A University at Buffalo-led research team is studying the details of how enzymes perform their job. The focus of the project is on understanding the molecular interactions that enable enzymes to accelerate chemical reactions.

This is a continuing profile series on the directors of the Department of Energy (DOE) Office of Science user facilities. These scientists lead a variety of research institutions that provide researchers with the most advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nano world, the environment, and the atmosphere.

The Genetics Society of America (GSA) is pleased to announce the 2020 recipients of its annual awards for distinguished service in the field of genetics. The awardees were nominated and selected by their colleagues and will be recognized with presentations at The Allied Genetics Conference (TAGC), held April 22-26, 2020, in the metro Washington, DC area.

A team of scientists has observed, for the first time, the presence of warm water at a vital point underneath a glacier in Antarctica--an alarming discovery that points to the cause behind the gradual melting of this ice shelf while also raising concerns about sea-level rise around the globe.

Scientists published the first assessment of the impact that invasive hippos imported by drug lord Pablo Escobar are having on Colombian aquatic ecosystems. The hippos are changing the area's water quality by importing large amounts of nutrients and organic material from the surrounding landscape.

The Department of Energy (DOE) recently announced that it will establish Quantum Information Science Centers to help lay the foundation for these technologies. As Congress put forth in the National Quantum Initiative Act, the DOE's Office of Science will make awards for at least two and up to five centers.

The Society for Laboratory Automation and Screening (SLAS) announced the winners of its annual New Product Awards Monday afternoon at the 9th Annual SLAS International Conference and Exhibition in San Diego, CA, USA.

The closing panel in The Listening Lounge at February's Splore festival was a fairly ambitious one, I wasn't sure whether it was going to work and I knew I was going to depend on my panelists – a psychologist, a brilliant young Zimbabwean New Zealander, an evangelical pastor and a campaign expert – to make it work.
I'm never really sure after these discussions what's actually happened – I've spent the whole time in the moment. But re-reading the transcript (thank you to Emma Hart for that), I felt good about it.
I also felt that the subtitle: "How do we all move…

For obvious reasons, there has been a lot of attention paid to work going into developing vaccines that could prevent Covid-19 infection, and drugs that could treat it. In particular, there has been some excitement about new animal trial data for remdesivir, a drug developed by Gilead Sciences. Gilead's share price rose nearly 10% on the day the trial data were announced.
It will be some time yet before the safety and efficacy of remdesvir is established, if ever (it's worth noting that it was tried, unsuccessfully, as a treatment for Ebola). And since I started work on this post…

Regular readers will know that I've been hanging out for the "market allocation" parts of the proposed Cannabis Legalisation and Control Bill, which will be the subject of a referendum this year.
While most media outlets ran inane stories last year on how many joints 14 grams added up to, it was clear to anyone who took the subject seriously that the questions of who would get to produce and sell cannabis and how licences would be awarded were vastly more important. And we've had to wait for answers to those.
Well, they're here. And it's very good news. From…

Like most people, I've been staying at home, doing a bit in the garden, cooking a lot and managing occasional bouts of anxiety. I've also written more here than I have done for a while. At a time when every Friday night has me missing my mates, it's been nice to see you all again.
But in the midst of it all – and after everything else disappeared – I got a new gig. It's with my friends from Spark Lab, it's called The Pivot Reports and it's a series of live-streamed shows over the next six weeks talking to business owners…

I got my sweet Jess for my birthday 14 years ago. Little did I know at the time that she would become my everything, the love of my life. She died 5 weeks

EPISODE SUMMARY This week, Dave and Brad drill down deep on a crucial topic in comics — word balloons! Then Dave talks about his recent Kickstarter, and why it didn't fund. Plus... how will the global pandemic affect comic ships, distributors, the USPS and ... webcomics? EPISODE NOTES Today's show is brought to you by Wacom — makers of the incredible Wacom One! This week, Dave and Brad drill down deep on a crucial topic in comics — word balloons! Then Dave talks

  I am looking for someone who can help me find and clear out excess data on one of my...

