England : London County Council, Public Assistance Department, 1935.

Berkeley, California : Tabor Sarah Books, 1988.

The Pac-12 Student-Athlete Advisory Committee voted to award the Oregon State women’s basketball team with the Pac-12 Sportsmanship Award for the 2019-20 season, honoring their character and sportsmanship before a rivalry game against Oregon in Jan. 2020 -- the day Kobe Bryant, his daughter, Gigi, and seven others passed away in a helicopter crash in Southern California. In the above video, Aleah Goodman and Madison Washington share how the teams came together as one in a circle of prayer before the game.

Nancy Heckman

Source: Statist. Surv., Volume 6, 113--141.

Abstract:
The popular cubic smoothing spline estimate of a regression function arises as the minimizer of the penalized sum of squares $sum_{j}(Y_{j}-mu(t_{j}))^{2}+lambda int_{a}^{b}[mu''(t)]^{2},dt$, where the data are $t_{j},Y_{j}$, $j=1,ldots,n$. The minimization is taken over an infinite-dimensional function space, the space of all functions with square integrable second derivatives. But the calculations can be carried out in a finite-dimensional space. The reduction from minimizing over an infinite dimensional space to minimizing over a finite dimensional space occurs for more general objective functions: the data may be related to the function $mu$ in another way, the sum of squares may be replaced by a more suitable expression, or the penalty, $int_{a}^{b}[mu''(t)]^{2},dt$, might take a different form. This paper reviews the Reproducing Kernel Hilbert Space structure that provides a finite-dimensional solution for a general minimization problem. Particular attention is paid to the construction and study of the Reproducing Kernel Hilbert Space corresponding to a penalty based on a linear differential operator. In this case, one can often calculate the minimizer explicitly, using Green’s functions.

Like conventional criminals, criminal hackers choose easy, lucrative targets. One group in the crosshairs is made up of companies that have data on millions of users, such as private sector entities with a Web presence. Why go after one user at a time when data is collected in one place? Criminal hackers also like to hunt small organizations that have modest capital but weak information security.

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Learn how Kirby Downey, a user creator in our community, made a red lightsaber from scratch in honor of the latest Star Wars movie, "The Rise of Skywalker" - designing all the components in SOLIDWORKS before making it come to life!

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The post Kirby Made His Own “Star Wars: The Rise of Skywalker” Lightsaber appeared first on SOLIDWORKS Tech Blog.

CNA Staff, May 9, 2020 / 06:01 am (CNA).- Pakistan’s government has declined to include the Ahmadi religious group in its National Commission for Minorities, drawing attention to the group whose Muslim self-identification is rejected by many Muslims.

In a note seen by Reuters, Pakistan’s Ministry of Religious Affairs said Ahmadis should not be included in the commission “given the religious and historical sensitivity of the issue.” Pakistan’s constitution does not recognize the Ahmadis as Muslim.

However, Ahmadis consider themselves part of Islam. The movement was founded in 1889 in British-ruled India. They consider their founder Mirza Ghulam Ahmad a “subordinate prophet.” Other Muslims see this as a violation of the tenet that Muhammad was the last prophet.

There are about 500,000 Ahmadis in Pakistan and up to 20 million adherents worldwide. Some observers estimate the Ahmadi population in Pakistan is higher, but persecution encourages Ahmadis to hide their identity.

Pakistan’s religious freedom record has been a matter of international concern.

The 2020 report of the U.S. Commission on International Religious Freedom has said Ahmadis continue to face “severe persecution from authorities as well as societal harassment due to their beliefs.”

Both government authorities and mobs target their places of worship. In October 2019, the report said, police in Punjab partially demolished a 70-year-old Ahmadiyya mosque.

Pakistan’s National Commission for Minorities gives some status, voice, and protections to minorities in a country where over 90% of people identify as Muslim.

