particular, the talk show host and comedian...

FILIPINOS are satisfied with President’s Rodrigo Duterte’s leadership in the country’s response to the coronavirus disease 2019 (Covid-19) pandemic, according to a latest foreign online survey. Palace spokesman Harry Roque Jr. shared to the media results of the “Global Crisis Perceptions” index released by insights firms Blackbox Research and Toluna. The global poll from April […]

A reader would like to know what they are entitled to after being hit by a car while passing through an intersection.

Japan will launch its first space operations unit within the Air Self-Defense Force on May 18 to monitor threats to Japanese satellites in outer space, ...

PESHAWAR: The Pakistan People’s Party and the representatives of medical organisations of Khyber Pakhtunkhwa have demanded an end to the privatisation of healthcare facilities in the province and provision of automated coronavirus testing machines to medical staff. The demand was made...

As many as 44 million people in Africa could be infected with Covid-19 in the first year of the pandemic if containment measures fail – causing 83,000 to 190,000 deaths – according to modelling by the World Health Organisation, reflecting fears of a potential widening crisis on the continent.The study, released on Thursday by WHO Africa, looked at 47 countries with a combined population of 1 billion people and suggested smaller countries alongside Algeria, South Africa and Cameroon were at a…

China’s military may have been spared any coronavirus infections, but the global health crisis has slowed the progress of Chinese President Xi Jinping’s plan to transform the People’s Liberation Army into a modern fighting force capable of long-range power-projecting operations, experts say.According to China’s defence ministry, the world’s largest armed force – with about 2.3 million personnel – has had zero confirmed cases of Covid-19. In contrast, the US and Russian militaries, ranked second…

Former Manchester United and England defender Rio Ferdinand believes there is no viable resolution to the resumption of the 2019-20 season that will satisfy all 20 Premier League clubs. Top-flight clubs are understood to have been told that the use of eight to 10 neutral grounds is the only way...

The post ‘Premier League will not be able to satisfy every club’ appeared first on Cyprus Mail.

On Friday the province conducted 397 COVID-19 tests. Since the outbreak began New Brunswick has conducted a total of 17,426 tests.

PESHAWAR: The Pakistan People’s Party and the representatives of medical organisations of Khyber Pakhtunkhwa have demanded an end to the privatisation of healthcare facilities in the province...

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Gharavi, a security consultant, was among ten human rights defenders arrested in Turkey in July 2017 at an information management and well-being workshop.

ADB tripled the size of its response to the COVID-19 pandemic to $20 billion and approved measures to streamline its operations for quicker and more flexible delivery of assistance, says ADB President Masatsugu Asakawa.

dsPIC33/PIC24 FRM, High-Speed Analog Comparator with Slope Compensation DAC

Are shark attacks and ice cream sales linked? Do drugs work? Being able to distinguish cause and effect is crucial. Now we have the maths to do it reliably

Food tastes satisfying thanks to the amino acid glutamate, which stimulates the umami taste. Sam Wong explains how to boost it in your recipes

The mysterious Liangzhu civilisation was a neolithic "Venice of the East", rivalling ancient Egypt and Mesopotamia with its engineering marvels

Next time you peel yourself a citrus fruit, follow our guide to make your own unique and memorable scientific baubles

Ditch the phone, don't stand too close and strive for optimal eye contact: the evidence-based approach to painless holiday schmoozing

The mysterious Liangzhu civilisation was a neolithic "Venice of the East", rivalling ancient Egypt and Mesopotamia with its engineering marvels

Are shark attacks and ice cream sales linked? Do drugs work? Being able to distinguish cause and effect is crucial. Now we have the maths to do it reliably

AI can check satellite images of the ocean and distinguish between floating materials such as seaweed or plastics, which could help clean-up efforts

Are shark attacks and ice cream sales linked? Do drugs work? Being able to distinguish cause and effect is crucial. Now we have the maths to do it reliably

The remains of three slaves found in Mexico contain the earliest signs of the hepatitis B virus and yaws bacteria in the Americas, suggesting transatlantic slavery introduced these diseases

Title: Prescription Drug Take-Back Day Set for Saturday
Category: Health News
Created: 4/26/2013 12:36:00 PM
Last Editorial Review: 4/29/2013 12:00:00 AM

Title: Doctor Salaries and Job Satisfaction: New Survey
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM

