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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article
Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
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567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious

What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery?




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Delhi enveloped in toxic haze, AQI in severe zone in some areas

Data from the CPCB's Sameer app, which provides hourly AQI updates, showed that out of the 38 monitoring stations, 13 were in the severe category with readings above 400




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Amazon is designed to spin like a flywheel: Brian Dumaine

In Bezonomics, the Fortune jounralist explains how Jeff Bezos has shrewdly changed the way business is done in today’s world




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Zomato’s losses widen in FY16




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Record profits: PNB Q2 consolidated net zooms 137% at ₹4,714 crore

On a standalone basis, PNB’s net profit for the quarter under review increased 145 per cent to ₹4,303 crore (₹1,756 crore)



  • Money & Banking

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Two Rajasthan youth who cheated Amazon delivery partner of ₹11.45 lakh in Mangaluru arrested




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Pilikula zoo gets new attractions in the form of Asiatic Lion, other animals and birds




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Vending zone to be functional from November 13




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Amazon launches its first free facility to impart technological skills to underserved students in Bengaluru

The Amazon Future Engineer Makerspace aims to empower students with hands-on learning in robotics, AI, and 3D printing




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CCI probe finds Zomato, Swiggy breached antitrust laws, documents show

The Competition Commission of India (CCI) investigation finds Zomato and Swiggy breached competition laws with exclusive deals favoring restaurant chains




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CCI probe: Zomato, Swiggy say committed to complying with competition law

Zomato and Swiggy termed news reports on the Competition Commission of India's (CCI) investigation "misleading", maintaining that the CCI is yet to pass its final order on the matter of unfair business practices, including alleged preferential treatment to some restaurant partners




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Visible-light heterogeneous photocatalysis with an ionic porous organic polymer (IPOP): synthesis of β-keto sulfoxides and benzothiophene diesters by tandem radical addition–oxidation reactions

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01382D, Research Article
Ajay Kumar Sahoo, Parag Tamuly, Jarugu Narasimha Moorthy
An IPOP, constructed constructed from cyanuric chloride and the readily accessible 2,5-di(pyridin-4-yl)thiazolo[5,4-d]thiazole (BpyTzTz), is shown to exhibit excellent visible light absorption and serve as a metal-free heterogeneous photocatalyst.
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Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives

Org. Chem. Front., 2024, 11,6319-6326
DOI: 10.1039/D4QO01368A, Research Article
Yu Lan, Peng Liu, Zekai Fang, Lili Shao, Qilong Cai, Xiaoming Wang
A variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.
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Recent advances in asymmetric synthesis of chiral benzoheterocycles via Earth-abundant metal catalysis

Org. Chem. Front., 2024, 11,6534-6557
DOI: 10.1039/D4QO01686F, Review Article
Jinhui Cai, Wenting Zhang, Usman Muhammad, Weishuang Li, Yanjun Xie
This review mainly focus on the assembly of chiral benzoheterocycles, such as dihydrobenzofurans, chromans, indolines, tetrahydroquinolines, etc., via Earth-abundant metal-catalyzed (Cu, Fe, Ni, and Ti) asymmetric synthesis in the last few decades.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enantioselective Addition of 3-hydroxyquinolin-2(1H)-one to Isatin and Pyrazole-4,5-dione Derived Ketimines

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01895H, Research Article
Yue Wei, Guishun Bai, Jiamin Wu, Yi Hua, Tao Zhang, Congyong Yue, Hong Wang, Xiaoze Bao
The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural products scaffolds in high yield with excellent enantioselectivities....
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Iridium-catalyzed asymmetric cascade allylation/lactonization of methyl salicylates: enantioselective construction of chiral benzodioxepinones

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01771D, Research Article
Bendu Pan, Yunru Wu, Yaqi Zhang, Xiaobo He, Long Jiang, Liqin Qiu
An efficient asymmetric cascade allylation/lactonization of methyl salicylates is achieved. The utilization of chiral-bridged biphenyl phosphoramidite ligand resulted in good results for the construction of a wide range of chiral benzodioxepinones.
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Palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids for the synthesis of fused isoquinolinones

