Hear about travel to Madagascar as the Amateur Traveler talks to Corinne Vale from reflectionsenroute.com about her travel to this island nation off southern Africa.

Ahmad Chalabi helped lead the U.S. into war in Iraq, but if he ever had regrets about his role in the invasion, and the years of violence it unleashed, "he never voiced them to me," writes FRONTLINE correspondent Martin Smith.

The DML News App offers the best in news reporting.

The post VIDEO: GOP senator says China made ‘conscious decision’ to allow COVID-19 to spread beyond border appeared first on Dennis Michael Lynch.

After being pulled over for what started as a traffic violation, two Windsor men were arrested and face multiple drug, property, and weapon related charges.

US Secretary of State John Kerry and Iranian Minister of Foreign Affairs Dr Mohammad Javad Zarif have been voted as the winners of this year’s Chatham House Prize.

(University of Queensland) Logging of native forests increases the risk and severity of fire and likely had a profound effect on the recent, catastrophic Australian bushfires, according to new research.In the wake of the country's worst forest fires in recorded history, University of Queensland researchers have been part of an international collaboration, investigating Australia's historical and contemporary land-use.

(Stony Brook University) In evolutionary terms, islands are the stuff of weirdness. It is on islands where animals evolve in isolation, often for millions of years, with different food sources, competitors, predators, and parasites...indeed, different everything compared to mainland species. As a result, they develop into different shapes and sizes and evolve into new species that, given enough time, spawn yet more new species.

(Texas A&M University) Spoiling foods, souring wine and worsening wounds have a common culprit -- a process called oxidation. Although the ill effects of these chemical reactions can be curtailed by antioxidants, creating a sturdy platform capable of providing prolonged antioxidant activity is an ongoing challenge.

Marriage vows are one thing, but the public service Code of Conduct, that's serious.

Active maintenance of β-cell identity through fine-tuned regulation of key transcription factors ensures β-cell function. Tacrolimus, a widely used immunosuppressant, accelerates onset of diabetes after organ transplantation, but underlying molecular mechanisms are unclear. Here we show that tacrolimus induces loss of human β-cell maturity and β-cell failure through activation of the BMP/SMAD signaling pathway when administered under mild metabolic stress conditions. Tacrolimus-induced phosphorylated SMAD1/5 acts in synergy with metabolic stress–activated FOXO1 through formation of a complex. This interaction is associated with reduced expression of the key β-cell transcription factor MAFA and abolished insulin secretion, both in vitro in primary human islets and in vivo in human islets transplanted into high-fat diet–fed mice. Pharmacological inhibition of BMP signaling protects human β-cells from tacrolimus-induced β-cell dysfunction in vitro. Furthermore, we confirm that BMP/SMAD signaling is activated in protocol pancreas allograft biopsies from recipients on tacrolimus. To conclude, we propose a novel mechanism underlying the diabetogenicity of tacrolimus in primary human β-cells. This insight could lead to new treatment strategies for new-onset diabetes and may have implications for other forms of diabetes.

Welcome back to Talk Evidence - where Helen Macdonald and Carl Heneghan take you through what's happening in the world of Evidence. This month we'll be discussing tramadol being prescripted postoperatively, and a new EBM verdict says that should change(1.36). How much preventable harm does healthcare causes (11.20. A canadian project to help...

A South Carolina man had extra trouble convincing his wife that his $250,000 lottery win was legitimate due to her memories of a past prank.

Europe's refugee resettlement capacity has grown dramatically, with resettlement places more than doubling since 2014, even as European countries have become an emerging center for innovation. As Europe accounts for a rising share of resettlement worldwide, will European policymakers claim a leadership role in shaping the global resettlement agenda or fall into this position by default?

Circulating levels of perfluorodecanoic acid, a type of perfluoroalkyl acid, may be associated with dental caries in children, according to a study published in the fall 2019 issue of the Journal of Public Health Dentistry.

This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Neil Perry. Neil's new book is "Spice Temple."

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Tez Kemp, La Madre Bakery

Kathy Tsaples, author of Sweet Greek Life, shared this recipe on Foodie Tuesday, a weekly segment on ABC Radio Melbourne's Drive program at 3.30pm.

Kathy Tsaple, author of Sweet Greek Life, shared this recipe on Foodie Tuesday, a weekly segment on ABC Radio Melbourne's Drive program at 3.30pm.

Ever since we launched our Free COVID-19 Alerting System, we’ve been continuously asked how we made it. In this blog…

The June 2020 issue of History of Psychiatry is now online. Full details follow below: “Wild melancholy. On the historical plausibility of a black bile theory of blood madness, or hæmatomania,” Jan Verplaetse. Abstract: Nineteenth-century art historian John Addington Symonds coined the term hæmatomania (blood madness) for the extremely bloodthirsty behaviour of a number of … Continue reading New History of Psychiatry: Melancholy, Madness, Chinese Psychiatry, Psychedelic Therapy, and More →

The best type of fabric for a breathable but effective COVID-19 mask.

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Tupac Mosley overcame homelessness to graduate as valedictorian, writes Jonathan E. Collins, but there’s an overlooked part of his inspirational story: policy.

Annotation. Spaghetti Cook Book.

"A special challenge of hard rock exploration is to identify targets of interest within complex geological settings. Interpretation of the geology can be made from direct geological observations and knowledge of the area, and from 2D or 3D seismic surveys. These interpretations can be developed into 3D geological models that provide the basis for predictions as to likely targets for drilling and/or mining. To verify these predictions we need to simulate 3D seismic wave propagation in the proposed geological models and compare the simulation results to seismic survey data. To achieve this we convert geological surfaces created in an interpretation software package into discretised block models representing the different lithostratigraphic units, and segment these into discrete volumes to which appropriate density and seismic velocity values are assigned. This approach allows us to scale models appropriately for desired wave propagation parameters and to go from local to global geological models and vice versa. Then we use these digital models with forward modelling codes to undertake numerous 3D acoustic wave simulations. Simulations are performed with single shot and with exploding reflector (located on extracted geological surface) configurations" -- Summary.

Wilde, Oscar, 1854-1900 -- Family.

Entitlement attitudes.

Lyricists -- Australia -- Biography.

Aboriginal Australians, Treatment of.

Edinburgh : printed for William Creech, 1787.

London : Cassell, 1895.

London : printed for Knight and Lacey, 1826.

London : printed for P. M'Queen, J. Laikington [sic], J. Mathews; Wilson and Spence, York; J. Binns, Leeds; Jo. Clarke and Co. Manchester [and 1 in Gainsborough, 1 in Leith], M.DCC.LXXXVIII [1788]

Boston : Wright & Potter Printing Co, 1898.

[between 1700 and 1799]

[between 1700 and 1799]

[between 1700 and 1799]

[between 1700 and 1799]