ess Strengthening National Accountability and Preparedness for Global Health Security (SNAP-GHS) By feedproxy.google.com Published On :: Thu, 19 Dec 2019 15:43:55 +0000 The project aims to identify the enablers and barriers to enhance data use by National Public Health Institutes (NPHIs), producing outputs that will facilitate strengthening of the role of NPHIs in monitoring potential public health threats, and in shaping and informing domestic policies on health security and preparedness. Global health security is underpinned by the actions taken at a national level to ensure capacities exist to sufficiently prepare for and respond to acute threats and crises. In many contexts, National Public Health Institutes (NPHIs) were first established because of, and in response to, specific public health challenges typically related to infectious diseases.The Strengthening National Accountability and Preparedness for Global Health Security (SNAP-GHS) project evolved from a series of roundtables and discussions hosted by the Centre on Global Health Security at Chatham House, in collaboration with the Graduate Institute of Geneva.The outcome of the project is a SNAP-GHS Toolkit to support NPHIs in better diagnosing and understanding the challenges to data use within their own institutes, as well as in relation to external stakeholders and agencies. The toolkit is intended to be used for further circulation and dissemination by the International Association of National Public Health Institutes (IANPHI).The project is led by the Centre on Global Health Security at Chatham House in collaboration with the Ethiopian Public Health Institute, the Nigeria Centre for Disease Control, and the National Institute for Health in Pakistan. Full Article
ess Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice [Research Articles] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control progression from simple steatosis to NASH are not fully known. Here, we tested the hypothesis that dietary vitamin E (VitE) supplementation would prevent NASH progression and associated metabolic alterations induced by a Western diet (WD). Hyperphagic melanocortin-4 receptor-deficient (MC4R–/–) mice were fed chow, chow+VitE, WD, or WD+VitE starting at 8 or 20 weeks of age. All groups exhibited extensive hepatic steatosis by the end of the study (28 weeks of age). WD feeding exacerbated liver disease severity without inducing proportional changes in liver triglycerides. Eight weeks of WD accelerated liver pyruvate cycling, and 20 weeks of WD extensively upregulated liver glucose and oxidative metabolism assessed by 2H/13C flux analysis. VitE supplementation failed to reduce the histological features of NASH. Rather, WD+VitE increased the abundance and saturation of liver ceramides and accelerated metabolic flux dysregulation compared with 8 weeks of WD alone. In summary, VitE did not limit NASH pathogenesis in genetically obese mice, but instead increased some indicators of metabolic dysfunction. Full Article
ess Lipid rafts in glial cells: role in neuroinflammation and pain processing [Thematic Reviews] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 Activation of microglia and astrocytes secondary to inflammatory processes contributes to the development and perpetuation of pain with a neuropathic phenotype. This pain state presents as a chronic debilitating condition and affects a large population of patients with conditions like rheumatoid arthritis and diabetes, or after surgery, trauma, or chemotherapy. Here, we review the regulation of lipid rafts in glial cells and the role they play as a key component of neuroinflammatory sensitization of central pain signaling pathways. In this context, we introduce the concept of an inflammaraft (i-raft), enlarged lipid rafts harboring activated receptors and adaptor molecules and serving as an organizing platform to initiate inflammatory signaling and the cellular response. Characteristics of the inflammaraft include increased relative abundance of lipid rafts in inflammatory cells, increased content of cholesterol per raft, and increased levels of inflammatory receptors, such as toll-like receptor (TLR)4, adaptor molecules, ion channels, and enzymes in lipid rafts. This inflammaraft motif serves an important role in the membrane assembly of protein complexes, for example, TLR4 dimerization. Operating within this framework, we demonstrate the involvement of inflammatory receptors, redox molecules, and ion channels in the inflammaraft formation and the regulation of cholesterol and sphingolipid metabolism in the inflammaraft maintenance and disruption. Strategies for targeting inflammarafts, without affecting the integrity of lipid rafts in noninflammatory cells, may lead to developing novel therapies for neuropathic pain states and other neuroinflammatory conditions. Full Article
