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Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield

Org. Biomol. Chem., 2024, 22,3009-3018
DOI: 10.1039/D4OB00211C, Paper
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
A single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A phosphamide nucleotide analog: a substrate for polymerase synthesis of DNA

Org. Biomol. Chem., 2024, 22,2963-2967
DOI: 10.1039/D4OB00089G, Communication
Jiong Meng, Qiaqia Guo, Xiaona Zhai, Song Yang, Shuai Wang, Pengcheng Wang, Debin Ji
A phosphamide nucleotide analog (dNTPγNH2) exhibited higher stability than dNTPs and can be recognized by DNA polymerases in PCR.
The content of this RSS Feed (c) The Royal Society of Chemistry




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3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00391H, Communication
Alexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov
3-Halo-1,2-oxazine N-oxide derivatives act as surrogates of vinyl nitrile oxides in tandem [3 + 2]-cycloaddition/[3 + 2]-cyclofragmentation with arynes leading to benzisoxazoles.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Tech adoption will not lead to loss of jobs

Every half per cent increase in GDP requires 10 per cent growth in travel




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Severe staff shortage leaves Tamil Nadu’s obstetricians and gynaecologists overworked

Doctors are forced to take turns doing frequent 24-hour shifts — in some cases two to three 24-hour shifts a week. Inquiries with government OB-GYNs reveal that several health facilities have been short-staffed for years, and vacant posts remain unfilled




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'Ritz looked fine! Absolutely fine!'

'He did some great work and people remember him from so many things, but he should have got some stronger parts.'




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So how does the browser actually render a website

September 2015 I had the privelage of giving a talk at JSConfEU 2015 in Berlin. My topic was about what the browser actually does to construct your website and show it on the screen. This is a topic I’ve been digging into for a few years now and it was really fun trying to distill … Continue reading "So how does the browser actually render a website"




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Government reduces subsidised tomato price to ₹80 a kg

After a re-assessment of the situation from across 500 plus points in the country, the government has decided to sell it at ₹80 per kg from July 16th, 2023




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Cabinet approves ₹22,303 cr subsidy on P&K fertilisers for Rabi crop season

The decision was informed by Information and Broadcasting Minister Anurag Thakur after the Cabinet meeting




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India’s smaller rice crop paves way for prolonged export curbs

Production in India, the world’s largest rice exporter, is under unusually intense focus after New Delhi banned exports of non-basmati white rice in July, sending global prices surging




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India may earmark $48 bln for next year's food, fertiliser subsidies

Food and fertiliser subsidies are expected to be increased in the Union Budget 2024, sources say




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Centre announces ₹24,420 crore subsidy for summer crop fertilizers




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Chickpea imports unlikely to ease prices, yellow peas seen as substitute

Limited availability of chickpeas in the world market could force India to import of yellow peas, which are available in abundance, say officials




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Government’s subsidised onion sale brings relief, prices drop in major cities

The government initiated the sale of onions at a subsidised rate through mobile vans and outlets of NCCF and NAFED.




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Director Venu Yeldandi on ‘Balagam’: Every character stems from real-life observations

As the Telugu film ‘Balagam’ wins hearts and international awards, director Venu Yeldandi talks about how he wanted the film to reflect native culture and relationships in Sircilla, Telangana




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SMBs are opening up to device as a service: Lenovo India CEO




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Acer Predator Helios 300 SpatialLabs launched in India

The premium gaming laptop supports glasses-free 3D gaming




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Govt curbs import of laptops, tablets on security concerns

Move to take care of security concerns, boost domestic manufacturing, say sources




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Absent history : the untold story of Special Branch Operations in Singapore, 1915-1942 / Ban Kah Choon.

Singapore : Horizon Books, 2002.




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Iraq : How, where, for whom? / Hanaa' Malallah & kennardphillipps = al-ʻIrāq: kayfa, ayna, li-man? / Hanāʼ Māl Allāh wa-kīnārdfīlībs.

