Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.

The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4', R5, R6 and R6' are as described herein.

The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.

The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.

The process and apparatus for mobile separation and recovery of used contaminants abrasive blasting material from a work site. Entrained contaminants within used blast material are removed by a self-contained mobile platform process using multiple stage cleaning system including dual cyclonic separation, multiple stage dust filters with large debris magnetic drum, airwash and vibratory separation in a flow through containment and blast media separation process.

A combined processing tool includes a shank of a cylindrical shape, a mandrel fixed to the shank, a frame rotation-universally fitted outside the mandrel, a burnishing unit for performing a burnishing to an inner peripheral surface of a workpiece by rolling members, a dimple forming unit for performing a dimple forming to the surface of the workpiece by surface compression members so as to universally appear from and disappear in the frame, a body fixed to a top portion of the shank, and a skiving unit for performing a cutting, wherein, on an outer peripheral region of the mandrel, an outer peripheral surface 31c and a concave and convex shape area which consists of concave parts and convex parts alternately arranged along an outer peripheral direction of the mandrel are formed, and wherein the concave and convex parts are alternately engaged in the compression members with being rotated.

Provided for are lubricant base stocks with improved filterability. The lubricant base stock includes a bright stock and an effective amount of a heavy neutral. The filterability of the base stock as measured by the Membrane Filtration Method is less than or equal to 400 seconds. Also provided for are lubricating oils with improved filterability and methods of improving the filterability of lubricant base stocks.

A composition is provided for use as a friction modifier for an automatic transmission, which comprises a condensation product of a hydroxypolycarbox-ylic acid, such as 2,3-di-hydroxybutanedioic acid or 2-hydroxybutanedioic acid, with an N,N-di(hydrocarbyl)alkylenediamine, where each hydrocarbyl group contains 1 to 22 carbon atoms, provided that the total number of carbon atoms in the two hydrocarbyl groups is at least about 9, and the alkylene group contains 2 to 4 carbon atoms.

It is known by the inventor that a universal synthetic lubricant additive that can greatly enhance the performance standards of existing lubricants, petroleum based or synthetic, imparts a new and desirable property not originally present in the existing oil or it reinforces a desirable property already possessed in some degree can greatly benefit the consumer. Although additives of many diverse types have been developed to meet special lubrication needs, their principal functions are relatively few in number. This universal synthetic lubricant additive (invention) with micro lubrication technology, when used as directed will reduce the oxidative or thermal degradation of the host oil, substantially reduce the deposition of harmful deposits in lubricated parts, minimize rust and corrosion, control frictional properties, reduce wear, temperature, sludge, varnishes and prevent destructive metal-to-metal contact, reduce fuel consumption and harmful emissions while improving performance through increased horsepower and torque.

The invention relates to a lubricant in the form of grease or thick lubricating gel or transmission oil, as well as motor or universal oils with a myriad of applications. As a result of its contents presented in the patent application is characteristic of low coefficient of friction ranging from 0.055 to 0.062. As the main component, the contents of the discussed lubricant includes three or four stearates of metals or hydroxistearates of metals, which interact and cause a noticeable reduction of friction drag on the lubricated surfaces. Additionally, these substances may include a number of other solid or liquid elements, which maintain low friction drags and, furthermore, improve the lubricant through increasing its load capacity, antirust characteristics, shear strength, etc. The lubricant made according to the invention underwent comparative tests against other greases and greasing oils, the accounts of which are included in the application as diagrams, descriptions of research tests and examples of the contents of the lubricant products.

A carriage is moved in a direction including a Y axis component in order to move a turning process tool that is attached to a tool spindle along a horizontal line that is perpendicular to a Z axis, and thus, a turning process is carried out on a workpiece which is attached to a workpiece spindle.

A carriage is moved in a direction including a Y axis component in order to move a turning process tool that is attached to a tool spindle along a horizontal line that is perpendicular to a Z axis, and thus, a turning process is carried out on a workpiece which is attached to a workpiece spindle.

A machine tool is provided with a chain-type bit-storing apparatus which includes a frame, two sprockets, a chain and a pivoting unit. The frame includes a cutout. The sprockets are placed in the frame. The chain is driven by the sprockets. The chain includes links each including a socket for containing a bit, two plates for supporting the socket, first and second blocks placed between the plates, first and second bearing units for rotationally supporting the first and second blocks on the plates, and a connecting unit for pivotally connecting the first block thereof to the second block of an adjacent link. The pivoting unit is used to pivot the socket of a selected one of the links to move an open end of the socket out of the frame through the cutout.