ess Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy [Thematic Reviews] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy. Full Article
ess GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells [Images In Lipid Research] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 Full Article
ess The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress [Bioenergetics] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Optic atrophy 1 (OPA1) is a dynamin protein that mediates mitochondrial fusion at the inner membrane. OPA1 is also necessary for maintaining the cristae and thus essential for supporting cellular energetics. OPA1 exists as membrane-anchored long form (L-OPA1) and short form (S-OPA1) that lacks the transmembrane region and is generated by cleavage of L-OPA1. Mitochondrial dysfunction and cellular stresses activate the inner membrane–associated zinc metallopeptidase OMA1 that cleaves L-OPA1, causing S-OPA1 accumulation. The prevailing notion has been that L-OPA1 is the functional form, whereas S-OPA1 is an inactive cleavage product in mammals, and that stress-induced OPA1 cleavage causes mitochondrial fragmentation and sensitizes cells to death. However, S-OPA1 contains all functional domains of dynamin proteins, suggesting that it has a physiological role. Indeed, we recently demonstrated that S-OPA1 can maintain cristae and energetics through its GTPase activity, despite lacking fusion activity. Here, applying oxidant insult that induces OPA1 cleavage, we show that cells unable to generate S-OPA1 are more sensitive to this stress under obligatory respiratory conditions, leading to necrotic death. These findings indicate that L-OPA1 and S-OPA1 differ in maintaining mitochondrial function. Mechanistically, we found that cells that exclusively express L-OPA1 generate more superoxide and are more sensitive to Ca2+-induced mitochondrial permeability transition, suggesting that S-OPA1, and not L-OPA1, protects against cellular stress. Importantly, silencing of OMA1 expression increased oxidant-induced cell death, indicating that stress-induced OPA1 cleavage supports cell survival. Our findings suggest that S-OPA1 generation by OPA1 cleavage is a survival mechanism in stressed cells. Full Article
ess Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification [RNA] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 pncRNA-D is an irradiation-induced 602-nt long noncoding RNA transcribed from the promoter region of the cyclin D1 (CCND1) gene. CCND1 expression is predicted to be inhibited through an interplay between pncRNA-D and RNA-binding protein TLS/FUS. Because the pncRNA-D–TLS interaction is essential for pncRNA-D–stimulated CCND1 inhibition, here we studied the possible role of RNA modification in this interaction in HeLa cells. We found that osmotic stress induces pncRNA-D by recruiting RNA polymerase II to its promoter. pncRNA-D was highly m6A-methylated in control cells, but osmotic stress reduced the methylation and also arginine methylation of TLS in the nucleus. Knockdown of the m6A modification enzyme methyltransferase-like 3 (METTL3) prolonged the half-life of pncRNA-D, and among the known m6A recognition proteins, YTH domain-containing 1 (YTHDC1) was responsible for binding m6A of pncRNA-D. Knockdown of METTL3 or YTHDC1 also enhanced the interaction of pncRNA-D with TLS, and results from RNA pulldown assays implicated YTHDC1 in the inhibitory effect on the TLS–pncRNA-D interaction. CRISPR/Cas9-mediated deletion of candidate m6A site decreased the m6A level in pncRNA-D and altered its interaction with the RNA-binding proteins. Of note, a reduction in the m6A modification arrested the cell cycle at the G0/G1 phase, and pncRNA-D knockdown partially reversed this arrest. Moreover, pncRNA-D induction in HeLa cells significantly suppressed cell growth. Collectively, these findings suggest that m6A modification of the long noncoding RNA pncRNA-D plays a role in the regulation of CCND1 gene expression and cell cycle progression. Full Article
