The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and/or rebaudioside B and/or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.

This disclosure describes a simple, low cost method to produce a modular dry mix that can easily be modified and customized to produce a wide range of easy to aerate, no ice cream machine needed, ice cream and frozen dairy and non-dairy desserts and products made by this process. The method relies on successive simultaneous particle size reduction and blending steps without the use of traditional mix drying operations. The formulations produced by this process are modular and allow quick and simple ingredient substitutions to create distinct finished products. The process yields mixes that produce stronger, more stable foams that don't leave an oily mouth feel. The disclosure also includes a formulation and process used to make ice cream, and related frozen dairy and non-dairy desserts at room temperature in one step where the ingredients do not need to be aged, or homogenized, and aeration occurs without the need for simultaneous cooling or freezing. The process allows the end-user to control and vary the texture, freezing rate, melting point and eating qualities of the product without the use of traditional, home or industrial ice cream machines and a product made by this process. A product produced from this mix consists of a (protein-concentrate and emulsifier)—stabilized, protein-based foam created by combining a powder mix with one or a combination of a large range of above freezing temp liquids then immediately whisking the mixture at room temp to a target overrun without pre-aging, and then freezing that product statically till desired hardness is achieved. The main execution of this process involves the use of dry powders that are transported and sold dry and then reconstituted by the end user before they are combined without pre-treatment, freezing homogenization or aging. The manufacturing process offers significant advantages over current dry mix production methods which require significant upfront investment and produce hard to customize mixes. The formulation and finished product making portions of the invention offer significant improvement over existing manufacturing methods for frozen desserts and dessert mixes that require simultaneous freezing and aeration in terms of cost, convenience, customizability, shelf-stability and environmental impact.

Disclosed herein is a nutrient delivery system that provides a nutritional formula for consumption. The nutrient delivery system includes a pod and a nutritional powder comprising at least one phospholipid. The nutritional formula has improved characteristics, such as decreased foaming.

It has unexpectedly been found that Pichia spp. strains have advantageous properties useful in the beer fermentation process. In particular, Pichia spp. yeast strains can be combined with normal beer yeast strains and different hop varieties in a fermentation process to produce synergistic effects—namely, the increased production of esters in the fermentation product. More specifically, the yeast can be used to produce increased levels of isoamyl acetate, isobutyl acetate, ethyl propionate, ethyl valerate, ethyl butyrate, ethyl decanoate and ethyl octanoate in beer. In addition, the Pichia spp. strain interacts differently with different hop varieties, so the flavor profile of beer can be tuned by using different combinations of Pichia spp. strains and hops. The present invention relates to a method of brewing beer using a Pichia spp. yeast strain and at least one hop variety, a beer obtainable by such a method and use of a Pichia spp. yeast strain according to the present invention.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

A tool bit includes a plurality of fins each having first and second ends and extended radially and longitudinally and including the second end thereof forming two opposite lateral sides each including a reinforcing section extended therefrom. Two adjacent fins of the plurality of fins form a recess therebetween, which has a curved periphery interconnecting two adjacent reinforcing sections of the two adjacent fins. Each fin defines a first length from the end thereof to the curved periphery of the recess extended from the second end thereof. The first length is smaller than a second length defined between two opposite peripheral sides of a hexagonal periphery of a connecting end of the tool bit.

The present invention relates to a shock absorbing hammer whose head has housings filled with pellet assembly inside. The pellet assembly includes both rigid pellets and soft pellets to absorb shock from external striking force impacted on the head of the main frame.

A tool having a main barrel with an inner cavity, a tool bit holder adapted to be removably secured within the inner cavity, the tool bit holder having a first inner cavity adapted for receiving a first reversible tool bit and a second inner cavity adapted to receive a non-reversible tool bit, wherein the inner cavity of the main barrel serves as a first sized nut driver, the first inner cavity of the tool bit holder serves as a second sized nut driver, and the second inner cavity of the tool bit holder serves as third sized nut driver, where first, second, and third sized nut drivers each have a different size.

A method for manufacturing a strap ring (1), made from a material woven with warp threads (3) and at least one weft thread (4) extending between the warp threads (3). The woven material is a tubular fabric (11) whose warp threads (3) extend parallel to the axis of extension of the tubular fabric (11), the strap ring (1) being made from an axial section (16) of the tubular fabric (11) which is axially cut up by cutting the warp threads (3).