You may have seen the news reports this week that German prosecutors have issued an arrest warrant for Dmitry Badin for a massive hack of the German Parliament that made headlines in 2016. The reports about the German arrest warrant all mention that German authorities "believe" that Badin is connected to the Russian GRU and its APT28 hacking group.

The folks over at Bellingcat have done their open source intelligence investigation thing, and provided a ton of evidence to show that Badin almost certainly is part of GRU... including the fact that he registered his 2018 car purchase to the public address of a GRU building. This is not the first time this has happened. A few years back, Bellingcat also connected a bunch of people to the GRU -- including some accused of hacking by the Dutch government -- based on leaked car registration info.

There's much, much more in the Bellingcat report, but the final paragraph really stands out. Bellingcat also found Badin -- again, a hacker who is suspected in multiple massive and consequential hacks, including of email accounts -- didn't seem to be all that careful with his own security:

The most surreal absence of “practice-what-you-breach” among GRU hackers might be visible in their lackadaisical attitude to their own cyber protection. In 2018, a large collection of hacked Russian mail accounts, including user name and passwords, was dumped online. Dmitry Badin’s email — which we figured out from his Skype account, which we in turn obtained from his phone number, which we of course got from his car registration — had been hacked. He had apparently been using the password Badin1990. After this, his email credentials were leaked again as part of a larger hack, where we see that he had changed his password from Badin1990 to the much more secure Badin990.

Yes, the password for at least one of his email accounts... was apparently his own last name and the year he was born. The cobbler's kids go shoeless again.

One of the key points we've been making concerning Attorney General William Barr and his DOJ's eager support for the terrible EARN-IT Act, is that much of it really seems to be to cover up the DOJ's own failings in fighting child porn and child exploitation. The premise behind the EARN IT Act is that there's a lot of child exploitation/child abuse material found on social media... and that social media companies should do more to block that content. Of course, if you step back and think about it, you'd quickly realize that this is a form of sweeping the problem under the rug. Rather than actually tracking down and arresting those exploiting and abusing children, it's demanding private companies just hide the evidence of those horrific acts.

And why might the DOJ and others be so supportive of sweeping evidence under the rug and hiding it? Perhaps because the DOJ and Congress have literally failed to live up to their mandates under existing laws to actually fight child exploitation. Barr's DOJ has been required under law to produce reports showing data about internet crimes against children, and come up with goals to fight those crimes. It has produced only two out of the six reports that were mandated over a decade ago. At the same time, Congress has only allocated a very small budget to state and local law enforcement for fighting internet child abuse. While the laws Congress passed say that Congress should give $60 million to local law enforcement, it has actually allocated only about half of that. Oh, and Homeland Security took nearly half of its "cybercrimes" budget and diverted it to immigration enforcement, rather than fighting internet crimes such as child exploitation.

So... maybe we should recognize that the problem isn't social media platforms, but the fact that Congress and law enforcement -- from local and state up to the DOJ -- have literally failed to do their job.

At least some elected officials have decided to call the DOJ's bluff on why we need the EARN IT Act. Led by Senator Ron Wyden (of course), Senators Kirsten Gillbrand, Bob Casey, Sherrod Brown and Rep. Anna Eshoo have introduced a new bill to actually fight child sex abuse online. Called the Invest in Child Safety Act, it would basically make law enforcement do its job regarding this stuff.

The Invest in Child Safety Act would direct $5 billion in mandatory funding to investigate and target the pedophiles and abusers who create and share child sexual abuse material online. And it would create a new White House office to coordinate efforts across federal agencies, after DOJ refused to comply with a 2008 law requiring coordination and reporting of those efforts. It also directs substantial new funding for community-based efforts to prevent children from becoming victims in the first place.