ess RNA helicase-regulated processing of the Synechocystis rimO-crhR operon results in differential cistron expression and accumulation of two sRNAs [Gene Regulation] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 The arrangement of functionally-related genes in operons is a fundamental element of how genetic information is organized in prokaryotes. This organization ensures coordinated gene expression by co-transcription. Often, however, alternative genetic responses to specific stress conditions demand the discoordination of operon expression. During cold temperature stress, accumulation of the gene encoding the sole Asp–Glu–Ala–Asp (DEAD)-box RNA helicase in Synechocystis sp. PCC 6803, crhR (slr0083), increases 15-fold. Here, we show that crhR is expressed from a dicistronic operon with the methylthiotransferase rimO/miaB (slr0082) gene, followed by rapid processing of the operon transcript into two monocistronic mRNAs. This cleavage event is required for and results in destabilization of the rimO transcript. Results from secondary structure modeling and analysis of RNase E cleavage of the rimO–crhR transcript in vitro suggested that CrhR plays a role in enhancing the rate of the processing in an auto-regulatory manner. Moreover, two putative small RNAs are generated from additional processing, degradation, or both of the rimO transcript. These results suggest a role for the bacterial RNA helicase CrhR in RNase E-dependent mRNA processing in Synechocystis and expand the known range of organisms possessing small RNAs derived from processing of mRNA transcripts. Full Article
ess The finiteness of the spectrum of boundary value problems defined on a geometric graph By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT V. A. Sadovnichii, Ya. T. Sultanaev and A. M. Akhtyamov Trans. Moscow Math. Soc. 80 (2020), 123-131. Abstract, references and article information Full Article
ess GoDaddy – “unauthorized individual” had access to login info By feedproxy.google.com Published On :: Tue, 05 May 2020 15:53:59 +0000 Web hosting behemoth GoDaddy just filed a data breach notification with the US state of California. Full Article Data loss data breach GoDaddy
ess The recalibration of Chinese assertiveness: China's responses to the Indo-Pacific challenge By feedproxy.google.com Published On :: Wed, 08 Jan 2020 11:14:26 +0000 8 January 2020 , Volume 96, Number 1 Read online Feng Liu In response to the changing geopolitical landscape in Asia, both China and the United States attempt to alter the regional order in their own favour, both in the economic and security realms. This article shows how diverging views on future arrangements are leading to strategic shifts and increasing tension between these two Great Powers. As part of its quest for Great-Power status, China has been actively pushing its regional initiatives such as the Belt and Road Initiative (BRI) and the Asian Infrastructure Investment Bank (AIIB), as well as adopting assertive security policies towards its neighbours. In contrast, in order to counter China's growing influence America's regional strategy is undergoing a subtle shift from ‘rebalancing to Asia’ to focusing on the ‘Indo-Pacific’ region. However, amid an intensifying trade war and other challenges facing the region, China has chosen to moderate its proactive foreign policy-orientation in the past few years. In particular, China has made attempts to downplay its domestic rhetoric, rebuild strategic relationship with India and Japan, and to reassure ASEAN states in the South China Sea. In response to the Indo-Pacific strategy, it would be more effective for China to articulate a more inclusive regional vision and promote an institutional framework that also accommodates a US presence in the region. Full Article
ess Asia’s Internet Shutdowns Threaten the Right to Digital Access By feedproxy.google.com Published On :: Tue, 18 Feb 2020 16:32:18 +0000 18 February 2020 Vasuki Shastry Associate Fellow, Asia-Pacific Programme @vshastry LinkedIn Internet shutdowns by Asian governments are curbing their citizens’ space for debate and tougher global regulation is needed, writes Vasuki Shastry. 