Herein are disclosed fluorescent dyes based around a framework for a ligand comprising a pyridyl group linked to a diaryl anilido unit. A variety of ligands based on this framework are disclosed. The ligands chelate to a BF2 center to produce the fluorescent dye. The disclosed dyes combine longer Stokes shifts (approximately 100 nm) with increased quantum yields. They are also photostable in aqueous and organic solutions for several hours. These dyes may be used in the labeling of biomolecules for bioimaging and assays. Also disclosed are methods for the synthesis of these dyes.

The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4', R5, R6 and R6' are as described herein.

The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.

A compound of formula (I) wherein R1 to R4 are, for example, each hydrogen, R5 is pyridyl, which has two or more substituents selected, for example, from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, and cyano; R6 is, for example, hydrogen; R7 is, for example, hydrogen, cyano, hydroxyl, formyl, C1-C4-alkyl, C1-C4-alkoxy, C2-C4-alkenyl, or C2-C4-alkynyl; and A1 to A5 are, independently selected, from, for example, N, and C—H; and its use as a pesticidal agent.

The present invention relates to a novel method for producing a pyridazinone compound and an intermediate thereof as shown in the following scheme: wherein the symbols are as defined in the specification.

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.

The present invention is concerned with a process for preparing 5-(2{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one or a pharmaceutically acceptable salt thereof.

An objective of the present invention is to provide a process for producing 4-carbonyl oxyquinoline derivatives useful as agricultural and horticultural pesticides and fungicides. The objective can be attained by a process for producing 4-carbonyl oxyquinoline derivatives represented by general formula (1), the process including reacting a quinolone derivative with a halogenated compound or an acid anhydride in the presence of a phase transfer catalyst and a base.

The present invention relates to electronic devices, in particular organic electroluminescent devices, comprising compounds of the formula (1), and the corresponding compounds.

The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.

A fastening assembly includes a connecting member, a mounting member mounted to the connecting member, and a sliding member. The mounting member includes a first fixing portion. The sliding member is slidably received in the mounting member and the connecting member. The sliding member includes a first end exposed out of the first fixing portion, and a second end slidably received in the connecting member. The second end of the sliding member is operable to be extended out of or substantially coplanar with an end of the connecting member. The fastening assembly can be utilized to mount a heat sink to a board.

An electronic device includes, a circuit board including a through hole, a member including a screw hole, a screw including a screw body having an outer diameter smaller than an inner diameter of the through hole and a screw head having an outer diameter larger than the inner diameter of the through hole, wherein the screw body penetrates through the through hole to engage with the screw hole and the screw head is disposed on an opposite side of the circuit board to the member, and a first washer provided between the screw head and the circuit board, the first washer including a first washer body and a plurality of first washer legs extending from the first washer body toward the circuit board, the first washer legs being in contact with the circuit board and having a characteristic of reducing stress on the circuit board upon being heated.

A method of manufacturing fastenings or fasteners with radial outer contours, especially screws or threaded bolts, made of solid metal is performed by a device. The method manufactures the fastenings or fasteners preferably on a multi-stage press. Several recesses running in an axial direction at a fixed radial distance are formed in the shank-shaped section of a blank. The prefabricated blank with the recesses is inserted into a multi-part split mold within a multi-stage press, whose die stocks have an inner profiling forming the outer contour, and are opened in the starting position, that at the places where the die stocks are opened, there are the recesses. During the closing movement of the die stocks, at least one radial outer contour is pressed on the shank-shaped section of the blank by radial action of forces, with the recesses preventing material from getting between the die stocks during the pressing process.

The theft-protected screw part in the form of a nut or a screw has a free end region and a ring-shaped depression formed at the end region for the engagement of a wrench for rotation the screw part. Viewed from radially outside to radially inside, the depression is delimited by an outer edge, a bottom and an inner edge. The outer edge forms outer abutment surfaces and the inner edge forms inner abutment surfaces for the wrench. The screw part is composed of a main part and an insert. The main part has a protrusion, which is located within the inner edge. The insert is designed in a ring shape, has a hole for accommodating the protrusion and forms the inner abutment surfaces.

The present invention is premised upon method of manufacturing rolled pierce nuts having a predetermined profile from a metal rod, more particularly to a method and apparatus delivering greater manufacturing flexibility through the use of multiple stations with flexible inputs and outputs.