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01573H, Research Article
Zhaolin Quan, Yubo Duan, Zhengkai Chen
A straightforward approach for the preparation of fused isoquinolinone derivatives via palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids is described.
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Transition-metal-free skeletal editing of benzoisothiazol-3-ones to 2,3-dihydrobenzothiazin-4-ones via single-carbon insertion

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01714E, Research Article
Ke Yang, Qin Li, Yanqi Luo, Dan Yuan, Chunjian Qi, Zhengyi Li, Bijin Li, Xiaoqiang Sun
Transition-metal-free ring expansion of benzoisothiazol-3-ones has been established to construct various 2,3-dihydrobenzothiazin-4-ones via single-carbon insertion.
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PIFA-Mediated cyclization of methyl(2-(1-phenylvinyl)phenyl)sulfane for the concise, flexible, and scalable de novo synthesis of C3-arylated benzo[b]thiophenes

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01589D, Research Article
Xinya Liu, Olivier Provot, Christine Tran, Jean-Francois Soule, Abdallah Hamze
The well-decorated arylated benzo[b]thiophene scaffold is a pivotal structural motif with diverse applications in medicinal chemistry. This paper outlines a de novo synthesis of C3-arylated benzo[b]thiophenes, showcasing its flexibility and...
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Design, synthesis, biological evaluation, and in silico studies of novel N-substituted-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamides as promising anticancer agents

RSC Adv., 2024, 14,35323-35335
DOI: 10.1039/D4RA04492D, Paper
Open Access
Navid Dastyafteh, Manica Negahdaripour, Mohammad Hosein Sayahi, Mina Emami, Younes Ghasemi, Elham Safaei, Homa Azizian, Zahra Pakrouh Jahromi, Mehdi Asadi, Mohammad Reza Mohajeri-Tehrani, Fateme Zare, Minoo Shahidi, Zahra Pooraskari, Sayed Mahmoud Sajjadi-Jazi, Bagher Larijani, Mohammad Mahdavi, Sara Ranjbar
Synthesis and cytotoxicity evaluation of novel benzimidazoles were explained. The most potent derivative was subjected to cell cycle, apoptosis, and in silico investigations. Compound 5o proved to be a promising anticancer agent.
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A mild and convenient protocol for the synthesis of quinoxalin-2(1H)-ones and benzimidazoles

RSC Adv., 2024, 14,35386-35390
DOI: 10.1039/D4RA06887D, Paper
Open Access
Zhenbiao Luo, Mingyuan Wang, Guidong Jiang, Xinye Wang, Liang Zhao, Zhihui Hu, Honghe Li, Qing Ji
We present a mild and simple method for the cyclization of N-protected o-phenylenediamines with carbonyl compounds in the presence of trifluoroacetic acid.
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N-doped carbon quantum dots for the selective detection of OCl− ions, bioimaging, and the production of Fe3O4 nanoparticles utilized in the synthesis of substituted imidazole

RSC Adv., 2024, 14,35448-35459
DOI: 10.1039/D4RA06474G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Namrata Priyadarshini Hota, Sathiyanarayanan Kulathu Iyer
Nitrogen-doped quantum dots (NCQD) were synthesized by solvothermal means using o-phenylenediamine and L-tartaric acid.
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Design, synthesis, and evaluation of novel thiadiazole derivatives as potent VEGFR-2 inhibitors: a comprehensive in vitro and in silico study

RSC Adv., 2024, 14,35505-35519
DOI: 10.1039/D4RA04158E, Paper
Open Access
Ibrahim H. Eissa, Walid E. Elgammal, Hazem A. Mahdy, Susi Zara, Simone Carradori, Dalal Z. Husein, Maymounah N. Alharthi, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Hazem Elkady, Ahmed M. Metwaly
This study aims to investigate the potential of designed 2,3-dihydro-1,3,4-thiadiazole derivatives as anti-proliferative agents targeting VEGFR-2, utilizing a multidimensional approach combining in vitro and in silico analyses.
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Design, synthesis, and in vitro and in vivo biological evaluation of triazolopyrimidine hybrids as multitarget directed anticancer agents

