High-growth firms (HGFs) – firms able to grow fast over a short period of time – contribute to most new jobs in advanced economies.

The OECD Port-Cities Programme aims to identify how ports can be assets for urban development. The programme therefore assesses the impact of ports on cities and regions. It also compares policies aimed at increasing positive regional impacts of ports and limiting negative effects.

A city’s brand is pivotal for its position in global society, particularly in global competition. Indeed, a city has many aspects of a commercial product. The very strong international brand that I represent is Prague, the million-strong capital of the Czech Republic.

The aquatic life benchmarks (for freshwater species) are based on toxicity values reviewed by EPA and used in the Agency's most recent risk assessments developed as part of the decision-making process for pesticide registration. Each Aquatic Life Benchmark is based on the most sensitive, scientifically acceptable toxicity endpoint available for a given taxon of all scientifically acceptable toxicity data available to EPA.

The OECD is to review its chemical hazard assessment programme with the aim of providing a more specialised service for member countries from 2015.

This new document focuses on the evaluation of test methods applied to determine the physico-chemical properties of different types of nanomaterials.

The Chemical Safety and Biosafety Progress Report is released every eight months. Its purpose is to provide an update on the projects, events and activities. Information on new publications as well as dates and venues of upcoming events and meetings are given.

The West Bengal government has asked the heads of all hospitals to ensure that immunisation programmes against vaccine-preventable diseases continue in full steam amid the Covid-19 outbreak. Immunisation should go on during COVID-19 outbreak to protect children and pregnant women from 'vaccine-preventable diseases' (VPD), the health and family welfare department said in a notification. It was addressed to the superintendents of all medical colleges and hospitals and the chief medical officer of health of all districts. Copy of the notification issued on May 6 was made available on Saturday.

The real issues in Bali are not technical or economic. The crisis we face, with climate change, demands a profound philosophical discussion, a reappraisal of who we are and what progress means, writes George Monbiot.

Minister for Industries, mines and parliamentary affairs Prakash Mehta will attend the programmes regarding 26/11 on behalf of chief minister Devendra Fadnavis.

Hyundai India has announced a unique ‘EMI Assurance' program due to the Covid-19 pandemic in the country. The new initiative supports working individuals with repayment of car loans in case any employment uncertainty.

Archives, Room Use Only - TK6015.R64 1904

Archives, Room Use Only - TK57.F67 1916

I’m sad to say that due to a personal matter, I’ve had to bow out of speaking at this year’s Mobilism conference. You might have seen PPK’s announcement to that effect, and I’m definitely disappointed I’ll miss the event.

Because let’s be honest: my absence isn’t going to do a damned thing to diminish how amazing this conference is going to be. Seriously, look at this lineup. Look at it. Learning from the likes of Scott Jenson, Stephen Hay, Jake Archibald, Lyza Gardner, and Jason Grigsby is too good to be true, and in Amsterdam? And if you haven’t already, watch Jeremy Keith’s epic mobile browser panel from last year, a performance he’s repeating again in May.

Yeah okay I’m officially depressed all over again about missing it.

Seriously though: while I won’t be there, you can be. If you haven’t already, go register for Mobilism 2012 in May. You’ll have one hell of a time.

About 20,000 kits to be distributed to policemen, healthcare workers in red zone areas, in first phase

Despite these times of distress, the Bannerghatta Biological Park’s (BBP) animal adoption programme has been generating a good response. On Saturday,