Basically, the bill would do a bunch of things to make sure that law enforcement is actually dealing with the very real problem of child exploitation, rather than demanding that internet companies (1) sweep evidence under the rug, and (2) break encryption:

• Quadruple the number of prosecutors and agents in DOJ’s Child Exploitation and Obscenity Section from 30 FTEs to 120 FTEs;
• Add 100 new agents and investigators for the Federal Bureau of Investigation’s Innocent Images National Initiative, Crimes Against Children Unit, Child Abduction Rapid Deployment Teams, and Child Exploitation and Human Trafficking Task Forces;
• Fund 65 new NCMEC analysts, engineers, and mental health counselors, as well as a major upgrade to NCMEC’s technology platform to enable the organization to more effectively evaluate and process CSAM reports from tech companies;
• Double funding for the state Internet Crimes Against Children (ICAC) Task Forces;
• Double funding for the National Criminal Justice Training Center, to administer crucial Internet Crimes Against Children and Missing and Exploited Children training programs;
• Increase funding for evidence-based programs, local governments and non-federal entities to detect, prevent and support victims of child sexual abuse, including school-based mental health services and prevention programs like the Children’s Advocacy Centers and the HHS’ Street Outreach Program;
• Require tech companies to increase the time that they hold evidence of CSAM, in a secure database, to enable law enforcement agencies to prosecute older cases;
• Establish an Office to Enforce and Protect Against Child Sexual Exploitation, within the Executive Office of the President, to direct and streamline the federal government’s efforts to prevent, investigate and prosecute the scourge of child exploitation;
• Require the Office to develop an enforcement and protection strategy, in coordination with HHS and GAO; and
• Require the Office to submit annual monitoring reports, subject to mandatory Congressional testimony to ensure timely execution.

While I always have concerns about law enforcement mission creep and misguided targeting of law enforcement efforts, hopefully everyone can agree that child exploitation does remain a very real problem, and one that law enforcement should be investigating and going after those who are actually exploiting and abusing children. This bill would make that possible, rather than the alternative approach of just blaming the internet companies for law enforcement's failure to take any of this seriously.

Just posted to Slate, by Isaac Butler: The Disappearance of John M. Ford. Key takeaway to Making Light readers who...

Blacow* speaks of four players: the Wargamer, the Power-Gamer, the Role-Player, and the Story-Teller. The Wargamer, what does he say?...

Shahi Tukda literally means a “royal piece” when translated from Urdu. A royal and rich dessert that’s super easy and different from the usual style?

craving more? check out TasteSpotting

'Seriously sometimes seems Google's moderators are only optimized to respond to social media outrage'

Three weeks after Google removed 49 Chrome extensions from its browser's software store for stealing crypto-wallet credentials, 11 more password-swiping add-ons have been spotted – and some are still available to download.…

OK, a third agreed with Thales when it asked the question

About a third of firms and organisations in Europe and the Middle East still believe the humble password is a good enough security measure, according to a survey carried out by French firm Thales.…

At last, we can write headlines with all the letters intact

For a company defined by design and attention to detail, the Butterfly keyboard was a tremendous humiliation for Apple. Conceived in 2015, it replaced the previous scissor-switch mechanism for one with a smaller profile, allowing Cupertino to continue shrinking already-svelte laptops.…

There's revenue to be had with being a participant in the payments web, and the Apple experience to measure up against

Samsung has announced it will launch a debit card.…

It's like three buses showing up at once carrying $8bn

India’s largest mobile carrier, Jio, has just scored a third new investor in three weeks!…

Клавиатуру не стали разбирать.

Hello, friends. We haven’t been releasing albums in quite a while, but we are still running our Discord server. We’ve been building a community for people who are interested in video game music, video games, and other assorted media, but are tired of the constant cynicism and negativity that permeate many communities with those interests. […]

A review by Rob Cranley (9). A great flight sim that absorbed many, many hours of my youth

Недавно мы писали, что Google, вслед за Apple, собирается выпустить свою собственную дебетовую карту. Сейчас о таких планах объявила компания Samsung.

What expression does — did — your mom use all the time? What skill did you learn from her?  What does (or did) she encourage you to do? These are great questions for any mom and child, whether the kid is 5 or 50. And if you click here, you can print out a very […]

These “cards” are really an excuse for kids to interview their moms and shower them with the ultimate gifts: attention to mom’s quirky uniqueness, gratitude, and offers of help! Here you go — click here! (Mother’s Day is SUNDAY!)