2020-02-18-Kashmir-Internet.jpg People look at their mobile phones after authorities restored low speed mobile internet services in Kashmir Valley on 25 January 2020. Photo: Getty Images. Internet shutdowns in Asia have become frequent and persistent, an ominous sign of shrinking public space for debate and discourse. The shutdowns have become an irresistible option for governments of all stripes and ideological affiliations. Democratic India, Sri Lanka, Indonesia and the Philippines are prodigious offenders. So are Asia’s more repressive regimes, notably China.In their defence, governments have offered real and imagined threats to national security as reasons for shutting down the pipes. It is useful to examine these claims as well as to objectively frame the issue. Are internet shutdowns in Asia legitimate and can be defended and explained as threats to national security? Or should we take a broader approach where international law, norms, values, rights and indeed economic stability could be invoked to curb this invidious practice?Let’s start with the shutdown in Kashmir, where Indian authorities clamped down on internet access for a straight 165 days, described by rights group Access Now as the ‘longest shutdown ever in a democracy’. The Kashmir Chamber of Commerce and Industry estimates that the shutdown had huge economic costs, estimated at over £1.9 billion.The economic cost of the continuing surveillance and shutdown in China’s Xinjiang province is likely to be higher. But India is a democracy and could be a role model, which is why the recent assertion of Communications and Information Technology Minister Ravishankar Prasad is worrying. He asserted in Parliament that the Indian citizen’s right to the internet was not a fundamental right. ‘While right of internet is important, security of the country is equally important…Can we deny (that) the internet is abused by terrorists…?’.The minister’s primary defence of the shutdown – that the internet was being abused by terrorists and others to foment unrest – has some merit. Our starting point therefore is that big tech platforms should be doing a significantly better job in monitoring content and in removing material designed to provoke violence and hatred. This is the original sin and Asian governments are right to worry about messaging platforms, for example, becoming preferred channels for venom and hate speech.To date, the big tech firms have made the right noises about monitoring and moderating content, but they have not gone far enough, providing governments with the excuse to routinely shut down access. To be blunt, self-regulation of the platforms is not working and tougher global regulation, enforcement and sanctions, possibly via the G20, would help.At the same time, better policing of the platforms will not resolve the issue entirely because governments regard internet shutdowns as a useful way to restrict human rights and to consolidate political control and surveillance over citizens. The international community – including nation-states, NGOs and the private sector – needs to come together and embrace two overarching principles:First, digital access is a fundamental human right and integrated into global declarations and norms.Second, to protect fragmentation and Balkanization of the internet, the digital pipes which carry data across national boundaries should be embedded into international law as being part of the global commons (just like oceans are under maritime law). This would raise the bar on countries which frequently restrict digital access to their citizens.Sensible though these recommendations might seem, it is obvious that many Asian governments would be loath to sign up to global declarations which would limit their policy options at home. There is an economic dimension to internet shutdowns, as the Kashmir case makes clear, which could be addressed by naming and shaming, just as the OECD’s Financial Action Task Force does for countries falling foul of money laundering regulations. Recommendations include:Digital access should be included in the UN’s Human Development Index.The World Bank’s closely followed Doing Business Index (DBI) should score countries favourably based on their commitment to offering unimpeded access to the internet. China and India watch the DBI rankings very closely and will be forced to pursue a more liberal approach if their rankings fall precipitously.Since internet shutdowns have a clear economic cost, particularly in payments and financial services, the International Monetary Fund (IMF) should make an annual determination of member countries (as part of its surveillance mandate) of the impact of shutdowns on economic activity and financial stability.Finally, all Asian governments have declared a public commitment to drive financial inclusion by providing digital access and identity to the poor and vulnerable. This mandate is at odds with frequent internet disruptions. A small vendor in Kashmir, Xinjiang or elsewhere in the region has limited or no recourse when the pipes are shut down. Central banks in