With the continuing development of beamlines for macromolecular crystallography (MX) over the last few years providing ever higher X-ray flux densities, it has become even more important to be aware of the effects of radiation damage on the resulting structures. Nine papers in this issue cover a range of aspects related to the physics and chemistry of the manifestations of this damage, as observed in both MX and small-angle X-ray scattering (SAXS) on crystals, solutions and tissue samples. The reports include measurements of the heating caused by X-ray irradiation in ruby microcrystals, low-dose experiments examining damage rates as a function of incident X-ray energy up to 30 keV on a metallo-enzyme using a CdTe detector of high quantum efficiency as well as a theoretical analysis of the gains predicted in diffraction efficiency using these detectors, a SAXS examination of low-dose radiation exposure effects on the dissociation of a protein complex related to human health, theoretical calculations describing radiation chemistry pathways which aim to explain the specific structural damage widely observed in proteins, investigation of radiation-induced damage effects in a DNA crystal, a case study on a metallo-enzyme where structural movements thought to be mechanism related might actually be radiation-damage-induced changes, and finally a review describing what X-ray radiation-induced cysteine modifications can teach us about protein dynamics and catalysis. These papers, along with some other relevant literature published since the last Journal of Synchrotron Radiation Radiation Damage special issue in 2017, are briefly summarized below.

An alternative approach to hard-X-ray photoelectron spectroscopy (HAXPES) has been established. The instrumental key feature is an increase of the dimensionality of the recording scheme from 2D to 3D. A high-energy momentum microscope detects electrons with initial kinetic energies up to 8 keV with a k-resolution of 0.025 Å−1, equivalent to an angular resolution of 0.034°. A special objective lens with k-space acceptance up to 25 Å−1 allows for simultaneous full-field imaging of many Brillouin zones. Combined with time-of-flight (ToF) parallel energy recording this yields maximum parallelization. Thanks to the high brilliance (1013 hν s−1 in a spot of <20 µm diameter) of beamline P22 at PETRA III (Hamburg, Germany), the microscope set a benchmark in HAXPES recording speed, i.e. several million counts per second for core-level signals and one million for d-bands of transition metals. The concept of tomographic k-space mapping established using soft X-rays works equally well in the hard X-ray range. Sharp valence band k-patterns of Re, collected at an excitation energy of 6 keV, correspond to direct transitions to the 28th repeated Brillouin zone. Measured total energy resolutions (photon bandwidth plus ToF-resolution) are 62 meV and 180 meV FWHM at 5.977 keV for monochromator crystals Si(333) and Si(311) and 450 meV at 4.0 keV for Si(111). Hard X-ray photoelectron diffraction (hXPD) patterns with rich fine structure are recorded within minutes. The short photoelectron wavelength (10% of the interatomic distance) `amplifies' phase differences, making full-field hXPD a sensitive structural tool.

SVAT4 is a computer program for interactive visualization of three-dimensional crystal structures, including chemical bonds and magnetic moments. A wide range of functions, e.g. revealing atomic layers and polyhedral clusters, are available for further structural analysis. Atomic sizes, colors, appearance, view directions and view modes (orthographic or perspective views) are adjustable. Customized work for the visualization and analysis can be saved and then reloaded. SVAT4 provides a template to simplify the process of preparation of a new data file. SVAT4 can generate high-quality images for publication and animations for presentations. The usability of SVAT4 is broadened by a software suite for simulation and analysis of electron diffraction patterns.

Serial crystallography is a powerful technique in structure determination using many small crystals at X-ray free-electron laser or synchrotron radiation facilities. The large diffraction data volumes require high-throughput software to preprocess the raw images for subsequent analysis. ClickX is a program designated for serial crystallography data preprocessing, capable of rapid data sorting for online feedback and peak-finding refinement by parameter optimization. The graphical user interface (GUI) provides convenient access to various operations such as pattern visualization, statistics plotting and parameter tuning. A batch job module is implemented to facilitate large-data-volume processing. A two-step geometry calibration for single-panel detectors is also integrated into the GUI, where the beam center and detector tilting angles are optimized using an ellipse center shifting method first, then all six parameters, including the photon energy and detector distance, are refined together using a residual minimization method. Implemented in Python, ClickX has good portability and extensibility, so that it can be installed, configured and used on any computing platform that provides a Python interface or common data file format. ClickX has been tested in online analysis at the Pohang Accelerator Laboratory X-ray Free-Electron Laser, Korea, and the Linac Coherent Light Source, USA. It has also been applied in post-experimental data analysis. The source code is available via https://github.com/LiuLab-CSRC/ClickX under a GNU General Public License.

SVAT4 is a computer program for interactive visualization of three-dimensional crystal structures. A wide range of functions are available for structural analysis.