A Hindu has been nominated to chair the minorities commission, whose members include representatives of Christian, Kalash, Sikh, and Zoroastrian communities. Government officials and the head of Pakistan’s Council of Islamic Ideology also have commission seats.

State Minister for Parliamentary Affairs Ali Muhammad Khan, a vocal opponent of including the Ahmadis on the commission, has referred to them as agents of chaos.

“If they want to avail constitutional rights they must accept the constitution first,” he told Reuters. “The Pakistani constitution considers them non-Muslims.”

Usman Ahmad, an Ahmadi representative, told Reuters it is a “complete myth” that they did not accept the constitution. He added that many people disagree with parts of the constitution but still have rights under it.   

He said his community is used to exclusion and has never accepted classification as non-Muslim.

“We’ve never joined such commissions that require us to accept our non-Muslim status,” he said.

Minister of Information Shibli Faraz has said the rights of all people were fully respected in the handling of the commission.

“Every country has the sovereign right to make judgments according to its ground realities,” he told Reuters.

Khan, the Minister for Parliamentary Affairs, had posted to Twitter, then deleted, a comment “There is only one punishment for insulting the Prophet - chopping off the head.” He said he believed in “legal procedures and court proceedings” for those accused of blasphemy. Twitter told him to delete the post, Reuters reports.

Pakistan’s blasphemy laws impose strict punishment on those who desecrate the Quran or who defame or insult Muhammad. Although the government has never executed a person under the blasphemy laws, accusations alone have inspired mob and vigilante violence.

The laws, introduced in the 1980s, are reportedly used to settle scores or to persecute religious minorities. While non-Muslims constitute only 3 percent of the Pakistani population, 14 percent of blasphemy cases have been levied against them.

Many of those accused of blasphemy are murdered, and advocates of changing the law are also targeted by violence.

The Governor of Punjab Salman Taseer was one such critic of the law who was assassinated in January 2011.

Just months later, in March 2011, Shahbaz Bhatti, the first Federal Minister For Minorities Affairs and the only Christian in Pakistan’s cabinet, was assassinated by extremists who characterized him as a blasphemer. Bhatti had criticized the law and defended Asia Bibi, a Catholic woman sentenced to death by hanging in 2010 for blasphemy.

Bibi spent nine years on death row, but left Pakistan for Canada in 2019 at the age of 53 after her death sentence was overturned in October 2018.

The verdict and her subsequent release from prison sparked protests from Islamic hardliners who support strong blasphemy laws.

In Punjab last year, a mob attacked a Christian community after a mosque broadcast over loudspeaker a claim that the Christians had insulted Islam. In another incident in Karachi, false blasphemy accusations against four Christian women prompted mob violence that forced nearly 200 Christian families to flee their homes, the U.S. Commission on International Religious Freedom said.

The situation in Pakistan has attention from some prominent Catholics.

In a Jan. 21, 2020 letter written on behalf of Philadelphia’s Pakistani Catholic community, then-Archbishop of Philadelphia Charles J. Chaput encouraged Pakistan’s Prime Minister Imran Khan to shape a culture of religious freedom

The U.S. Commission on International Religious Freedom’s latest annual report said religious freedom conditions in Pakistan continued to deteriorate last year, citing “The systematic enforcement of blasphemy and anti-Ahmadiyya laws, and authorities’ failure to address forced conversions of religious minorities—including Hindus, Christians, and Sikhs—to Islam.”

The bipartisan federal commission advises the U.S. government on policy. Its report recommended that the U.S. government name Pakistan a country of particular concern for “systematic, ongoing, and egregious violations of religious freedom.”

In December 2018, for the first time, the U.S. State Department designated Pakistan a “Country of Particular Concern.” The designation, which can trigger sanctions under U.S. law, had been recommended by the U.S. Commission for International Religious Freedom in 2017 and 2018.

The latest commission report recommended that Pakistan be re-designated a “Country of Particular Concern,” given “systematic, ongoing, and egregious violations of religious freedom.”

The OM Madagascar team mobilises the Malagasy church for prayer through radio programmes and SMS messages.