In a combination machining lathe, a workpiece holding device holds a workpiece in a manner that permits the workpiece to rotate around an axis parallel to a direction of a horizontal Z axis. A tool post holds a tool that comprises a holder and a bit. The tool held by the tool post is indexed to a position in which the longitudinal axis of the holder is parallel to an X axis direction. The bit of the tool held by the tool post is angled such that a longitudinal axis of the bit is disposed in a position tilted away from the X axis direction closer to a horizontal axis in a plane containing the X axis and the Y axis. A turning operation is performed while the tool and/or the workpiece are moved relative to each other in a direction of the longitudinal axis of the bit.

A system and method are disclosed for transporting deterministic traffic in a gigabit passive optical network. A system that incorporates teachings of the present disclosure may include, for example, an Optical Line Termination (OLT) for exchanging data traffic in a Gigabit Passive Optical Network (GPON) having a controller programmed to generate a timeslot schedule for transport of a desired bandwidth of constant bit rate (CBR) data traffic by selecting one or more timeslots from periodic frame clusters operating according to a GPON Transmission Convergence (GTC) protocol. Additional embodiments are disclosed.

A multi-channel optoelectronic device is configured to establish a redundant status link with a remote device. The optoelectronic device can transmit N transmit optical signals to the remote device over a plurality of transmit channels and receive N receive optical signals from the remote device over a plurality of receive channels. The optoelectronic device includes one or more spare transmit and receive channels. When used with a remote device having spare transmit and receive channels, each device can establish a status link with the other and use the status link to switch out transmit and/or receive channels to identify and permanently switch out the worst transmit and/or receive channels. Alternately, the device can interoperate with a non-status-link enabled remote device by determining that the remote device is not status-link enabled, transitioning to a low transmit power mode, and transmitting and receiving over a plurality of default transmit and receive channels.

It is an object of the present invention to provide a sintered cBN compact having excellent wear resistance and fracture resistance even in machining centrifugally cast iron having a property of being difficult to machine, and to provide a sintered cBN compact tool. A sintered cBN compact of the present invention contains 20% by volume or more and 65% by volume or less of cBN and, as a binder, 34% by volume or more and less than 80% by volume of Al2O3, at least one selected from the group consisting of nitrides, carbides, carbonitrides, borides, and boronitrides of Zr and solid solutions thereof (hereinafter, referred to as “X”), and ZrO2, the total amount of X and ZrO2 being 1.0% by volume or more and 6.0% by volume or less, the volume ratio of ZrO2 to Al2O3, ZrO2/Al2O3, being 0.010 or more and less than 0.100, in which the ratio Itetragonal ZrO2(101)/IαAl2O3(110) is 0.1 or more and 3 or less, where Itetragonal ZrO2(101) is the intensity of the (101) plane of tetragonal ZrO2 and IαAl2O3(110) is the intensity of the (110) plane of αAl2O3 among X-ray diffraction peaks of the sintered cBN compact.

In a cutting tool for chip removing machining a holder for a cutter has a body received therein and movable with surfaces to bear against the cutter for defining the position of the cutter in the direction of an intended axis of rotation of the holder as well as a screw which may be screwed in a threaded bore in the holder. Spring members are arranged to act between the holder and the body for biasing the body against said screw portions.

Provided is a surface-coated cemented carbide insert obtained by containing at least WC powder and Co powder as raw materials, including a WC-based cemented carbide obtained by forming and sintering mixed raw materials containing at least any of (a) Zr compound powder, Nb compound powder, and Ta compound powder, (b) complex compound powder of Nb and Ta, and Zr compound powder, (c) complex compound powder of Nb, Ta, and Zr, (d) complex compound powder of Nb, Zr, and Ta compound powder, and (e) complex compound powder of Ta and Zr, and Nb compound powder, as essential powder components, as a substrate, and forming a hard coating layer on the substrate by vapor deposition, in which a Co enrichment surface region is formed in a substrate surface, Co content in the Co enrichment surface region satisfies to be between 1.30 and 2.10 (mass ratio) of Co content in cemented carbide.

A biosensor is provided. The biosensor is used to sense a biological sample and has a code representing features of the biosensor. The biosensor includes a substrate and a conductive layer. The conductive layer is disposed on a first side of the substrate and includes a first conductive loop and a second conductive loop. The first conductive loop is formed between a first node and a second node and has a first impedance. The second conductive loop is formed between the second node and a third node and has a second impedance. The code is determined according to a comparison result between the second impedance and the first impedance.

