The growing popularity of voice-activated technologies is forcing educators to think about the role such tools play in preparing students for the jobs of the future.

Students are learning how to research and write scripts, hone interviewing techniques, and edit video footage, and some teenagers are even earning certifications in media technology.

Ceftobiprole medocaril is an advanced-generation cephalosporin prodrug that has qualified infectious disease product status granted by the US-FDA and is currently being evaluated in phase 3 clinical trials in patients with acute bacterial skin and skin structure infections (ABSSSIs) and in patients with Staphylococcus aureus bacteremia. In this study, the activity of ceftobiprole and comparators was evaluated against more than 7,300 clinical isolates collected in the United States from 2016 through 2018 from patients with skin and skin structure infections. The major species/pathogen groups were S. aureus (53%), Enterobacterales (23%), Pseudomonas aeruginosa (7%), β-hemolytic streptococci (6%), Enterococcus spp. (4%), and coagulase-negative staphylococci (2%). Ceftobiprole was highly active against S. aureus (MIC_50/90, 0.5/1 mg/L; 99.7% susceptible by EUCAST criteria; 42% methicillin-resistant S. aureus [lsqb]MRSA[rsqb]). Ceftobiprole also exhibited potent activity against other Gram-positive cocci. The overall susceptibility of Enterobacterales to ceftobiprole was 84.8% (>99.0% susceptible for isolate subsets that exhibited a non-extended-spectrum β-lactamase [lsqb]ESBL[rsqb]-phenotype). A total of 74.4% of P. aeruginosa, 100% of β-hemolytic streptococci and coagulase-negative staphylococci, and 99.6% of Enterococcus faecalis isolates were inhibited by ceftobiprole at ≤4 mg/L. As expected, ceftobiprole was largely inactive against Enterobacterales that contained ESBL genes and Enterococcus faecium. Overall, ceftobiprole was highly active against most clinical isolates from the major Gram-positive and Gram-negative skin and skin structure pathogen groups collected at U.S. medical centers participating in the SENTRY Antimicrobial Surveillance Program during 2016–2018. The broad-spectrum activity of ceftobiprole, including potent activity against MRSA, supports its further evaluation for the potential ABSSSI indication.

Recent studies highlight the abundance of commensal coagulase-negative staphylococci (CoNS) on healthy skin. Evidence suggests that CoNS actively shape the skin immunological and microbial milieu to resist colonization or infection by opportunistic pathogens, including methicillin resistant Staphylococcus aureus (MRSA), in a variety of mechanisms collectively termed colonization resistance. One potential colonization resistance mechanism is the application of quorum sensing, also called the Accessory Gene Regulator (agr) system, which is ubiquitous among staphylococci. Common and rare CoNS make autoinducing peptides (AIPs) that function as MRSA agr inhibitors, protecting the host from invasive infection. In a screen of CoNS spent media we found that Staphylococcus simulans, a rare human skin colonizer and frequent livestock colonizer, released potent inhibitors of all classes of MRSA agr signaling. We identified three S. simulans agr classes, and have shown intraspecies cross-talk between non-cognate S. simulans agr types for the first time. The S. simulans AIP-I structure was confirmed, and the novel AIP-II and AIP-III structures were solved via mass spectrometry. Synthetic S. simulans AIPs inhibited MRSA agr signaling with nanomolar potency. S. simulans in competition with MRSA reduced dermonecrotic and epicutaneous skin injury in murine models. Addition of synthetic AIP-I also effectively reduced MRSA dermonecrosis and epicutaneous skin injury in murine models. These results demonstrate potent anti-MRSA quorum sensing inhibition by a rare human skin commensal, and suggest that cross-talk between CoNS and MRSA may be important in maintaining healthy skin homeostasis and preventing MRSA skin damage during colonization or acute infection.

Saskia perseveres through language learning and connects with a young Albanian girl who becomes a follower of Jesus.

Saskia perseveres through language learning and connects with a young Albanian girl who becomes a follower of Jesus.

991 people in the US were asked about their mastery of three common tech tasks; the results aren't too encouraging.

Saskia perseveres through language learning and connects with a young Albanian girl who becomes a follower of Jesus.

Saskia perseveres through language learning and connects with a young Albanian girl who becomes a follower of Jesus.

Saskia perseveres through language learning and connects with a young Albanian girl who becomes a follower of Jesus.

Saskia perseveres through language learning and connects with a young Albanian girl who becomes a follower of Jesus.

It's 2020 and time to upgrade your business skill set. Creativity and persuasion are the most desirable soft business skills, while blockchain and cloud computing skills dominate as the most in-demand hard skills as we begin the new decade.

Eight senior Penn State Scranton accounting and finance students participated in the United Way of Lackawanna and Wayne Counties’ annual Volunteer Income Tax Assistance (VITA) program, preparing about 2,250 free tax returns for low-income families and individuals throughout the region.

Many of education's most common questions skip a logical step or two, warns Alfie Kohn.

Partnering with parents can help students of any age who have trouble with social or mental health issues. But the devil is in the details, finds an analysis of more than 100 studies.

Preschool-age children who frequently play number-related games at home show better math skills and growth by the end of kindergarten, finds a new study in the journal Child Development.

Dover, Del. (October 23, 2017) – The state of Delaware wants to hear from small business owners, community leaders and interested citizens as the new Division of Small Business, Development & Tourism charts a path forward. There will be three listening sessions this week – one in each county – to allow the public to […]

Conversational commerce, as it is more popularly known, is any form of online communication that takes place during an e-commerce purchase.