Madagascar’s ongoing crisis continues to defy definition. Some call Andry Rajoelina’s taking power in March 2009 a popular uprising. Others say this was a military-supported coup, pure and simple. The legitimacy of the new regime remains in question both internally and externally, and peace agreements mediated by the international community lie in tatters.

While the reality and extent of the coup announced yesterday by military officers is still uncertain, the latest events demonstrate the fragility of the situation in Madagascar and the urgent need for a new international strategy to end the long crisis. Negotiations should now focus on international support to the electoral process based on strict conditions.

A l’approche de la décision de la SADC, il est important qu’elle porte toute son attention sur les mesures qui permettent de garantir l’équité de traitement entre les protagonistes. Sans modifier le texte de la feuille de route, les autorités ont la possibilité de prouver leur volonté de garantir la neutralité du processus, afin que l’opposition soit libre de faire le choix d’entrer ou non dans cette transition sur une base équilibrée. Le rejet des autorités de ces mesures exposerait leur absence de volonté de voir se dérouler une transition et des élections crédibles. Il démontrerait également leur choix de plonger le pays dans l’instabilité plutôt que d’accepter des mesures qui renforcent la transition. Le refus de l’opposition d’adhérer au processus ne pourrait plus être justifié par un déséquilibre de la solution proposée.

During the last few months, new options for resolving the Madagascar crisis have emerged in the form of the most recent roadmap proposed by the mediation team of the Southern African Development Community (SADC). Accepted by the authorities and rejected by elements of the opposition, the roadmap remains the subject of debate and there is still no agreement on how to achieve a peaceful transition. In a few weeks from now, the SADC is due to make a statement on the document and accept, reject or amend it. There are other options for changing the course of events without changing the roadmap and these should be explored as quickly as possible.

Madagascar, one of the world’s poorest countries, has been mired in political crisis, since 2009, when 34-year-old former radio disc jockey Andry Rajoelina toppled President Marc Ravalomanana in a military coup d’état.

Madagascar’s recent elections marked an ostensible return to democracy, but unless the new government works hard to implement meaningful political, economic and social reforms, the prospect of further crisis is just a matter of time.

CNA Staff, May 9, 2020 / 06:01 am (CNA).- Pakistan’s government has declined to include the Ahmadi religious group in its National Commission for Minorities, drawing attention to the group whose Muslim self-identification is rejected by many Muslims.

In a note seen by Reuters, Pakistan’s Ministry of Religious Affairs said Ahmadis should not be included in the commission “given the religious and historical sensitivity of the issue.” Pakistan’s constitution does not recognize the Ahmadis as Muslim.

However, Ahmadis consider themselves part of Islam. The movement was founded in 1889 in British-ruled India. They consider their founder Mirza Ghulam Ahmad a “subordinate prophet.” Other Muslims see this as a violation of the tenet that Muhammad was the last prophet.

There are about 500,000 Ahmadis in Pakistan and up to 20 million adherents worldwide. Some observers estimate the Ahmadi population in Pakistan is higher, but persecution encourages Ahmadis to hide their identity.

Pakistan’s religious freedom record has been a matter of international concern.

The 2020 report of the U.S. Commission on International Religious Freedom has said Ahmadis continue to face “severe persecution from authorities as well as societal harassment due to their beliefs.”

Both government authorities and mobs target their places of worship. In October 2019, the report said, police in Punjab partially demolished a 70-year-old Ahmadiyya mosque.

Pakistan’s National Commission for Minorities gives some status, voice, and protections to minorities in a country where over 90% of people identify as Muslim.

A Hindu has been nominated to chair the minorities commission, whose members include representatives of Christian, Kalash, Sikh, and Zoroastrian communities. Government officials and the head of Pakistan’s Council of Islamic Ideology also have commission seats.

State Minister for Parliamentary Affairs Ali Muhammad Khan, a vocal opponent of including the Ahmadis on the commission, has referred to them as agents of chaos.