2021 for taxi-style usage in selected areas. This is level 4 automation: no human driver will be needed to take over. But the car won't be able to go everywhere. Likely that means the cars will be restricted to very well mapped areas without challenging conditions. Ford says the higher cost of the computer and sensing equipment restricts its use to fleets which rack up very high mileage per vehicle per year. The car will be a more expensive piece of capital equipment that requires very high usage rates to pay the cost of capital. I find the 2021 launch date to be a little surprising since Ford seems late to the party. On the other companies seem think they...

Today, Thursday 24 September 2004 there were 164523 hits on one artist's web site. Asbjorn Lonvig's, www.lonvig.dk it is. That's from Denmark in Scandinavia. It might be a new World Record? Is the "well-known" artist he who exhibits on Guggenheim in New York? Or is it he who has 164523 internet hits on one single day?

On accorde "The World of Art Award" (WAA) aux artistes, aux galeries et aux musées qui poursuivent les "meilleures pratiques" dans l'art et la culture. Cette concurrence cherche à attirer dies artistes, galeries, les musées qui redéfinissent des normes de l'excellence d'art. Ceux qui défie des trends et des tendances existantes dans l'art et la culture.

Date: May 1, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2018 Doodle game celebrating Garden Gnomes!
 

 

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Help stop the spread of COVID-19 by following these steps.  
 

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Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

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Prenatal alcohol exposure (PAE) affects at least 10% of newborns globally and leads to the development of fetal alcohol spectrum disorders (FASDs). Despite its high incidence, there is no consensus on the implications of PAE on metabolic disease risk in adults. Here, we describe a cohort of adults with FASDs that had an increased incidence of metabolic abnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight and obesity. Using a zebrafish model for PAE, we performed population studies to elucidate the metabolic disease seen in the clinical cohort. Embryonic alcohol exposure (EAE) in male zebrafish increased the propensity for diet-induced obesity and fasting hyperglycemia in adulthood. We identified several consequences of EAE that may contribute to these phenotypes, including a reduction in adult locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent diet-responsive transcriptional changes. Taken together, our findings define metabolic vulnerabilities due to EAE and provide evidence that behavioral changes and primary organ dysfunction contribute to resultant metabolic abnormalities.

Brown and beige adipose tissues contain thermogenic fat cells that can be activated by β3-adrenergic receptor agonists. In rodents, such drugs both diminish obesity and improve glucose homeostasis. In this issue of the JCI, O’Mara et al. and Finlin and Memetimin et al. report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis.

It’s release day for my new MM romance! My last release was Christmas 2018, so I’m very excited to finally have a new book for you. When I was in Australia earlier this year, I got hooked on Bondi Rescue, and this (completely fictional!) romance between a trainee and an older, very closeted lifeguard was born. […]

iFixit hasn't yet done a full teardown of the new Magic Keyboard designed for the new iPad Pro models, but the repair site today partnered with x-ray company Creative Electron to create Magic Keyboard x-rays that give us a view of just what's inside.


The Magic Keyboard uses scissor switch keys instead of butterfly keys, which have now been effectively eliminated from Apple's product lineup. The scissor switch mechanism is clearly visible in the x-ray view, and iFixit calls it the simplest mechanism in the accessory, but the biggest improvement compared to the Smart Keyboard.

Below the keyboard, there are metal plates that iFixit believes are for reinforcing the keyboard's body against bending, and the trackpad is a new design that's different from MacBook trackpads.

There appear to be multiple buttons under the trackpad to capture presses, while the MacBook Trackpads have no buttons and simulate presses with haptic feedback.


There are at least two spring loaded hinge designs at the folding point, featuring both a small coil and a larger coil, plus there are two cables for connecting the Smart Connector to the keyboard for power and data transfer.

Lots and lots of magnets are visible in the x-ray, with the magnets used to hold the Magic Keyboard on the ‌iPad Pro‌. There's a whole ring of tiny magnets around the camera cutout, which iFixit said was a "lot of little polarized bits" to line up, space out, and configure with the ‌iPad Pro‌ components.

