Closing trial courts to the public and postponing non-essential proceedings during the covid19 emergency makes good sense as a public health measure but shuts the public out of proceedings that under normal circumstances are rightfully accessible. Constitutional rights of criminal defendants are protected not just by the right to counsel but also by public scrutiny of hearings, judges, prosecutors and other public officials. Many problems would have been avoided if only courts would embrace televised proceedings and modern communications technologies.

The Angels removed Mark Langston with a no-hitter intact after seven innings in 1990, in what could serve as a cautionary tale for the 2020 season.

From across the U.S., these virtual learning experiences can help your kids learn with help from museums, a memorial and even lei-making.

This wasn't the way the UCLA men's and women's basketball teams envisioned their seasons would end. The NCAA tournaments were canceled Thursday.

If colleges have to pay out millions in tuition refunds because of coronavirus, it could mean higher tuition and reduced financial aid in coming years.

Smart Summon, the feature that lets Teslas drive themselves through parking lots, is drawing increasing criticism.

LIFE after death is real, according to a woman who astonishingly claims to have entered another dimension where she saw bright lights and her dead father.

GEORGE SOROS made a chilling warning about the state of global markets in 2012 that has fresh relevance today as world leaders grapple with the unprecedented challenge of rebuilding the post-coronavirus economy.

If there’s something worth investing in, that would be ‘experiences’. Creating fun memories, especially when traveling, is priceless. If you are into experiencing only the best, check out the following ideas and enjoy: Go on...

The post 5 Experiences to Suit Every Taste appeared first on Geeky Traveller.

GEORGE SOROS made a chilling warning about the state of global markets in 2012 that has fresh relevance today as world leaders grapple with the unprecedented challenge of rebuilding the post-coronavirus economy.

CRUISE holidays offer a number of luxurious leisure activities as part of the package. However, for an extra cost passengers can enjoy more exclusive experiences, but only if they stick to this rule.

NEGRONIS are a popular Italian cocktail and a great way to toast the sunshine or enjoy as an aperitif. Here's how to make a classic Negroni.

Interested in waiving the green flag at an Indy 500 practice, and looking to stay busy during the Month of May? IndyCar and IMS have a solution.

'It starts with the team and the students'; athletic director Jack Swarbrick ponders possibilities for Notre Dame Stadium this year

Wagyu steak, baby lamb chops, dumplings, pie and more were served with fine wine at the IndyStar Wine & Food Experience at Clay Terrace in Carmel.

During the coronavirus pandemic, it's business as usual at Mug-N-Bun restaurant, and Historic Steer In embraces its drive-in roots.

28 of the best Indianapolis restaurants serve tastings.

Tickets to the September food festival featuring some 30 Indianapolis restaurants are on sale.

Wagyu steak, baby lamb chops, dumplings, pie and more were served with fine wine at the IndyStar Wine & Food Experience at Clay Terrace in Carmel.

'It starts with the team and the students'; athletic director Jack Swarbrick ponders possibilities for Notre Dame Stadium this year

Interested in waiving the green flag at an Indy 500 practice, and looking to stay busy during the Month of May? IndyCar and IMS have a solution.

Israel's coronavirus patient 74, also known as Dani, posts about her experience on social media.

Formula 1 almost doubles the shutdown period for teams as the coronavirus crisis continues to play havoc with the 2020 championship.

Albert Jarrett was among some 10,000 West Indians who crossed the Atlantic to join the war effort.

It's difficult to count the number of video games in which someone is standing around a corner clutching a weapon and waiting for their mortal enemy to pass. But until recently it wasn't possible to physically experience that scenario.

Baines, a six-time all-star, led the league in a batting category just once over a 22-year career. If that' the new bar for the Hall, it's time to talk about Freddy Garcia and Placido Polanco, too. (Note: It should never be time to talk about Freddy Garcia and Placido Polanco.)

Dune HD announces a new partnership with Qarva designed to enhance the IPTV experience. The integration of Qarva’s FastSwitch technology into Dune HD’s digital media players and set-top boxes will give IPTV subscribers improved interaction and higher quality through faster channel changing and the elimination of packet loss. The joint solution will be demonstrated by Dune HD on stand 17 at TV Connect MENA 2012.

An enhanced, high quality experience is proven to increase subscriber loyalty and is central to operators reducing churn and growing revenues. FastSwitch improves the viewing experience by dramatically reducing the lag associated with controlling IPTV services, bringing response times down from 5 seconds to less than half a second - in line with the speeds achieved through traditional TV broadcast channels. Through its integral Packet Loss Recovery technology, FastSwitch also eliminates IPTV issues such as picture freezing and blocking, delivering an improved viewing performance.

Trump has gutted the asylum system that grew in part out of our shame over our heartless refugee policies in the 1930s.