RSC Adv., 2024, 14,35239-35254
DOI: 10.1039/D4RA06704E, Paper
Open Access
Heba A. Adawy, Samar S. Tawfik, Abdullah A. Elgazar, Khalid B. Selim, Fatma E. Goda
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.
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Reaction of unsymmetrical α-bromo-1,3-diketones with N-substituted thioureas: regioselective access to 2-(N-arylamino)-5-acyl-4-methylthiazoles and/or rearranged 2-(N-acylimino)-3-N-aryl-4-methylthiazoles

RSC Adv., 2024, 14,35585-35600
DOI: 10.1039/D4RA05436A, Paper
Open Access
Ranjana Aggarwal, Shilpa Sharma, Naman Jain, Dionisia Sanz, Rosa M. Claramunt, Patricia Delgado, M. Carmen Torralba
Hantzsch's [3 + 2] cyclic condensation of α-bromo-1,3-diketones with N-substituted thioureas.
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Zeolitic imidazolate framework-67 in chitosan-grafted hydrogel as an effective catalyst for peroxymonosulfate activation to degrade antibiotics and dyes

RSC Adv., 2024, 14,35628-35637
DOI: 10.1039/D4RA06537A, Paper
Open Access
Atipong Nachaichot, Kunlarat Phonlakan, Supinya Nijpanich, Soraya Pornsuwan, Surangkhana Budsombat
Zeolitic imidazolate framework-67 (ZIF-67) was synthesized in situ in the hydrogel of chitosan-grafted poly(acrylic acid) (chitosan-g-PAA) to activate peroxymonosulfate (PMS) and degrade tetracycline (TC).
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Piezoresistivity and strain-sensing behaviour of poly(butylene adipate-co-terephthalate)/multiwalled carbon nanotube nanocomposites

RSC Adv., 2024, 14,35715-35726
DOI: 10.1039/D4RA04826A, Paper
Open Access
Kedar Nath Dhakal, Ralf Lach, Wolfgang Grellmann, Beate Krause, Jürgen Pionteck, Rameshwar Adhikari
The interconnectedness of the exfoliated multi-walled carbon nanotubes well dispersed in the PBAT matrix (TEM image; left) leads to strain-sensing properties at lower strains as illustrated by the variation of ΔR/R0 as a function of mechanical strain with time (right).
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Synthesis of Cu/Mn/Ce polymetallic oxide catalysts and catalytic ozone treatment of wastewater

RSC Adv., 2024, 14,35993-36004
DOI: 10.1039/D4RA06052K, Paper
Open Access
Jinlong Zhong, Xue feng Mao, Guanyu Wang, Heng Li, Junfang Li, Sijian Qu, Jianwei Zhao
Non-homogeneous ozone-catalyzed oxidation technology is one of the effective ways of treating wastewater, the core of which lies in the development of efficient ozone oxidation catalysts.
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Complexes between 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) and cucurbit[n]uril hosts modulate the yield and fate of photolytically-generated AAPH radicals

RSC Adv., 2024, 14,35980-35991
DOI: 10.1039/D4RA07150F, Paper
Open Access
Angie C. Forero-Girón, Mauricio Oyarzún, Kevin Droguett, Denis Fuentealba, Soledad Gutiérrez-Oliva, Barbara Herrera, Alejandro Toro-Labbé, Eduardo Fuentes-Lemus, Michael J. Davies, Camilo López-Alarcón, Margarita E. Aliaga
AAPH-cucurbit[n]uril systems were experimentally and theoretically studied. Radical yields formed upon photolysis of AAPH were altered by complexation with CB[8] in a stoichiometry-dependent manner, however, radical yields were not changed by CB[6].
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Gujarat HC asks why illegal building in Rajkot game zone was not demolished for a year