the region need to step in by offering some level of protection, just like deposit insurance coverage.It is clear that many of these recommendations would be rejected outright by many Asian governments. They regard internet shutdowns as part of their policy toolkit to deal with external and internal threats to national security. In pursuing such a rigid approach, governments are wilfully curbing their citizens’ space for debate and ignoring a much broader issue of rights to digital access.Armed with a hammer, it is tempting for governments to regard the internet as a nail. The international community and citizens’ groups have an obligation to make such hammering very expensive. Full Article
ess Justice for the Rohingya: Lessons from the Khmer Rouge Tribunal By feedproxy.google.com Published On :: Wed, 08 Apr 2020 12:22:46 +0000 8 April 2020 Sandra Smits Programme Manager, Asia-Pacific Programme The Cambodian case study illustrates the challenges of ensuring justice and accountability for the Rohingya in Myanmar. 2020-04-08-Rohingya.jpg Coast guards escort Rohingya refugees following a boat capsizing accident in Teknaf on 11 February 2020. Photo: Getty Images. International criminal justice provides a stark reminder that state sovereignty is not an absolute, and that the world’s most heinous crimes should be prosecuted at an international level, particularly where domestic systems lack the capacity or will to hold perpetrators to account. The post-Cold War period witnessed a dramatic rise in the number of international tribunals with jurisdiction over war crimes and serious human rights abuses in countries including Cambodia, East Timor, Rwanda, Liberia, Sierra Leone and Yugoslavia. With these processes approaching, or having reached the end of their dockets, many have called for the creation of new tribunals to address more recent conflicts, including the army crackdown in Myanmar in 2017 that resulted in evidence of crimes against humanity against the Rohingya. In January this year, the International Court of Justice (ICJ) imposed emergency provisional measures on Myanmar, instructing it to prevent genocidal violence against its Rohingya minority. But a final judgement is expected to take years and the ICJ has no way of enforcing these interim measures. Myanmar has already responded defiantly to international criticism. Model for justiceMyanmar is not the first country to face scrutiny for such crimes in Southeast Asia. The Extraordinary Chambers in the Courts of Cambodia (ECCC), more commonly known as the Khmer Rouge Tribunal was established in 1997 to prosecute Khmer Rouge leaders for alleged violations of international law and serious crimes perpetrated during the Cambodian genocide. This provides an opportunity to consider whether the Tribunal can act as a ‘hybrid’ model for justice in the region. The first lesson that can be taken from the Cambodian context is that the state must have the political will and commitment to pursue accountability. It was indeed the Cambodian government itself, who requested international assistance from the United Nations (UN), to organize a process for holding trials. The initial recommendation of the UN-commissioned Group of Experts was for the trial to be held under UN control, in light of misgivings about Cambodia’s judicial system. Prime Minister Hun Sen rejected this assessment and in prolonged negotiations, continued to spearhead the need for domestic involvement (arguably, in order to circumscribe the search for justice). This eventually resulted in the creation of a hybrid body consisting of parallel international and Cambodian judges and prosecutors with supermajority decision-making rules. It is worth noting that the Hun Sen government initially chose to do business with former Khmer Rouge leaders, until it became more advantageous to embrace a policy of putting them on trial. It is possible to infer from this that there will be no impetus for action in Myanmar until it is domestically advantageous to do so. At present, this appetite is clearly lacking, demonstrated by de-facto leader Aung San Suu Kyi shying away from accountability and instead defending the government’s actions before the ICJ.One unique aspect of the Khmer Rouge Tribunal has been the vast participation by the Cambodian people in witnessing the trials as well as widespread support for the tribunal. This speaks to the pent-up demand in Cambodia for accountability and the importance of local participation. While international moral pressure is clear, external