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Synthesis of Biaryl Ketones by Arylation of Weinreb Amides with Functionalized Grignard Reagents under Thermodynamic Control vs. Kinetic Control of N,N-Boc2-Amides

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00813C, Communication
Guangchen Li, Michal Szostak
A highly efficient method for chemoselective synthesis of biaryl ketones by arylation of Weinreb amides (N-methoxy-N- methylamides) with functionalized Grignard reagents is reported. This protocol offers rapid entry to functionalized...
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Highly Z-selective synthesis of 1,3-oxathiol-2-ylidenes and 4-methylene-oxazolidine-2-thiones via atom-specific 5-exo-dig cyclization of propargyl alcohol with isothiocyanate

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00083C, Paper
S. Antony Savarimuthu, D. G. Leo Prakash, S. Augustine Thomas, Thirumanavelan Gandhi, Mrinal K. Bera
The Z-selectivity observed in imine and alkene motifs after 5-exo-dig cyclization of propargyl alcohol and isothiocyanate is rare in the literature and this selectivity can be attributed to electronic and steric factors of the imine and alkene motif respectively.
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Selenium-promoted electrophilic cyclization of arylpropiolamides: synthesis of 3-organoselenyl spiro[4,5]trienones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00609B, Paper
Ana Maria S. Recchi, Pedro H. P. Rosa, Davi F. Back, Gilson Zeni
A synthetic approach to regioselective synthesis of 3-organochalcogenyl spiro[4,5]trienones and 3-organochalcogenyl[4,5]triene-2,6-diones is described through the reaction of arylpropiolamides with an electrophilic chalcogen source.
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Diversity oriented multi-component reaction (DOS–MCR) approach to access natural product analogues: regio- and chemo-selective synthesis of polyheterocyclic scaffolds via one-pot cascade reactions

Org. Biomol. Chem., 2020, 18,3082-3092
DOI: 10.1039/D0OB00368A, Paper
Lakshmanan Palanivel, Vasuki Gnanasambandam
Skeletally diverse and complex polyheterocyclic hybrid scaffolds have been accessed via one-pot three-component reaction by exploiting the build/couple/pair strategy of diversity oriented synthesis.
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The silver catalyzed direct C–H functionalization of quinones with dialkyl amides

Org. Biomol. Chem., 2020, 18,3027-3031
DOI: 10.1039/D0OB00323A, Communication
Sakthivel Pandaram, Adarsh Krishna T. P., Andivelu Ilangovan
A novel and efficient strategy for the direct C–H amidoalkylation of quinones via a radical pathway has been achieved using readily available alkyl amides and an AgNO3-TBHP catalyst system. This is the first ever example of the synthesis of novel amidoquinone derivatives.
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Rh(III)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones

Org. Biomol. Chem., 2020, 18,3038-3042
DOI: 10.1039/D0OB00396D, Communication
Changduo Pan, Gao Huang, Yujia Shan, Yiting Li, Jin-Tao Yu
A Rh(III)-catalyzed direct C4 alkylation of indoles with allylic alcohols to access β-indolyl ketones was developed.
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Construction of pH sensitive smart glutathione peroxidase (GPx) mimics based on pH responsive pseudorotaxanes

Org. Biomol. Chem., 2020, 18,3125-3134
DOI: 10.1039/D0OB00122H, Paper
Jiaxi Li, Wenlong Jia, Ganghui Ma, Xiaoyin Zhang, Shaojie An, Tao Wang, Shan Shi
Two pH-sensitive smart glutathione peroxidase (GPx) mimics were developed by using pH-responsive pseudorotaxanes based on cucurbit[6]uril and organoselenium compounds.
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Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation

Org. Biomol. Chem., 2020, 18,3135-3141
DOI: 10.1039/D0OB00252F, Paper
Chiao Wen Chen, Ching Chi Wang, Xin Ru Li, Henryk Witek, Kwok-Kong Tony Mong
Polymethylhydrosiloxane (PMHS): a sub-stoichiometric reducing agent for reductive etherification of carbohydrate substrates and its application for one-pot protecting group manipulation
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Enantioselective synthesis of chiral α-alkynylated thiazolidones by tandem S-addition/acetalization of alkynyl imines

Org. Biomol. Chem., 2020, 18,3117-3124
DOI: 10.1039/D0OB00365D, Paper
Mei-Xin Wang, Juan Liu, Zhen Liu, Yingcheng Wang, Qi-Qiong Yang, Wenyu Shan, Yu-Hua Deng, Zhihui Shao
A SPINOL-CPA catalyzed asymmetric [2 + 3]-annulation of in situ generated alkynyl imines and 1,4-dithiane-2,5-diol has been developed to afford enantiopure α-alkynylated thiazolidones.
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Experimental results and computational insight into sequential reactions of β-(2-aminophenyl)-α,β-ynones with aryl isocyanates/benzoyl isothiocyanate

