EXCLUSIVE BY NIK SIMON: Premiership clubs are working towards six different return-to-play scenarios and could cancel six rounds of fixtures to salvage the 2019-20 season.

The Trump administration is working on placing a temporary ban on the issuance of some work-based visas like H-1B, which are popular among highly-skilled Indian IT professionals, as well as students visas and work authorisation that accompanies them, as unemployment levels

The Trump administration is working on placing a temporary ban on the issuance of some work-based visas like H-1B, which are popular among highly-skilled Indian IT professionals, as well as students visas and work authorisation that accompanies them, as unemployment levels

The young budding fashionista Janhvi Kapoor has absolutely impressed us with her sartorial picks. It's so amazing to see the way the actress's fashion has evolved. From lehengas to gowns, she has been slaying in each outfit and making stunning

Kajol's sister and Bollywood-South Indian film actress Tanishaa Mukerji has been doing rounds on the internet these days. She has been treating her fans with her beautiful pictures one after the other and her recent traditional look is what we

A few days ago, Vijay Deverakonda expressed his anger against websites publishing fake news about him. For those who are unversed, in a recent video, angry Vijay revealed that some websites spread fake news against his charitable trust, which gained all

While Kareena Kapoor Khan celebrated Mother's Day with Taimur, Karisma Kapoor shared an image with Babita and Kareena

Gauri too had shared a collage of pictures on her Instagram in the morning featuring Aryan, Suhana, and AbRam and a picture with her mother.

1. Vitamin D-deficient Patients Twice As Likely To Develop Severe COVID-19 Symptoms  Green Prophet
2. Researchers Have Discovered a Strong Correlation Between Severe Vitamin D Deficiency and COVID-19 Mortality Rates  Technology Networks
3. If your body has low levels of this, you have a higher chance of dying from COVID-19  Ladders
4. New study links low vitamin D levels with high COVID-19 death rate  Gulf News
5. Vitamin D is associated with a low COVID-19 death rate  Tech Explorist
6. View Full coverage on Google News

1. Medium-intensity earthquake strikes Delhi, adjoining areas; 3rd amid Covid-19 lockdown  Hindustan Times
2. Earthquake of magnitude 3.5 hits Delhi-NCR  Times of India
3. Earthquake in Delhi: Tremors felt in national capital region  The Financial Express
4. Magnitude 3.4 Earthquake Strikes Delhi, Epicentre Near UP Border  News18
5. Breaking news live : Eathquake tremors felt in Delhi, adjoining areas  Times of India
6. View Full coverage on Google News

So, you're snowed in your house with two feet of snow and need a way out, but are too lazy to shovel. Luckily, you happened to have a welder, some steel, a bicycle, a 3.5HP go-kart, and some wood laying around. So what do you do? You make a plow to get yourself out!

RIDING YOUR BIKE not today

LIKE A BOSS!

LIKE A BOSS level: epic

They’re a simple little candy, Mike and Ike, just elongated jelly beans. Listen in for some fun flavors they’ve come in and our suggestions for the future.

Since the Middle Ages, alchemists have sought to transmute elements, the most famous example being the long quest to turn lead into gold. Now, Princeton University theorists have proposed a different approach to this ancient ambition — just make one material behave like another. The researchers demonstrate that any two systems can be made to look alike, even if just for the smallest fraction of a second.

Nach seinen provokanten Aussagen zur Corona-Pandemie diskutieren die Grünen über einen Parteiausschluss von Tübingens Oberbürgermeister Boris Palmer. Nun macht ihm die FDP Avancen.

Edwin Cabrera, a father of two, was unlocking his e-bike after dropping off a pizza on Fort George Hill near Fairview Ave. on May 3 when two suspects jumped out of the shadows and attacked him around 9 p.m.

The Ride of Your Life is raising money for the construction of a new bike park in Yellowknife.
( Photos: 15, Comments: 7 )

Coronavirus reopening: more beaches and parks

A low-pressure trough pushing into Northern California from the Pacific will bring widespread showers to the part of the state most in need of rain.

So you've decided to hike Machu Picchu? Well great! There's no doubt that you're in for the experience of a lifetime. However, the truth of the matter is that now you've got some additional decisions to make. You see, there's more than one route to arrive to the world-famous Inca site, and even once you've arrived there are a few choices to make as well.

But don't fret! If you're looking to hike Machu Picchu, we've got the information you need to start planning your trip.

Hike Machu Picchu: Arriving to the Site

1. Classic Inca Trail

The Classic Inca Trail is a four-day trek stretching some 42 kilometers along an ancient road built by the Incas themselves. This is undoubtedly the most famous route to Machu Picchu, and it's the one way that offers the opportunity to enter the city through its storied Sun Gate. Frankly, we've got tons of information on the Inca Trail on other pages of our site, so we won't waste too much space being redundant here. Check out these pages for more information on the trail's itinerary as well as for access to an Inca Trail map.