About 95 percent of watermelon is just water, which helps nourish your skin and make it radiant from within

Brian Michalski was honored as the 2014 Delaware Tree Farmer of the Year at the annual meeting of the Delaware Forestry Association in Bridgeville recently. Michalski is a four-time chair of the state Tree Farm Committee and has operated his 59-acre tree farm near Greenwood, Sussex County since it was first certified in 1997. He has also been DFA’s president for four years.

Delaware Secretary of Agriculture Michael T. Scuse recognized long-time Delaware State University Department Chair Dr. Richard Barczewski with the Secretary’s Award for Distinguished Service to Delaware Agriculture. With thirty-five years of dedicated service, Barczewski was recognized for developing Delaware’s agricultural industry though educating generations of agriculturalists, promoting animal agriculture, and service to agricultural organizations, including 4-H and FFA.

The NSW Government has issued an update with the following information:The Home Affairs Department recently announced that the Subclass 491 Skilled Work Regional visa will replace the present 489 visa in Nov 2019.The visa in the new subclass will have…

The State of Queensland has released a new QSOL and nomination criteria for migration program in the present year. The highlights are:Onshore ApplicantsIn order to obtain the 489 visas applicants must be living in the regional areas of Queensland for…

There is a high Demand in Australia for all categories of skilled workers, as per a recent report of Deloitte. It says that many jobs are unfilled and also that the employers cannot find workers possessing the required skills. Vacancy rates are…

The English language abilities of an applicant are likely to get a rank based on proficiency in the new British visa regime that is getting finalized by UK after it makes an exit from the EU.UK Immigration and Need for an Evaluation The authorities…

The Japanese policy makers are looking to frame a policy for bringing foreign workers to counter the rapidly growing – aging population, without naming it as an actual immigration policy. Japanese Conservatives give high importance to the cultural…

Before matters started getting worse between Russia and the United States, Russians could get the US travel visa within a week. But now, Russians have to wait for a minimum of eight months, making them restless. It is too long to wait for a travel visa…

The Denmark government has announced a new campaign in order to recruit and retain well educated and skilled individuals from non-European countries.The new plan includes tax perks, a fast-track employment system and simplified immigration.The plans…

  The earliest computers were often pushed to the limit performing even a single task, between hammering the hard drive, swapping memory frantically, and crunching through computations. With Microsoft W...

Becoming the youngest country also means that the demand for jobs will see a substantial growth, thus amplifying the challenges in the job market.

DMN's editor-in-chief hunts the social through the streets of Prague and the "luxe bunker" offices of Socialbakers

The Congress has mandated that the H1-B visa has an annual limit cap of 65,000 visas during each fiscal year. Moreover, the first 20,000 petitions filed by beneficiaries having a US master's degree get an exemption from the cap.A few major changes Presently,…

A merit-based immigration plan being put together by Jared Kushner, White House senior adviser it could lead to an escalation in US visas for extremely skilled workers, sources revealed on 24 Apr 2019.Merit-based Immigration ProposalKushner is assumed…

Under the Nasscom FutureSkills platform, there are thousands of hours of free and paid content available for learners to learn at the level suited to them

A McKinsey survey reveals data-driven organisations are 23 times more likely to acquire customers, six times as likely to retain customers, and 19 times as likely to be profitable.

Budget 2020: Let’s grow both edtech and skill-tech

While Bangladesh captain Akbar Ali apologised for the "unfortunate incident", his Indian counterpart Priyam Garg felt it is something that should not have happened.

Warner, who is the captain of Sunrisers Hyderabad in the IPL, was swinging the bat like a sword and he suddenly bursts into laughter when the director says cut.

More than 16,000 passenger jets are grounded worldwide, according to industry researcher Cirium, as the coronavirus obliterates travel and puts unprecedented strain on airline finances.

In today’s world, employers need to be shown, not told, what your skills are. So, set up that GitHub account, post your projects there, develop an opinion, and create a portfolio rather than a resume.

SoftBank has set an indicative price of 1,500 yen ($13.23) per share for its initial public offering (IPO), a regulatory filing showed on Friday, making the deal worth 2.4 trillion yen ($21.16 billion) in one of the world’s biggest-ever listings.

With classes and all other activities being suspended till March 31 due to coronavirus, the Indian Institute of Technology (IIT) Gandhinagar has launched 'Project Isaac' to engage students confined to their rooms or homes in productive activities.

Weeks of lockdown in the country to fight coronavirus may have reduced greenhouse gas emissions enabling people to breathe cleaner air and feast on blue skies, but it is only a temporary phase and will not benefit the environment in the long run.

Various apps and online social media platforms are aiding people in these trying times to upskill themselves and learn something new

It's true that our skin needs regular breaks from makeup and repetitive layers of creams and moisturisers, more so for those with inflamed skin.

Cognizant has reported a decline of 16.78% in net income at $367 million for the quarter ended March 31, 2020, as compared to $441 million in the same period a year ago.

Quebec held two draws in October and issued 162 invitations to apply to the aspirants in the Quebec Skilled Worker Program. A Gradual ProgressFirstly, On October 23, it invited 89 persons to meet the labor market requirements. Also, the Candidates…

The immigration authorities in Ontario held their largest draw on December 11th4wsqor 2019, and issued 667 Notifications of Interest to such candidates who had a profile in Express Entry Pool. This was the first draw in the Skilled Trades stream after…

Winds are from the Northwest at 24.2 gusting to 35.7 MPH (21 gusting to 31 KT). The pressure is 1009.3 mb and the humidity is 35%. The wind chill is 35. Last Updated on May 9 2020, 11:53 am EDT.