Bioprinting station (1) comprising:—a Bioprinting device (4) adapted to deposit a pattern of biological material (2) onto an area of interest (3a) of a substrate (3),—an imaging system (15) adapted to acquire an image of the substrate (3) and to reveal on the acquired image the area of interest (3a) with respect to a remaining part (3b) of the substrate (3), the acquired image of the substrate (3) being processed so as to detect the revealed area of interest (3a) on the acquired image and to determine the pattern corresponding to the area of interest (3a) detected on the acquired image.

An apparatus for sampling and storing biological fluids from a human or animal subject is provided. In one embodiment of the present disclosure, the apparatus includes a main body, lancet carrier or hub, lancet, lancet trigger, capillary tube, and sample compartments for collecting and storing dried blood and other bodily fluids. The lancet hub supports a lancet and provides for moving the lancet longitudinally between a first retracted position and a second extended position. The device includes a capillary tube having an internal diameter sized to draw and retain fluid from a contacted source using capillary action. The main body of the apparatus further includes a sample compartment for holding sampling and storage materials. In at least one embodiment of the present disclosure, the sample compartment can be accessed by lifting sample compartment lid. Also included is a new “fan” or “daisy” shaped collection material format for use in collecting and preserving samples.

The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.

The invention refers to a device for recording biometric data, such as lines of finger or hand. A rest is provided on the device for the hand and finger, respectively, as well as an illuminating unit. According to the invention an illuminating unit and/or rest is provided that can traverse and be positioned.

A 3D image sensor includes a depth pixel that includes; a photo detector generating photo-charge, first and second floating diffusion regions, a first transfer transistor transferring photo-charge to the first floating diffusion region during a first transfer period in response to a first transfer gate signal, a second transfer transistor transferring photo-charge to the second floating diffusion region during a second transfer period in response to a second transfer gate signal, and an overflow transistor that discharges surplus photo-charge in response to a drive gate signal. Control logic unit controlling operation of the depth pixel includes a first logic element providing the first transfer gate signal, a second logic element providing the second transfer gate signal, and another logic element providing the drive gate signal to the overflow transistor when the first transfer period overlaps, at least in part, the second transfer period.

A system and method for mounting a section onto a substrate, the system comprising: a fluid channel including: a fluid channel inlet that receives the section, processed from a bulk embedded sample by a sample sectioning module positioned proximal the fluid channel inlet, a section-mounting region downstream of the fluid channel inlet, and a fluid channel outlet downstream of the section-mounting region; a reservoir in fluid communication with the fluid channel outlet; and a manifold, fluidly coupled to the reservoir, that delivers fluid from the reservoir to the fluid channel inlet, thereby transmitting fluid flow that drives delivery of the section from the fluid channel inlet toward the section-mounting region.

Techniques and devices for measuring polarization crosstalk in birefringence optical media including polarization maintaining fiber.

A ring binder mechanism includes an elongate plate having a longitudinal axis. Hinge plates are supported by the plate for pivoting relative to the elongate plate. Ring members are mounted on the hinge plates and moveable between a closed position and an open position. A control structure is supported by the elongate plate and controllably pivots the hinge plates to move the ring members between the closed and open positions. The control structure has a travel bar connected to the hinge plates for moving the hinge plates between the closed and open positions. A spring biases the travel bar toward the closed position.

A cover (10) is disclosed for holding objects such as papers and reports. The cover (10) is formed of a member (12) having a front cover (14), a spine (16) and a back cover (18), a ring binder (22) and a paper surround (24). The paper surround (24) encapsulates the ring binder (22) and secures it to the member (12). The cover can be either a top bound or side bound cover.

A binder assembly for receiving and retaining articles and that includes a cover having a spine portion and at least one cover leaf portion and a first binder element and a second binder element having a plurality of first and second retaining fingers, respectively. The first and second binding elements are moveable between 1) an open position wherein articles are permitted to be removed from or mounted to the binder assembly, and 2) a closed position wherein articles mounted to the binder assembly are prevented from being removed. The binder assembly further includes an elongated retainer/lock constructed to releasably attach to the first and second binding elements in the closed position thereof with the spine portion of the cover therebetween for locking the first and second binding elements in the closed position and securing the first and second binding elements to the spine portion of the cover.

A ring binder mechanism has an elongate housing, a pair of locking elements, a translation bar, a pair of elongate hinge plates having mating ring halves extending there-from, a plurality of mating ring halves, and an actuator. Movement of the actuator moves the hinge plates, translation bar, and locking elements to cause the ring halves to disengage so a user can place holed paper over the open ring halves, or closes the ring halves together to secure the paper with the closed-loop rings thus form while simultaneously locking the rings in the closed-loop configuration to prevent inadvertent opening.