ABSTRACT

The recent discovery of complete ammonia oxidizers (comammox) contradicts the paradigm that chemolithoautotrophic nitrification is always catalyzed by two different microorganisms. However, our knowledge of the survival strategies of comammox in complex ecosystems, such as full-scale wastewater treatment plants (WWTPs), remains limited. Analyses of genomes and in situ transcriptomes of four comammox organisms from two full-scale WWTPs revealed that comammox were active and showed a surprisingly high metabolic versatility. A gene cluster for the utilization of urea and a gene encoding cyanase suggest that comammox may use diverse organic nitrogen compounds in addition to free ammonia as the substrates. The comammox organisms also encoded the genomic potential for multiple alternative energy metabolisms, including respiration with hydrogen, formate, and sulfite as electron donors. Pathways for the biosynthesis and degradation of polyphosphate, glycogen, and polyhydroxyalkanoates as intracellular storage compounds likely help comammox survive unfavorable conditions and facilitate switches between lifestyles in fluctuating environments. One of the comammox strains acquired from the anaerobic tank encoded and transcribed genes involved in homoacetate fermentation or in the utilization of exogenous acetate, both pathways being unexpected in a nitrifying bacterium. Surprisingly, this strain also encoded a respiratory nitrate reductase which has not yet been found in any other Nitrospira genome and might confer a selective advantage to this strain over other Nitrospira strains in anoxic conditions.

IMPORTANCE The discovery of comammox in the genus Nitrospira changes our perception of nitrification. However, genomes of comammox organisms have not been acquired from full-scale WWTPs, and very little is known about their survival strategies and potential metabolisms in complex wastewater treatment systems. Here, four comammox metagenome-assembled genomes and metatranscriptomic data sets were retrieved from two full-scale WWTPs. Their impressive and—among nitrifiers—unsurpassed ecophysiological versatility could make comammox Nitrospira an interesting target for optimizing nitrification in current and future bioreactor configurations.

The lignin biosynthetic pathway is highly conserved in angiosperms, yet pathway manipulations give rise to a variety of taxon-specific outcomes. Knockout of lignin-associated 4-coumarate:CoA ligases (4CLs) in herbaceous species mainly reduces guaiacyl (G) lignin and enhances cell wall saccharification. Here we show that CRISPR-knockout of 4CL1 in poplar (Populus tremula x alba) preferentially reduced syringyl (S) lignin, with negligible effects on biomass recalcitrance. Concordant with reduced S-lignin was downregulation of ferulate 5-hydroxylases (F5Hs). Lignification was largely sustained by 4CL5, a low-affinity paralog of 4CL1 typically with only minor xylem expression or activity. Levels of caffeate, the preferred substrate of 4CL5, increased in line with significant upregulation of caffeoyl shikimate esterase1. Upregulation of caffeoyl-CoA O-methyltransferase1 and downregulation of F5Hs are consistent with preferential funneling of 4CL5 products toward G-lignin biosynthesis at the expense of S-lignin. Thus, transcriptional and metabolic adaptations to 4CL1-knockout appear to have enabled 4CL5 catalysis at a level sufficient to sustain lignification. Finally, genes involved in sulfur assimilation, the glutathione-ascorbate cycle, and various antioxidant systems were upregulated in the mutants, suggesting cascading responses to perturbed thioesterification in lignin biosynthesis.

Shih-Jung Hsu and Bo Cheng

In the presence of wind or background image motion, flies are able to maintain a constant retinal slip velocity via regulating flight speed to the extent permitted by their locomotor capacity. Here we investigated the retinal slip compensation of tethered blue-bottle flies (Calliphora vomitoria) flying semi-freely along an annular corridor in a magnetically levitated flight mill enclosed by two motorized cylindrical walls. We perturbed the flies’ retinal slip via spinning the cylindrical walls, generating bilaterally averaged retinal slip perturbations from -0.3 to 0.3 m·s^–1 (or -116.4 to 116.4 deg.·s^–1) When the perturbation was less than ~0.1 m·s^–1 (38.4 deg.·s^–1), the flies successfully compensated the perturbations and maintained a retinal slip velocity by adjusting their airspeed up to 20%. However, with greater retinal slip perturbation, the flies’ compensation became saturated, as the flies’ airspeed plateaued, indicating that they were unable to further maintain a constant retinal slip velocity. The compensation gain, i.e., the ratio of airspeed compensation and retinal slip perturbation, depended on the spatial frequency of the grating patterns, being the largest at 12 m^–1 (0.04 deg.^–1).

