Background:

Visceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.

Background:

The Center to Reduce Cancer Health Disparities (CRCHD), NCI, implemented Screen to Save, NCI's Colorectal Cancer Outreach and Screening Initiative to promote awareness and knowledge of colorectal cancer in racial/ethnic and rural populations.

The repetitive immunization at multiple sites (RIMMS) protocol capitalizes on the animal's innate immune system, which is genetically preprogrammed to recognize many antigens. By repetitively immunizing the animal, B cells that recognize the antigen are kept continuously expanding until the lymph nodes are harvested for hybridoma generation. This is a good method for making a more diverse repertoire of antibodies or antibodies directed against conformational epitopes.

While smoking is inextricably linked to oral/head and neck cancer (HNSCC), only a small fraction of smokers develop HNSCC. Thus, we have sought to identify other factors, which may influence the development of HNSCC in smokers including microbiology. To determine microbial associations with HNSCC among tobacco users, we characterized oral microbiome composition in smokers with and without HNSCC. 16S rRNA MiSeq sequencing was used to examine the oral mucosa microbiome of 27 smokers with (cases) and 24 without HNSCC (controls). In addition, we correlated previously reported levels of DNA damage with the microbiome data. Smokers with HNSCC showed lower microbiome richness compared with controls (q = 0.012). Beta-diversity analyses, assessed as UniFrac (weighted and unweighted) and Bray–Curtis distances, showed significant differences in oral mucosal microbiome signatures between cases and controls (r² = 0.03; P = 0.03) and higher interindividual microbiome heterogeneity in the former (q ≤ 0.01). Higher relative abundance of Stenotrophomonas and Comamonadaceae and predicted bacterial pathways mainly involved in xenobiotic and amine degradation were found in cases compared with controls. The latter, in contrast, exhibited higher abundance of common oral commensals and predicted sugar degradation pathways. Finally, levels of DNA damage in the oral cavity were correlated with the microbiome profiles above. Oral microbiome traits differ in smokers with and without HNSCC, potentially informing the risk of eventual HNSCC and shedding light into possible microbially mediated mechanisms of disease. These findings present data that may be useful in screening efforts for HNSCC among smokers who are unable to quit.

BACKGROUND AND PURPOSE:

It is not known how radiomics using ultrasound images contribute to the detection of BRAF mutation. This study aimed to evaluate whether a radiomics study of gray-scale ultrasound can predict the presence or absence of B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation in papillary thyroid cancer.

BACKGROUND AND PURPOSE:

Brain metastases are a common finding on brain MRI. However, the factors that dictate their size and distribution are incompletely understood. Our aim was to discover a statistical model that can account for the size distribution of parenchymal metastases in the brain as measured on contrast-enhanced MR imaging.

SUMMARY:

Polymorphous low-grade neuroepithelial tumors of the young (PLNTYs) are recently described CNS tumors. Classically, PLNTYs are epileptogenic and are a subtype of a heterogeneous group of low-grade neuroepithelial tumors that cause refractory epilepsy, such as angiocentric gliomas, oligodendrogliomas, gangliogliomas, and pleomorphic xanthoastrocytomas. Although they are a relatively new entity, a number of imaging and histologic characteristics of PLNTYs are already known. We present the imaging and pathologic findings of such a tumor as well as the surgical approach and clinical management.

SUMMARY:

The remarkable temperature sensitivity of the brain is widely recognized and has been studied for its role in the potentiation of ischemic and other neurologic injuries. Pyrexia frequently complicates large-vessel acute ischemic stroke and develops commonly in critically ill neurologic patients; the profound sensitivity of the brain even to minor intraischemic temperature changes, together with the discovery of brain-to-systemic as well as intracerebral temperature gradients, has thus compelled the exploration of cerebral thermoregulation and uncovered its immutable dependence on cerebral blood flow. A lack of pragmatic and noninvasive tools for spatially and temporally resolved brain thermometry has historically restricted empiric study of cerebral temperature homeostasis; however, MR thermometry (MRT) leveraging temperature-sensitive nuclear magnetic resonance phenomena is well-suited to bridging this long-standing gap. This review aims to introduce the reader to the following: 1) fundamental aspects of cerebral thermoregulation, 2) the physical basis of noninvasive MRT, and 3) the physiologic interdependence of cerebral temperature, perfusion, metabolism, and viability.

The constantly increasing number of new real estate projects which have been implemented in the Mekong Delta region has led to the rising land price and strong fluctuation in the local property market.

Real estate insiders and experts said it is essential to develop strict penalties to combat those operating fraudulent property businesses to protect the legitimate rights of consumers and legitimate enterprises.

By 2060, we will have approximately two trillion square feet of buildings across the globe.

“Dear Designer” is a blog series on orienting novice practitioners to the discipline of instructional design and learning experience design.

The post Dear Designer: 3 Considerations for Length When Shifting to VILT appeared first on e-Learning Feeds.