actors cannot simply impose justice for the Rohingya when there is no domestic incentive or support to pursue this. The reality is that the anti-Rohingya campaign has galvanized popular support from the country’s Buddhist majority. What is more, the Rohingya are not even seen as part of Myanmar so there is an additional level of disenfranchisement.Secondly, the Cambodian Tribunal illustrates the need for safeguards against local political interference. The ECCC was designed as national court with international participation. There was an agreement to act in accordance with international standards of independence and impartiality, but no safeguards in place against serious deficiencies in the Cambodian judicial system. Close alliances between judges and the ruling Cambodian People’s Party, as well as high levels of corruption meant the tribunal effectively gave Hun Sen’s government veto power over the court at key junctures. Despite the guise of a hybrid structure, the Cambodian government ultimately retained the ability to block further prosecutions and prevent witnesses from being called. In Myanmar, political interference could be a concern, but given there is no popular support for justice and accountability for crimes committed against the Rohingya, the prospects of a domestic or hybrid process remain unlikely. However, there are still international options. The investigation by the International Criminal Court (ICC) into crimes that may have taken place on the Myanmar–Bangladesh border represents a potential route for justice and accountability. The UN Human Rights Council has also recently established the Independent Investigative Mechanism for Myanmar (IIMM), mandated to collect and preserve evidence, as well as to prepare files for future cases before criminal courts.Finally, the Cambodian case illustrates the culture of impunity in the region. The ECCC was conceived partly as a showcase for international standards of justice, which would have a ‘contagion effect’ upon the wider Cambodian and regional justice systems. Cambodia was notorious for incidents in which well-connected and powerful people flouted the law. This culture of impunity was rooted in the failure of the government to arrest, try and punish the Khmer Rouge leadership. The Tribunal, in holding perpetrators of the worst crimes to account, sought to send a clear signal that lesser violations would not be tolerated in the same way. Arguably, it did not achieve this in practice as Cambodia still has a highly politicized judicial system with high levels of corruption and clear limits to judicial independence. What this illustrates is that the first step towards accountability is strengthening domestic institutions. The United Nation’s Special Rapporteur on the situation of human rights in Myanmar has urged domestic authorities to embrace democracy and human rights, highlighting the need to reform the judicial system in order to ensure judicial independence, remove systemic barriers to accountability and build judicial and investigatory capacity in accordance with international standards. Based on this assessment, it is clear that domestic institutions are currently insufficiently independent to pursue accountability.The ECCC, despite its shortcomings, does stand as proof that crimes against humanity will not go completely unpunished. However, a process does not necessarily equal justice. The region is littered with justice processes that never went anywhere: Indonesia, Nepal, and Sri Lanka. International recourse is also challenging in a region with low ratification of the ICC, and the absence of regional mechanisms like the Inter-American Court of Human Rights, the European Court of Human Rights, and the African Court on Human and Peoples’ Rights (although their remit is not mass atrocity prosecutions). The Cambodian case study illustrates the challenges of ensuring justice and accountability within the region. The end of impunity is critical to ensure peaceful societies, but a purely legalistic approach will fail unless it is supported by wider measures and safeguards. It is these challenges, that undermine the prospects for ensuring justice for the Rohingya within Myanmar. Full Article