‘Demolition order proves that officials knew the structure was illegal,’ the Chief Justice said




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Can Brazil save the Amazon rainforest? Marina Silva is trying

‘The challenge of being the leader of COP30 next year, in the heart of the Amazon forest, is huge,’ said Marina Silva, Brazil’s environment minister and top climate diplomat, at an event recently




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Amazon No Smiles

This is going to be a chronological report of Amazon's latest, and so far most incompetent, assault on small publishers and self-published authors: Friday Saturday Sunday Hello from Amazon Selling Partner Support, I realize the importance this has for you and your business. I know this has an impact on your business, and I

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Rhenium(I) and technetium(I) complexes with megazol derivatives: towards the development of a theranostic platform for Chagas disease

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02714K, Paper
Ana Cristina Resende Gonçalves, Silvia Helena Libardi, Júlio Cesar Borges, Ronaldo Junio de Oliveira, Carla Gotzmann, Olivier Blacque, Sergio Albuquerque, Carla Duque Lopes, Roger Alberto, Pedro Ivo da Silva Maia
The diagnosis and treatment of Chagas disease (CD) in the chronic phase remains a challenge. With that in mind, a potential theranostic device based on the trypanocidal agent known as...
The content of this RSS Feed (c) The Royal Society of Chemistry




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An octanuclear 3-phenyl-5-(2-pyridyl)pyrazolate/phenylsilsesquioxane complex: synthesis, unique structure, and catalytic activity

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02690J, Communication
Alexey Bilyachenko, Victor N Khrustalev, Zhibin Huang, Lidia S. Shul'pina, Pavel Dorovatovskii, Elena Shubina, Nikolay S. Ikonnikov, Nikolai N. Lobanov, Karim G. Rahimov, Di Sun
First metallasilsesquioxane bearing pyrazolylpyridine ligands, Cu8-based complex 1, adopts cage structure with two zigzag-like copper tetramers sandwiched by two cyclic Si5 silsesquioxane ligands. Four 3-phenyl-5-(2-pyridyl)pyrazolate ligands in 1 exhibit dual...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Heteroleptic mononuclear Cu(I) halide complexes containing carbazolyl substituted phenyl diphosphine and monophosphine: structures and photophysical and electroluminescent properties

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02469A, Paper
Zhun Chen, Wei Xu, Ruiqin Zhu, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Guijiang Zhou, Hai-Mei Qin
Heteroleptic mononuclear Cu(I) halide complex 4 containing carbazolyl groups in diphosphine and monophosphine shows high PLQY (0.75) and a short decay lifetime (1.9 μs) with a high kr value of 3.95 × 105 s−1.
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Hydrate of neutral iron(III) complex based on pyruvic acid thiosemicarbazone ligand with abrupt spin-crossover with T1/2=340 K and wide hysteresis loop of 45 K

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02901A, Paper
Maxim Andreevich Blagov, Alexander V. Akimov, Anatoly S Lobach, Leokadiya Zorina, Sergey Simonov, Konstantin Zakharov, Alexander Vasiliev, Natalia Spitsyna
The hydrate of neutral iron(III) complex based on pyruvic acid thiosemicarbazone ligand [FeIII(Hthpy)(thpy)]·H2O (1) was synthesized and characterized using FT-IR spectroscopy, powder and single-crystal X-ray diffraction, dc magnetic measurements, EPR...
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Effect of mono- and dinuclear thiosemicarbazone platinacycles in the proliferation of a colorectal carcinoma cell line

Dalton Trans., 2024, 53,17803-17818
DOI: 10.1039/D4DT01490A, Paper
Open Access
Francisco Reigosa-Chamorro, Sandra Cordeiro, M. Teresa Pereira, Beatriz Filipe, Pedro V. Baptista, Alexandra R. Fernandes, José M. Vila
The study of the antiproliferative activity of thiosemicarbazone platinacycles puts forward their high selectivity and low IC50 values.
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Tunability of triplet excited states and photophysical behaviour of bis-cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline

Dalton Trans., 2024, 53,17934-17947
DOI: 10.1039/D4DT01996B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarzyna Choroba, Joanna Palion-Gazda, Mateusz Penkala, Patrycja Rawicka, Barbara Machura
The impact of cyclometalating ligands on the photophysical behaviour of heteroleptic Ir(III) complexes with imidazo[4,5-f][1,10]phenanthroline. [Ir(ppy)2(imphen)]+ is a 3MLLCT emitter, while [Ir(pybzth)2(imphen)]+ has a predominant 3LCN∩C character.
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Reactions of a geminal Sc/P Lewis pair with pyridotetrazole and beyond

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02838D, Paper
Yiwen Guan, Xian Xu, Xin Xu
An FLP pyridyl nitrene adduct was isolated from the denitrogenative reaction of the Sc/P complex with pyridotetrazole. FLP reactivity of the Sc/P complex with many small molecules were investigated with the generation of metallacyclic complexes.
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The neuroscience of psychotherapy [electronic resource] : healing the social brain / Louis J. Cozolino

[New York] : W. W. Norton & Company, Incorporated, 2024.




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Carbon quantum dot (CQD)-dithizone-based thin-film chemical sensors for the specific detection of lead ions in water resources

Environ. Sci.: Water Res. Technol., 2024, 10,2858-2868
DOI: 10.1039/D4EW00452C, Paper
Tanmay Vyas, Hritik Kumar, Sandeep Choudhary, Abhijeet Joshi
Dithizone-CQD-based thin-film chemical sensors for the detection of lead ions in various water resources.
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Microwave irradiation synthesis of CoFe2O4/rGO to activate peroxymonosulfate for the degradation of 2-aminobenzothiazole in water

Environ. Sci.: Water Res. Technol., 2024, 10,2946-2960
DOI: 10.1039/D4EW00459K, Paper
Wei Wei, Shiqian Gao, Feiyue Qian, Chongjun Chen, Youyi Wu
CoFe2O4/rGO MNPs synthesized via an in situ microwave irradiation method were used as a heterogeneous catalyst to activate PMS for the degradation of ABT. Its mechanism was explored, and the catalytic system was applied to real water samples.
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Improved microbial water quality and ozone performance following coagulation: implications for carbon based advanced treatment for potable reuse

Environ. Sci.: Water Res. Technol., 2024, Advance Article
DOI: 10.1039/D4EW00638K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Christina M. Morrison, Ariel J. Atkinson, Daniel Gerrity, Eric C. Wert
Coagulation/flocculation of secondary effluent with FeCl3 (1) removed MS2 bacteriophage and bacterial endospores up to 2–3 LRVs, (2) removed rapid surrogates at levels correlative with microbial removal, and (3) improved downstream O3 performance.
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Simultaneous removal of acetaminophen, sulfamethoxazole, and iohexol from real wastewater in continuous mode by an immobilized sulfur-doped Bi2O3/MnO2 photocatalyst

Environ. Sci.: Water Res. Technol., 2024, Advance Article
DOI: 10.1039/D4EW00501E, Paper
Vishal Kumar Parida, Mario Vino Lincy Gnanaguru, Suneel Kumar Srivastava, Shamik Chowdhury, Ashok Kumar Gupta
The photocatalytic potential of the Z-scheme 2S-Bi2O3/MnO2 immobilized photocatalyst for the simultaneous degradation of ACT, SMX, and IOX from MBBR-sand filter treated wastewater is studied for the first time, purely from a practical perspective.
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Zomato, Swiggy hike platform fee in certain cities amid festive season




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Nara Lokesh meets Amazon Web Services MD Rachel Skaff and Indra Nooyi, among others, in Las Vegas

Nara Lokesh seeks investments from Amazon Web Services and Salesforce for AI and technology development in Andhra Pradesh




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ED raids offices of sellers using Amazon, Flipkart platforms in FEMA probe

Amazon and Flipkart have for years faced allegations from Indian brick-and-mortar retailers that they violate foreign investment rules by working with select preferred sellers