Aathma Public Charitable Trust ensures a compassionate closure to hundreds of unclaimed bodies. Members of the trust hope more people will extend a helping hand on their mission

The fund manager sees opportunities in sectors such as education and microfinance.

The post We are betting on the Indonesian consumer story: Northstar co-founder Walujo appeared first on DealStreetAsia.

Shunwei’s investments in this region are close adaptations of those found in China.

The post China experience more relevant to India, Indonesia than US: Shunwei’s Tuck Lye Koh appeared first on DealStreetAsia.

Grab is in the midst of developing maps that are built with self-driving vehicles in mind.

The post Grab to launch geo-mapping services in Indonesia this year amid EV push appeared first on DealStreetAsia.

Ninja Van's country head Eric Saputra talks about the challenges and opportunities of operating in Indonesia.

The post Ninja Van sets its sights on Indonesia’s mom-and-pop e-commerce plays appeared first on DealStreetAsia.

In January, Wandou raised $48-million Series B from SBI Holdings, Sugi Holdings, and XJ Holding.

The post SBI Holdings-backed e-commerce firm Wandou bullish on Sino-Japanese market appeared first on DealStreetAsia.

Investree is currently in the process of raising a Series C round and is likely to close it by the end of this quarter.

The post Indonesia’s Investree carves out strategy to expand ops in Vietnam, Philippines appeared first on DealStreetAsia.

Mekari, which was formed out of the merger of four startups, snagged Series B and C funding last year.

The post Indonesia has room for multiple SaaS players targeting SMEs, says Mekari CEO Soh appeared first on DealStreetAsia.

Fundraising conversations will increasingly be centred around business models and sustainability.

The post Indonesia 2020: Tougher funding environment to trigger consolidation appeared first on DealStreetAsia.

Startups and investors are pushing for a shift to a “sustainable growth” model.

The post Four top takeaways from Indonesia PE-VC Summit 2020 appeared first on DealStreetAsia.

The tougher scrutiny could dampen investment flows into the region.

The post Financial discipline focus for startups in Indonesia in 2020 appeared first on DealStreetAsia.

A solid foothold in Indonesia is one of the important prerequisites for overseas expansion.

The post For Indonesian startups, strong foothold in local market is first priority appeared first on DealStreetAsia.

Generation Z, or people born in the mid-to-late 90s or later, make up 30% of the population in the archipelago.

The post Gen Z is rewriting the Indonesian consumer sector story appeared first on DealStreetAsia.

At 24 per cent of Indonesia’s GDP, the country’s logistics costs are among the highest in Southeast Asia.

The post Current challenges in Indonesian logistics sector throw up opportunities appeared first on DealStreetAsia.

Bangkok Bank plans to acquire another Indonesian lender after buying a controlling stake in Indonesian Bank Permata.

The post Bangkok Bank plans to acquire another Indonesian lender appeared first on DealStreetAsia.

RISE said it will use the funds to expand beyond Thailand to Singapore, Indonesia and Malaysia.

The post SEA Digest: Thailand’s RISE, Indonesia’s Webtrace raise seed funding appeared first on DealStreetAsia.

The total cost of the project is estimated at $285 million.

The post IFC mulls $60m financing for Indorama’s Uzbekistan cotton farm project appeared first on DealStreetAsia.

Company: P & I Management Consultants
Experience: 2 to 3
location: India
Ref: 24341086
Summary: Job Description: Spanish Language Expert -Ludhiana. Graduate with ability to calculate cost/prices, with 2-3 year experience in dealing with customers/Vendors. Training will be given as Purchase Executive for buying metals/Minerals....

Republican football club owner has reputation for working behind scenes

‘As the president tries to crack down on immigration, he runs into countervailing market forces’

Jamie Laing has appeared to flout lockdown rules after he returned to London with his girlfriend Sophie Habboo. The Made in Chelsea couple had left the capital to isolate in the Cotswolds.

She is still grieving the death of partner Nipsey Hussle after he was murdered last year.

Mark Wahlberg is reportedly using taxpayer cash to pay staff in his London restaurant amid the coronavirus pandemic.

Here are the key developments related to Coronavirus pandemic on May 9.

random5erendipity:

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Brandon Newman's stock rose considerably in the past six months. The 2019 guard from Valparaiso will play at Montverde (Florida) Academy as a senior.

Valparaiso Vikings were set up for a tournament run before defection of star guard, who has offers from IU and Purdue.

Filed under: Europe, North America, France, United Kingdom, United States

Continue reading London, Rome, Paris Top TripAdvisor's Most-Reviewed Cities List

London, Rome, Paris Top TripAdvisor's Most-Reviewed Cities List originally appeared on Gadling on Tue, 17 Dec 2013 14:11:00 EST. Please see our terms for use of feeds.

A bodyguard of Eastern Cape Social Development MEC Siphokazi Mani-Lusithi has been arrested with four others by the Green Scorpions for illegal hunting on a private farm outside East London, as well as for breaking Covid-19 lockdown regulations.

Invitation Only Research Event

Event participants

HE Professor Kwaku Danso-Boafo, High Commissioner for Ghana to the United Kingdom
Chair: Alex Vines OBE, Research Director, Area Studies and International Law; Head, Africa Programme, Chatham House

7 October 2014

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion of autophagy-related 5 (ATG5), results in accumulation of intracellular VEGFA, indicating that VEGFA is a basal autophagic substrate. Mechanistically, decorin increased the VEGFA clearance rate by augmenting autophagic flux, a process that required RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compartments. We validated these findings by demonstrating the physiological relevance of this process in vivo. Mice starved for 48 h exhibited a sharp decrease in overall cardiac and aortic VEGFA that could be blocked by systemic chloroquine treatment. Thus, our findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic clearance in response to decorin and canonical pro-autophagic stimuli. We posit that the VEGFR2/AMPK/PEG3 axis integrates the anti-angiogenic and pro-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression. These results support future therapeutic use of decorin as a next-generation protein therapy to combat cancer.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Endorepellin, the C-terminal fragment of the heparan sulfate proteoglycan perlecan, influences various signaling pathways in endothelial cells by binding to VEGFR2. In this study, we discovered that soluble endorepellin activates the canonical stress signaling pathway consisting of PERK, eIF2α, ATF4, and GADD45α. Specifically, endorepellin evoked transient activation of VEGFR2, which, in turn, phosphorylated PERK at Thr980. Subsequently, PERK phosphorylated eIF2α at Ser51, upregulating its downstream effector proteins ATF4 and GADD45α. RNAi-mediated knockdown of PERK or eIF2α abrogated the endorepellin-mediated up-regulation of GADD45α, the ultimate effector protein of this stress signaling cascade. To functionally validate these findings, we utilized an ex vivo model of angiogenesis. Exposure of the aortic rings embedded in 3D fibrillar collagen to recombinant endorepellin for 2–4 h activated PERK and induced GADD45α vis à vis vehicle-treated counterparts. Similar effects were obtained with the established cellular stress inducer tunicamycin. Notably, chronic exposure of aortic rings to endorepellin for 7–9 days markedly suppressed vessel sprouting, an angiostatic effect that was rescued by blocking PERK kinase activity. Our findings unravel a mechanism by which an extracellular matrix protein evokes stress signaling in endothelial cells, which leads to angiostasis.

A woman from a least-reached group of people accepted Christ during Discipleship Centre student outreach.

Sometimes it's not about handing out blankets, meals or having conversations, noticed OM worker Elizabeth when volunteering in the refugee ministry in Serbia.