Org. Biomol. Chem., 2020, 18,3177-3189
DOI: 10.1039/D0OB00087F, Paper
Antonio Arcadi, Massimiliano Aschi, Marco Chiarini, Fabio Marinelli, Vincenzo Marsicano, Gustavo Portalone
The selective formation of quinazoline vs. benzoxazine  and benzothiazine derivatives from β-(2-aminophenyl)-α,β-ynones and aryl isocyanates/benzoyl isothiocyanate was explored. DFT calculations provide a plausible rationale.
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Study on the ArI-catalyzed intramolecular oxy-cyclization of 2-alkenylbenzamides to benzoiminolactones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00612B, Communication
Huixia Liu, Xiaojun Deng, Xie Huang, Nan Ji, Wei He
A metal-free synthetic method toward the preparation of benzoiminolactones through oxy-cyclization of 2-alkenylbenzamides mediated by a catalyst/oxidant (ArI/mCPBA) system was developed.
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Visible light promoted continuous flow photocyclization of 1,2-diketones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00532K, Paper
Francesco Secci, Stefania Porcu, Alberto Luridiana, Angelo Frongia, Pier Carlo Ricci
A continuous flow Norrish–Yang photocyclization of 1,2-diketones has been developed and applied to the synthesis of functionalized 2-hydroxycyclobutanones, under blue light irradiation.
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Rhodium-Catalyzed ortho-Acrylation of Aryl Ketone O-Methyl Oximes with Cyclopropenones

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00064G, Communication
Yafeng Liu, Yuan Tian, Kexin Su, Xin Guo, Baohua Chen
An efficient Rh-catalyzed ortho-acrylation reaction for the synthesis of chalcones from O-methyl ketoximes and cyclopropenones via C–H bond activation has been described. This cross-coupling reaction exhibits high functional group tolerance...
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Synthesis of unsymmetrical benzils via palladium-catalysed α-arylation–oxidation of 2-hydroxyacetophenones with aryl bromides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00575D, Paper
Open Access
Takanori Matsuda, Souta Oyama
Unsymmetrical benzils are synthesised by a one-pot tandem palladium-catalysed α-arylation and oxidation of 2-hydroxyacetophenones with aryl bromides.
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Copper(I)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00546K, Paper
Hao Cui, Ke Li, Yue Wang, Manman Song, Congcong Wang, Donghui Wei, Er-Qing Li, Zheng Duan, François Mathey
A copper/Ganphos-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described, producing the spiro[pyrrolidin-3,3'-oxindole]s in good yields with high ee.
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Enantioselective Synthesis of Indanone Spiro-Isochromanone Derivatives via Dinuclear Zinc-Catalyzed Michael/Transesterification Tandem Reaction

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00541J, Paper
Xiao-Chao Yang, Meng Xu, Jin-Bao Wang, Meng-Meng Liu, Francois Mathey, Yuan-Zhao Hua, Mincan Wang
An enantioselective Michael/transesterification tandem reaction of α-hydroxy indanones with ortho-ester chalcones was realized by dinuclear zinc catalysts. A series of enantiomerically pure spiro[indanone-2,3’-isochromane-1-one] derivatives were obtained in good yields with...
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Three-component synthesis of 1,4-benzothiazines via iodide-catalyzed aerobic C–H sulfuration with elemental sulfur

Org. Biomol. Chem., 2020, 18,3234-3238
DOI: 10.1039/D0OB00074D, Communication
Jingjing Jiang, Xiaolong Tuo, Zhuquan Fu, Huawen Huang, Guo-Jun Deng
Five to Six: Beyond the well-established thiazole formation from elemental sulfur, this method provides the first access to the corresponding six-membered N,S-heterocyclic products via direct functionalization of multiple C–H bonds.
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Phenylboronic acid-catalyzed tandem construction of S–S and C–S bonds: a new method for the synthesis of benzyl disulfanylsulfone derivatives from S-benzyl thiosulfonates

Org. Biomol. Chem., 2020, 18,3243-3248
DOI: 10.1039/D0OB00442A, Communication
Raju Jannapu Reddy, Md. Waheed, Gamidi Rama Krishna
A novel and unique phenylboronic acid-catalyzed tandem construction of S–S and C–S bonds via dimerization–sulfonylation has been disclosed for the synthesis of benzyl disulfanylsulfone derivatives.
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A visible-light-induced “on–off” one-pot synthesis of 3-arylacetylene coumarins with AIE properties