Binder apparatus are described. An example binder apparatus includes a housing, a first support rail positioned within the housing and a second support rail positioned within the housing. The binder apparatus also includes first and second closure members coupled to the respective support rails. The closure members are positioned on the respective support rails to enable locking elements of the closure members to interlock when the binder apparatus is in a closed position. The binder apparatus also includes a lever comprising tabs that are received by recesses defined by the support rails. An interaction between the tabs and the support rails enables the support rails to be moved relative to one another and the locking elements to be moved to an unlocked position.

Disclosed herein is an organizer comprising a unique structural configuration to house and store both non-perforated documents and perforated documents. The organizer comprises a ring binder that is associated with an expandable compartment that is arranged peripheral to the ring binder.

A binding device includes binding rod portions, coupling portions for coupling a plurality of the binding rod portions, and an axis portion serving as a center upon opening/closing of binding rods. The coupling portions have lower portions to which the axis portion is provided at a position close to base portions of the binding rods so that a leaf bound at the binding rod portions can be flipped along the binding rods and flipped through 360 degrees and leaves can make contact with each other with the axis portion sandwiched therebetween. The axis portion includes a shaft portion and receiving portions for the shaft portion. The receiving portions are provided to the coupling portions the shaft portion is disposed therein.

Binder apparatus are described. An example binder apparatus includes a housing and a first carrier rail having a first longitudinal edge and a second longitudinal edge. The first carrier rail defining a notch adjacent the second longitudinal edge. The housing biasing the first carrier rail by engaging the first longitudinal edge. The binder apparatus includes a second carrier rail having a third longitudinal edge and a fourth longitudinal edge. The housing biasing the second carrier rail by engaging the third longitudinal edge. The second longitudinal edge hingably engaging the fourth longitudinal edge, the notch defining an opening having a first edge and a second edge opposite the first edge. The binder includes a slider having a control element extending therefrom. The control element comprising a first control surface and a second control surface. The first control surface to engage the first edge to urge the first and second carrier rails to an open position, the second control surface to engage the second edge to urge the first and second carrier rails to a closed position.

Placing sheets around a retainer or between a retainer and clamp and securing a clamp against the sheets and retainer for compressively fixing the pages against the retainer.

A binding device includes a plurality of binding rings, a holding member which enables the binding rings to be disposed with a spacing therebetween, an operating member having a surface to which base portions of the binding rings are secured such that the binding rings are disposed with a spacing therebetween, the operating member including a pair of operating pieces movable in the holding member in a longitudinal direction of the holding member, and an opening-closing member which causes the binding rings to be changed in an opening direction. The opening-closing member includes an elastic member. The elastic member is provided in the operating member such that a distance between the operating pieces in an opening-closing direction of the binding rings is maintained at a distance enabling the pair of the operating pieces to be moved and is arranged to move the pair of the operating pieces defining the operating member relative to each other in respective opposite directions and so as to elastically urge the pair of the operating pieces in a direction allowing the binding rings to be held in an opened state.

A ring binder, with a fixed bar (1), bearing hooks (2) and a moving bar (3), wherein the fixed bar (1) is immovably fixed on a spine plate of a folder; the bearing hooks (2) are fixed on the upper surface of the fixed bar (1); the moving bar (3) is movably lapped over one side of the fixed bar (1); the lower surface of the moving bar (3) and the lower surface of the fixed bar (1) are clamped and connected with each other; the moving bar (3) can rotate relative to the fixed bar (1) and slide along the length direction of the fixed bar (1); a spring (4) connected between the moving bar (3) and the fixed bar (1); and moving shackles (5) fixed on the upper surface of the moving bar (3). As the ring binder lacks a base plate, a housing, etc., both the opening and the closing of the binder are convenient and the cost of the ring binder is reduced.

A binder includes a back part disposed between ring parts, each of the ring parts being openable and closable. to constitute a binder. A penetration hole is formed at a portion of the ring parts intersecting with the back part, thereby allowing the binder to expand and contract to a certain degree in a longitudinal direction thereof.

A ring binder mechanism for retaining loose-leaf pages securely holds closed ring members together to prevent inadvertent loss of pages retained by the mechanism. The mechanism comprises a housing supporting two hinge plates for pivoting motion to open and close paired ring members mounted on the plates. Free ends of the paired ring members have interlocking configurations that securely join together when the ring members close. The configurations prevent misalignment of the closed ring members in all directions transverse to longitudinal centerlines of the ring members. The mechanism also includes locking elements that interact with the hinge plates to block their pivoting motion when the ring members are closed. This holds the free ends of the closed paired ring members together so that the interlocking configurations of the ring members remain interengaged.