Ducati India कंपनी भारतीय बाजार में अपनी दमदार बाइक Multistrada 950 को लॉन्च करने जा रही है। हालांकि यह बाइक काफी समय पहले ही लॉन्च हो जाती लेकिन भारत सहित दुनियाभर में फैले वायरस और लॉकडाउन के चलते कंपनी को इसकी लॉन्चिंग टाल दी थी।

The US Army has built a prototype device that allows wearers to go glove-free in freezing conditions. It works by heating the forearm, which helps keep the fingertips warm

Electric cars depend on cobalt as a key ingredient in their batteries, but a new analysis reveals we may run out by 2030, while car firm Tesla is moving to other types of battery in China

We’re used to tweaking our digital selves to look thinner or more attractive. A new generation of Instagram filters could drastically change how we perceive ourselves

Adrian Tchaikovsky's latest novel The Doors of Eden rewrites Earth's evolutionary history, with highlights including fish that upload their minds to supercomputers and cats that rule over primates

Clothes that light up by themselves could be a high-tech replacement to high-visibility gear worn by cyclists and construction workers

Julia Ebner infiltrated the hidden forums that extremists use. Her experiences lay bare how they hijack social media and video games to spread hate – and how to beat them

Inside a mountain in the Arctic, Microsoft is building a backup of open-source software that it says will keep the code safe for 1000 years

The covid-19 pandemic has many of us stuck at home. The result could completely reshape how we use the internet, writes Annalee Newitz

A high-speed 3D printer is being tested by the US Army for producing spare steel parts near the front lines – it could also make weapons or aircraft parts

Last week, former Vice President Joe Biden told the world that he “unequivocally” denied accusations by Tara Reade, a former staffer in his Senate office, that he sexually assaulted her in the early ’90s.

On Friday evening, Reade responded: Prove it.

“Joe Biden should take the polygraph,” Reade told former television anchor Megyn Kelly, in an interview that aired on Kelly’s YouTube channel. “I will take one if Joe Biden takes one, but I’m not a criminal.”

Read more at The Daily Beast.

Big Oil Companies Face Tough Comparisons as Earnings Near American and European oil giants spend a lot of time talking about their differentiated strategies and approaches to hot-button issues such as climate change. But their bottom lines are still primarily driven by the same common factor: commodity prices. That shared reality doesn’t bode well for […]

Premier League clubs are fearful that a significant number of first-team stars may refuse to return to action if the league's Project Restart plan gets the green light.

UP Board 2020: 12वीं के छात्र जिनकी परीक्षाएं हो गई हैं, वे परिणाम का इंतजार कर बेसब्री से कर रहे होंगे।

UP Board Class 10th Result 2020: 10वीं पास करने के बाद अच्छी नौकरी निलना मुश्किल होता है, पर ऐसा नहीं है कि 10वीं पास के लिए नौकरियों का मौका ही नहीं है।

When the Soviet Union lands on the moon first people in the US are shocked. But For All Mankind provides an even bigger surprise when one cosmonaut's identity is revealed, says Emily Wilson

Startup Cerebras has built a wafer-size chip for AI, but it isn’t the only one possible

Lucas Joppa, founder of Microsoft's AI for Earth program, is taking an engineering approach to environmental issues

John Deere, the nearly 200-year-old tractor manufacturer, now considers itself a software company

Your weekly selection of awesome robot videos

The fastest, safest, and most exciting way to launch a quadrotor may be ballistically

The SnotBot project uses drones, data, and deep learning to tell us about the health of whales and the oceans

This is the Popcorn Popping Lid with Butter Vents available from Uncommon Goods ($11). You just fill a microwave-safe 10-inch bowl with your choice of popping corn, set the lid on top, add a pat of butter to each of the lid's butter vents, and let the microwaving begin! Of course if you're anything like me you'll balance as much butter as you can atop each of those vents because, I don't know if you knew this about me, but I love butter. I don't really like it cold but *microwave beeping* sometimes when I'm really feeling down I'll just melt two sticks and drink it. Keep going for a couple more shots because they exist.

FIFA 20 Team of the Season So Far Premier League Squad is now live and features Lionel Messi, Luis Suarez and Antoine Griezmann.

XSEED and Natsume make up. Chris rubs his sore feet. Emmanuel’s ear drums get blown out by a Shenmue fan. Alex is STILL posting stories....

It’s a new year but it has the same old shenanigans. Not finishing games, PC hackers, getting distracted by shiny new toys, and Tarutaru addiction....

Jonathan crashes the RPGCast this week because he heard that Chris, Anna Marie, Kelley, Peter, and Nathan were dissing on Tactics Ogre. We also discuss child care our Now Playing. But don't worry, while the news is slim, it's also pleasantly robust.

ARMED forces veterans are facing a threat from an enemy they cannot see.

From Stay at Home T-shirts to NHS baseball caps, here’s a selection from small labels donating some or all of their profits to charities helping healthcare workers and the Covid-19 response

Researchers have developed a set of recommendations to manage the mental health of frontline medical workers during viral outbreaks, such as COVID-19.

A new study found that organic nitrates do not have clinically relevant effects on bone mineral density or bone turnover in postmenopausal women, and the medications caused significant side effects.

A new computational method for assigning the donor in single cell RNA sequencing experiments provides an accurate way to unravel data from a mixture of people. The Souporcell method could help study how genetic variants in different people affect which genes are expressed during infection or response to drugs, and help research into transplants, personalized medicine and malaria.