Methods for manufacturing laminated membranes for MEAs, such methods comprising (i) providing a substrate, a catalyst ink fluid, and a first membrane fluid; (ii) providing a second membrane fluid; (iii) simultaneously coating the catalyst ink fluid onto the substrate, the first membrane fluid onto the catalyst ink fluid, and the second membrane fluid onto the first membrane fluid; and (iv) applying a reinforcement layer (such as ePTFE) and allowing for full imbibement. The second membrane fluid (i) consists of alcohol or (ii) is an alcohol-rich fluid comprising polymer electrolyte.

Provided herein are systems and methods for biomass digestion and products formed thereof. The products include one or more biogases, U.S. Environmental Protection Agency classified Class A Biosolids, and pathogen reduced organic liquid fertilizer. Through the digestion of waste materials using sequential phases in an efficient digestion process, enhanced biomass conversion efficiency and improved output of products (in quantity and/or quality) are obtained with a significant reduction in dwell time in each phase.

A method and processes to solubilize and transform phosphorus contents of rock phosphate (RP) into bio-organo-phosphate (BOP) fertilizer have been developed and integrated. The methods include collecting and sorting of organic wastes; blending with RP; subjecting the blend to biocomposting; collection, isolation, selection and growth optimization of consortia of efficient phosphorus solubilizing microorganisms (PSM) and novel plant growth regulating microorganisms (PGRM); where in PSM produce organic acids and other organic compounds using compost substrate at mesophillic stage, whereas the organic acids released during composting also act in synergism of PSM, thus forming a carbon rich acidic culture resulting in the solubilization of rock phosphate.

A method for producing biochar particles or pellets which use sulphur and other additives. The method includes producing a mixture with biochar and additives selected from sulphur, lignin, and gluten. The mixture is mixed with water and passed through an extruder to produce an extrudate. The extrudate is then cut into pellets. The pellets are then tumbled/spun with each other and heated to result in mostly spheroidal pellets whose mechanical characteristics allow them to be used with well-known agricultural equipment. The biochar can be produced with sulphur incorporated as an outer coating. To produce this sulphur coated biochar, the method includes feeding a biomass feedstock to a pyrolysis reactor, pyrolyzing the feedstock into biochar particles, size-sorting the biochar particles, and coating the biochar particles with the sulphur coating material.

A method and system for treatment of biological wastes for preparation of fertilizers is provided. The method and system involves mixing a biological waste with a dilute sulfuric acid in a predetermined ratio. The mixture of the biological waste and the dilute sulfuric acid is then filtered to obtain an organic slurry and an acidic liquid. Thereafter, the organic slurry is thermally cracked at an elevated temperature to obtain at least one of an ammonia gas, one or more flue gases, and char and ash. The method and system further involves utilizing the ammonia gas, the char and ash, and the acidic liquid for preparation of the fertilizers.

Techniques for navigating semi-autonomous mobile robots are described. A semi-autonomous mobile robot moves within an environment to complete a task. A navigation server communicates with the robot and provides the robot information. The robot includes a navigation map of the environment, interaction information, and a security level. To complete the task, the robot transmits a route reservation request to the navigation server, the route reservation request including a priority for the task, a timeslot, and a route. The navigation server grants the route reservation if the task priority is higher than the task priorities of conflicting route reservation requests from other robots. As the robot moves within the environment, the robot detects an object and attempts to classify the detected object as belonging to an object category. The robot retrieves an interaction profile for the object, and interacts with the object according to the retrieved interaction profile.

A system that receives and analyzes a connected vehicle's safety feature activation and the location of activation on a road to determine if a hazard condition exist and providing an alert on a subscriber's vehicle or wireless device. Weather information for the location of the activation, highway engineering information for the location of the activation and other connected vehicles' safety feature activation at the location are also considered in the determination if the hazardous condition exists on the road. The hazardous condition alert can also be sent to the highway transportation department so that the hazardous condition can be mitigated.

