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Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide

OBJECTIVE

We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the complete cohort after 2 years of follow-up.

RESEARCH DESIGN AND METHODS

A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments.

RESULTS

No infusion-related adverse events were observed. β-Cell function declined after UCB infusion. Area under the curve C-peptide was 24.3% of baseline 1 year postinfusion (P < 0.001) and 2% of baseline 2 years after infusion (P < 0.001). Flow cytometry revealed increased regulatory T cells (Tregs) (P = 0.04) and naive Tregs (P = 0.001) 6 and 9 months after infusion, respectively.

CONCLUSIONS

Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide.




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Oklahoma Lawmakers Ramp Up Security at Capitol After Teacher Protests

The increase in security was imposed by majority Republicans as a new session of the legislature opened last week.




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A Washington State Judge Told Striking Teachers to Return to Work. They Refused

The judge told teachers that the strike could be causing substantial harm to students.




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Understanding the Stolen Generations through their stories : from the inaugural Stolen Generation Summit Elder Abuse Prevention and Positive Aging Summit : a resource for the aged care workforce / ARAS.

Two Aboriginal Elders, one of whom had been removed from her family as a child, and the other who was affected by siblings and other family members being removed, provided consent to share their personal stories specifically for this resource, with the vision that people would be better informed and communication improved when delivering care. To respect their privacy, their stories have been de-identified.




tol

Forgotten bastards of the Eastern Front : an untold story of World War II / Serhii Plokhy.

World War, 1939-1945 -- Aerial operations, American.




tol

Nobody's soldier : the life of Andrii Antonenko : an autobiography / as told to Peter Antonenko.

Antonenko, Andrii, 1922-




tol

Diagnostik und allgemeine Symptomatologie der Lungenkrankheiten ... / von Albert Fraenkel.

Wien : Urban & Schwarzenberg, 1890.




tol

Diastolic aortic murmurs without valvular lesions / by G. A. Gibson.

Edinburgh : Young J. Pentland, 1903.




tol

Dictionnaire technologique : dans les langues Française, Anglaise et Allemande ; renfermant les termestechniques usités dans les arts et métiers et dans l'industrie en général / rédigé par Alexandre Tolhausen. Revu p

Leipzig : Tauchnitz, 1873-1876.




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Die acute Entzundung des hautigen Labyrinthes des Ohres (Otitis labyrinthica s. intima) irrthumlich fur Meningitis cerebro-spinalis epidemica gehalten : fur praktische Aerzte dargestellt / von R. Voltolini.

Breslau : E. Morgenstern, 1882.




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Die Anwendung der Galvanokaustik im Innern des Kehlkopfes und Schlundkopfes : nebst einer kurzen Anleitung zur Laryngoskopie und Rhinoskopie / von Rudolph Voltolini.

Wien : W. Braumuller, 1867.




tol

Die eitrigen Entzündungen des Eileiters : histologische Untersuchungen / von Herm. Schridde.

Jena : Fischer, 1910.




tol

Die Entdeckung des Blutkreislaufs durch Michael Servet, 1511-1553 / von Henri Tollin.

Jena : H. Dufft, 1876.




tol

Die Influenza : ihre Geschichte, Epidemiologie, Aetiologie Symptomatologie und Therapie, sowie ihre Complicationen und Nachkrankheiten / von A. Ripperger.

Munchen : J.F. Lehmann, 1892.




tol

Die Localisation der Hautkrankheiten : histologisch und klinisch / bearbeitet von Oscar Simon.

Berlin : A. Hirschwald, 1873.




tol

Die pathogenese der epidemischen Diphtherie : nach ihrer histologischen Begründung / von M.J. Oertel.

Leipzig : F.C.W. Vogel, 1887.




tol

Die pathologisch-histologischen untersuchungsmethoden / von prof. dr. G. Schmorl.

Leipzig : Vogel, 1905.




tol

Die Symptomatologie der Kleinhirn-Erkrankungen / von Arthur Adler.

Wiesbaden : J.F. Bergmann, 1899.




tol

Die Verdauung als histologische Methode / von A. Ewald und W. Kuhne.

[Germany] : [publisher not identified], 1876.




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Dissertationes medicæ in Universitate Vindobonensi habitæ ad morbos chronicos pertinentes / Max. Stollii ; edidit et præfatus est Josephus Eyerel.

Viennæ : Typis Christiani Friderici Wappler, 1788-92.