A binder clip having flexible sidewalls biased to close around a rigid retainer for securing pages wrapped around the retainer or pinched by the binder clip and retainer for manually forming a book.

A recyclable ring binder apparatus comprises a ring metal incorporating a set of binder rings that are formed of a pair of ring halves. The ring metal can be firmly fastened to a spine section of a binder hardcover by utilizing a post and a small arched snap clamp with a tap. The tap of the snap clamp can be pressed around a neck of the post utilizing a quick release clipping mechanism. The snap clamp can be accessed with an index finger and slid away from the post to remove the ring metal from the hardcover. The ring metal, the hardcover, the snap clamp and the post can be quickly separated into their perspective categories due to the clipping mechanism. Hence, it retains conformance of all components of the ring binder apparatus for recycling without increasing development and production cost.

Disclosed herein is an organizer comprising a unique structural configuration to house and store both non-perforated documents and perforated documents. The organizer comprises a ring binder that is associated with an expandable compartment that is arranged peripheral to the ring binder.

A binding device is provided which allows reduction in profile. A binding device 10 includes: a holding member 16 having a length which allows a plurality of openable-closable binding rings 12 and 14 to be disposed with a spacing therebetween; an operating member 18 secured inside the holding member 16; and an opening/closing member 40. The operating member 18 includes a pair of operating pieces 30 and 32 on which the binding rings 12 and 14 are secured. For housing the opening/closing member 40, an opening/closing member housing portion 36 is provided in a manner such as to be recessed from a reverse side, opposite to a surface on which the binding rings 12 and 14 are secured, towards the surface side. The opening/closing member 40 is secured to the opening/closing member housing portion 36 of the operating member 18 on the reverse side opposite to the surface on which the binding rings 12 and 14 are secured, and is formed to, when the binding rings 12 and 14 are opened, cause the binding rings 12 and 14 to be changed in an opening direction so that the operating pieces are moved in a longitudinal direction of the holding member 16 and are held in a direction approaching an inner surface of the holding member 16, within the holding member 16.

The present invention is directed to an item holding assembly that may include a binder and portfolio with one releasably attached to the other enabling quick and easy separation for use of one independent of the other. In a preferred embodiment, binder and portfolio panels can overlie one another, particularly when releasably engaged in a manner that releasably attaches them. A flap, such as part of the panel or the panel of one is received in a pocket formed in the panel of the other to facilitate and preferably provide releasable attachment.

A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.

A ring binder has a standard ring assembly having a ring base and upstanding rings, a ring assembly support having a plurality of indents positioned along its sides, a binder connector having a plurality of upstanding tabs, and a plurality of binder covers each having a center spine with a plurality of slots configured to accept each of the plurality of binder connector tabs. The ring binder is assembled by the insertion of the binder connector tabs into slots of the binder cover and then into the indents of the ring assembly support. The ring binder can be sold assembled or as a kit, which would include a plurality of interchangeable binder covers.

A ring binder mechanism includes a housing, a ring support, and rings for holding loose-leaf pages. Each ring includes a first ring member and a second ring member that are moveable between a closed position and an opened position. An actuator is mounted on the housing for moving the ring members from the closed position to the opened position. A travel bar has at least one locking element and is moveable between a locked position wherein the ring members are locked in the closed position and an unlocked position wherein the ring members are capable of being moved to the opened position. An intermediate connector operably connects the travel bar to the actuator. A portion of the intermediate connector is captured by and moveable with a wide section of a mounting groove in the travel bar so the intermediate connector can move relative to the travel bar.

A ring mechanism for retaining loose-leaf pages includes a housing and ring members for holding loose-leaf pages that are moveable relative to the housing between an open and closed position. An actuation system moves the ring members and includes hinge plates pivotally mounted on the housing and an actuator actuating pivoting movement of the hinge plates. A travel bar of the actuation system is moveable by the actuator between a locked position blocking pivoting movement of the hinge plates and an unlocked position allowing pivoting movement of the hinge plates. The actuation system is adapted to deform while moving the travel bar from the locked position toward the unlocked position to delay the pivoting motion of the hinge plates from the movement of the actuator.

A desk leaf base has a base formed of a trapezoidal tubular body in a trapezoidal shape in a side view, closed from a bottom surface to a certain height in both sides, and opened in an upper portion therefrom. An inclined front wall of the tubular body is removed from one side to the other side, in a range from the height to a higher height lower than a top surface. A binder mounted along an elongated top surface of the base has an elongated body and rings. The elongated body is mounted along the top surface of the base with an approximately same width as the top surface. The rings are mounted on the body and capable of opening and closing. Each ring includes linear portions that protrude from the body inclining upward on front and back sides when closing.