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Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article
Open Access
Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article
Open Access
Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
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Advances in antibacterial agents for Mycobacterium fortuitum

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00508B, Review Article
Carlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando Fumagalli
This review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00663A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin Krátký
Linking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.
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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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Compacted

New Arrival: Skoda might be late to enter the sub-four-metre SUV segment, but the all-new Kylaq shows that it’s not unprepared




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India's climate policies expected to reduce CO2 emissions by around 4 billion tonnes by 2030: Report

The study by Delhi-based independent think tank Council on Energy, Environment and Water (CEEW) said policies for India's power, residential and transport sectors have already saved 440 million tonnes of carbon dioxide (MtCO2) between 2015 and 2020.




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Over ₹13 crore funds needed to support farmers in drought-affected areas of Nellore, says Collector

Ten in the district have been declared as ‘drought mandals’ by the NDMA; over 50% of crop was lost in Sitaramapuram while 30-40% of crops were lost in the remaining nine mandals




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Scientists found a bacteria tricked a wasp to get rid of its males

A new study reports Wolbachia may have taken it a bit too far, after scientists found it manipulated the evolution of Encarsia formosa wasps




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90-year-old farmer convicted, sentenced to one-year imprisonment for encroaching 36 guntas of government land in Karnataka

Small and marginal farmers are worried about being punished for encroachment, demand action against influential people who allegedly encroached on government land




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Strain rate controls alignment in growing bacterial monolayers

Soft Matter, 2024, 20,8468-8479
DOI: 10.1039/D4SM00625A, Paper
Blake Langeslay, Gabriel Juarez
A model of cell alignment in confined growing bacterial monolayers connecting net monolayer deformation to the behavior of individual cells.
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Mechanical characterization of freestanding lipid bilayers with temperature-controlled phase

Soft Matter, 2024, 20,8524-8537
DOI: 10.1039/D4SM00706A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Arash Yahyazadeh Shourabi, Roland Kieffer, Djanick de Jong, Daniel Tam, Marie-Eve Aubin-Tam
Lipid membranes formed in a microfluidic device are studied with temperature-controlled optical tweezers, revealing how mechanical properties of ripple phase and gel-fluid phase-separated membranes change when heated above the transition temperature.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Liquid crystalline collagen assemblies as substrates for directed alignment of human Schwann cells

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00534A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Homa Ghaiedi, Luis Carlos Pinzon Herrera, Saja Alshafeay, Leonard Harris, Jorge Almodovar, Karthik Nayani
Collagen is a key component of the extracellular matrix (ECM) and well-oriented domains of collagen are important for mimicking the local cell environment in vitro. Here, we demonstrate macroscopic alignment on collagen in 2-D substrates and 3-D hydrogels.
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A generalized model for predicting different morphologies of bacterial swarming on a porous solid surface

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM01072H, Paper
Uttam Kumar, Pushpavanam Subramaniam
In this study, we develop a comprehensive two-phase model to analyze the dynamics of bacterial swarming on porous substrates. The two distinct phases under consideration are the cell and aqueous...
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Ashes of Doom / directed by: Grant Munro, Don Arioli ; produced by: Robert Verrall, Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2008




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The Circle / directed by: Mort Ransen ; produced by: John Kemeny ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2020




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Monkey on the Back / directed by: Julian Biggs ; produced by: Grant McLean ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2016




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Eye Witness No. 74 / directed by: Jack Long, William Davidson ; produced by: Jack Olsen, Nicholas Balla ; production agency: National Film Board of Canada (Ottawa)

Montreal : National Film Board of Canada, 2024




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Beyond Kicks / directed by: Gary Toole ; produced by: Michael McKennirey, George Pearson ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2021




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Still Longshots / directed by: David Finch, Maureen Marovitch ; produced by: Dan Emery, David Finch, Germaine Ying Gee Wong, Sally Bochner, Ravida Din ; production agencies: Picture This Productions (Montreal), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2018




