While the phased-in reopening of schools in South Africa in the midst of Covid-19 remains provisional and sensitive, the Western Cape Education Department has advised principals and school management teams to wait a few more days before returning.

Messages to mothers and words of support were front and centre as Edmontonians cruised by MacTaggart Place retirement residence on Saturday afternoon.

Residents in Okotoks, Alta. were about to help support those less fortunate in their community by donating non-perishable food items in a drive hosted by a local baseball club.

Alberta reported 59 new COVID-19 cases on Saturday, bringing the total number of active cases in the province to 1.837.

Two-time women's World Cup winner Alex Morgan and husband Servando Carrasco have welcomed a new player to their team.

The DML News App offers the best in news reporting.

The post REPORT: Rock vocalist’s daughter rescued from Peru by US Embassy amid coronavirus ban appeared first on Dennis Michael Lynch.

After more than a month at sea, isolated to their cabins, dozens of Canadian cruise ship workers have arrived back on home soil.

School, friends and normal day to day interactions have taken a virtual shift. However, for those with limited access to the internet, devices and other technology, isolation can be challenging.

Many in the region had to dust off their snow shovels for at least one more dig out on Saturday morning after a polar vortex blasted parts of the province, catching many off guard.

12 November 2014 , Volume 90, Number 6

gali_nette posted a photo:

South Dakota Governor Kristi Noem sent letters to two Sioux tribes demanding they remove COVID-19 checkpoints because they interfere with traffic.

Prime Minister Justin Trudeau called Saturday for caution and expressed concern about loosening lockdown measures in Montreal, the epicenter of Canada's coronavirus outbreak. While several Canadian provinces, including Quebec, are preparing reopening measures and a gradual revival of their economies, Trudeau stressed prudence and said that the country is not yet out of danger. Quebec is the worst-hit province in Canada, with more than half of both the country's 67,000 cases of coronavirus and 4,700 deaths.

The government said it's distributing the promising coronavirus drug, remdesivir, to some hard-hit states. Eventually, all 50 states should get it.

"Passing along a message from Mother Nature," the National Weather Service in Binghamton, New York, tweeted alongside a photo of a car covered in light snow. "Happy Mother's Day Weekend."

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to form β-cholesterylglucoside (β-GlcChol) in vitro. β-GlcChol is a member of sterylglycosides present in diverse species. How GBA1 and GBA2 mediate β-GlcChol metabolism in the brain is unknown. Here, we purified and characterized sterylglycosides from rodent and fish brains. Although glucose is thought to be the sole carbohydrate component of sterylglycosides in vertebrates, structural analysis of rat brain sterylglycosides revealed the presence of galactosylated cholesterol (β-GalChol), in addition to β-GlcChol. Analyses of brain tissues from GBA2-deficient mice and GBA1- and/or GBA2-deficient Japanese rice fish (Oryzias latipes) revealed that GBA1 and GBA2 are responsible for β-GlcChol degradation and formation, respectively, and that both GBA1 and GBA2 are responsible for β-GalChol formation. Liquid chromatography–tandem MS revealed that β-GlcChol and β-GalChol are present throughout development from embryo to adult in the mouse brain. We found that β-GalChol expression depends on galactosylceramide (GalCer), and developmental onset of β-GalChol biosynthesis appeared to be during myelination. We also found that β-GlcChol and β-GalChol are secreted from neurons and glial cells in association with exosomes. In vitro enzyme assays confirmed that GBA1 and GBA2 have transgalactosylation activity to transfer the galactose residue from GalCer to cholesterol to form β-GalChol. This is the first report of the existence of β-GalChol in vertebrates and how β-GlcChol and β-GalChol are formed in the brain.

Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion of autophagy-related 5 (ATG5), results in accumulation of intracellular VEGFA, indicating that VEGFA is a basal autophagic substrate. Mechanistically, decorin increased the VEGFA clearance rate by augmenting autophagic flux, a process that required RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compartments. We validated these findings by demonstrating the physiological relevance of this process in vivo. Mice starved for 48 h exhibited a sharp decrease in overall cardiac and aortic VEGFA that could be blocked by systemic chloroquine treatment. Thus, our findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic clearance in response to decorin and canonical pro-autophagic stimuli. We posit that the VEGFR2/AMPK/PEG3 axis integrates the anti-angiogenic and pro-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression. These results support future therapeutic use of decorin as a next-generation protein therapy to combat cancer.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Written from, different angles and spaces, the poems below testify to the great force of motherhood, which nurtures, strengthens, and manifests love. Happy Mother’s Day – Ann-Margaret Lim Words My mother loved words. Not necessarily in...

For drummer Conroy Gordon, the hardest part of being locked away day after day in the narrow confines of a stranded cruise ship is his inability to tell his two daughters when Daddy will be home. For the past month, he has been battling this...

This report draws on a six-year longitudinal study of Palm Beach County, FL, examining parenting, child care enrollment, and other factors that encourage early school success. The authors find kindergarten-age children of Black immigrants have significantly higher odds of being ready for school than children of Latina immigrant or Black U.S.-born mothers.

May 9 marked a very special day for all Russians as the day of the victory over Nazi Germany in the Great Patriotic war. At 00:16 hours on that day in 1945 Act of Military Surrender was signed by the German military leaders in Berlin. The...

(CMC): Trinidad and Tobago says its borders are to remain closed until June, even as it embarks on softening restrictions to re energise the economy, which had been halted by COVID-19.   Prime Minister Dr Keith Rowley said the...

Mother’s Day is usually a much-anticipated, celebratory day for Trinette Lilly and her siblings. However, this year, they were not looking forward to today because it marks the first anniversary of the brutal slaying of their mother, Antonette...

This special issue focuses on The Role of Community Health Workers as First Responders in the COVID-19 Outbreak. 

Recorded May 5, 2020.

This is a part of the American Diabetes Associations ongoing project providing resources for practicing clinicians on the care of Diabetes during the Covid-19 pandemic.  Today’s discussion is an audio version of a webinar recorded on May 5, 2020.

Presented by:

Betsy Rodriguez, BSN, MSN, DCES
Centers for Disease Control and Prevention

Colleen Barbero, PhD
Centers for Disease Control and Prevention

Denise Octavia Smith, MBA, CHW, PN, SFC
National Association of Community Health Workers

Este manual ofrece a los formuladores de políticas y especialistas una guía accesible y práctica sobre las iniciativas gubernamentales referentes a la diáspora. Este manual contiene un menú, seleccionado cuidadosamente, de opciones normativas y programáticas viables basadas en experiencias reales en distintas partes del mundo.

Ce manuel pratique et simple d’utilisation à l’usage des décideurs et des praticiens fait le point des mesures les plus récentes prises par les pouvoirs publics en direction des diasporas. La question qui se pose aux responsables politiques n’est pas tant de savoir si les diasporas peuvent être utiles à leur pays d’origine, mais comment elles le sont et quels types de politiques et de programmes publics sont à même de favoriser ces relations.

This edited volume develops a pragmatic approach to the engagement of highly skilled members of the diaspora for the benefit of their countries of origin. The book, edited by a World Bank senior economist, is based on empirical work in middle-income and high-income economies.

This year’s Mother’s Day has undoubtedly been impacted by the COVID-19 virus. Plans to show appreciation to the one you call ‘mama’ have been thwarted due to worldwide quarantine conditions. But while there may not be the usual elaborate dinner at...

This 2008 pocket guide compiled some of the most credible, accessible, and user-friendly government and non-governmental data sources pertaining to U.S. and international migration. The guide includes additional links to relevant organizations, programs, research, and deliverables, along with a glossary of frequently used immigration terms.