Background

Fluid overload in patients undergoing hemodialysis contributes to cardiovascular morbidity and mortality. There is a global trend to lower dialysate sodium with the goal of reducing fluid overload.

In this paper, a decision tree is presented, constructed on the basis of hydrogeological characteristics (water table depth, freshwater thickness, surface area required and distance between wells), to choose the optimal groundwater extraction method in the case of a coastal unconfined aquifer. A comparison is made of the groundwater extraction methods in a freshwater aquifer of limited thickness occurring in coastal dunes in the eastern region of the Province of Buenos Aires (Argentina). The negative effects brought about by the wrong use of the groundwater extraction methods are analysed, because, as a result of excessive extraction, such methods lead to the dramatic decrease of the freshwater reserves. The decision tree is a useful tool to assist decision-makers as it suggests the most suitable groundwater extraction method options (vertical wells or wellpoints), as well as identifying areas that are unsuitable for sustainable groundwater extraction.

OBJECTIVE

Debate continues regarding the influence of dietary fats and sugars on the risk of developing metabolic diseases, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). We investigated the effect of two eucaloric diets, one enriched with saturated fat (SFA) and the other enriched with free sugars (SUGAR), on intrahepatic triacylglycerol (IHTAG) content, hepatic de novo lipogenesis (DNL), and whole-body postprandial metabolism in overweight males.

Recurrent hotspot (p.Gly17Val) mutations in RHOA encoding a small GTPase, together with loss-of-function mutations in TET2 encoding an epigenetic regulator, are genetic hallmarks of angioimmunoblastic T-cell lymphoma (AITL). Mice expressing the p.Gly17Val RHOA mutant on a Tet2-null background succumbed to AITL-like T-cell lymphomas due to deregulated T-cell receptor (TCR) signaling. Using these mice to investigate therapeutics for AITL, we found that dasatinib, a multikinase inhibitor prolonged their survival through inhibition of hyperactivated TCR signaling. A phase I clinical trial study of dasatinib monotherapy in 5 patients with relapsed/refractory AITL was performed. Dasatinib was started at a dose of 100 mg/body once a day and continued until days 10–78 (median day 58). All the evaluable patients achieved partial responses. Our findings suggest that AITL is highly dependent on TCR signaling and that dasatinib could be a promising candidate drug for AITL treatment.Significance:Deregulated T-cell receptor signaling is a critical molecular event in angioimmunoblastic T-cell lymphoma and can be targeted with dasatinib.

It all boils down to how resilient the region is, says an urban planner and designer based in Manila.

Trong 7 tháng đầu năm 2019, giá sắt thép xuất khẩu của Việt Nam chỉ đạt mức trung bình 650,6 USD/tấn, giảm mạnh 12,4% so với cùng kỳ năm ngoái.

शनि कर्म के देवता हैं और आपके किए गए कार्य का फल जरूर देते हैं। शनिदेव को मनाने के लिए किए जाने वाले सनातनी उपाय को करके आप कुंडली के उन दोषों को दूर कर सकते हैं जिनके कारण आपको कष्ट उठाने पड़ते हैं।

A geopolitical battle is being played out in orbit as countries vie for the best satellite navigation system

An AI search engine takes one-tenth of a second to search more than 2 billion satellite images, identifying natural or built features that look alike, such as forests or military bases

AI can check satellite images of the ocean and distinguish between floating materials such as seaweed or plastics, which could help clean-up efforts

Huge constellations of satellites like SpaceX’s Starlink could make ground-based astronomy impossible, and we’re running out of time to deal with the problem

China has connected the world’s first portable ground station for quantum communication to the Mozi satellite, and has plans to launch another quantum satellite soon

The International Astronomical Union has concluded a review of satellite mega constellations such as SpaceX's Starlink satellites and found they will have a major impact on large telescopes, but not naked eye astronomy

A private satellite that is low on fuel could survive five more years because another satellite has come to its rescue – a technique that could be used by future service spacecraft

The bot learned language from people on Twitter—but it also learned values

We’re jumping onto the bandwagon of folks looking for a Vita version of that new Digimon game. We’re also checking our TGS info cards to...