pi Screening for Glucose Perturbations and Risk Factor Management in Dysglycemic Patients With Coronary Artery Disease--A Persistent Challenge in Need of Substantial Improvement: A Report From ESC EORP EUROASPIRE V By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Dysglycemia, in this survey defined as impaired glucose tolerance (IGT) or type 2 diabetes, is common in patients with coronary artery disease (CAD) and associated with an unfavorable prognosis. This European survey investigated dysglycemia screening and risk factor management of patients with CAD in relation to standards of European guidelines for cardiovascular subjects. RESEARCH DESIGN AND METHODS The European Society of Cardiology’s European Observational Research Programme (ESC EORP) European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) V (2016–2017) included 8,261 CAD patients, aged 18–80 years, from 27 countries. If the glycemic state was unknown, patients underwent an oral glucose tolerance test (OGTT) and measurement of glycated hemoglobin A1c. Lifestyle, risk factors, and pharmacological management were investigated. RESULTS A total of 2,452 patients (29.7%) had known diabetes. OGTT was performed in 4,440 patients with unknown glycemic state, of whom 41.1% were dysglycemic. Without the OGTT, 30% of patients with type 2 diabetes and 70% of those with IGT would not have been detected. The presence of dysglycemia almost doubled from that self-reported to the true proportion after screening. Only approximately one-third of all coronary patients had completely normal glucose metabolism. Of patients with known diabetes, 31% had been advised to attend a diabetes clinic, and only 24% attended. Only 58% of dysglycemic patients were prescribed all cardioprotective drugs, and use of sodium–glucose cotransporter 2 inhibitors (3%) or glucagon-like peptide 1 receptor agonists (1%) was small. CONCLUSIONS Urgent action is required for both screening and management of patients with CAD and dysglycemia, in the expectation of a substantial reduction in risk of further cardiovascular events and in complications of diabetes, as well as longer life expectancy. Full Article
pi Dallas Cowboys sign former first-round pick Cameron Erving By www.upi.com Published On :: Wed, 06 May 2020 19:14:49 -0400 The Dallas Cowboys agreed to terms with free-agent offensive lineman Cameron Erving, the team announced Wednesday. Full Article
pi Bryce Harper calls MLB 'dumb' to keep stars out of Olympics By www.upi.com Published On :: Fri, 08 May 2020 08:21:27 -0400 Philadelphia Phillies star Bryce Harper thinks Major League Baseball is "dumb" for its policy that makes the Olympics off-limits for baseball's best players. Full Article
pi Korea's K-League soccer returns with rules against spitting, talking By www.upi.com Published On :: Fri, 08 May 2020 10:49:47 -0400 K-League soccer resumed with a game behind closed doors Friday in South Korea, with players prohibited from spitting and talking. Full Article
pi Type 2 Diabetes in Children and Young Adults: A "New Epidemic" By clinical.diabetesjournals.org Published On :: 2002-10-01 Francine Ratner KaufmanOct 1, 2002; 20:President's Pen Full Article
pi Plasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS At baseline, 178 lipids were measured by mass spectrometry in 3,668 participants without diabetes from the Malmö Diet and Cancer Study. The population was randomly split into discovery (n = 1,868, including 257 incident cases) and replication (n = 1,800, including 249 incident cases) sets. We used orthogonal projections to latent structures discriminant analyses, extracted a predictive component for T2DM incidence (lipid-PCDM), and assessed its association with T2DM incidence using Cox regression and lifestyle factors using general linear models. RESULTS A T2DM-predictive lipid-PCDM derived from the discovery set was independently associated with T2DM incidence in the replication set, with hazard ratio (HR) among subjects in the fifth versus first quintile of lipid-PCDM of 3.7 (95% CI 2.2–6.5). In comparison, the HR of T2DM among obese versus normal weight subjects was 1.8 (95% CI 1.2–2.6). Clinical lipids did not improve T2DM risk prediction, but adding the lipid-PCDM to all conventional T2DM risk factors increased the area under the receiver operating characteristics curve by 3%. The lipid-PCDM was also associated with a dietary risk score for T2DM incidence and lower level of physical activity. CONCLUSIONS A lifestyle-related lipidomic profile strongly predicts T2DM development beyond current risk factors. Further studies are warranted to test if lifestyle interventions modifying this lipidomic profile can prevent T2DM. Full Article