2. One-Day Inca Trail

Whether you're crunched for time or simply don't feel physically up to four full days of trekking, don't fret--a small taste of the world-famous Inca Trail is still available to you! A number of tour companies offer an abridged version of the trek, either one full day of hiking or a shortened day followed by a night of camping and a dawn arrival at Machu Picchu. Besides the Inca Trail's famed destination, the one-day version of the trek also takes you past Wiñay Wayna, another favorite ruins along the trail. The bad news here is that you'll still need to reserve one of only a few hundred daily Inca Trail passes, meaning that, just like the full Inca Trail, you'll need to book this trek months in advance.

3. Lares Trail

Just north of the world-famous Sacred Valley sits the comparatively lesser-known Lares Valley, and whereas the former can be swarmed with tourists especially during the high season, life in the Lares Valley continues humming along relatively unchanged. So whether you're looking for a simpler, more culturally-immersive experience or if you just didn't book an Inca Trail pass in time, the Lares Trail is an excellent option! Lucky for you, we've already gathered plenty of information on the Lares Trail including the trek's daily itinerary and a side-by-side comparison of the Lares and Inca Trails if you're struggling to decide how to hike Machu Picchu.

4. Vilcabamba Traverse Route

Warning--this option is neither for the faint of heart nor the out of shape! The Vilcabamba Traverse Route is one of the newest on the Peru trekking circuit, clocking in at nearly 100 kilometers over the course of a week of trekking. Though very difficult, the route is especially rewarding--think a variety of diverse biomes and the ruins of Choquequirao, often compared to Machu Picchu although less than 40% of the site has been excavated (pictured above). Though visited by only 5,000 or so brave trekkers last year, be warned--the local government is pushing a plan to build a cable car to the site! If you want to see the ruins in their current, undisturbed state, it would be best to go sooner than later.

Hike Machu Picchu: Once You're There

5. Huayna Picchu

Just because you've finally arrived at Machu Picchu doesn't mean your hiking experience has to end! The famous mountain soaring in the background of most iconic Machu Picchu photos is possible to hike, and the experience is certainly recommended. The views from the top are great, and on the way down you can even take a back route to the storied Temple of the Moon. For more information on Huayna Picchu, you can check out this past post on our site.

So that's it for today! If you're planning to hike Machu Picchu and have any questions you'd like to ask us, feel free to reach out in the comments section below. And, if you've already done one of these hikes, feel free to share your experience as well. We appreciate all of your comments!

Comparing “Likes” with “Tweets” of the Most Shared Stories

The government says it is "stepping up action" to stop the "totally unacceptable" crossings.

Flying in Canada during the time of COVID-19 requires a lot extra care, and CTV Senior Political Correspondent Glen McGregor gives a first-hand account on CTVNews.ca.

Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation. Members of the NF-κB family of transcription factors are key drivers of inflammation that activate sets of genes in response to inflammatory signals. Such responses are typically short-lived and can be suppressed by proteins that act post-translationally, such as the SOCS (suppressor of cytokine signaling) family. Less is known about direct transcriptional regulation of these responses, however. Here, using a combination of in vitro approaches and in vivo animal models, we show that endotoxin treatment induced expression of the well-characterized transcriptional repressor Krüppel-like factor 3 (KLF3), which, in turn, directly repressed the expression of the NF-κB family member RELA/p65. We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhibited elevated levels of circulating Ly6C+ monocytes and macrophage-derived inflammatory cytokines. These findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammation.

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

Uber lost US$2.9 billion in the first quarter as its overseas investments were hammered by the coronavirus pandemic, but the company is looking to its growing food delivery business and aggressive cost-cutting to ease the pain. The ride-hailing...

A new program is giving bicycles to Indigenous youth who move to Winnipeg for school to help them get around the city as they pursue their studies.

Christina shares about the love between a refugee man and his disabled son, whom she met while volunteering in Šid, Serbia.

Twice a week Lourie Ferreira heads out into rural Zambian communities to show God's love through dentistry.

“Seeing how these boys lived…put my own life into perspective,” said Anne Davidson, after spending time with youth living on the streets of Lusaka.

"Wow! Roohi, What a classic performance we are giving," said Karan Johar

"Wow! Roohi, What a classic performance we are giving," said Karan Johar

Planning to buy a brand-new, affordable two-wheeler but BS6 price hike worrying you? Here are the five cheapest bikes and scooter(s) that are BS6 compliant and won't burn a hole in your pocket. And there is a moped too!

Hero MotoCorp has confirmed through its official website that BS6 versions of the XPulse 200T and Xtreme 200R are coming soon. No word on BS6 Xtreme 200R yet.

Honda Associates had earlier voluntarily pledged to donate their 1-day salary towards the relief aid.

The BMW 310 twins might not have a features upgrade or riding modes compared to the updates the TVS Apache RR310 got.

It has been well over three weeks our motorcycles have been parked and there are now nearly three more weeks to go before the coronavirus lockdown hopefully lifts. When you do finally get back on the road, remember to check these six things.

BS6 TVS Apache RR 310: With the BS6 upgrade, TVS Motor Company has turned around the RR 310's personality for the better. And add to that, it is now loaded with features – something that is very attractive to young buyers.