The present invention provides a method for manufacturing a fitting that has a configuration where a fitting plate and a blind nut are integrally formed and also provides a tap tool for use in this method. According to the present invention, performing tap processing to an internal diameter portion to integrally form a portion corresponding to the blind nut, when a tap tool having a protrusion at an end thereof is utilized to be inserted into the bag-like blind hole at a planned part of the blind nut and the tap processing is carried out, the protrusion provided at the end of the tap tool comes into contact with an inner wall at the end of the bag-like blind hole, and a pressed material thereby forms a convex shape on an outer side of the bag-like blind hole.

A magnetized nut for fastening a compressor wheel of an exhaust turbocharger to a turbo shaft. The nut has a base body made of a non-magnetic material forming a hollow space for accommodating a magnetic material, and a method for the production of the magnetized nut. In order to provide a magnetized nut that is produced in a simple and cost-effective manner and ensures as equal a distribution of mass as possible with regard to the rotational axis of the nut, the magnetic material is introduced into the hollow space using injection molding.

A rolling machine comprises parallel guides delimiting a workpiece conveying channel extending from a plurality of per se known rolling tools to a machined workpiece unloading arrangement, wherein, upstream of the workpiece unloading arrangement, one of the channel delimiting guides is operatively coupled to a structural element swingably supported by a pivot pin, the structural element being integral with the piston rod of a cylinder-piston unit slidably driving the structural element together with the channel delimiting guide, thereby providing a side unloading opening for the workpiece.

A full-round head nail having an offset head is configured with a gusset formed integrally between an undersurface of the offset head and a superior portion of a shank. The head of the nail is relatively thin, and the shank is positioned radially off center of the round head such that no heel is formed at a point tangential to both the head and the shank. The gusset has a lofted surface tapering radially from a roundness at the zero heel to a taper at the toe. The gusset reinforces the junction of the shank with the head, supports the toe of the head, and distributes the force of a load on the head through a longitudinal axis of the shank, preventing the toe from bending or yielding and prevents the shank from yielding to the stresses of the load applied.

A set of tooling for making pointed headed bolts of a given diameter in numerous lengths with roll thread ready threaded to the head and partially threaded shanks in a four forming station forming machine, the tools being configured to work on wire stock as received at the first station of a diameter larger than or substantially the same as the roll diameter and not greater than the nominal diameter of the bolt, including at least two sequential head forming tools for mounting on the slide, an extrusion pointing tool for mounting on the die breast, a roll diameter extrusion tool for mounting on the die breast and a head support tool mountable in a station on the slide at multiple axial positions corresponding to standard lengths of the bolts being made, the head support tool being arranged to work at either the extrusion pointing station or the roll diameter extrusion station.

A fastener includes a t-nut having a barrel and a flange. The flange includes an opening which leads to a threaded barrel. The threaded barrel extends from the opening in the flange to a distal end portion thereof. An end cap has an annular recess on a first side thereof and has a raised annular ridge on a second side thereof. The raised annular ridge of the end cap is affixed to the flange of the t-nut by welding the end cap to the flange. Dirt, water and moisture cannot enter the barrel because the end cap is sealed to the flange. Additionally, the barrel may be relatively short as it is fully threaded prior to the affixation of the end cap to the flange.

Provided is a method for manufacturing an FRP member with insert which enables to reduce a machining time to improve productivity. First, a threaded hole 11 is formed in an insert 3. An FRP member 2 where at least the threaded hole 11 of the insert 3 is covered with a coating 4 made of FRP is molded. A counter-bored hole 31 that penetrates the coating 4 of the FRP member 2 to communicate with the threaded hole 11 of the insert 3 is formed, to thereby obtain an FRP component 1 with insert. Accordingly, a machining step after molding the FRP member 2 in which dry machining is required includes only the boring step of forming the counter-bored hole 31 in the FRP member 2. Thus, the machining time can be reduced, and the productivity can be improved.

In FIG. 2, a diameter Dd of drilling edges of a drill is selected smaller than a valley diameter d1 of a male thread of a tap portion, and an inner diameter D1 of a female thread is defined by the valley diameter d1 of the male thread. Therefore, a predetermined radial gap is formed between the male thread 30 formed by the tap portion and the drill. When a tap with the drill is reversely rotated to be pulled out from the female thread after cutting the female thread, the tap released from the restriction may deflectively displace in the diameter direction upon pulling out the male thread of the tap portion from the female thread. However, the drill hardly contacts with the female thread, so that the occurrence of the defective product due to the contact is suppressed.