pi Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Many patients with hyperglycemic crises present with combined features of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). The implications of concomitant acidosis and hyperosmolality are not well known. We investigated hospital outcomes in patients with isolated or combined hyperglycemic crises. RESEARCH DESIGN AND METHODS We analyzed admissions data listing DKA or HHS at two academic hospitals. We determined 1) the frequency distributions of HHS, DKA, and combined DKA-HHS (DKA criteria plus elevated effective osmolality); 2) the relationship of markers of severity of illness and clinical comorbidities with 30-day all-cause mortality; and 3) the relationship of hospital complications associated with insulin therapy (hypoglycemia and hypokalemia) with mortality. RESULTS There were 1,211 patients who had a first admission with confirmed hyperglycemic crises criteria, 465 (38%) who had isolated DKA, 421 (35%) who had isolated HHS, and 325 (27%) who had combined features of DKA-HHS. After adjustment for age, sex, BMI, race, and Charlson Comorbidity Index score, subjects with combined DKA-HHS had higher in-hospital mortality compared with subjects with isolated hyperglycemic crises (adjusted odds ratio [aOR] 2.7; 95% CI 1.4, 4.9; P = 0.0019). In all groups, hypoglycemia (<40 mg/dL) during treatment was associated with a 4.8-fold increase in mortality (aOR 4.8; 95% CI 1.4, 16.8). Hypokalemia ≤3.5 mEq/L was frequent (55%). Severe hypokalemia (≤2.5 mEq/L) was associated with increased inpatient mortality (aOR 4.9; 95% CI 1.3, 18.8; P = 0.02). CONCLUSIONS Combined DKA-HHS is associated with higher mortality compared with isolated DKA or HHS. Severe hypokalemia and severe hypoglycemia are associated with higher hospital mortality in patients with hyperglycemic crises. Full Article
pi Men take Guinness record for ping pong ball catches in shaving cream By www.upi.com Published On :: Fri, 08 May 2020 11:21:28 -0400 A pair of Idaho men tackled an unusual Guinness World Record by most table tennis balls caught in shaving foam on the head in 30 seconds (team of 2). Full Article
pi Despite Flurry of Actions, Trump Administration Faces Constraints in Achieving Its Immigration Agenda By www.migrationpolicy.org Published On :: Wed, 24 Apr 2019 10:39:18 -0400 Though it has achieved success in some areas, the Trump administration’s many efforts to stiffen immigration enforcement in the U.S. interior and at the Southwest border are being consistently stymied by court injunctions, existing laws and settlements, state and local resistance, congressional pushback, and migration pressures that are beyond the government’s ability to swiftly address, as this article explores. Full Article
pi From Control to Crisis: Changing Trends and Policies Reshaping U.S.-Mexico Border Enforcement By www.migrationpolicy.org Published On :: Fri, 02 Aug 2019 12:09:41 -0400 How did the U.S. border enforcement picture go in the span of two years from the lowest levels of illegal immigration since 1971 to a spiraling border security and humanitarian crisis? This report draws on enforcement and other data as well as analysis of changing migration trends and policies to tell this story. The authors outline key elements for a new strategy that can succeed over the long term. Full Article
pi Panthers' Derrick Brown to become first 2020 Round 1 pick to sign rookie deal By www.upi.com Published On :: Fri, 08 May 2020 20:02:40 -0400 Former Auburn defensive tackle Derrick Brown agreed to his rookie contract with the Carolina Panthers on Friday. Full Article