A spring-based mechanism for saving labor of a bicycle rider is disclosed and in one embodiment includes an axle operatively connected to a chain wheel and a first set of bearings via a gear assembly; a housing for mounting a shaft therein wherein the first set of bearings is provided at one end of the shaft; a second set of bearings provided at the other end of the shaft; a spring in the housing and having one end attached to one end of the shaft and the other end attached to the other end of the housing; and a clutch provided externally of the other end of the housing, the clutch being operatively connected to the second set of bearings and including a lock lever. The mechanism can store elastic force by counterclockwise pedaling and release the stored energy by disengaging a clutch from the mechanism when riding uphill.

A foldable chair, operable between a seating configuration and a rolling transport configuration, the foldable chair comprising a plurality of legs with a roller secured to the distal end of each leg and the proximal end of each leg secured to a column base. Extending from the column base is a column with a first and second end, the column first end secured to the column base and the second end of the column secured to a first platform or seat cushion. A second platform extends downwardly from the first platform for attaching a carrying case. Also included is a backrest rotatably secured to the first platform such that when the backrest is perpendicular to the first platform two roller elements are fully shrouded. When the backrest is rotated 90 degrees and disposed substantially parallel to the seat cushion the roller elements are exposed for rolling contact with the ground surface.

A luggage assembly includes a first piece of luggage and a second piece of luggage. An attachment member is affixed to the second piece of luggage. The attachment member couples the second piece of luggage to the first piece of luggage so that the first and second pieces of luggage are self-stabilized while upright and inclined, and while in motion and while stationary.

An apparatus and method for forming a self-stabilized luggage assembly is disclosed. In one embodiment the method includes coupling a first piece of luggage in contact with a second piece of luggage using an adjustable stabilizer configured to couple a handle on the first piece of luggage to a handle on the second piece of luggage while wheels on the bottom of the first and second pieces of luggage remain on the ground when the first and second pieces of luggage are tilted, upright, moving, and stationary. Other embodiments are described and claimed.

A method, apparatus and system for testing the self-sealing properties of a concrete sample. The method may include providing an apparatus for creating a consistent and reproducible crack in a concrete sample and creating a consistent and reproducible crack in the concrete sample with the apparatus. The method may further include providing a fluidic delivery system that provides a consistent flow of fluid for testing the self-sealing properties of the concrete sample and testing the self-sealing properties of the concrete sample with the system.

An under deck mid cabin entry system for a mono hull boat including an entry console and exposed top and front surfaces. Front and top openings extend to the top edge of the front surface and collectively define a generally L shaped entryway. The entry console is disposed to the side of a center console and provides access to steps extending beneath the main deck. A top step is within the entry console proximate to the front surface and the steps curve towards a central beam of the boat and descend into the mid cabin such that a bottom step proximate to a floor of the mid cabin directs a user into a central area of the mid cabin and terminates to avoid obstructing movement in the central area.

An apparatus including a fairing having a tail portion and an end portion capable of suppressing a vortex-induced vibration of a tubular. The apparatus further including a stabilizing member attached to the end portion of the fairing, the stabilizing member dimensioned to increase a thickness of the end portion of the fairing and a flange member attached to the stabilizing member, the flange member dimensioned to increase a chord dimension of the fairing so as to improve a stability of the fairing.

Disclosed is a drillship having a vortex suppression block with a recessed flow stabilizing part in a moon pool. The flow stabilizing section is formed so that a bottom of the vortex suppression block that protrudes from a bottom of a hull toward a stern in the moon pool is recessed in an upward direction of the hull to stabilize a flow in the moon pool and reduce a variation in resistance of the drillship. The flow stabilizing section (30) is formed by partly recessing the bottom of the vortex suppression block toward an upper portion of the hull. The drillship having this configuration provides resistance performance improvement and flow stabilization of the drillship.

A foldable bimini for a boat that is rigid and bi-directionally stable in an erected orientation, the bimini including a rigid arch-shaped frame fixedly mountable onto the boat having a disengageable bimini mount; and a foldable bimini support, including a rigid arch member pivotally mounted to the rigid arch shaped frame and at least one rigid leg pivotally mounted to the rigid arch member and releasably connectable to the frame.