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Du traitement électrique des tumeurs fibreuses de l’utérus, d’après la méthode du Dr. Apostoli / par Lucien Carlet.

Paris : O. Doin, 1884.




tol

Einführung in die Dermatologie / von S. Bettmann.

Wiesbaden : J.F. Bergmann, 1914.




tol

Elements of histology / by E. Klein.

London : Cassell, 1883.




tol

The elements of pathological histology : with special reference to practical methods / by Anton Weichselbaum ; translated by W.R. Dawson.

London : Longmans, Green, 1895.




tol

Erpétologie générale, ou, Histoire naturelle complète des reptiles / par A.M.C. Duméril et par G. Bibron.

Paris : Roret, 1834-1854.




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Essai de pneumatologie médicale : recherches physiologiques, cliniques et thérapeutiques sur les gaz / par J.-N. Demarquay.

Londres : Paris, 1866.




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Essai d'hématologie pathologique / par G. Andral.

Paris : Fortin, Masson et Ce, 1843.




tol

Constantia is reunited with her father, the emperor Tiberius II Constantinus, and given as bride to Ælla, king of Northumbria. Stipple engraving by F. Bartolozzi, 1799, after J.F. Rigaud.

London (Poets Gallery Fleet Street) : Publish'd ... by Thos. Macklin, Novr. 30. 1799.




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Orlando rescuing Olympia from a sea-monster. Etching by F. Bartolozzi, 1763, after Lodovico Carracci.

London (in Cheapside) : Published according to Act of Parliament, by J Boydell engraver, 1763.




tol

Toledo, Spain: buildings and streets. Coloured etching, 17--.

A Paris (rue St Jacques au dessus de celle des Mathurins au Gd. St. Remy : ches Huquier fils, graveur, [between 1700 and 1799]




tol

Development of tolerance and cross-tolerance to psychomotor effects of benzodiazepines in man / by Kari Aranko.

Helsinki : Department of Pharmacology and Toxicology, University of Helsinki, 1985.




tol

Wintrobe's atlas of clinical hematology

9781605476148 hardcover




tol

Priming-mediated stress and cross-stress tolerance in crop plants

9780128178935 (electronic bk.)




tol

Kanerva’s Occupational Dermatology

9783319686172




tol

Daily routine in cosmetic dermatology

9783319202501




tol

Clinical Manual of Dermatology

Huang, William W. author.
9783030239404




tol

Challenging cases in dermatology.

El-Darouti, Mohammad Ali.
9783030218553 (electronic bk.)




tol

Biologic and systemic agents in dermatology

9783319668840 (electronic bk.)




tol

Atlas of male genital dermatology

Hall, Anthony, author.
9783319997506 (electronic bk.)




tol

Atlas of Lasers and Lights in Dermatology

Cannarozzo, Giovanni. author.
9783030312329




tol

Advances in parasitology.

9780123742292 (electronic bk.)




tol

A treatise on topical corticosteroids in dermatology : use, misuse and abuse

9789811046094




tol

[~21.8 MB mp3] A Leading Figure In The New Apostolic Reformation

Story: Several apostles affiliated with the movement helped organize or spoke at Rick Perry's recent prayer rally. A leading apostle, C. Peter Wagner, talks about the movement and its missions, which include acquiring leadership positions in government, the media, and arts and entertainment.




tol

09.28.11: You told me you couldn't fly




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Stolen Collection of Persian Poetry Found With Help of 'Indiana Jones of the Art World' Goes on Auction

The 15th-century edition of Hafez's "Divan" will be sold at Sotheby's next month




tol

Van Gogh Masterpiece Stolen From Dutch Museum Shuttered by COVID-19

Thieves pilfered "The Parsonage Garden at Nuenen in Spring 1884" from the Singer Laren in the early hours of Monday morning




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Paleontologists Find Antarctica’s First Frog Fossil

The find could help pin down when the South Pole turned icy




tol

Deep-Sea Mining’s Environmental Toll Could Last Decades

A study of microbial communities at the site of a 1989 deep-sea mining test suggests the fragile ecosystem may take half a century to fully recover




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A Story of an Empire, Told Through Tea

The Met has revamped its British Galleries, drawing on luxurious artifacts to highlight the country's history of exploitation




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Happy birthday Vijay Deverakonda: Tollywood’s ‘Dear Comrade’ who auctioned his first Filmfare Award for charity – The New Indian Express

Happy birthday Vijay Deverakonda: Tollywood's 'Dear Comrade' who auctioned his first Filmfare Award for charity  The New Indian Express



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