pi Lipid and Inflammatory Cardiovascular Risk Worsens Over 3 Years in Youth With Type 2 Diabetes: The TODAY clinical trial By care.diabetesjournals.org Published On :: 2013-06-01 TODAY Study GroupJun 1, 2013; 36:1758-1764TODAY Study Full Article
pi Kidney Disease and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study By care.diabetesjournals.org Published On :: 2014-01-01 Ian H. de BoerJan 1, 2014; 37:24-30DCCT/EDIC 30th Anniversary Summary Findings Full Article
pi Exploring the Potential of the SGLT2 Inhibitor Dapagliflozin in Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Pilot Study By care.diabetesjournals.org Published On :: 2015-03-01 Robert R. HenryMar 1, 2015; 38:412-419Evolving Tactics With Inhibition of Sodium-Glucose Cotransporters Full Article
pi Prevalence of Hyper- and Hypoglycemia Among Inpatients With Diabetes: A national survey of 44 U.S. hospitals By care.diabetesjournals.org Published On :: 2007-02-01 Deborah J. WexlerFeb 1, 2007; 30:367-369BR Epidemiology/Health Services/Psychosocial Research Full Article
pi In-Hospital Prognosis of Ppatients With Fasting Hyperglycemia After First Myocardial Infarction By care.diabetesjournals.org Published On :: 1991-08-01 John J O'SullivanAug 1, 1991; 14:758-760Short Report Full Article
pi Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study By care.diabetesjournals.org Published On :: 2014-01-01 John M. LachinJan 1, 2014; 37:39-43DCCT/EDIC 30th Anniversary Summary Findings Full Article
pi Rapid Rise in Hypertension and Nephropathy in Youth With Type 2 Diabetes: The TODAY clinical trial By care.diabetesjournals.org Published On :: 2013-06-01 TODAY Study GroupJun 1, 2013; 36:1735-1741TODAY Study Full Article
pi Neuropathy and Related Findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study By care.diabetesjournals.org Published On :: 2014-01-01 Catherine L. MartinJan 1, 2014; 37:31-38DCCT/EDIC 30th Anniversary Summary Findings Full Article
pi Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?: Health Be Damned! Pour on the Sugar By care.diabetesjournals.org Published On :: 2014-04-01 George A. BrayApr 1, 2014; 37:950-956Current Concepts of Type 2 Diabetes Prevention Full Article
pi Diabetes and Obesity in the Offspring of Pima Indian Women With Diabetes During Pregnancy By care.diabetesjournals.org Published On :: 1993-01-01 David J PettittJan 1, 1993; 16:310-314Supplement 1: Diabetes in Native Americans Full Article
pi Insulinotropic Action of Glucagonlike Peptide-I-(7-37) in Diabetic and Nondiabetic Subjects By care.diabetesjournals.org Published On :: 1992-02-01 David M NathanFeb 1, 1992; 15:270-276Short Report Full Article
pi Precipitation of Autoimmune Diabetes With Anti-PD-1 Immunotherapy By care.diabetesjournals.org Published On :: 2015-04-01 Jing HughesApr 1, 2015; 38:e55-e57e-Letters: Observations Full Article
pi Metformin Improves Glucose, Lipid Metabolism, and Reduces Blood Pressure in Hypertensive, Obese Women By care.diabetesjournals.org Published On :: 1993-10-01 Dario GiuglianoOct 1, 1993; 16:1387-1390Short Report Full Article
pi The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview By care.diabetesjournals.org Published On :: 2014-01-01 David M. NathanJan 1, 2014; 37:9-16DCCT/EDIC 30th Anniversary Summary Findings Full Article
pi Israeli High Court permits Benjamin Netanyahu to form government despite indictments By www.upi.com Published On :: Wed, 06 May 2020 18:59:47 -0400 A panel of 11 judges ruled that Israeli Prime Minister Benjamin Netanyahu can form a government after reaching a deal with rival Benny Gantz. Full Article
pi Train kills 15 migrant workers sleeping on tracks in Aurangabad, India By www.upi.com Published On :: Fri, 08 May 2020 09:30:14 -0400 Officials said 15 migrant workers were killed Friday when a cargo train ran them over as they slept on the tracks near Aurangabad, India. Full Article
pi Dalcetrapib Reduces Risk of New-Onset Diabetes in Patients With Coronary Heart Disease By care.diabetesjournals.org Published On :: 2020-05-01 Gregory G. SchwartzMay 1, 2020; 43:1077-1084Emerging Therapies: Drugs and Regimens Full Article