Disclosed is a bicycle for water and land including: a first floating means, which is provided on and rotates with a front wheel frame that rotates in conjunction with a handlebar, for unfolding on both sides by means of buoyancy to buoy the front wheel frame when entering water; a second floating means, which is provided on a rear wheel frame, for unfolding on both sides by means of buoyancy to buoy the rear wheel frame when entering water; and propellers, which are provided on a plurality of spokes that are installed on the rear wheel frame so that the surfaces face the direction in which the rear wheel rotates, for generating propelling force in water.

The present disclosure relates to a grouting and welding combined connection joint and an offshore installation method thereof, characterized in that: it comprises a set of grouting systems disposed inside of the annular space formed by an inner shell of the central pore canal of a column with large cross section and an outer wall of a column with small cross section, as well as a group of brackets welded on a top deck of a column with small cross section and an inner shell of the central pore canal of the column with large cross section. The grouting and welding combined connection joint provided by the present disclosure has advantages of being able to adapt to the connection of different dimensions of columns, and having simple offshore installation, highly reliable structural safety and low cost.

The present invention discloses an inside mobile ballast arrangement for sailboats, said arrangement using a dense material and being preferably in a watertight/gas-tight compartment, the whole system on low friction bearings and being close to the bottom of the hull, this arrangement being able to move longitudinally from front to rear and vice versa, along the X axis, independently or simultaneously with a perpendicular displacement, i.e. from port to starboard and vice versa, along the Y axis.

An oil spill clean-up apparatus and method, and more specifically to a self-contained oil spill clean-up vessel with ice displacement capabilities. One preferred oil spill clean-up system includes a vessel subsystem, an ice displacement subsystem, and an oil spill skimming subsystem. Preferred oil spill clean-up systems may include at least one storage subsystem. Preferred oil spill clean-up systems may include an oil/water separation and removal subsystem.

A controller is coupled to a plurality of moisture sensors positioned within the grain bin at various spaced-apart locations. The controller determines a grain moisture level adjacent each moisture sensor and compares the grain moisture level to a predetermined maximum moisture level. The controller is coupled to a grain spreader that is configured to selectively distribute incoming grain into the grain bin and operates the spreader to distribute incoming grain to create a shortened airflow path through the grain that encompasses the moisture sensors having determined grain moisture levels above the predetermined maximum moisture level. The controller is coupled to a fan that is coupled to the grain bin and configured to provide airflow through the grain in the grain bin. The controller operates the fan to provide greater airflow through the grain along the shortened airflow path than is provided along airflow paths outside the shortened airflow path.

Earth-boring tools include a body, one or more blades projecting outwardly from the body, and cutting elements carried by the blade. The cutting elements include at least one shearing cutting element and at least one gouging cutting element. Methods of forming an earth-boring tool include mounting a shearing cutting element comprising an at least substantially planar cutting face to a body of an earth-boring tool, and mounting a gouging cutting element comprising a non-planar cutting face to the body of the earth-boring tool. The gouging cutting element may be positioned on the body of the earth-boring tool such that the gouging cutting element will gouge formation material within a kerf cut in the formation material by the shearing cutting element, or between kerfs cut in the formation material by a plurality of shearing cutting elements.

A method of manufacturing a tool bit includes machining a working end into a piece of hexagonal bar stock. A shank adjacent the working end is machined, leaving a hexagonal drive portion adjacent the shank. The tool bit is heat treated, and a coating is applied to the working end, the shank, and the hexagonal drive portion of the tool bit to inhibit corrosion of the tool bit. At least a portion of the shank is polished to remove the coating from the portion of the shank.

Embodiments of the invention relate to superabrasive compacts including multiple superabrasive cutting portions and methods of repairing a rotary drill bit that employs at least one of such superabrasive compacts.

A method of manufacturing a drill bit having a bit body and a plurality of blades extending radially from the bit body is disclosed, wherein the method includes adhering a first matrix material to at least a portion of a mold cavity corresponding to an outer surface of the bit body, loading a second matrix material into the other portions of the mold cavity, and heating the mold contents to form a matrix body drill bit.

A method of manufacturing a roller cone drill bit may include forming a body of a single piece having an upper end and a lower end; machining at the lower end of the body at least two journals extending downward and radially outward from a central axis of the body; machining at least one of a ball passage, a hydraulic fluid passageway, a grease reservoir, and a lubricant passageway; and mounting roller cones on the at least two journals.