“If they want to avail constitutional rights they must accept the constitution first,” he told Reuters. “The Pakistani constitution considers them non-Muslims.”

Usman Ahmad, an Ahmadi representative, told Reuters it is a “complete myth” that they did not accept the constitution. He added that many people disagree with parts of the constitution but still have rights under it.   

He said his community is used to exclusion and has never accepted classification as non-Muslim.

“We’ve never joined such commissions that require us to accept our non-Muslim status,” he said.

Minister of Information Shibli Faraz has said the rights of all people were fully respected in the handling of the commission.

“Every country has the sovereign right to make judgments according to its ground realities,” he told Reuters.

Khan, the Minister for Parliamentary Affairs, had posted to Twitter, then deleted, a comment “There is only one punishment for insulting the Prophet - chopping off the head.” He said he believed in “legal procedures and court proceedings” for those accused of blasphemy. Twitter told him to delete the post, Reuters reports.

Pakistan’s blasphemy laws impose strict punishment on those who desecrate the Quran or who defame or insult Muhammad. Although the government has never executed a person under the blasphemy laws, accusations alone have inspired mob and vigilante violence.

The laws, introduced in the 1980s, are reportedly used to settle scores or to persecute religious minorities. While non-Muslims constitute only 3 percent of the Pakistani population, 14 percent of blasphemy cases have been levied against them.

Many of those accused of blasphemy are murdered, and advocates of changing the law are also targeted by violence.

The Governor of Punjab Salman Taseer was one such critic of the law who was assassinated in January 2011.

Just months later, in March 2011, Shahbaz Bhatti, the first Federal Minister For Minorities Affairs and the only Christian in Pakistan’s cabinet, was assassinated by extremists who characterized him as a blasphemer. Bhatti had criticized the law and defended Asia Bibi, a Catholic woman sentenced to death by hanging in 2010 for blasphemy.

Bibi spent nine years on death row, but left Pakistan for Canada in 2019 at the age of 53 after her death sentence was overturned in October 2018.

The verdict and her subsequent release from prison sparked protests from Islamic hardliners who support strong blasphemy laws.

In Punjab last year, a mob attacked a Christian community after a mosque broadcast over loudspeaker a claim that the Christians had insulted Islam. In another incident in Karachi, false blasphemy accusations against four Christian women prompted mob violence that forced nearly 200 Christian families to flee their homes, the U.S. Commission on International Religious Freedom said.

The situation in Pakistan has attention from some prominent Catholics.

In a Jan. 21, 2020 letter written on behalf of Philadelphia’s Pakistani Catholic community, then-Archbishop of Philadelphia Charles J. Chaput encouraged Pakistan’s Prime Minister Imran Khan to shape a culture of religious freedom

The U.S. Commission on International Religious Freedom’s latest annual report said religious freedom conditions in Pakistan continued to deteriorate last year, citing “The systematic enforcement of blasphemy and anti-Ahmadiyya laws, and authorities’ failure to address forced conversions of religious minorities—including Hindus, Christians, and Sikhs—to Islam.”

The bipartisan federal commission advises the U.S. government on policy. Its report recommended that the U.S. government name Pakistan a country of particular concern for “systematic, ongoing, and egregious violations of religious freedom.”

In December 2018, for the first time, the U.S. State Department designated Pakistan a “Country of Particular Concern.” The designation, which can trigger sanctions under U.S. law, had been recommended by the U.S. Commission for International Religious Freedom in 2017 and 2018.

The latest commission report recommended that Pakistan be re-designated a “Country of Particular Concern,” given “systematic, ongoing, and egregious violations of religious freedom.”

For Irish teens Nicole and Saoirse, interacting with their church’s Immersion student, Bree, led to an understanding of the gospel.

ANDY MURRAY will swap a tennis racket for a games controller when he takes part in a virtual Madrid Open later this month.

Big Zuu is headed back out on tour - but not as we know it.