pi Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study By care.diabetesjournals.org Published On :: 2016-10-01 Khalid A. JadoonOct 1, 2016; 39:1777-1786Emerging Technologies and Therapeutics Full Article
pi PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2019-09-01 Vanita R. ArodaSep 1, 2019; 42:1724-1732Emerging Therapies: Drugs and Regimens Full Article
pi Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?: Health Be Damned! Pour on the Sugar By care.diabetesjournals.org Published On :: 2014-04-01 George A. BrayApr 1, 2014; 37:950-956Current Concepts of Type 2 Diabetes Prevention Full Article
pi The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview By care.diabetesjournals.org Published On :: 2014-01-01 David M. NathanJan 1, 2014; 37:9-16DCCT/EDIC 30th Anniversary Summary Findings Full Article
pi Oral Semaglutide Versus Empagliflozin in Patients With Type 2 Diabetes Uncontrolled on Metformin: The PIONEER 2 Trial By care.diabetesjournals.org Published On :: 2019-12-01 Helena W. RodbardDec 1, 2019; 42:2272-2281Emerging Therapies: Drugs and Regimens Full Article
pi Diabetes Technology Update: Use of Insulin Pumps and Continuous Glucose Monitoring in the Hospital By care.diabetesjournals.org Published On :: 2018-08-01 Guillermo E. UmpierrezAug 1, 2018; 41:1579-1589Diabetes Care Symposium Full Article
pi A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone. RESEARCH DESIGN AND METHODS Patients with diabetes and chronic DFUs were randomized (double-blind) to either active TWO2 therapy or sham control therapy—both in addition to optimal SOC. The primary outcome was the percentage of ulcers in each group achieving 100% healing at 12 weeks. A group sequential design was used for the study with three predetermined analyses and hard stopping rules once 73, 146, and ultimately 220 patients completed the 12-week treatment phase. RESULTS At the first analysis point, the active TWO2 arm was found to be superior to the sham arm, with a closure rate of 41.7% compared with 13.5%. This difference in outcome produced an odds ratio (OR) of 4.57 (97.8% CI 1.19, 17.57), P = 0.010. After adjustment for University of Texas Classification (UTC) ulcer grade, the OR increased to 6.00 (97.8% CI 1.44, 24.93), P = 0.004. Cox proportional hazards modeling, also after adjustment for UTC grade, demonstrated >4.5 times the likelihood to heal DFUs over 12 weeks compared with the sham arm with a hazard ratio of 4.66 (97.8% CI 1.36, 15.98), P = 0.004. At 12 months postenrollment, 56% of active arm ulcers were closed compared with 27% of the sham arm ulcers (P = 0.013). CONCLUSIONS This sham-controlled, double-blind randomized controlled trial demonstrates that, at both 12 weeks and 12 months, adjunctive cyclical pressurized TWO2 therapy was superior in healing chronic DFUs compared with optimal SOC alone. Full Article
pi USCIS Fee Increase Proposed Rule Could Represent the Latest Step in Reshaping Immigration to United States By www.migrationpolicy.org Published On :: Thu, 19 Dec 2019 09:48:55 -0500 While much attention has been given to the move by U.S. Citizenship and Immigration Services to raise its application fees—including an 83 percent hike to apply for U.S. citizenship—the policy changes embedded in the proposed rule have been less scrutinized. The changes, including the elimination of most fee waivers for lower-income applicants, would likely reduce the number and shift the profile of those getting a green card or other immigration status. Full Article
pi Dr. Loree Bolin is ADA’s 2020 Humanitarian Award recipient By www.ada.org Published On :: Thu, 16 Jan 2020 10:10:00 -0600 Dr. Loree Bolin’s humanitarian work has drawn accolades from the dental community in her home state of Washington, and now Dr. Bolin is being recognized nationally by being named the recipient of the ADA’s 2020 Humanitarian Award, bestowed by the ADA Board of Trustees. Full Article
pi Special Olympics athletes get dental help thanks to ADA member dentist By www.ada.org Published On :: Tue, 21 Jan 2020 11:15:00 -0600 As the world gets ready for the Special Olympics Sweden Invitational Games in February, one of the ADA’s member dentists will be watching as the Special Smiles program he founded will be used to screen and attend to the dental needs of the competing athletes. Full Article
