A protein shredder that occurs in cell membranes of brain cells apparently also indirectly regulates the fat metabolism. The shredder, known as gamma-secretase, is considered a possible target for drugs against cancer and Alzheimer's disease. However, the results suggest that such agents may have long-range effects that need to be watched closely.

Investors pulled $16.2 billion from stocks in the past week in the largest weekly redemption since the March stock market slump, according to the Bank of America's weekly flows data.

Coronavirus: The symptoms

A sick child died after their mother was kept on hold by the NHS 111 helpline for more than an hour as she desperately sought medical help.

Read our live updates on coronavirus HERE Coronavirus: The symptoms

Follow our live coronavirus updates here Coronavirus: the symptoms

Follow our live coronavirus updates here

The teenage daughter of a man who was stabbed to death in the street issued an emotional plea today for justice on the first anniversary of his killing.

The death toll of coronavirus patients in UK hospitals has passed 15,000.

They want to 'bring a bit of colour' into people's lives amid the nationwide lockdown with balloon artwork

Mr White also took issue with the duchess's allegation that the publisher "acted dishonestly" when deciding which parts of her letter to her father to publish.

Detectives are hunting for an Asian-inspired Gucci messenger bag in connection with the fatal stabbing in south London.

This is the first picture of a father with a "heart of gold" who was fatally stabbed in the street near his home in south-west London.

A young NHS worker was stabbed to death in east London just days before his father's funeral.

The death toll linked to coronavirus in England is around 40 per cent higher than previously reported, new figures show.

Dominic Raab has paid tribute to the frontline health and care workers who have given their lives to fighting coronavirus, as he confirmed more than 108 such deaths so far.

A total of 26,097 people have died in hospitals, care homes and the wider community after testing positive for coronavirus, Public Health England has said.

The UK discovered the true toll of coronavirus deaths today when the Government unveils figures for fatalities in hospitals, care homes and the community .

The number of coronavirus deaths in the UK has increased by 674 – bringing the national total to 26,771.

Two teenagers have been charged with the murder of NHS worker David Gomoh in east London.

A father-of-two who spent 19 days in an induced coma in hospital has made an "incredible" recovery from coronavirus in time to celebrate his son's second birthday.

Singer Cher Lloyd has revealed her father is "seriously unwell" in hospital.​

The sister of a man whose body was found dumped in woodland launched an appeal today on the first anniversary of his disappearance to catch the "monsters" who killed him.

Two young children had their throats cut during an attack by their father at the family home in east London, an inquest has heard.

A four-year-old girl battling a rare form of leukaemia has been reunited with her dad after seven weeks apart in lockdown.

Boris Johnson's father has told how he broke Covid-19 lockdown rules to buy a newspaper after the Prime Minister's son was born.

A father has been charged with murdering his two young children who had their throats cut at the Ilford family home.

Pianist-singer behind “Tutti Frutti,” “Good Golly Miss Molly” and “Long Tall Sally” set the template that a generation of musicians would follow

The post Little Richard, Founding Father of Rock Who Broke Musical Barriers, Dead at 87 appeared first on My Site.

Imaging specialist produces clearest pictures yet from dramatic Nasa mission

From creamy gnudi to champagne macarons, the dishes at USA TODAY's Wine & Food Experience in Chicago didn't disappoint.

Britons marked the 75th anniversary of WWII victory with a speech by Queen Elizabeth II, the only British leader left who was there on May 8, 1945.

He announced that his partner Georgia Groome was pregnant in April.

This Friday, May 8 would've marked Ahmaud Arbery's 26th birthday. And though he's no longer with them, the Arbery family is finding comfort in the fact that Georgia state...

"To use that American expression, he almost took one for the team" Read our live coronavirus updates HERE

He has now been absent from the front line of the Government response for a month, after his three-week recovery period at the Chequers official residence in Buckinghamshire.

New TV drama charts story of infamous 2001 coughing scandal

Mad Men actor played along as Winnie Fallon showed him her new colouring book

It’s certainly a sometimes food – but if you already cook with animal fat, you’ll save money and prevent waste by rendering it yourself

Let’s talk about the four letter f-word: fats. Over the past 60 odd years they’ve been drenched in confusing controversy – to eat or not to eat, what kind should we eat, and according to who?

Animal fats have the worst reputation of all. I’m not here to argue the health facts – but please take the time to look at the research regarding what we replaced many old fashioned animal fats with, namely hydrogenated vegetable oils. Nutritionists suggest neither should play a major role in your diet – but many people who happily reach for margarine still flinch at lard.

The actor's father left the family home shortly after he was born

Fairfield Halls, London
In his show Taxi Tour, the comic from last year’s Britain’s Got Talent offers only standard-issue middle-aged standup

Kojo Anim was a star of the black standup circuit for years, but “Britain’s Got Talent changed my life,” he tells his Croydon crowd. The Londoner has booked his Taxi Tour off the back of an appearance in last year’s final, and recounts how that brush with fame – and his Christian faith, and new fatherhood – picked him back up after a grim period in his life. The emotional honesty is refreshing, but plays only a cameo role in an otherwise unadventurous show. Anim certainly does have talent, but – on this evidence – it’s for performing, not for writing distinctive material.

The show opens with a justification for appearing on BGT, and an account of his experience of overnight celebrity. But it soon devolves into standard issue middle-aged standup comparing his unglamorous childhood with that of today’s pampered youth. His parents play their expected role, giving their son broad accents to mimic when not walloping him for the slightest impertinence. “Only an African parent,” reports our host ruefully, “will beat their own child when they see another child doing something.”

Chris Hemsworth admits that being a father is his priority and means more to him than being a movie star.

Brighton owner Tony Bloom believes it would be unfathomable to relegate clubs from the Premier League if the season cannot be completed due to the coronavirus pandemic.

Manchester City defender Aymeric Laporte has purchased kit worn by late French boxer Alexis Vastine auction to raise money for French healthcare workers.

The father of Atletico Madrid midfielder Thomas Partey has confirmed that his son is in talks with Arsenal over a summer transfer.