FLOUR shortages across the UK mean new and old bakers alike are struggling to make their favourite recipes. If you've run out of self-raising flour, can you make the British classic scones with plain flour?

CHEESE SCONES are a great way of using up excess cheese while also being a delightful treat all the family will enjoy. Here's a quick recipe on how to make cheese scones.

Indianapolis native Doug Jones portrays the "Amphibious Man" in critically acclaimed film "The Shape of Water."

Kevin Jones performs his song, "I Can See The Stars" before the Tom Odell show at the Moroccan Lounge in Los Angeles.

Eric Bell, a funeral director in Pittsboro, Ind., says the longest he's waited to hold a memorial service is two months for a deceased person. He explains why.

With schools and campuses closed, high school seniors are planning for college just like they are finishing their high school careers: virtually.

For 2020 "Sports Mom of the Year," Kyle Neddenriep received heartfelt nominations from fathers, mothers, husbands, sons, daughters and friends.

Indiana on Monday joined a handful of states, including several of its neighbors, by shutting down nonessential travel and businesses.

The Franklin Skeleton Crew is connecting small businesses with the community in an unconventional way.

Marcus Winslow, cousin of James Dean, still drives Dean's favorite car

For 2020 "Sports Mom of the Year," Kyle Neddenriep received heartfelt nominations from fathers, mothers, husbands, sons, daughters and friends.

A chronology of key events

A chronology of key events

Key facts, figures and dates

Key facts, figures and dates

Scientists map ancient underwater landslides in the region chosen for Jakarta's replacement.

Indians don’t care about megapixels while buying phones: Survey  Hindustan Times

Morocco has rapidly expanded its fleet of drones as it battles the coronavirus pandemic, deploying them for aerial surveillance, public service announcements and sanitisation.

Contrarian bettors are off to their best start through the first four weeks of the season since 2003.

It’s been frustrating to watch more moderate positions be characterized as solely driven by political calculations.

Obviously, due to the recent COVID-19 outbreak, summer plans are on hold until further notice. And for families who rely on camp during the warmer months, this can be problematic. Although traditional summer camps might be out of the question this year, there are plenty of virtual options that will keep kids of all ages entertained. Whether they're looking to keep their academics sharp (hey, no one likes that pesky summer slide, right?) or just want some good, old-fashioned fun, these online summer camps will deliver.

In the past, we’ve all witnessed sim-jacking attacks that allow a hacker to impersonate the targeted victim to steal the phone number. Hackers can gain access to unauthorized information related to the victim using the vulnerability, ‘SimJacker’ was that vulnerability. Recently there’s a similar vulnerability that has popped up, which uses the same SMS-technology to […]

The post WIB Vulnerability: Sim-Card that Allows Hackers to Takeover Phones appeared first on ReadWrite.

The popularity of wedding drone photography is constantly rising. It’s not surprising because these flying machines can take really amazing photos and videos. But many people still aren’t sure about the necessity of aerial photography at weddings or different events. We’ve gathered for you the most important information you need to know about drones if […]

The post What You Need to Know to Use Drones for Your Wedding appeared first on ReadWrite.

The devices have reached 50% of US homes, but fallen flat as a channel

Please visit Search Engine Land for the full article.

Yesterday was a really fun day spent at Nokia World, the Finnish handset maker’s annual shindig. Conveniently, this year it was held in my home city of London and I got to cover the event for TechCrunch Europe. On day one, Nokia unveiled three new smartphones running Symbian^3, the C6, C7 and E7, which I [...]

Micronesia

The Amateur Traveler talks to Sam Oppenheim who makes a rare 4th appearance on the show to talk about Bali in Indonesia. Sam started his exploration of Bali in Ubud which is the cultural capital of the area. He met two of the people mentioned in the popular book Eat, Pray, Love: Wayan and Ketut Liyer. In Ubud he attended some of the traditional Balinese dances (Legong, Barong and Kecak). Sam explored the Hindu temples and the resort area of Kuta Beach with its famous nightlife, dove a ship wreck and explored the island by motorcycle. Sam’s does regret was not getting down to Nusa Dua on the southern tip with its wonderful sunsets or out to Komodo.

The Amateur Traveler talks to Lash from LashWorldTour.com about the Island of Java in the nation of Indonesia. She cycled through the countryside and visited the major cities of this populous island in Indonesia.