An apparatus and method for manufacturing a downhole tool that reduces failures occurring along a bondline between a cemented matrix coupled around a blank. The cemented matrix material is formed from a powder and a binder material. The blank includes an internal blank component and a coating coupled around at least a portion of the surface of the internal blank component. The internal blank component includes a top portion and a bottom portion. The internal blank component is substantially cylindrically shaped and defines a channel extending through the top portion and the bottom portion. The coating is a metal in some exemplary embodiments. The coating reduces the migration of the binder material into the blank thereby allowing the control of intermetallic compounds thickness within the bondline.

An elliptical climbing exercise apparatus includes a base frame, a swing unit including a pair of swing arms, a pedal unit including a pair of pedal shafts respectively pivotally connected to the swing arms, a damping unit including a rotating wheel with a spindle, a guiding unit including a pair of cranks respectively affixed to the two opposite ends of the spindle, a pair of rockers respectively pivotally connected to the cranks and a pair of links respectively pivotally connected to the rocker. Cooperation between the base frame, the swing unit, the pedal unit, the resistance unit and the guiding unit is used to achieve a training of the leg muscles.

A stationary strength training equipment includes a frame assembly, a lockable bilateral user interface installed on the frame assembly, a balancing structure connected to the lockable bilateral user interface, a plurality of user selectable weights supported by the frame assembly and connected to the balancing structure, a load detecting strain gauge disposed on the user selectable weights to detect a weight of the user selectable weights being lifted, and an informing device connected to the lockable bilateral user interface to detect and show a warning signal to a user. The lockable bilateral user interface further includes a locking mechanism assembly and a central pivot assembly; the balancing structure is able to rotate along the central pivot assembly, and the locking mechanism assembly selectively restricts a rotation of the balancing structure.

A combination massage table with one or more resistance bands (hereinafter, a combination table) is disclosed. In some embodiments, the combination table may comprise: a massage table; the one or more resistance bands; and a means for attaching the one or more resistance bands to the massage table; such that a client using the combination table receives at least one improved health benefit as compared against massage therapy without any resistance band use. Furthermore, methods for using the combination table are disclosed. Such methods may comprise: preparing the combination table for use; preparing the client so the client is laying on top of an upper surface of the combination table; and massaging the client while the client at least intermittently engages one or more resistance bands that are attached to the combination table; wherein in the at least intermittent engagement of the one or more resistance bands while the client is being massaged results in the at least one improved health benefit to the client.

A dynamic stretching, strengthening and stabilization device is provided for postural correction and retraining. The device has a pair of closed loop resistance tubes and a central harness member which positions the closed loop resistance tubes roughly in the form of a FIG. 8. Each loop of the resistance tube is sized to accommodate the arm and shoulder of the user. The device may be used in a stabilization mode or stretching/strengthening mode, and transitions easily between these modes to correct and retrain the user's posture.

The present disclosure relates to compositions comprising at least one fluoroolefin and an effective amount of a stabilizer comprising at least one ascorbic acid, terephthalate, or nitromethane, or mixtures thereof. The stabilized compositions may be useful in cooling apparatus, such as refrigeration, air-conditioning, chillers and heat pumps, as well as in applications as foam blowing agents, solvents, aerosol propellants, fire extinguishants, and sterilants.

A munition is described including a reactive fragment having an energetic material dispersed in a metallic binder material. A method is also described including forming a energetic material; combining the energetic material with a metallic binder material to form a mixture; and shaping the mixture to form a reactive fragment. The munition may be in the form of a warhead, and the reactive fragment may be contained within a casing of the warhead.

Provided is a fuel of catalytic metal-containing ionic liquid (MCIL) and an IL, to spur hypergolic ignition of such liquids upon contact with an oxidizer to define a hypergolic bipropellant.

A binary exploding target package, a process of forming an exploding target from the contents of the binary exploding target package, and the exploding target formed therefrom. The binary exploding target package includes a first, target container and a second container. An oxidizer composition is contained within one of the containers and a catalyst composition is contained within the other container. An exploding target is formed by mixing the oxidizer and catalyst compositions, and introducing the mixture into the target container to form an exploding target just prior to using the exploding target as a target for a shooting exercise.