ess Harnessing Wind Power - Part 1 By www.ams.org Published On :: Wed, 5 Oct 2011 14:01:45 -0400 Mathematics contributes in many ways to the process of converting wind power into usable energy. Large-scale weather models are used to find suitable locations for wind farms, while more narrowly focused models incorporating interactions arising from factors such as wake effects and turbulence specify how to situate individual turbines within a farm. In addition, computational fluid dynamics describes air flow and drag around turbines. This helps determine the optimal shapes for the blades, both structurally and aerodynamically, to extract as much energy as possible, and keep noise levels and costs down. Mathematics also helps answer two fundamental questions about wind turbines. First, why three blades? Turbines with fewer blades extract less energy and are noisier (because the blades must turn faster). Those with more than three blades would capture more energy but only about three percent more, which doesn.t justify the increased cost. Second, what percentage of wind energy can a turbine extract? Calculus and laws of conservation provide the justification for Betz Law, which states that no wind turbine can capture more than 60% of the energy in the wind. Modern turbines generally gather 40-50%. So the answer to someone who touts a turbine that can capture 65% of wind energy is "All Betz" are off. For More Information: Wind Energy Explained: Theory, Design and Application, Manwell, McGowan, and Rogers, 2010. Full Article
ess The World’s Best 40 Under 40 MBA Professors By www8.gsb.columbia.edu Published On :: Wed, 06 May 2020 17:34:19 +0000 Organizations Wednesday, April 29, 2020 - 13:30 Full Article
ess For Many Small Businesses, U.S. Coronavirus Aid Falls Short By www8.gsb.columbia.edu Published On :: Wed, 06 May 2020 17:45:47 +0000 Business Economics and Public Policy Healthcare Friday, May 1, 2020 - 13:45 Full Article
ess euromicron AG successfully completes 2019 capital increase By www.euromicron.de Published On :: Fri, 23 Aug 2019 10:01:00 +0200 euromicron AG, a medium-sized technology group and expert on the digital networking of business and production processes, has now fully placed the capital increase it resolved on July 10, 2019. Full Article
ess Jamaica Olympic stars winless in Oregon By sportsjamaica.com Published On :: In-form American sprinter, Michael Rodgers, ran a world-leading 9.94 seconds and there were no Caribbean Full Article
ess So You Want To Save Humanity? Manage Nature Like A Business By www.forbes.com Published On :: Thu, 30 Apr 2020 00:00:00 GMT In the wake of the COVID-19 crisis, any economic stimulus measures must safeguard nature or governments risk exposing humanity to further pandemics. Full Article
ess Your Slow Website is Killing Your Business- Level up with our affordable VPS server By forums.digitalpoint.com Published On :: Sat, 09 May 2020 09:28:51 +0000 Full Article
ess Outcomes of the Meeting of the Friends of the Co-Chairs on liability and redress, Bonn, 7-10 May 2008. By www.cbd.int Published On :: Mon, 16 Jun 2008 00:00:00 GMT Outcomes of the Meeting of the Friends of the Co-Chairs on liability and redress, Bonn, 7-10 May 2008 Full Article
ess New Publication: Rules, Procedures and Mechanisms Applicable to Processes under the Cartagena Protocol on Biosafety. By www.cbd.int Published On :: Mon, 16 Jun 2008 00:00:00 GMT New Publication: Rules, Procedures and Mechanisms Applicable to Processes under the Cartagena Protocol on Biosafety. Full Article
ess Press Release: Largest international gathering on Biosafety meets in Bonn to finalize arrangements for the Cartagena Protocol. By www.cbd.int Published On :: Wed, 18 Jun 2008 00:00:00 GMT Full Article
ess Press Release: International Community to Meet in Germany for a United Nations Conference on Living Modified Organisms and Biodiversity. By www.cbd.int Published On :: Wed, 18 Jun 2008 00:00:00 GMT Full Article
ess Press release: Agreement reached to work towards a legally binding instrument on Liability and Redress with regard to GMOs. By www.cbd.int Published On :: Wed, 18 Jun 2008 00:00:00 GMT Full Article
ess Biosafety Protocol News Vol. 3 Issue 5 - Experiences and Lessons Learned in Capacity-Building By www.cbd.int Published On :: Fri, 16 Jan 2009 00:00:00 GMT Full Article
ess Biosafety Protocol News Issue 6 - Public Awareness and Participation: Experiences and Lessons Learned from Recent Initiatives By www.cbd.int Published On :: Tue, 21 Jul 2009 00:00:00 GMT Full Article
ess Report of the Group of the Friends of the Co-Chairs on Liability and Redress in the Context of the Cartagena Protocol on Biosafety on the Work of its First Meeting. By www.cbd.int Published On :: Thu, 18 Feb 2010 00:00:00 GMT Full Article