Hear about travel to Indonesia as the Amateur Traveler talks to repeat guest Chris Willis about his trip to Indonesia. The main objective of Chris’s trip was to photograph Komodo dragons in the wild. Komodo dragons live on 2-3 islands which are not near any airport so getting there is half the experience.

Hear about travel to the countries of Kiribati, Tuvalu and Nauru in Micronesia as the Amateur Traveler talks to Stefan from Rapid Travel Chai about these small difficult to reach island nations. 

Hear about travel to Lombok in Indonesia as the Amateur Traveler talks to Jason Andrew Jenkins from AnEpicEducation.com about his family's recent 5 week trip to this island paradise.

Hear about travel to the island of Sumatra in Indonesia as the Amateur Traveler talks to Luke Mackin from wildsumatra.com about this far-flung destination he now calls home.

Hear about travel to Lombok in Indonesia as the Amateur Traveler talks to Jason Andrew Jenkins from AnEpicEducation.com about his family's recent 5 week trip to this island paradise.

BEST DEALS ON HEADPHONES:

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The only thing more important to runners than their sneakers is a quality pair of headphones and a killer playlist. Running without music is like some form of medieval torture: it sucks. And cheap, crappy headphones just aren't going to cut it.

When shopping for a quality pair of headphones to wear while running, you'll want to look at a few key factors: Are they sweatproof/waterproof? Will they stay in your ears? Are the volume controls easily accessible? If you answer no to any of these questions, then you know the headphones aren't going to work. Read more...

I think it is pretty amazing how nature alone can teach us so many things and can make us realise the real beauty and meaning of life. For some, it may be boring and for some it is the answer they have been longing for. Whether it is an old tree or a clear blue […]

The post To All Those Who Love Nature And The Ones Who Don’t appeared first on Dumb Little Man.

I’m excited to introduce something I’ve wanted to do for quite a long time — private one-on-one calls between me and my readers! This new product is a way for us to have private one-on-one conversations tailored to whatever you want. I got into this business is because I wanted to help women achieve their …

INTRODUCING One-on-Ones with Adventurous Kate! Read More »

The post INTRODUCING One-on-Ones with Adventurous Kate! appeared first on Adventurous Kate.

Yue Chen
May 1, 2007; 6:812-819
Research

8 January 2020 , Volume 96, Number 1

Many clinical studies and epidemiological investigations have clearly demonstrated that women are twice as likely to develop cholesterol gallstones as men, and oral contraceptives and other estrogen therapies dramatically increase that risk. Further, animal studies have revealed that estrogen promotes cholesterol gallstone formation through the estrogen receptor (ER) α, but not ERβ, pathway. More importantly, some genetic and pathophysiological studies have found that G protein-coupled estrogen receptor (GPER) 1 is a new gallstone gene, Lith18, on chromosome 5 in mice and produces additional lithogenic actions, working independently of ERα, to markedly increase cholelithogenesis in female mice. Based on computational modeling of GPER, a novel series of GPER-selective antagonists were designed, synthesized, and subsequently assessed for their therapeutic effects via calcium mobilization, cAMP, and ERα and ERβ fluorescence polarization binding assays. From this series of compounds, one new compound, 2-cyclohexyl-4-isopropyl-N-(4-methoxybenzyl)aniline (CIMBA), exhibits superior antagonism and selectivity exclusively for GPER. Furthermore, CIMBA reduces the formation of 17β-estradiol-induced gallstones in a dose-dependent manner in ovariectomized mice fed a lithogenic diet for 8 weeks. At 32 μg/day/kg CIMBA, no gallstones are found, even in ovariectomized ERα (^–/–) mice treated with 6 μg/day 17β-estradiol and fed the lithogenic diet for 8 weeks. In conclusion, CIMBA treatment protects against the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER signaling pathway in female mice. CIMBA may thus be a new agent for effectively treating cholesterol gallstone disease in women.­

Get the latest cybersecurity news, opinion and advice.

8 January 2020 , Volume 96, Number 1

Researcher: Andrew Beveridge, Macalester College
Moment Title: Dis-playing the Game of Thrones
Description: Andrew Beveridge uses math to analyze Game of Thrones.