Techniques for reinforcing concrete using rebar are disclosed. Some example embodiments may include prestressed concrete structures reinforced by twisted, threaded reinforcing bars. An example reinforcing bar for a prestressed concrete structure may include an elongated, generally cylindrical rod; an external thread disposed on the generally cylindrical rod, the external thread formed from an elongated, generally nonlinear channel wrapped about a radial surface of the generally cylindrical rod in a generally helical fashion. A base portion of the nonlinear channel may be disposed substantially against the radial surface of the generally cylindrical rod and/or an upstanding portion of the nonlinear channel may extend generally orthogonally from the radial surface of the generally cylindrical rod.

Disclosed is a tap driver and tap driver system for rigid tapping, which includes a unique flexure system. In some embodiments, an integrated flexure component and housing configuration provides and may provide both a more economical and a universal configuration of the tap driver flexure component that allows the central body to be integrated with and into different types of tap drivers.

A form tap for tapping an article may include a longitudinal shank having a mounting end opposite a tip, the shank having a shank length, and a thread portion with a plurality of threads for engaging a surface of the article. The thread portion includes a first region, a second region and a third region. The form tap includes a plurality of lobes extending though the first and second regions from the tip to the second region end, the lobes being spaced circumferentially around the shank and lying on a crest circumference. Each lobe may be disposed between respective first and second convex relief portions and each relief portion may be spaced radially inward from the crest circumference. Each lobe has a lobe width, the lobe width at the second region end being greater than the lobe width at the tip. The third region is free of lobes.

A clinch-type fastener is formed by simultaneously creating an undercut during the same forging that creates the head and displacer of the fastener. A fastener blank is compressed end-to-end between top and bottom dies whereby the axial compression of a blank causes the outward bulging of the shank at its midline. Simultaneously, a tapered end point and a tangential interference band are formed provided by a curvilinear-shaped bulge in the shank. As the bulge is formed an undercut is created between the bulge and a shoulder which extends downwardly from a head of the fastener. This method of formation and the fastener produced thereby are particularly suited to the manufacture of small clinch pins having a diameter in the range of 1.0 mm.

A process for producing hollow bolts including a longitudinal bore with the hollow bolts being provided with circumferential notches. The hollow bolts are provided with longitudinal grooves extending between elevations determining the bolt diameter, wherein circumferential notches are rolled onto the hollow bolts provided with the longitudinal grooves and the elevations, the longitudinal grooves being of such cross-section that some of the material displaced during rolling-on of the notches flows into the longitudinal grooves.

A testing method for the bolt to be used under the conditions of excessive wind force by which bolts made of Cr—Mo steel can be separated into a group of bolts usable in cold areas and a group of bolts unusable in cold areas without conducting Charpy impact test involving complicated operation, specifically, a testing method for determining whether bolts made of heat-treated Cr—Mo steel are usable or unusable in cold areas, wherein the determination is conducted on the basis of both J parameter calculated by formula: J=(Si %+Mn %) (P %+Sn %) 104 (wherein P %, Si %, Mn % and Sn % are contents (mass %) of phosphorus (P), silicon (Si), manganese (Mn) and tin (Sn) respectively as disclosed in the inspection certificate of the Cr—Mo steel) and bolt diameter.

Embodiments of the present invention are directed to improved designs of railroad spikes and improved methods of manufacturing the same. According to one exemplary embodiment, a method for manufacturing a railroad spike may comprise the steps of: preparing a metal blank having a substantially circular cross-section; subjecting the metal blank to at least one cold heading process and at least one cold extrusion process to form a railroad spike having (a) a circular head with a fillet at its bottom side that is angled to engage a railroad tie plate or rail base and (b) a non-threaded shank with a substantially square cross-section and a chiseled tip; and coating the railroad spike with an anti-corrosion material.

The invention relates to a method for producing hollow body elements (200), for example, nut elements which are applied to components which are normally made of steel (280), in particular, for producing hollow body elements having an essentially quadratic or rectangular external profile (202). Said method consists of cutting individual elements of a profile in the form of a profile rod (1) or a winding after holes (204) have previously been stamped in the profile, a threaded cylinder (206) is subsequently, optionally, formed using a follow-on composite tool (10) which consists of several working stations. The invention is characterized in that a penetrating process and a punching process are carried out in the working station. The invention also relates to hollow body elements (200), components, follow-on composite tools (10) and rolling mills (600, 602).