Have you ever thought that your home might provide areas of learning experiences for your child? As a teacher of young children, I would ask parents to look at their homes as a unique way of engaging children with their immediate and daily environment. Doing so not only prepares the children for school academic learning, but also for physical, social and emotional growth.

Assuredly, IoT (Internet of Things) has the potential to improve customer experience. The rapid expansion of technology has impacted businesses in many ways. Besides, IoT enables data sharing, inventory management, security, and increased efficiency and productivity. But, what is IoT? Well, in simple words, IoT is the network of interconnected devices that embedded with sensors, software, […]

The post Why You Need to Consider IoT in Improving Customer Experience appeared first on ReadWrite.

BEST DEALS ON GAMING LAPTOPS:

• MSI - Modern 15 15.6" Laptop — $749

• ASUS - ROG G531GT 15.6" Gaming Laptop — $999.99

• Dell - G3 15.6" Gaming Laptop — $999.99

It's time to level up.

If you didn't already know, PC gamers take great pride in the way they play. These are the folks who delight in the fact that PC gaming is just so much better than playing on a console, and if this Reddit thread is any indication — this way of thinking isn't going away any time soon.

While it can take a year or two for gaming consoles to adapt to updated technology, PCs see that improvement hit almost instantly. New rigs and laptops hit the market faster, as opposed to consoles that make you wait for months until their release.  Read more...

Rita J. King, co-director and EVP for business development at Science House, recently conducted a series of interviews with business leaders, exploring the challenges and hurdles companies face in evolving business landscapes. In this interview, King chats with Craig Lemasters, CEO of Global Executive Group, about what companies face when navigating the digital transformation. They […]

"[F]lying during a pandemic turned out to be more stressful—and surreal—than I’d planned for," writes McKay Copkins in The Atlantic. After two months of social distancing Copkins went on a reporting trip that required a plane flight. He was looking forward to the trip, but as soon as he got on the plane he realized that air travel is no fun during a pandemic.

I arrived at my assigned row, and found a stocky, gray-haired man in the seat next to mine. When I moved to sit down, he stopped me. “Sit there,” he said gruffly, pointing to the aisle behind us. “Social distance.”

Not eager for a confrontation, I decided to comply. Within seconds, though, a flight attendant materialized and ordered me back to my assigned seat. My recalcitrant would-be seatmate, vigorously objecting to this development, responded by blocking my entrance to the row with his leg.

Photo by Ethan McArthur on Unsplash Read the rest

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.

31 July 2014 , Volume 70, Number 4

A long view of the problems of modern migration

EJ Blanchette-Mackie
Jun 1, 1995; 36:1211-1226
Articles

Dawn L. Brasaemle
Dec 1, 2007; 48:2547-2559
Thematic Reviews

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene–Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca2+-dependent iCGRP release. MGO, GO, and 3-DG were about equally potent in the millimolar range. We hypothesized that another dicarbonyl, 3,4-dideoxyglucosone-3-ene (3,4-DGE), which is present in peritoneal dialysis (PD) solutions after heat sterilization, activates nociceptors. We also showed that at body temperatures 3,4-DGE is formed from 3-DG and that concentrations of 3,4-DGE in the micromolar range effectively induced iCGRP release from isolated murine skin. In a novel preparation of the isolated parietal peritoneum PD fluid or 3,4-DGE alone, at concentrations found in PD solutions, stimulated iCGRP release. We also tested whether inflammatory tissue conditions synergize with dicarbonyls to induce iCGRP release from isolated skin. Application of MGO together with bradykinin or prostaglandin E2 resulted in an overadditive effect on iCGRP release, whereas MGO applied at a pH of 5.2 resulted in reduced release, probably due to an MGO-mediated inhibition of transient receptor potential (TRP) V1 receptors. These results indicate that several reactive dicarbonyls activate nociceptors and potentiate inflammatory mediators. Our findings underline the roles of dicarbonyls and TRPA1 receptors in causing pain during diabetes or renal disease.

S. A. Nazarov
Trans. Moscow Math. Soc. 80 (2020), 1-51.
Abstract, references and article information

1 November 2019

The 'Security and Prosperity in Asia' conference looked at the impact of international law in the Asia-Pacific with a focus on regional economic and security issues such as the South China Sea disputes.

Research Event

Event participants

K. Anis Ahmed, Publisher, Dhaka Tribune and Bangla Tribune; Author of Good Night, Mr. Kissinger, Co-director, Dhaka Literary Festival
Meenakshi Ganguly, South Asia Director, Human Rights Watch
Chair: Ed Cumming, Writer, The Independent

The sports industry is harnessing digital engagement to enhance fan experiences and cope with threats to its traditional business model