Org. Biomol. Chem., 2020, 18,3346-3353
DOI: 10.1039/D0OB00479K, Paper
Xinjie Wu, Ming Jia, Mengmeng Huang, Jung Keun Kim, Zheng Zhao, Junkai Liu, Jinhu Xi, Yabo Li, Yangjie Wu
A mild one-pot approach to 3-arylacetylene coumarins with potential AIE activities was developed via photosensitizer-free photocatalysis and thermocatalysis.
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Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides

Org. Biomol. Chem., 2020, 18,3354-3359
DOI: 10.1039/D0OB00419G, Paper
Amritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy
1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).
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Modular synthesis of oligoacetylacetones via site-selective silylation of acetylacetone derivatives

Org. Biomol. Chem., 2020, 18,3297-3302
DOI: 10.1039/D0OB00501K, Paper
Parantap Sarkar, Yuya Inaba, Hayato Shirakura, Tomoki Yoneda, Yasuhide Inokuma
Aliphatic oligoketones with tailored carbonyl and substituent sequences were modularly synthesized utilizing site-selective formation of enol silyl ethers. Their unique conformational preferences in solid-state were revealed by X-ray crystallography.
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A base-promoted tandem approach to bicyclic 8-membered ring ketones

Org. Biomol. Chem., 2020, 18,3249-3253
DOI: 10.1039/D0OB00618A, Communication
Emerson E. F. dos Santos, Gabriela F. P. de Souza, Deborah A. Simoni, Airton G. Salles
A base-promoted tandem route toward unprecedented bicyclic furan/8-membered ring ketones is reported.
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KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones

Org. Biomol. Chem., 2020, 18,3360-3366
DOI: 10.1039/D0OB00494D, Paper
Zhen Yang, Jing He, Yueting Wei, Weiwei Li, Ping Liu
A series of diverse fused [1,2,4]triazolo[3,4-c]quinoxalines was obtained by an efficient KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones.
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Gold(III)-catalyzed azide-yne cyclization/O–H insertion cascade reaction for the expeditious construction of 3-alkoxy-4-quinolinone frameworks

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00745E, Paper
Jingjing Huang, Han Su, Ming Bao, Lihua Qiu, Yuanqing Zhang, Xinfang Xu
A gold-catalyzed cascade reaction has been developed, and it provides an expeditious access to 3-alkoxy-4-quinolines and applications in alkaloid synthesis.
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Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00721H, Paper
Jaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha , Ravi Shankar Lankalapalli
Multicomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation by DDQ that afforded a diverse array of products is described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones...
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Spiroconyone A, a new phytosterol with a spiro [5,6] ring system from Conyza japonica

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00666A, Paper
Long-Gao Xiao, Yu Zhang, Hong-Li Zhang, Ding Li, Qiong Gu, Gui-Hua Tang, Qian Yu, Lin-Kun An
The first rearranged phytosterol (spiroconyone A) with an unusual spiro [5,6] ring system and two new TDP1 inhibitors 7 and 10 showing a strong synergistic effect with topotecan were isolated from Conyza japonica.
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Arylation of Indoles Using Cyclohexanones Dually-Catalyzed by Niobic Acid and Palladium-on-Carbons

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00702A, Paper
Kazuho Ban, Yuta Yamamoto, Hironao Sajiki, Yoshinari Sawama
3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C...
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'My goal is playing for Manchester United one day'

Rajib Boy from Kolkata is 16-year-old and a talented footballer, recently selected after a national scouting contest to attend a Manchester United Football Club training camp.




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'I'd have done anything else other than write this book': Akhil Sharma

New York-based writer Akhil Sharma 's novel Family Life has received rave reviews. The autobiographical book traces the journey of a family that moves to the US from India, its eldest son suddenly suffering a freak accident.




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Cos use foreign money for political funding. Isn’t that influencing polls?

A recent Intelligence Bureau (IB) report has claimed that some well-known NGOs are working to stall economic development at the behest of their foreign donors. Activists and rights groups have been up in arms ever since the report was leaked.




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Swiss accounts are a diversion. Bulk of black money is right here in India

The scent of 'black money' is in the air again. At the Supreme Court's order, Modi sarkar has set up a Special Investigation Team to look into cases of illegal outflow of money to foreign havens.




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Hate crime: Two Sikhs attacked in US, one dead

Two elderly Sikhs were shot at by unidentified assailants in Sacramento in US, leaving one dead and the other in critical condition, triggering panic in the neighbourhood having a sizeable Sikh population.