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Bevel Up - Drugs, Users and Outreach Nursing / directed by: Nettie Wild ; produced by: Fiona Gold, Juanita Maginley, Betsy Carson, Nettie Wild, Svend-Erik Eriksen, Rina Fraticelli ; production agencies: National Film Board of Canada (Montreal), British Co

Montreal : National Film Board of Canada, 2016




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The Moccasin Game / directed by: Frank Corcoran ; produced by: Dennis Sawyer ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




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Turnaround : A Story of Recovery / directed by: Moira Simpson ; produced by: Jennifer Torrance, Moira Simpson, John Taylor, Kathleen Shannon ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2017




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The Agony of Jimmy Quinlan / directed by: George Mihalka, George Williams ; produced by: Robert Duncan, Janice Brown, Andy Thomson, Peter Katadotis ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2008




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An Easy Pill to Swallow / directed by: Robert Lang ; produced by: Tom Daly, Arthur Hammond ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2013




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Poundmaker's Lodge : A Healing Place / directed by: Alanis Obomsawin ; produced by: Andy Thomson, Alanis Obomsawin, Marrin Canell, Robert Verrall ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2013




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If Only ... / directed by: Marc Aubry ; produced by: Robert Forget ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2021




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My Little Underground / directed by: Élise Simard ; produced by: David Verrall, Roddy McManus, Michael Fukushima ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2012




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Donna's Story / directed by: Doug Cuthand ; produced by: Graydon McCrea, Jerry Krepakevich ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2011




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For John / directed by: Dale Montour ; produced by: Alanis Obomsawin, Sally Bochner ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2018




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Kamitshikaut / directed by: Shaushiss Fontaine ; produced by: Manon Barbeau ; production agencies: National Film Board of Canada (Montreal), Corporation Wapikoni mobile (Montreal)

Montreal : National Film Board of Canada, 2023




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Alone in the Abyss / directed by: Claudie Ottawa ; produced by: Manon Barbeau, Patricia Bergeron, Manon Barbeau, Yves Bisaillon, Ravida Din ; production agencies: Corporation Wapikoni mobile (Montreal), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2018




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Pieces of a Dream : A Story of Gambling / directed by: Michelle Wong ; produced by: Bonnie Thompson, Jerry Krepakevich, Graydon McCrea ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




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The Drag / directed by: Carlos Marchiori ; produced by: Wolf Koenig, Robert Verrall ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2014




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King Size / directed by: Kaj Pindal ; produced by: Robert Verrall, Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2013




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At Home : A Model Person / directed by: Lynne Stopkewich ; produced by: Yves J. Ma, Tracey Friesen ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2012




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At Home : The Wound Inside / directed by: Darryl Nepinak ; produced by: Brendon Sawatzky, Alicia Smith, David Christensen ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2012




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In the Center Ring / directed by: Lynn Smith ; produced by: Wolf Koenig, Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2015




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Happy Birthday / directed by: Lynn Smith ; produced by: Wolf Koenig, Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2015




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Purple Hat / directed by: Lynn Smith ; produced by: Wolf Koenig, Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2013




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Volcano / directed by: Kaj Pindal ; produced by: Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2023




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Fringe Benefits / directed by: Kaj Pindal ; produced by: Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2023




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Funeral / directed by: Kaj Pindal ; produced by: Wolf Koenig ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2023




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Nutrition / directed by: Bretislav Pojar, Don Arioli, Grant Munro ; produced by: Robert Verrall ; production agency: National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2024




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Reflections on Practice : People in Context / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




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Reflections on Practice : Safety / directed by: Nettie Wild ; production agencies: British Columbia Centre for Disease Control. Street Nurse Program (Vancouver), National Film Board of Canada (Montreal)

Montreal : National Film Board of Canada, 2019




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Reflections on Practice : Relationship Building / directed by: Nettie Wild ; production agencies: National Film Board of Canada (Montreal), British Columbia Centre for Disease Control. Street Nurse Program (Vancouver)

Montreal : National Film Board of Canada, 2019