ess Report of the Group of the Friends of the Co-Chairs on Liability and Redress in the Context of The Cartagena Protocol on Biosafety on the Work of Its Second Meeting By www.cbd.int Published On :: Wed, 31 Mar 2010 00:00:00 GMT Full Article
ess Report of the Ad Hoc Technical Expert Group on Risk Assessment and Risk Management Under the Cartagena Protocol on Biosafety By www.cbd.int Published On :: Fri, 09 Jul 2010 00:00:00 GMT Full Article
ess Report of the First Meeting of the Ad Hoc Technical Expert Group on Risk Assessment and Risk Management under the Cartagena Protocol on Biosafety By www.cbd.int Published On :: Fri, 09 Jul 2010 00:00:00 GMT Full Article
ess The full transcripts of the Second Series of Regional Real-time Online Conferences on Risk Assessment and Risk Management (February 2010). By bch.cbd.int Published On :: Fri, 09 Jul 2010 00:00:00 GMT Full Article
ess Report of the Group of the Friends of the Co-Chairs on Liability and Redress in the Context of the Cartagena Protocol on Biosafety on the Work of its Third Meeting By bch.cbd.int Published On :: Thu, 22 Jul 2010 00:00:00 GMT Full Article
ess Launch of the Forum on the Strategic Plan and the Assessment and Review, 1-28 February 2010. By bch.cbd.int Published On :: Fri, 04 Feb 2011 00:00:00 GMT Full Article
ess An Introductory Note in Preparation for Signature and Ratification of the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By bch.cbd.int Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
ess The Nagoya - Kula Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety opens for signature at the United Nations Headquarters, New York. By www.un.org Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
ess New Publication: The Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety. English Version. By bch.cbd.int Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
ess The Nagoya - Kula Lumpur Supplementary Protocol on Liability and Redress to the Cartagena Protocol on Biosafety will be opened for signature on 7 March 2011, at the United Nations Headquarters, New York. By www.cbd.int Published On :: Wed, 11 May 2011 00:00:00 GMT Full Article
ess Report of the African Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Mon, 12 Sep 2011 00:00:00 GMT Full Article
ess Report of the Asia-Pacific Regional Workshop on the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Thu, 08 Dec 2011 00:00:00 GMT Full Article
ess Report of the Inter-Regional Workshop on Capacity Needs for the Implementation of the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress By www.cbd.int Published On :: Tue, 26 Jun 2012 00:00:00 GMT Full Article
ess Online Forum on Public Awareness, Education and Participation Concerning the Safe Transfer, Handling and Use of Living Modified Organisms (4 - 18 June 2012) By bch.cbd.int Published On :: Wed, 27 Jun 2012 00:00:00 GMT Full Article
ess 10th Issue of the Biosafety Protocol News is now available entitled: The role of media in promoting biosafety awareness By bch.cbd.int Published On :: Fri, 12 Oct 2012 00:00:00 GMT Full Article
ess Report of the Africa Regional Capacity-building Workshop on Public Awareness, Education and Participation concerning the Safe Transfer, Handling and Use of Living Modified Organisms By bch.cbd.int Published On :: Tue, 26 Feb 2013 00:00:00 GMT Full Article
ess Report of the Asia-Pacific regional training workshop on public awareness, education and participation concerning the safe transfer, handling and use of LMOs is now available. By bch.cbd.int Published On :: Tue, 30 Jul 2013 00:00:00 GMT Full Article
ess Germany ratified the Nagoya - Kuala Lumpur Supplementary Protocol on Liability and Redress on 27 August 2013. By bch.cbd.int Published On :: Thu, 29 Aug 2013 00:00:00 GMT Full Article
ess Round table on access to information, public participation and access to justice regarding LMOs/GMOs, 16-17 October 2013, Geneva, Switzerland. By www.unece.org Published On :: Fri, 06 Sep 2013 00:00:00 GMT Full Article
ess The Report of the Joint Aarhus Convention/CBD round table on access to information, public participation and access to justice regarding LMOs/GMOs is now available. By www.unece.org Published On :: Thu, 19 Dec 2013 00:00:00 GMT Full Article
ess The report of the meeting of the Ad Hoc Technical Expert Group on Risk Assessment and Risk Management is now available. By www.cbd.int Published On :: Wed, 16 Jul 2014 00:00:00 GMT Full Article
ess The report of the Ad Hoc Technical Expert Group on Risk Assessment and Risk Management is now available. By www.cbd.int Published On :: Tue, 16 Feb 2016 00:00:00 GMT Full Article