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Coronavirus Pandemic: WhatsApp limits forwarding to one chat at a time to curb fake news

WhatsApp is also working directly with NGOs and governments, including the WHO and over 20 national health ministries, to help connect people with accurate information.




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Apple announces new iPhone SE 2020, to come with minimum 64 GB storage

It has the same iPhone 8 design, but the camera and processor are new.




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PUBG Mobile India Series 2020: Prize money, date of tournament and registration details

The tournament has a Rs 50 lakh prize pool.




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'I don't do films that just want to make money'

Nithya Menen's fiery interview.




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'No one expects from me to play a lead heroine'

'I've been tagged as a Punchnama girl, where I break everyone's hearts. I wanted to be a heroine in that film but what did they make me?'





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'An actor's job is one of the toughest'

'I believe there is room for everybody, and we have already shown what space we are fitting in. For instance, I can't do what Ananya (Panday) and Sara (Ali Khan) can do and vice versa.'




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'I am living my life on one leg'

'I am constantly balancing, whether it's time with Saif, whether it's Taimur, whether it's with my mom-in-law, whether it's my own family, whether it's 30-35 days of doing brands, then 50 days of shooting a film... there's a lot going on...'




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Shraddha does something she has NEVER DONE BEFORE

'I have to pinch myself to believe that 10 years have just gone by.'




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Folklife News & Events: Navajo Dancers Jones Benally Family September 10 Noon

Please us for our next Homegrown Concert:

Jones Benally Family Dancers
Navajo (Diné) traditional dance from Arizona
TUESDAY, SEPTEMBER 10, 2019, 12:00 PM
Coolidge Auditorium, Ground Floor
Thomas Jefferson Building
The Library of Congress


World Champion hoop dancer and traditional healer Jones Benally, his daughter Jeneda, his son Clayson, and his three young grandchildren form the Jones Benally Family Dancers. Navajo dance is a sacred tradition encompassing a wide variety of forms, all of which aim to heal the body, mind, or spirit. When presented outside the Navajo community, these dances are modified for public viewing, but they retain their deep capacity to move hearts and minds. The family sings, chants, plays traditional rhythm instruments, and performs a repertoire of over 20 dances, including traditional forms such as basket dance, eagle dance, feather dance, and corn grinding. They are particularly well known for the hoop dance, in which they evoke traditional figures and shapes using five, nine, a dozen, or many more hoops.

Jones Benally is a respected elder of the Navajo Nation in northeastern Arizona. His skill as a hoop dancer has won him worldwide acclaim and multiple world champion titles as well as the first Heard Museum Hoop Dance Legacy Award. Jones was featured as a singer in the 1993 film Geronimo. He works as a traditional healer, and was among the first traditional medical practitioners to be employed by a "Western" medical facility, where he worked for nearly 20 years. Jones Benally is also recognized by the state of Arizona as an Arizona Indian Living Treasure. Jeneda and Clayson Benally have performed with their father for over three decades, and have also made their mark (along with brother Klee) as the Native American Music Award-winning "alter-Native" punk band Blackfire. The siblings' newest project is the duo Sihasin ("hope"). Jones Benally's grandchildren are the next generation to take up the family legacy of Navajo music and dance.

Request ADA accommodations five days in advance at 202-707-6362 or ADA@loc.gov

More information is at this link!




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Do we need a loneliness minister?

One of the many ironies of modern living is that while technology is bringing people closer, the sense of loneliness is growing. That’s because a text message can never replace a hug, and virtual Siri a real friend. ​




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How your smartphone became poll-savvy

On the Neta app, which describes itself as “Leaders ka report card”, users can also share their opinion in the form of video reviews and comments, tag their MLA and conduct polls, with the most active users being highlighted in a separate section called ‘star citizens’




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Gravitational Biology II: Interaction of Gravity with Cellular Components and Cell Metabolism / Wolfgang Hanke [and more]

Online Resource




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Translation mechanisms and control / edited by Michael B. Mathews, Rutgers New Jersey Medical School; Nahum Sonenberg, McGill University; John W.B. Hershey, University of California, Davis

Hayden Library - QH450.5.T195 2019




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Never home alone: from microbes to millipedes, camel crickets, and honeybees, the natural history of where we live / Rob Dunn

Hayden Library - QH309.D866 2018




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Proceedings of the Symposium on Biomathematics (SYMOMATH) 2018: conference date, 31 August-2 September 2018: location, Depok, Indonesia / editors, Hengki Tasman, Bevina Desjwiandra Handari and Hiromi Seno

Online Resource




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Biological innovations that built the world: a four-billion-year journey through life and earth history / Roberto Ligrone

Online Resource




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Hormones, Metabolism and the Benefits of Exercise.

Online Resource