A method for manufacturing a thread-forming screw having a shank and a thread formed in one piece with the shank and region-wise circumferentially arranged on the shank, is disclosed. After the formation of the thread on the shank, a plurality of recesses is subsequently stamped into the thread. Then, a plurality of compact cutting elements is welded into the recesses in the thread, where the cutting elements are made of a hard material and have a hardness greater than the hardness of the thread. Additionally, a stamping device for carrying out the method is also disclosed.

A spiral fluted tap is provided which includes a threaded portion having an external thread corresponding to an internal thread to be cut and a cutting edge formed along a spiral flute formed to divide the external thread, and being screwed into a prepared hole that is provided on a workpiece to cut an internal thread by the cutting edge on an inner circumferential surface of the prepared hole with discharging chips toward a shank via the spiral flute, the spiral flute having a stepped portion at a rear end of a chamfer portion or in a portion on a shank side from the rear end of the chamfer portion in the threaded portion, and a flute bottom diameter on a distal end side of the spiral fluted tap from the stepped portion being smaller than a flute bottom diameter on a shank side from the stepped portion.

In various embodiments, a tapered thread roll, a set of tapered thread rolls, a thread rolling tool, and a thread rolling method are provided for rolling angled or tapered threads onto a workpiece to create a threaded workpiece. In at least one embodiment, the threaded workpiece may comprise a polished rod or a polished rod precursor as specified by the American Petroleum Institute for use in an oil-field sucker-type pump, for example.

A threading cutting insert achieves high shape accuracy of a screw to be processed, and saves on manufacturing cost. Therefore in the threading cutting insert, a plurality of tooth-shaped cutting edges are formed in a cross ridge line portion between a rake face and flanks formed in a cutting side face, wherein the plurality of mountain-shaped cutting edges provides at least one finishing cutting edge for transferring a shape of a screw, and at least one roughing cutting edge formed in a tooth shape smaller than that of the finishing cutting edge. A flank of the finishing cutting edge includes a first flank, and a second flank having a clearance angle larger than that of the first flank, wherein the finishing cutting edge, the first flank, and the second flank are sequentially provided in that order from the rake surface in a direction of a lower surface of the insert.

A full-round head nail having an offset head is configured with a gusset formed integrally between an undersurface of the offset head and a superior portion of a shank. The head of the nail is relatively thin, and the shank is positioned radially off center of the round head such that no heel is formed at a point tangential to both the head and the shank. The gusset has a lofted surface tapering radially from a roundness at the zero heel to a taper at the toe. The gusset reinforces the junction of the shank with the head, supports the toe of the head, and distributes the force of a load on the head through a longitudinal axis of the shank, preventing the toe from bending or yielding and prevents the shank from yielding to the stresses of the load applied.

A pivoting split thread chasing die with fastener is disclosed. In one example, the fastener can include a retainer that captures the fastener within one half of the thread chasing die. The thread chasing die may make it easier for a user to refurbish threads of large bolts and studs.

A slotted inverse tap, compressible for insertion past damaged entry threads in blind holes. (FIG. 1 thru FIG. 5) The tool can be made to smaller sizes than that of prior art. An elongate slot (23) proceeds through a first threaded end (21), then well into a reduced diameter cylindrical body (25). After insertion to the hole bottom, a tabbed shim (28) is inserted to the slot from its side, then pressed down until stopped. The shim (28) enforces mating engagement with undamaged internal threads. A second end of hex and/or squared or other configuration facilitates use of a tap wrench or other tool for rotational extraction. Damaged threads are reformed/re-cut upon rotational withdrawal.

A faceted bone screw and a method for manufacturing the same includes a screw thread configuration having facets that are substantially transverse to the thread. The facets are generally made up of a plurality of transitioning peaks and valleys which vary the depth of the thread and are disposed in one or more locations throughout the threaded portion of the bone screw. The facets operate to reduce the torque required to drive the bone screw into bone, while at the same time operate to assist in anchoring the bone screw within the bone once inserted therein, and thereby reduce the possibility for the screw backing out after insertion.