It is a tiny spit of land that lies in the Firth of Clyde two miles off the coast of Troon where colonies of seabirds have made their homes for centuries.

The UEFA Regions' Cup finals draw was held during half-time of Bayern v Liverpool.

Movies are barely earning money compared to the games people don't even have to pay for up front—because in-app purchases are making bank.

For OMers working in Angola, the key to successful ministry has been time investing in relationships.

Omadacycline is a novel aminomethylcycline with activity against Gram-positive and -negative organisms, including Haemophilus influenzae, which is one of the leading causes of community-acquired bacterial pneumonia (CABP). The evaluation of antimicrobial agents against H. influenzae using standard murine infection models is challenging due to the low pathogenicity of this species in mice. Therefore, 24-hour dose-ranging studies using a one-compartment in vitro infection model were undertaken with the goal of characterizing the magnitude of the ratio of the area under the concentration-time curve (AUC) to the MIC (AUC/MIC ratio) associated with efficacy for a panel of five clinical H. influenzae isolates. These five isolates, which had MIC values of 1 or 2 mg/L, were exposed to omadacycline total-drug epithelial lining fluid (ELF) concentration-time profiles based on those observed in healthy volunteers following intravenous omadacycline administration. Relationships between change in log₁₀ colony forming units (CFU) from baseline at 24 hours and total-drug ELF AUC/MIC ratio for each isolate and the isolates pooled together were evaluated using Hill-type models and non-linear least squares regression. As evidenced by the high coefficient of determination (r²) of 0.88 to 0.98, total-drug ELF AUC/MIC ratio described the data well for each isolate and the isolates pooled together. The median total-drug ELF AUC/MIC ratio associated with net bacterial stasis and 1- and 2-log₁₀ CFU/mL reductions from baseline at 24 hours was 6.91, 8.91, and 11.1, respectively. These data were useful to support the omadacycline dosing regimens selected for the treatment of patients with CABP, as well as susceptibility breakpoints for H. influenzae.

Omadacycline, a novel aminomethylcycline antibiotic with activity against Gram-positive and -negative organisms, including tetracycline-resistant pathogens, received FDA approval in October, 2018 for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). A previously-developed population pharmacokinetic (PK) model based on Phase 1 intravenous and oral PK data was refined using data from infected patients. Data from 10 Phase 1 studies used to develop the previous model were pooled with data from three additional Phase 1 studies, a Phase 1b uncomplicated urinary tract infection study, one Phase 3 CABP study, and two Phase 3 ABSSSI studies. The final population PK model was a three-compartment model with first-order absorption using transit compartments to account for absorption delay following oral dosing and first-order elimination. Epithelial lining fluid (ELF) concentrations were modeled as a sub-compartment of the first peripheral compartment. A food effect on oral bioavailability was included in the model. Sex was the only significant covariate identified, with 15.6% lower clearance for females relative to males. Goodness-of-fit diagnostics indicated a precise and unbiased fit to the data. The final model, which was robust in its ability to predict plasma and ELF exposures following omadacycline administration, was also able to predict the central tendency and variability in concentration-time profiles using an external Phase 3 ABSSSI dataset. A population PK model, which described omadacycline PK in healthy subjects and infected patients, was developed and subsequently used to support pharmacokinetic-pharmacodynamic (PK-PD) and PK-PD target attainment assessments.

A first-leg comeback has put Manchester City in the driving seat as Real Madrid travel to north-west England facing a 2-1 deficit.

The Czech Republic meet Serbia, France play Croatia, Romania take on Georgia and Hungary are up against Poland in September's UEFA Futsal EURO 2018 play-offs.

Hosts Slovenia have been handed a tough group with Italy and Serbia while France's debut finals match will be against holders Spain after the draw was made in Ljubljana.

The 2018/19 UEFA European Under-19 Championship qualifying round draw has been made in Nyon, starting the road to the July 2019 finals in Armenia.