[London, England] : The Mosaic Rooms, an A.M. Qattan Foundation Project, [2012]




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Porphyrin-linked graphdiyne as a substrate for constructing single-atom catalysts with transition metals towards oxygen reduction reactions and oxygen evolution reactions

Mater. Chem. Front., 2024, 8,3741-3746
DOI: 10.1039/D4QM00555D, Research Article
Jiejie Ping, Mei Wu, Manyu Liu, Yan Jiang, Wenhui Shang, Menggai Jiao, Jiahao Ruan, Nan Wang, Zhiyu Jia
Porphyrin-linked graphdiyne anchored with transition metals exhibits outstanding electrochemical performance, attributed to the modifications in the coordination environment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Oasis Labs' Dawn Song in Conversation with Tom Simonite

Oasis Labs CEO and Founder Dawn Song spoke with WIRED's Tom Simonite as part of WIRED25, WIRED's second annual conference.




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Obsessed - How This Guy Became a Whistling Champion

International Grand Champion Sean Lomax loves whistling more than most. Watch him break down how he achieves his show-stopping performances. Sean Lomax Professional Whistler https://www.whistlinfool.com https://www.patreon.com/The_Virtuoso_Whistler BUSINESS CONTACT: whistleonrecords@gmail.com 702.541.4177




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Obsessed - How This Guy Builds Record-Breaking Balloon Sculptures

Jeremy Telford built the world's largest balloon sculpture. But that's only one of the impressive things he has done with balloons.




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How Remote Jobs Can Make the Future of Work More Inclusive and Accessible | WIRED Brand Lab

BRANDED CONTENT | Produced by WIRED Brand Lab with Comcast Business | For some, the daily commute is simple. But for people with disabilities, older workers or those needing childcare friendly hours, traditional commuting can be physically prohibitive. And for those who live outside of urban areas, transit times can be extreme. What can we do to keep this talent in the workforce? Telecommuting is one solution for a more inclusive future of work.




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Obsessed - How This Guy Became a Pizza Spinning World Champion

Sleight of Hand Pizza owner and chef Justin Wadstein is a 13-time world pizza champion. Here's how he takes the simple act of tossing dough to the next level with flips, spins, shoulder rolls, and other moves.




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Obsessed - How This Artist Uses A.I. & Data to Teach Us About the World

Artist Refik Anadol doesn't work with paintbrushes or clay. Instead, he uses large collections of data and machine learning algorithms to create mesmerizing and dynamic installations.




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Why Scientists and Artists Want The Blackest Substances on Earth

Artists and scientists are searching for ever more light-absorbing materials. To find out what's behind the quest for ultra-blacks, WIRED's Arielle Pardes talked with artist Stuart Semple and physicist John Lehman about these amazing materials.




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Obsessed - How This Guy Makes His Own Novelty Instruments

Len Solomon has been making instruments out of random objects for over 30 years. He's performed as a one-man-band all over the world, and The Majestic Bellowphone is perhaps his DIY novelty masterpiece. Check out Len Solomon's YouTube channel at https://www.youtube.com/user/bellowphone.




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Obsessed - How This Guy Builds Mesmerizing Kinetic Sculptures

A self-taught artist with a background in physics, David C. Roy has been creating mesmerizing wooden kinetic sculptures for nearly 40 years. Powered solely through mechanical wind-up mechanisms, pieces can run up to 48 hours on a single wind.




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Obsessed - How This Guy Balances Impossible Rock Structures

Michael Grab's mind-bending rock formations aren't held together by glue or steel rods. Shockingly, his rock piles are stacked using only the laws of gravity. His rock formations have taken the internet by storm, and brought an even greater attention to rock balancing.




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Obsessed - How This Guy Stacks Playing Cards Impossibly High

Have you ever played a card game then decided to see how high you could stack the cards? Bryan Berg has made card stacking an art form. He holds numerous Guinness World Records (so many he's lost count), and keeps upping the ante on the difficulty. Stacking a house of cards on a running dryer? Why not!




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Obsessed - How This Artist Makes Magnetic Fluid Sculptures

Ferrofluid is a liquid with nano-sized iron particles that was developed by NASA in the 1960s. Artist Eric Mesplé has been experimenting with this magnetic liquid in his art for the past dozen years, and the results are mesmerizing.




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Absurd Planet: WIRED’s Absurd Creatures Series Gets New Life on Netflix

What began as the Absurd Creature of the Week column, and became the Absurd Creatures web video series, is now Absurd Planet, only on Netflix.




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Obsessed - How This Guy Paddles Kayaks Over Massive Waterfalls

Lots of people like kayaking, and some even enjoy white water, but Rafael Ortiz takes it to another level. Rafael is obsessed with kayaking over massively steep waterfalls.