This MPI webinar features U.S. Department of Justice (DOJ) officials discussing the department’s efforts to improve communications with Limited English Proficient (LEP) communities in federal and federally-funded programs and activities.

This MPI webinar features U.S. Department of Justice (DOJ) officials discussing the department’s efforts to improve communications with Limited English Proficient (LEP) communities in federal and federally-funded programs and activities.

This report highlights gaps and anomalies in labor protection, while recognizing that U.S. law sets significant standards for minimum wage, overtime pay, child labor, safe and healthy workplaces, antidiscrimination, labor organizing, and collective bargaining.

This Migration Policy Institute webinar discusses labor enforcement laws during the Clinton, Bush and Obama administrations and chronicles gaps in labor protection.

This webinar discusses labor enforcement laws during the Clinton, Bush, and Obama administrations and chronicles gaps in labor protection, while also discussing the elements necessary for an effective labor standards enforcement system and why labor standards enforcement should become a pillar of immigration policymaking.

So once I went on a night out and I kissed a drunk girl and she was hinting she wanted to come home with me but I didn't let it happen. If this happens again will it be weird if I bring a girl home at like 3 in the morning and I live with my parents. Do I have to hide her? What if we have sex? In the morning my mum just come in and opens the door to get my washing. What if she does this and there is a girl in the bed? Will I get in trouble? I don't know anything about this stuff. I'm 21 do people this age even do this or is it only people in there 30s? It will be nice to spend the night with a girl. Is it a bad idea. I have no brothers or friends so I don't know what people do. I want to know for the next time?

He catches the fish, breathes on them, then throws them back. These infected fish will infect all bodies of water with Covid-19. He goes saltwater and fresh water fishing 

My friend the dumb joe will ask me for money and try and sell me his garbage because he needs money for a bus fare. He will talk to Asian girls because I think he is not good enough for white girls. He try's to many things. Let's go over some of them. The army the police an astronaut he worked at 5 different supermarkets he got a night job for about 3 weeks and never sleeper at all. He wanted to go to China but cancelled he wanted to go to Auckland but cancelled he wanted to go to Singapore but cancelled. He brought a moped and sold it a week later. He wanted a BMW but didn't get one after he told me he was getting it. He sold me a speaker for $20 and a month later he asked for it back for free and he did not get it. He was on his way to buy a computer and he runs in to a friend and asked him can I have your computer for $200 when the one he was going to buy was $180. He will never learn to drive when he drove into a lamppost. And meny more weird things as well. What is wrong with him?

I’ve liked him for a year and I told him, but he told me to date someone else. I started to forget about him, but then he told me that he liked me too. We’re dating now but I don’t think that I feel the same was as when I first started liking him. What should I do?

I have an online gf it seems kind of serious but we've never really made attempts on meeting but i slept with someone irl,is that cheating? Should I tell her?

....GOING TO DO WHEN THEY BELIEVE THEY APPLY TO THEM BUT THEY HAVEN'T BEEN HOLY SPIRIT BAPTIZED? TODAY'S CHRISTIANS HAVEN'T BEEN "QUICKENED BACK TO LIFE" (EPHESIANS 2:1)  BY HIS "POWER THAT CAME UPON THEM" (ACTS 1:8) WITH HOLY SPIRIT BAPTISM (ACTS 1:5) AS THEY WERE "BORN AGAIN OF THE SPIRIT" (JOHN 3:5-7) FROM THEIR "DEAD SPIRITS" (ROMANS 5:12-14) AND WERE "RESURRECTED" (I COR 15) FROM THEIR GRAVES" (EZEKIEL 37:12-14). WHAT ARE THESE "DEAD SPIRITS" GOING TO DO? 

I have a fwb trade with this guy who doesnt respect me at all and hurts my feelings because I'm not as attractive as he is and gets annoyed if I dont meet his demands,how do I stop this fwb? I'm scared if he does he'll tell people or get mad at me.