According to iFixit, there's more going on in the Magic Keyboard than there is in many laptops, which could explain its price point. Apple charges $299 for the 11-inch Magic Keyboard and $349 for the 12.9-inch version.

This article, "An X-Ray View of Apple's Magic Keyboard for iPad Pro" first appeared on MacRumors.com

Discuss this article in our forums

We're still waiting to hear news about Apple Card's performance relative to the major card issuers, but that hasn't stopped Samsung from announcing plans to launch an "innovative" debit card as part of a new mobile-first money management platform the company has been developing over the last year.


Announced on Thursday in a blog post by Samsung Pay vice-president Sang Ahn, the forthcoming debit card is in partnership with finance company SoFi and will be backed by a cash management account.

"In 2020, Samsung Pay will be expanding our service from being a rewarding way to shop and pay, to also being a rewarding way to manage money," writes Ahn. "Over the past year we have been busy developing a mobile-first money management platform. Our vision is to help consumers better manage their money so that they can achieve their dreams and goals. Now more than ever, mobile financial services and money management tools will play an even bigger role in our daily lives while also opening up new possibilities."

The debit card is scheduled to launch this summer. Other than that, Samsung hasn't offered any details on how it will work, but expect it to integrate with Samsung's existing mobile payment system.

Launched in August 2019, ‌Apple Card‌ is a credit card linked to Apple Pay and built into the Wallet app on iPhone. Apple partnered with Goldman Sachs to launch the card, and in October the investment bank hailed it as "the most successful credit-card launch ever." Nine months later, neither Apple nor Goldman Sachs has offered any concrete details on its performance.

During the global health crisis, Apple has introduced an ‌Apple Card‌ Assistance Program that allows ‌‌Apple Card‌‌ holders to skip their March and April payments without incurring interest charges for that billing cycle. For more details on how the card works, check out our comprehensive Apple Card guide.
This article, "Samsung Announces 'Innovative' Debit Card Launching this Summer" first appeared on MacRumors.com

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Microsoft plans to add trackpad and mouse support to its Word, Excel, and PowerPoint apps for iPad by the fall, according to TechCrunch and The Verge.

iPadOS 13.4 introduced trackpad and mouse support on all iPad models released in the past four to five years. Keyboards with trackpads include Apple's Magic Keyboard and Brydge's Pro+ for the iPad Pro and Logitech's Combo for the 10.2-inch iPad and the 10.5-inch iPad Air.

When using a trackpad, the cursor displays as a circle on the screen, popping up only when you have a finger on the trackpad. The circle then morphs into various other shapes when hovering over app icons, text fields, or other on-screen elements.

This article, "Microsoft to Add Trackpad Support to Word, Excel, and PowerPoint Apps on iPad" first appeared on MacRumors.com

Discuss this article in our forums

The Label's "The_Otherside" is this week's addition to Apple Arcade on the iPhone, iPad, and Apple TV. The game is described as both a turn-based RPG and a strategy board game:

Otherside is a turn based RPG and strategy board game where you will control four survivors who hope to push back the shadowy threat. Make your way through each level solving puzzles, fighting monsters, and destroying the spirit anchors that threaten our dimension.

Do you have what it takes to restore the town back to normal and save the day?

"The_Otherside" is available on the App Store with an Apple Arcade subscription. The service provides iPhone, iPad, Apple TV, and Mac users with access to over 100 games with no in-app purchases or ads for $4.99 per month.
This article, "Apple Arcade's Latest Game Combines Turn-Based RPG With Strategy Board Game" first appeared on MacRumors.com

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The Ursa Majors are ready for votes and the nominees have been revealed. Voting can be found at their website and is open throughout the month of March. Two categories, however, received no nominees due to being an insufficient number of nominations and will not be put up to vote for a winner. Those two categories being Fursuits and Non-Fiction.

If you enjoy film, fiction, art, or any other of the many items that are up for selection as the best of the best for the year of 2019 be sure to vote this month. If you like non-fiction or fursuits, well, you can always be sure to nominate next year.

The nominees are:

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