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Obsessed - How This Guy Makes Incredible Sand Art

Artist Andres Amador takes "playing with sand" to a whole new level. His free-flowing and fractal-inspired works of art exist for only a short amount of time, eventually getting swallowed up by the ocean's tides. But, in that timeframe, Andres is able to create unique pieces that are indelible and impactful.




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Obsessed - How This Girl Takes Indoor Skydiving to the Next Level

Sydney Kennett is one of the world's best indoor skydivers. The 14-year-old champion moves with the grace of a ballerina inside wind tunnels that propel air in excess of 100 miles per hour. Sydney holds numerous top prizes at competitions around the world, and she's even a Guinness World Record holder.




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Obsessed - How This Woman Makes Mesmerizing Light Sculptures

Interactive Light Artist Jen Lewin creates interactive sound and LED art that can be the scale of an entire landscape. Humans across the planet understand light, so Jen can create pieces that everyone across the world can comprehend and interact with.




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Obsessed - How This Craftsman Weaves Huge Wooden Sculptures

Charlie Baker is an artist and builder who weaves materials found in nature to make astonishing and beautiful wooden structures. Charlie's creations are made so they look like they could've grown that way, and this ethos permeates the majority of his work. We follow Charlie as he scavenges for wood and looks to start work on another piece. Find out more about Charlie Baker and Baker Structures at: http://www.bakerstructures.com/ and on Instagram at @bakerstructures




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Obsessed - How This Guy Replicates Diamonds

John Hatleberg creates replicas of famous diamonds. Watch as the conceptual gem artist takes us all the way through his process, from making molds of original famous diamonds to cutting his own versions.




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Obsessed - How This Guy Makes Lifelike Cardboard Sculptures

Cardboard artist James Lake describes his work as "a cardboard sculpture in its purest sense." James takes recycled materials and turns them into significant pieces of art.




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RE:WIRED 2021: Beeple on Art as a Subscription

Digital artist Mike Winkelmann, a.k.a. Beeple, shares how his latest piece, “Human One,” will continue to update over time—and what that means for how digital art will be viewed in the future.




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Obsessed - How This Guy Builds Amazing Lego Models

PJ Catalano is a Master Model Builder at Legoland California Resort. He's been working at Legoland for 8 years and has built some truly incredible things. PJ talks about everything that goes into building Lego, from all the math he has to do to the various techniques he's learned that keep his models standing strong.




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Obsessed - How This Woman Makes Epic Gingerbread Houses

Emily Garland loves building gingerbread houses. As a gingerbread house builder, she's made stunning replicas of some of the most famous buildings in the world. Emily takes WIRED through her entire process, and shows us how one of her houses goes from a plan to reality.




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How Nose Swabs Detect New Covid-19 Strains

Scientists from around the world are using nose swabs to track the emergence of SARS-CoV-2 variants. Here's how it works.




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Obsessed - How This Guy Mastered Fingerboarding

Did you play with fingerboards when you were younger? Welcome to the next-level of fingerboarding. Mike Schneider is a professional fingerboarder, the owner of FlatFace Fingerboards, and is really, really good at fingerboarding. Mike has been manufacturing his own fingerboards and scaled-down skateparks since he was 9 years-old. In Dracut, Massachusetts, you can find the FlatFace Fingerboards building. Here, Mike spends 40+ hours a week practicing, building, and socializing with other fingerboarders in what can only be described as "Fingerboard Heaven."




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Obsessed - How This Guy Makes Real-Life Marvel Gadgets

Jake Laser engineers DIY superhero gadgets from his garage. Jake has a massive following on YouTube, bringing to life things we only thought could be fiction. Captain America's shield, Spider-Man's wall-climbing, and Iron Man's lasers are just a few examples of some of his biggest projects. Check out Jake's channel: https://www.youtube.com/c/JLaservideo




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Obsessed - How This Woman Mastered Jump Rope

For most of us, jumping rope may seem like a simple childhood pastime, but for this woman, it's a way of life. Tori Boggs is a professional jump roper, and as you may expect, she's really good at jumping rope. Tori explains what her jump rope life is like, and breaks down how she's helping take the sport to the next level.




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Obsessed - Inside the World's Greatest Dungeons & Dragons Game

Remember that game of Dungeons & Dragons you started when you were 11? What if it never stopped? Robert Wardhaugh has been the Dungeon Master for a D&D game that's been going on for over 40 years. In his game, once you start playing...you keep playing.