A fastener suitable for use in airplane manufacture or repair that is coated with a pre-mixed moisture cure sealant. The sealant layer is coated with a frangible moisture barrier that will break apart when the fastener is installed, thus exposing the sealant to atmospheric moisture. Once exposed to moisture, the sealant will begin to cure. Preferred embodiments also provide a moisture indicator that provides a visual indication that the outer moisture resistant layer has been damaged.

An apparatus to produce a self-piercing and clinch nut includes a first forging die assembly, a second forging die assembly, a third forging die assembly, a transfer mechanism, and a controller. The first forging die assembly is configured to subject a blank to first processing. The second forging die assembly is adjacent to the first forging die assembly and configured to subject the blank to second processing after the blank has undergone the first processing in the first forging die assembly. The third forging die assembly is adjacent to the second forging die assembly and configured to subject the blank to third processing after the blank has undergone the second processing in the second forging die assembly. The controller is configured to control the first forging die assembly, the second forging die assembly, the third forging die assembly, and the transfer mechanism to operate.

In the case of a screw having at least one thread (26) that is formed by a rolling process, especially a flat-die rolling process, whereby the thread (26) consists of two ridges of material (28a, 28b) which are shaped from a blank (12) by means of cold-forming during the rolling process in such a way that the thread has a closing crease (32) where the ridges of material (28a, 28b) meet each other, it is provided that the closing crease (32) is situated in the area of a flank (30a, 30b) of the thread (26).

A releasable lock nut assembly for securing a bearing on a threaded hub may include a thrust washer including a disk portion and a peripheral skirt extending axially away from the disk portion, the peripheral skirt having a plurality of openings and a characteristic diameter measured at an axial location of the openings, and a protuberance proximate to at least one of the openings. The assembly may also include a lock ring inserted into the thrust washer, where the lock ring includes a plurality of tangs that extend beyond a lock ring major diameter such that the tangs fit within the openings of the thrust washer. The protuberance may be deformed such that all of the peripheral skirt is within the characteristic diameter, and the protuberance may define an internal envelope of the thrust washer where the internal envelope is larger than the major diameter of the lock ring.

A thread-furrowing screw comprises a shaft portion made of solid material and a thread portion attached to the shaft portion, which thread portion is wound from a profiled metal strip.

Tap and die devices are provided to repair internal and external threads, respectively. The tap and die devices are provided with components that coaxially align the tap and die to the nut or fitting being repaired. The tap and die devices are easily portable, compact tools that can be used in tight places.

A locking device for preventing unauthorized retraction of a telescopic prop is made up of an adjustable clamp which can be fitted round the outer circumference of the prop together with a fastener for tightening the clamp, such as a nut and bolt with anti-tamper heads and a shield to prevent access to the head with a gripping instrument. The device can be placed around the outer circumference of an extended prop adjacent to the collar such that once the clamp is tightened the collar is sandwiched between the locking device and the pin. Alternatively the device can be placed around the outer circumference of the inner tube of the prop adjacent to and abutting the end of the outer tube of the prop in order to prevent unauthorized retraction of the prop.

A nail-forming apparatus and method to rapidly form nails typically with circular heads is provided. One aspect relates to a sequential wire piece positioner configured for sequentially positioning wire pieces respectively adjacent a plurality of nail head formers. The wire piece positioner may include several carriages related to moving and forming the wire pieces.

Disclosed herein is a method for manufacturing a screw comprising a continuous thread with a variable thread pitch, in which method a blank is rolled between two rolling dies, wherein in each rolling die a rolling profile is formed that comprises a host of curved non-parallel depressions. The depressions are designed and arranged in such a manner that during rolling no volume transport, or as little volume transport as possible, in the axial direction takes place, or a volume transport from a region of the blank where a thread section with a larger thread pitch is to be formed, to a region in which a thread section with a smaller thread pitch is to be formed takes place.

A method for manufacturing a bolting part, such as a screw or a nut. The bolting part having a head with a periphery having at least one shoulder extending in a radial plane. The method includes at least the following forming steps: shearing of a wire of material so as to obtain a part of determined length, calibration of the part so as to correct the geometry of the part, rough machining of the calibrated part so as to obtain the head of the bolting part, and finishing of the rough-machined part by means of a third punch so as to form a head having at least one shoulder. The calibration, rough machining and finishing steps being carried out only by cold heading.