The Smithsonian’s National Air and Space Museum announced that it will receive a $6 million donation from the Thomas W. Haas Foundation to establish an […]

The post Air and Space Museum receives $6 million donation for Public Observatory Program appeared first on Smithsonian Insider.

With roughly 5,500 individuals remaining in the wild, the black rhino population is critically endangered. To help save these iconic African giants, at risk for […]

The post A Planet in Peril: Q&A with Suzan Murray of the Smithsonian Global Health Program appeared first on Smithsonian Insider.

Kasun Buddika, Ishara S. Ariyapala, Mary A. Hazuga, Derek Riffert, and Nicholas S. Sokol

Stressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Extensively characterized in cultured cells, the existence of such structures in stressed adult stem cell pools remain poorly characterized. Here we report that Drosophila orthologs of mammalian SG components AGO1, ATX2, CAPRIN, eIF4E, FMRP, G3BP, LIN-28, PABP, and TIAR are enriched in adult intestinal progenitor cells where they accumulate in small cytoplasmic messenger ribonucleoprotein complexes (mRNPs). Treatment with sodium arsenite or rapamycin reorganized these mRNPs into large cytoplasmic granules. Formation of these intestinal progenitor stress granules (IPSGs) depended on polysome disassembly, led to translational downregulation, and was reversible. While canonical SG nucleators ATX2 and G3BP were sufficient for IPSG formation in the absence of stress, neither of them, nor TIAR, either individually or collectively, were required for stress-induced IPSG formation. This work therefore finds that IPSGs do not assemble via a canonical mechanism, raising the possibility that other stem cell populations employ a similar stress-response mechanism.

Members of the Human Origins Program team at the Smithsonian's National Museum of Natural History describe why they love their job.

The post Human Origins Program team members at the National Museum of Natural History on why they love their job appeared first on Smithsonian Insider.

A team from the Smithsonian is starting a pilot program to aid people in restoring their damaged family heirlooms. Click photo to learn more….

The post Smithsonian starts program to help people restore storm-damaged heirlooms appeared first on Smithsonian Insider.

Residents of the southeastern United States might occasionally come across an oddity along a barbed-wire fence: a series of insects, mice or even small birds […]

The post Tiny, fierce and disappearing: breeding program aims to help the loggerhead shrike appeared first on Smithsonian Insider.

(The Paypers) Forter has released the seventh edition of its Fraud Attack Index, tracking shifting behaviours...

By expending too many resources to inspect cleaner low-emitting vehicles, coupled with a lack of effective ways to deal with the dirtiest ones, states are missing opportunities to reduce air pollution.

Although the federal program that sets fuel economy standards for cars and light-duty trucks has helped reduce U.S. dependence on imported oil and lower emissions of greenhouse gases, changes to the program could further cut the nations petroleum dependence and provide more flexibility to carmakers.

The National Research Council today released its assessment of U.S. doctoral programs, which includes data on over 5,000 programs in 62 fields at 212 universities nationwide.

Despite being used for several decades, test-based incentives have not consistently generated positive effects on student achievement, says a new report from the National Research Council.

As the gap in life expectancy between the highest and lowest earners in the U.S. has widened over time, high earners have disproportionately received larger lifetime benefits from government programs such as Social Security and Medicare, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

A new report from the National Academies of Sciences, Engineering, and Medicine says that Medicare’s value-based payment programs could take into account social risk factors – such as low socio-economic position, residence in disadvantaged neighborhoods, or race and ethnicity – but any proposal to do so will entail both advantages and disadvantages that need to be carefully considered.

A new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine proposes updated revisions to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) to better align with the Dietary Guidelines for Americans and promote and support breast-feeding.

The U.S. Global Change Research Program (USGCRP) has made significant accomplishments to advance the science of global environmental change and improve the understanding of its impact on society through activities such as developing Earth-observing systems, improving Earth-system modeling capabilities, and advancing understanding of carbon-cycle processes, says a new report from the National Academies of Sciences, Engineering, and Medicine.