pi ADA joins coalition calling for vaping regulation By www.ada.org Published On :: Thu, 06 Feb 2020 08:51:00 -0600 The American Dental Association, along with 75 organizations, is urging Congress to support legislation to regulate vaping devices and liquids in the same manner the Food and Drug Administration regulates cigarettes and other tobacco products. Full Article
pi New HPI Industry Report now available By www.ada.org Published On :: Thu, 06 Feb 2020 11:26:00 -0600 Dental spending reached $136 billion in 2018 — 3.7% of all health spending — and what the ADA Health Policy Institute is calling a “historic high” in the new HPI Industry Report released Feb. 4. Full Article
pi Vaping bill passes House By www.ada.org Published On :: Mon, 02 Mar 2020 16:37:00 -0600 The U.S. House of Representatives Feb. 28 passed a comprehensive bill designed to address the youth tobacco epidemic. Full Article
pi FDA alerts health care providers of EpiPen auto-injector errors By www.ada.org Published On :: Thu, 26 Mar 2020 14:04:00 -0500 The U.S. Food and Drug Administration announced March 24 that it is alerting health care professionals, patients and caregivers of EpiPen autoinjector errors related to device malfunctions and user administration. Full Article
pi HPI poll examines impact of COVID-19 on dental practices By www.ada.org Published On :: Wed, 01 Apr 2020 12:27:00 -0500 The ADA Health Policy Institute launched an ongoing biweekly poll the week of March 23 that shows 76% of dentists surveyed had closed their offices to all but emergency patients during the COVID-19 pandemic. Another 19% indicated their offices are closed completely. Full Article
pi Code Maintenance Committee approves new codes associated with vaping, teledentistry By www.ada.org Published On :: Thu, 02 Apr 2020 10:27:00 -0500 On the heels of the ADA’s December interim policy on vaping comes a new CDT code that references counseling services about high-risk substance use including vaping. Full Article
pi Harvard dental student recipient of health literacy essay contest By www.ada.org Published On :: Thu, 02 Apr 2020 10:49:00 -0500 An essay on community water fluoridation yielded a Harvard University dental student a first-place win in the annual American Dental Association’s Health Literacy in Dentistry essay contest. Full Article
pi Second week of HPI polling shows dentists’ response to COVID-19 By www.ada.org Published On :: Fri, 10 Apr 2020 12:32:00 -0500 The second round of results from the ADA Health Policy Institute poll on the impact of COVID-19 on dental practices showed significant financial impact, with collections for the vast majority of dentists less than 5% of what is typical in their practice. Full Article
pi ADA streams webinar April 27 on respiratory protection By www.ada.org Published On :: Thu, 23 Apr 2020 14:40:00 -0500 A recorded webinar will stream April 27 outlining the Association’s interim recommendation for personal protective equipment in dental settings as some states consider loosening social distancing mandates. Full Article
pi Third wave of HPI polling shows dentists’ response to COVID-19 By www.ada.org Published On :: Mon, 27 Apr 2020 10:32:00 -0500 The third round of results from the ADA Health Policy Institute poll on the impact of COVID-19 on dental practices was released April 27, with 79% of dentists reporting their practices are closed except for emergencies and 17% are closed completely. Full Article
pi HPI releases webinar on economic impact of COVID-19 By www.ada.org Published On :: Thu, 07 May 2020 11:59:00 -0500 The ADA Health Policy Institute held a webinar April 29 with leading experts from across the dental industry to discuss how COVID-19 has affected the dental economy and what they think the future will bring. Full Article
pi Crude oil prices drop after API reported lower-than-expected draw By www.upi.com Published On :: Wed, 16 Jan 2019 09:13:03 -0500 Oil prices fell early Wednesday, likely a result of lower-than-expected draws in an API with traders awaiting official EIA inventory data later in the day. Full Article
